- Case report: Severe hepatic fibrosis induced by chronic cholestasis of congenital biliary dilation treated by laparoscopic surgery after immunonutrition support- An infantile case. [Case Reports]Front Pediatr. 2022; 10:1101000.FP
- CONCLUSIONS: Severe liver fibrosis was suspected to be continuous cholestasis of CBD after birth. CBD with severe liver fibrosis may avoid liver transplantation by two-stage surgery with hepatoprotection therapy and immunonutritional support.
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- Blood biochemical parameters of Murrah buffalo (Bubalus bubalis) reared in the high salinity area of Bangladesh. [Journal Article]J Adv Vet Anim Res. 2022 Dec; 9(4):736-742.JA
- CONCLUSIONS: The blood parameters that were measured and remained within reference ranges show that Murrah buffaloes can adapt to saline water with little to no impairment to their liver and renal functions. The differences in the ages and sexes of the animals within the study groups highlight that mature female buffaloes suffer more from skin disorders and attempt to adjust to exotic conditions by changing the functioning of their liver and kidney.
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- Association between periodontitis and periodontal indices in newly diagnosed bronchial asthma. [Journal Article]J Adv Periodontol Implant Dent. 2022; 14(2):97-103.JA
- Background. Periodontitis is an inflammatory disease of the tooth-supporting structures. Current data suggest that periodontal disease may be a risk factor for asthma. The present study aimed to assess the prevalence of periodontitis and its relationship with the severity of asthma in asthmatic patients. Methods. This study was conducted on 70 newly diagnosed asthmatic patients as the case group …
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- Beta-Lactamase-Producing Gram-Negative Bacterial Isolates Among the Patients Attending a Tertiary Care Hospital, Kathmandu, Nepal. [Journal Article]Microbiol Insights. 2023; 16:11786361221150761.MI
- Over the times, carbapenems have been the choice of drug for treating multidrug-resistant (MDR) and extended spectrum beta-lactamase (ESBL)-producing organisms. The current study aimed at determining the occurrence of metallo beta-lactamase (MBL) and AmpC beta-lactamase (ABL) in gram negative bacteria isolated from clinical samples. A cross-sectional study was conducted amongst the patients visit…
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- The mitigative effect of lotus root (Nelumbo nucifera Gaertn) extract on acute alcoholism through activation of alcohol catabolic enzyme, reduction of oxidative stress, and protection of liver function. [Journal Article]Front Nutr. 2022; 9:1111283.FN
- CONCLUSIONS: The results of the current study showed that the methanolic extract of lotus root had the highest activation rate of ethanol dehydrogenase. Network pharmacology results suggest that lotus root extract may play a role in the treatment of alcoholism by regulating signaling pathways, such as neuroactive ligand-receptor interactions, as well as biological processes, such as regulation of secretion, regulation of ion transport, response to lipopolysaccharides, and response to alcohol. Animal experiments confirmed the therapeutic effect of lotus root on acute alcoholism mechanistically through activation of alcohol catabolic enzyme, reduction of oxidative stress and protection of liver function.
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- Adipokine levels and their association with clinical disease severity in patients with dengue. [Preprint]medRxiv. 2023 Jan 09M
- Adipokines have not been studied in acute dengue, despite their emerging role in inducing and regulating inflammation. Therefore, we sought to identify adipokine levels in patients with varying severities of acute dengue to understand their role in disease pathogenesis. We determined the levels of leptin, resistin, omentin, adiponectin, as well as IFNβ, and NS1 using quantitative ELISA in patient…
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- MicroRNA-mediated regulation of reactive astrocytes in central nervous system diseases. [Review]Front Mol Neurosci. 2022; 15:1061343.FM
- Astrocytes (AST) are abundant glial cells in the human brain, accounting for approximately 20-50% percent of mammalian central nervous system (CNS) cells. They display essential functions necessary to sustain the physiological processes of the CNS, including maintaining neuronal structure, forming the blood-brain barrier, coordinating neuronal metabolism, maintaining the extracellular environment…
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- Biosynthesized magnesium oxide nanoparticles from Tamarindus indica seed attenuate doxorubicin-induced cardiotoxicity by regulating biochemical indexes and linked genes. [Journal Article]Biomater Adv. 2023 Jan 18; 146:213291.BA
- The phytochemicals of Tamarindus indica seed hydroalcoholic extract were exploited as a biocatalyst for the sustainable synthesis of magnesium oxide nanoparticles (MgO-NPs). This research investigated the cardioprotective effects of biosynthesized magnesium oxide nanoparticle (MgO-NPs). The biosynthesized seed MgO-NPs were characterized by ultraviolet-visible spectroscopy (UV-Vis), X-ray diffract…
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- Risk factor analysis and a new prediction model of venous thromboembolism after pancreaticoduodenectomy. [Journal Article]BMC Surg. 2023 Jan 28; 23(1):25.BS
- CONCLUSIONS: The novel model developed in this study is highly targeted and enables personalized assessment of VTE occurrence in patients who undergo PD. The predictors are easily accessible and facilitate the assessment of patients by clinical practitioners.
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- Deficiency of NLR family member NLRC5 alleviates alcohol induced hepatic injury and steatosis by enhancing autophagy of hepatocytes. [Journal Article]Toxicol Appl Pharmacol. 2023 Jan 25 [Online ahead of print]TA
- Steatosis is regarded as an early response of the liver to excessive alcohol consumption, which ultimately results in alcoholic liver disease (ALD). Hepatocytes are the primary drivers of the pathological process known as hepatic damage and steatosis, which is characterized by significant fat accumulation and an abundance of fat vacuoles. NLRs, a family member of pattern recognition receptors, ha…
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- Hepatoprotective Effect of Morin Hydrate in Type 2 Diabetic Wistar Rats Exposed to Diesel Exhaust Particles. [Journal Article]Appl Biochem Biotechnol. 2023 Jan 28 [Online ahead of print]AB
- Studies have shown that exposure to air pollutants such as diesel exhaust particles (DEP) exacerbate diabetes complications. Morin hydrate (MH), a plant bioflavonoid, provides hepatoprotection due to its diverse pharmacological properties. This study examines the hepatoprotective effects of MH in Wistar rats with type 2 diabetes exposed to diesel exhaust (DE). Procured male Wistar rats (n = 60) w…
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- Toxicity bioassay and sub-lethal effects of profenofos-based insecticide on behavior, biochemical, hematological, and histopathological responses in Grass carp (Ctenopharyngodon idella). [Journal Article]Ecotoxicology. 2023 Jan 28 [Online ahead of print]E
- Profenofos (organophosphate) is among the major toxicant polluting freshwater bodies, exerting a significant effect on fish health. The LC50 value of Profenofos (PRO) was resolved in Grass carp (Ctenopharyngodon idella) with average body weight (55.82 ± 5.42 g) and determined the 96 h LC50 value as 7.2 µg/L for the assay. Twenty-one-day exposures to 1.8 µg/ L and 3.6 µg/ L doses were conducted to…
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- Changes in the content of Puerarin-PLGA nanoparticles in mice under the influence of alcohol and analysis of their antialcoholism. [Journal Article]J Appl Biomater Funct Mater. 2023 Jan-Dec; 21:22808000221148100.JA
- To observe the metabolic changes and antialcoholic effect of Puerarin-PLGA nanoparticles (PUE-NP) in mice. PUE-NP was prepared and characterized by particle size distribution and morphology. The mouse models with acute alcoholism were established to observe their behavioral changes after alcohol poisoning. The expressions of biologically active enzymes such as CRE, BUN, AST, ALT in serum and SOD …
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- Supplementation with sesame oil suppresses genotoxicity, hepatotoxicity and enterotoxicity induced by sodium arsenite in rats. [Journal Article]Lipids Health Dis. 2023 Jan 27; 22(1):14.LH
- CONCLUSIONS: Our data indicated that SSO protected the liver, colon and bone marrow potentially via anti-inflammatory and anti-apoptotic activities. The data suggest that sesame oil has potential therapeutic applications against chemical toxicities induced by arsenic.
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- Effects of acute heat stress on haemato-biochemical parameters, oxidative resistance ability, and immune responses of hybrid yellow catfish (pelteobagrus fulvidraco × P. vachelli) juveniles. [Journal Article]Vet Res Commun. 2023 Jan 28 [Online ahead of print]VR
- This study investigated the effect of heat stress on the physiological parameters, oxidation resistance ability and immune responses in juvenile hybrid yellow catfish. Heat stress group exposed to 35 °C and control to 28 °C. Blood and liver were sampled at different hours' post-exposure. Results showed that red blood cell (RBC), white blood cell (WBC) counts, Hemoglobin (HGB) levels and hematocri…
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- In vitro activity of ceftobiprole and dalbavancin against a collection of coagulase-negative staphylococci isolates from clinical samples with reduced susceptibility to daptomycin and/or resistant to linezolid or glycopeptides. [Journal Article]Enferm Infecc Microbiol Clin (Engl Ed). 2023 Jan 25 [Online ahead of print]EI
- CONCLUSIONS: Ceftobiprole and dalbavancin demonstrated a high in vitro activity against our collection of CoNS isolates.
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- Predicting Post-operative Anemia and Blood Transfusion Following Total Knee Arthroplasty. [Journal Article]J Arthroplasty. 2023 Jan 24 [Online ahead of print]JA
- CONCLUSIONS: The post-operative anemia and blood transfusion model accurately predicted each outcome. Patients with less than a 5% probability of post-operative anemia may not benefit from a complete blood count (CBC) at post-operative day one. Application of this criteria may save the healthcare system hundreds of millions of dollars.
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- Immune response gene 1 deficiency aggravates high fat diet-induced nonalcoholic fatty liver disease via promotion of redox-sensitive AKT suppression. [Journal Article]Biochim Biophys Acta Mol Basis Dis. 2023 Jan 24 [Online ahead of print]BB
- Nonalcoholic fatty liver disease (NAFLD) is the most common chronic liver disorder worldwide. Immune response gene 1 (IRG1) catalyzes the production of bio-active itaconate, which is actively involved in the regulation of signal transduction. A recent study has found that the expression of IRG1 was significantly down-regulated in obesity-associated fatty liver, but the potential roles of IRG1 in …
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- Effect of high-pathogenicity island (HPI) on TGF-β1/Smad3 pathway in mouse model of E. coli strains causing diarrhea in calf. [Journal Article]Res Vet Sci. 2022 Sep 22; 156:1-6.RV
- CONCLUSIONS: The study concludes that E. coli HPI induced and enhanced the over expression of TGF-β1/Smad3 pathway and ultimately caused pathological anomalies.
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- The Influence of the FFAR4 Agonist TUG-891 on Liver Steatosis in ApoE-Knockout Mice. [Journal Article]Cardiovasc Drugs Ther. 2023 Jan 27 [Online ahead of print]CD
- CONCLUSIONS: Pharmacological stimulation of FFAR4 may represent a promising lead in the search for drugs that inhibit NAFLD.
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- 3D-EPI blip-up/down acquisition (BUDA) with CAIPI and joint Hankel structured low-rank reconstruction for rapid distortion-free high-resolution T 2 * mapping. [Journal Article]Magn Reson Med. 2023 Jan 27 [Online ahead of print]MR
- CONCLUSIONS: The proposed technique enables rapid 3D distortion-free high-resolution imaging and T 2 * $$ {\mathrm{T}}_2^{\ast } $$ mapping. Specifically, 3D-BUDA enables 1-mm isotropic whole-brain imaging in 22 s at 3T and 9 s on a 7T scanner. The combination of multi-echo 3D-BUDA with CAIPI acquisition and joint reconstruction enables distortion-free whole-brain T 2 * $$ {\mathrm{T}}_2^{\ast } $$ mapping in 47 s at 1.1 × 1.1 × 1.0 mm3 resolution.
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- Liver injury on admission linked to worse outcomes in COVID-19: an analysis of 14,138 patients. [Journal Article]
- CONCLUSIONS: Routine liver chemistry testing should be implemented and used for risk stratification at the time of COVID-19 diagnosis.
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- Impact of baseline abnormal liver enzymes in the outcome of COVID-19 infection. [Journal Article]
- CONCLUSIONS: LFT abnormalities are frequently seen in COVID-19 patients, reflect SARS-CoV-2 associated inflammation and may predict adverse outcomes. LFT may be useful to aid decision-making in the ED for hospital admission or scheduled outpatient reevaluation.
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- The Effects of Sunitinib in Healthy and Cisplatin-Induced Rats. [Journal Article]Chem Biodivers. 2023 Jan 26 [Online ahead of print]CB
- Sunitinib is a multitargeted kinase inhibitor that inhibits many receptor tyrosine kinases and has been used in the treatment of gastrointestinal stromal tumors, metastatic renal cell carcinoma, and pancreatic neuroendocrine tumors. In this study, the effects of sunitinib given to rats, both alone and after stress with cisplatin, were investigated. The animals were divided into four groups - (1) …
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- Cluster randomized control trial to reduce peer victimization: An autonomy-supportive teaching intervention changes the classroom ethos to support defending bystanders. [Journal Article]Am Psychol. 2023 Jan 26 [Online ahead of print]AP
- Peer victimization is a worldwide crisis unresolved by 50 years of research and intervention. We capitalized on recent methodological advances and integrated self-determination theory with a social-ecological perspective. We provided teachers with a professional development experience to establish a highly supportive classroom climate that enabled the emergence of pro-victim student bystanders du…
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- Cardiac Resynchronization Therapy Improves Outcomes in Patients With Intraventricular Conduction Delay But Not Right Bundle Branch Block: A Patient-Level Meta-Analysis of Randomized Controlled Trials. [Journal Article]Circulation. 2023 Jan 26 [Online ahead of print]Circ
- CONCLUSIONS: CRT is associated with reduced HFH or death in patients with QRS ≥150 ms and LBBB or IVCD, but not for those with RBBB. Aggregating RBBB and IVCD into a single "non-LBBB" category when selecting patients for CRT should be reconsidered.
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- Comparison of efficacy of anti-diabetics on non-diabetic NAFLD: A network meta-analysis. [Systematic Review]Front Pharmacol. 2022; 13:1096064.FP
- CONCLUSIONS: In accordance with the Network Ranking plot, Rosiglitazone was the best anti-diabetic medicine for improving ALT, and vildagliptin was the best for improving AST in patients with non-diabetic NAFLD.
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- Contrast Sensitivity and Patient Reported Outcomes After Bilateral Implantation of a Bi-Aspheric Hydrophobic Trifocal Diffractive Intraocular Lens. [Journal Article]Clin Ophthalmol. 2023; 17:247-258.CO
- CONCLUSIONS: This novel bi-aspheric diffractive trifocal IOL provides good contrast sensitivity outcomes under bright and dim lighting conditions. Patients were satisfied with the surgery, with no relevant visual symptoms.
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- Novel models for early prediction and prevention of acute respiratory distress syndrome in patients following hepatectomy: A clinical translational study based on 1,032 patients. [Journal Article]Front Med (Lausanne). 2022; 9:1025764.FM
- CONCLUSIONS: We reported the incidence of ARDS in patients undergoing hepatectomy and developed two simple and practical prediction models for early predicting postoperative ARDS in patients undergoing hepatectomy. These tools may improve clinicians' ability to early estimate the risk of postoperative ARDS and timely prevent its emergence.
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- Design of a multicenter randomized clinical trial for treatment of Alcohol-Associated Hepatitis. [Journal Article]Contemp Clin Trials Commun. 2023 Apr; 32:101074.CC
- CONCLUSIONS: The study provided a direct comparison of the survival benefits and safety profiles of anakinra plus zinc vs. prednisone in patients with severe AH.
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