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11,488 results
  • [Hepatotoxicity and mechanism of Rhododendri Mollis Flos based on zebrafish model]. [Journal Article]
    Zhongguo Zhong Yao Za Zhi. 2023 Jan; 48(1):140-147.Chen ML, Li ZQ, … Zhao CJ
  • This study used the zebrafish model to explore the hepatotoxicity of Rhododendri Mollis Flos(RMF). The mortality was calculated according to the number of the survival of zebrafish larvae 4 days after fertilization under different concentration of RMF, and the dose-toxicity curve was fitted to preliminarily evaluate the toxicity of RMF. The liver phenotypes under the sublethal concentration of RM…
  • Psoralen induces liver injury and affects hepatic bile acids metabolism in female and male C57BL/6J mice. [Journal Article]
    Phytother Res. 2023 Feb 01 [Online ahead of print]Chen MY, Wang Q, … Zhou K
  • Psoralen is a major component of Fructus Psoraleae that could induce liver injury. In this study, C57BL/6J mice were administered with psoralen at doses of 80 mg/kg for 3, 7 and 14 days. Blood and liver samples were collected for serum biochemistry and histopathology examinations, respectively. Psoralen led to liver injury with significantly increased liver weight and liver coefficient and up reg…
  • [A real-world study of the effects of endocrine therapy on liver function in breast cancer]. [Journal Article]
    Zhonghua Wai Ke Za Zhi. 2023 Feb 01; 61(2):107-113.Li YC, Deng ZX, … Shen SJ
  • Objective: To compare the effect of different endocrine therapy drugs on liver function in patients with early breast cancer. Methods: A retrospective cohort study was conducted to include 4 318 patients with early breast cancer who received adjuvant endocrine therapy in Department of Breast Surgery, Peking Union Medical College Hospital from January 1, 2013 to December 31, 2021. All the patients…
  • InP/ZnS quantum dots cause liver damage in rare minnow (Gobiocypris rarus) larvae. [Journal Article]
    Comp Biochem Physiol C Toxicol Pharmacol. 2023 Jan 27 [Online ahead of print]Chen H, Wu Y, … Jin L
  • InP/ZnS quantum dots (QDs) are widely used in biomedical imaging and light-emitting component manufacturing industries, but there are few studies on their biological toxicity. In this study, we conducted experiments with rare minnow larvae and found that InP/ZnS QDs can cause liver damage. InP/ZnS QDs appeared only in the intestine of larvae and were not enriched in other parts of the larvae. The…
  • Hepatoprotective Effect of Morin Hydrate in Type 2 Diabetic Wistar Rats Exposed to Diesel Exhaust Particles. [Journal Article]
    Appl Biochem Biotechnol. 2023 Jan 28 [Online ahead of print]Folorunso IM, Lawal AO, … Iwaloye O
  • Studies have shown that exposure to air pollutants such as diesel exhaust particles (DEP) exacerbate diabetes complications. Morin hydrate (MH), a plant bioflavonoid, provides hepatoprotection due to its diverse pharmacological properties. This study examines the hepatoprotective effects of MH in Wistar rats with type 2 diabetes exposed to diesel exhaust (DE). Procured male Wistar rats (n = 60) w…
  • The Effects of Sunitinib in Healthy and Cisplatin-Induced Rats. [Journal Article]
    Chem Biodivers. 2023 Jan 26 [Online ahead of print]Demirtas L, Gürbüzel M, … Kemal Arslan Y
  • Sunitinib is a multitargeted kinase inhibitor that inhibits many receptor tyrosine kinases and has been used in the treatment of gastrointestinal stromal tumors, metastatic renal cell carcinoma, and pancreatic neuroendocrine tumors. In this study, the effects of sunitinib given to rats, both alone and after stress with cisplatin, were investigated. The animals were divided into four groups - (1) …
  • Curcumin-resveratrol nano-formulation counteracting hyperammonemia in rats. [Journal Article]
    Metab Brain Dis. 2023 Jan 25 [Online ahead of print]Nasr M, Ahmed-Farid OAH, Ahmed RF
  • Malnutrition and low dietary protein intake could be risk factors for developing peripheral and central hyperammonemia, especially in pediatrics. Both curcumin and resveratrol proved to be effective against several hepatic and cerebral injuries. They were reported to be beneficial in lowering circulating ammonia levels, yet both are known for their low bioavailability. The use of pharmaceutical n…
  • Hypertransaminasemia in cancer patients receiving immunotherapy and immune-based combinations: the MOUSEION-05 study. [Review]
    Cancer Immunol Immunother. 2023 Jan 25 [Online ahead of print]Rizzo A, Mollica V, … Massari F
  • CONCLUSIONS: According to our results, ICIs monotherapy and immune-based combinations were associated with higher risk of all-grade and grade 3-4 hypertransaminasemia. Monitoring liver function should be recommended in cancer patients treated with ICIs monotherapy or immune-based combination, and in case of underlying liver disease, a careful risk-benefit assessment appears as a mandatory need.
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