- Inhibition of acetaminophen-induced hepatotoxicity in mice by exogenous thymosinβ4 treatment. [Journal Article]
- IIInt Immunopharmacol 2018 May 21; 61:20-28
- CONCLUSIONS: Exogenous Tβ4 treatment exerts protective effects against APAP-induced hepatotoxicity in mice. The underneath molecular mechanisms may involve autophagy enhancement and inhibition of oxidative stress by Tβ4.
- [Experimental promotion of liver regeneration after portal vein branch ligation]. [Journal Article]
- RCRozhl Chir 2018; 97(5):239-245
- CONCLUSIONS: Application of IL-6, TNF-α, MAB TGF-β1 and MSC seems to provide suitable stimulation for achieving faster FLRV growth. Nevertheless, many controversial questions still remain to be answered with respect to the mechanism of their respective effects.Key words: liver regeneration portal vein embolization large animal experiment mesenchymal stem cells cytokines.
- [Sinusoidal obstruction syndrome induced by monocrotaline in a large animal experiment - a pilot study]. [Journal Article]
- RCRozhl Chir 2018; 97(5):214-221
- CONCLUSIONS: We established a large animal model of SOS induced by monocrotaline administration (36 mg/kg via portal vein). This model can contribute to research of therapeutic modalities for this disease or to evaluation of surgical treatment of patients with SOS.Key words: sinusoidal obstruction syndrome monocrotaline oxaliplatin hepatotoxicity experimental model.
- Human memory reconsolidation: A guiding framework and critical review of the evidence. [Journal Article]
- PBPsychol Bull 2018 May 24
- Research in nonhuman animals suggests that reactivation can induce a transient, unstable state in a previously consolidated memory, during which the memory can be disrupted or modified, necessitating...
Research in nonhuman animals suggests that reactivation can induce a transient, unstable state in a previously consolidated memory, during which the memory can be disrupted or modified, necessitating a process of restabilization in order to persist. Such findings have sparked a wave of interest into whether this phenomenon, known as reconsolidation, occurs in humans. Translating research from animal models to human experiments and even to clinical interventions is an exciting prospect, but amid this excitement, relatively little work has critically evaluated and synthesized existing research regarding human memory reconsolidation. In this review, we formalize a framework for evaluating and designing studies aiming to demonstrate human memory reconsolidation. We use this framework to shed light on reconsolidation-based research in human procedural memory, aversive and appetitive memory, and declarative memory, covering a diverse selection of the most prominent examples of this research, including studies of memory updating, retrieval-extinction procedures, and pharmacological interventions such as propranolol. Across different types of memory and procedure, there is a wealth of observations consistent with reconsolidation. Moreover, some experimental findings are already being translated into clinically relevant interventions. However, there are a number of inconsistent findings, and the presence of alternative explanations means that we cannot conclusively infer the presence of reconsolidation at the neurobiological level from current evidence. Reconsolidation remains a viable but hotly contested explanation for some observed changes in memory expression in both humans and animals. Developing effective and efficient new reconsolidation-based treatments can be a goal that unites researchers and guides future experiments. (PsycINFO Database Record
- Economic Impact of Aging on the Initial Spine Care of Patients With Acute Spine Trauma: From Bedside to Teller. [Journal Article]
- NNeurosurgery 2018 May 22
- CONCLUSIONS: Given the escalating demand for surgical and nonsurgical spine treatment in the age of aging population, the timely results of this study underline key aspects of the economic impact of the spine care of the elderly. Further investigations are needed to fulfill significant knowledge gaps on the economics of caring for elderly with AST.
- A review of novel technologies and techniques associated with identification of bloodstream infection aetiologies and rapid antimicrobial genotypic and quantitative phenotypic determination. [Journal Article]
- ERExpert Rev Mol Diagn 2018 May 23
- Introduction The antimicrobial aspect of management of patients with blood stream infections (BSI) and sepsis is time critical. In an era of increasing antimicrobial resistance, rapid detection and i...
Introduction The antimicrobial aspect of management of patients with blood stream infections (BSI) and sepsis is time critical. In an era of increasing antimicrobial resistance, rapid detection and identification of bacteria with antimicrobial susceptibility is crucial to direct therapy early in the course of illness. Molecular techniques offer a potential solution to this. Areas covered In the present review the authors have discussed a number of novel solutions utilising a variety of molecular techniques for pathogen detection, identification and antimicrobial susceptibility. The review is not designed to cover all solutions ever developed or be an exhaustive literature review, instead the authors have focused on what they have had experience using or currently view as new and exciting with potential to revolutionise BSI diagnosis. The authors searched PubMed (Medline) and Google Scholar with terms: BSI, Bacteraemia, Candidaemia, Diagnostics, AST, Rapid, AMR and Blood Culture. The authors attended recent clinical microbiology technology congresses. Expert commentary There are multiple exciting novel technologies at differing stages of development with potential to revolutionise diagnosis of BSI. More work is needed, as well as a standardised assessment of different platforms in order to better understand the clinical and financial impacts these will have in microbiology laboratories.
- Growth performance, blood parameters, carcass characteristics and meat quality traits in Potchefstroom Koekoek chickens fed Lippia javanica leaf meal. [Journal Article]
- TATrop Anim Health Prod 2018 May 22
- Lippia javanica leaves may have nutraceutical bioactivity and thus could be a viable alternative to antibiotic growth promoters in poultry diets. To test this hypothesis, a feeding trial was carried ...
Lippia javanica leaves may have nutraceutical bioactivity and thus could be a viable alternative to antibiotic growth promoters in poultry diets. To test this hypothesis, a feeding trial was carried out to determine the effects of dietary inclusion of Lippia javanica leaf meal (LJ) on growth performance, blood parameters, carcass characteristics and meat quality of indigenous Potchefstroom Koekoek (PK) chickens. The leaf meal was used to dilute a commercial chicken grower diet at a rate of 25 or 50 g/kg diet. Two additional experimental diets, a positive control (commercial chicken grower diet with antibiotics, CON+) and a negative control (commercial chicken grower diet without antibiotics, CON-), were also formulated. Feed intake and growth performance were measured over a period of 13 weeks before slaughtering for carcass and meat quality measurements. Blood was collected in week 11 to determine haematological and serum biochemical parameters. Diet had no effect on overall FCE but significantly (P < 0.05) affected bilirubin, alanine aminotransferase (ALT), aspartate transaminase (AST), sodium, potassium, cholesterol and magnesium levels in blood. When included at 50 g/kg, LJ increased carcass weight (P < 0.05). Meat from CON- (6.07) and LJ50 (6.08) chickens had a higher pH than from CON+ (5.9) and LJ25 (5.8) chickens. Breast muscle in CON- chickens had higher (P < 0.05) lightness (L*) value (53.2) compared to chickens fed on other diets. It was observed that meat from LJ25 chickens had the highest for redness value (2.3). It was concluded that L. javanica leaf meal can be included up to 50 g/kg in Potchefstroom koekoek chicken diets without causing negative effects on the birds' feed intake, utilisation and weight gain. Diet-induced changes observed in blood parameters and meat quality fell within the expected normal ranges for indigenous chickens.
- Carnosic Acid Impedes Cell Growth and Enhances Anti-cancer Effects of Carmustine and Lomustine in Melanoma. [Journal Article]
- BRBiosci Rep 2018 May 22
- Background: Carnosic acid (CA), a major polyphenolic diterpene present in Rosmarinus officinalis , has been reported to have multiple functions, including anti-tumor activity. Methods: The MTT assa...
Background: Carnosic acid (CA), a major polyphenolic diterpene present in Rosmarinus officinalis , has been reported to have multiple functions, including anti-tumor activity. Methods: The MTT assay, BrdU incorporation, wound healing, and colony formation were used to detect melanoma B16F10 cell growth and proliferation. Flow cytometry was used for cell cycle detection. p21 and p27 expression was detected by Western blotting. B16F10 cell xenograft model was established, and treated with CA, carmustine (BCNU), or lomustine (CCNU). Results: This study finds that CA exhibits significant growth inhibition and cell cycle arrest in melanoma B16F10 cells. We also find that CA triggers cell cycle arrest at G0/G1 phase, and enhances p21 expression. Additionally, CA can enhance BCNU- and CCNU-mediated cytotoxicity and cell cycle arrest in B16F10 cells. Finally, we find that CA inhibits tumor growth, and reduces the values of aspartate aminotransferase (AST) and alanine aminotransferase (ALT) in vivoConclusion: This study concludes that CA may be safe and useful as a novel chemotherapeutic agent.
- Safety of pazopanib and sunitinib in treatment-naive patients with metastatic renal cell carcinoma: Asian versus non-Asian subgroup analysis of the COMPARZ trial. [Journal Article]
- JHJ Hematol Oncol 2018 May 22; 11(1):69
- CONCLUSIONS: A distinct pattern and severity of adverse events was observed in Asians when compared with non-Asians with both pazopanib and sunitinib. However, the two drugs were well tolerated in both subpopulations.
New Search Next
- [EFFECT OF STAPHYLO CO CCAL PEPTID O GLYCAN ON OSTEO CL AST DIFFERENTIATION]. [Journal Article]
- ZXZhongguo Xiu Fu Chong Jian Wai Ke Za Zhi 2016 Aug 08; 30(8):1006-1010
- CONCLUSIONS: PGN-sa can promote raw264.7 cells to differentiate into osteoclasts with bone resorption activity.