- Swimming exercise reduces oxidative stress and liver damage indices of male rats exposed to electromagnetic radiation. [Journal Article]Life Sci. 2023 Jan 30 [Online ahead of print]LS
- CONCLUSIONS: The study findings showed that the SE is beneficial in attenuating the harmful effects of RF-EMR emitted from the Wi-Fi on the liver.
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- High fat diet is protective against kidney injury in hypertensive-diabetic mice, but leads to liver injury. [Journal Article]PLoS One. 2023; 18(2):e0281123.Plos
- Chronic kidney disease (CKD) is a worldwide health burden with increases risk of end-stage renal function if left untreated. CKD induced in the context of metabolic syndrome (MS) increases risks of hypertension, hyperglycemia, excess body fat and dyslipidemia. To test if combining a high-fat diet (HFD) regimen onto the hypertensive/ diabetic phenotype would mimic features of MS induced-CKD in mic…
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- Neutrophil Depletion Attenuates Acute Liver Stress after Exhaustive Exercise in Mice. [Journal Article]Med Sci Sports Exerc. 2022 Dec 09 [Online ahead of print]MS
- CONCLUSIONS: These results suggested that neutrophils play a critical role in increasing liver stress by regulating inflammation.
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- Effects of maternal cigarette smoke exposure on the progression of nonalcoholic steatohepatitis in offspring mice. [Journal Article]
- Cigarette smoke (CS) is a dominant carcinogenic agent in a variety of human cancers. CS exposure during pregnancy can adversely affect the fetus. Non-alcoholic fatty liver disease (NAFLD) is considered as a hepatic manifestation of a metabolic disorder, and ranges from simple steatosis to cirrhosis leading to hepatocellular carcinoma. Non-alcoholic steatohepatitis (NASH) is a more severe phase of…
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- [Hepatotoxicity and mechanism of Rhododendri Mollis Flos based on zebrafish model]. [Journal Article]Zhongguo Zhong Yao Za Zhi. 2023 Jan; 48(1):140-147.ZZ
- This study used the zebrafish model to explore the hepatotoxicity of Rhododendri Mollis Flos(RMF). The mortality was calculated according to the number of the survival of zebrafish larvae 4 days after fertilization under different concentration of RMF, and the dose-toxicity curve was fitted to preliminarily evaluate the toxicity of RMF. The liver phenotypes under the sublethal concentration of RM…
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- [Zuogui Jiangtang Qinggan Prescription promotes recovery of intestinal mucosal barrier in mice with type 2 diabetes mellitus and nonalcoholic fatty liver disease by improving intestinal flora homeostasis]. [Journal Article]Zhongguo Zhong Yao Za Zhi. 2023 Jan; 48(2):525-533.ZZ
- This study aimed to investigate the recovery effect of Zuogui Jiangtang Qinggan Prescription on intestinal flora homeostasis control and intestinal mucosal barrier in type 2 diabetes mellitus(T2DM) with nonalcoholic fatty liver disease(NAFLD) induced by a high-fat diet. NAFLD was established in MKR transgenic mice(T2DM mice) by a high-fat diet(HFD), and subsequently treated for 8 weeks with Zuogu…
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- Psoralen induces liver injury and affects hepatic bile acids metabolism in female and male C57BL/6J mice. [Journal Article]Phytother Res. 2023 Feb 01 [Online ahead of print]PR
- Psoralen is a major component of Fructus Psoraleae that could induce liver injury. In this study, C57BL/6J mice were administered with psoralen at doses of 80 mg/kg for 3, 7 and 14 days. Blood and liver samples were collected for serum biochemistry and histopathology examinations, respectively. Psoralen led to liver injury with significantly increased liver weight and liver coefficient and up reg…
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- Biochemical Analysis of the Blood of Cattle after Vaccination with a Heterologous Vaccine for Lumpy Skin Disease. [Journal Article]Bull Exp Biol Med. 2023 Feb 01 [Online ahead of print]BE
- We studied the biochemical parameters of the blood of cattle after immunization against lumpy skin disease with a vaccine made from an attenuated heterologous goat pox virus (strain G20-LKV). Blood samples were obtained from animals on days 7, 14, and 21 after vaccination. The vaccine did not affect biochemical parameters of the blood. A slight increase in total protein and AST on day 14 indicate…
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- Impact of protein supply on the productive performance of growing lambs drinking natural saline water and fed low-quality forage under semi-arid conditions. [Journal Article]
- Consuming saline water causes animals salinity stress, which leads to many adapting metabolic changes that could negatively affect its performance and the quality of the derived products. Therefore, this study aimed to evaluate the impact of increasing diet protein level on the productive performance of growing lambs drinking natural saline water in Egyptian semi-arid region. Twenty-four growing …
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- Reduced Peripheral Blood Mitochondrial DNA Copy Number as Identification Biomarker of Suspected Arsenic-Induced Liver Damage. [Journal Article]Biol Trace Elem Res. 2023 Jan 31 [Online ahead of print]BT
- Arsenic (As) can cause liver damage and liver cancer and is capable of seriously affecting human health. Therefore, it is important to identify biomarkers of arsenic-induced liver damage. Mitochondria are key targets of hepatotoxicity caused by arsenic. The mitochondrial DNA copy number (mtDNAcn) is the number of mitochondrial DNA (mtDNA) copies in the genome. mtDNA is vulnerable to exogenous che…
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- [A real-world study of the effects of endocrine therapy on liver function in breast cancer]. [Journal Article]Zhonghua Wai Ke Za Zhi. 2023 Feb 01; 61(2):107-113.ZW
- Objective: To compare the effect of different endocrine therapy drugs on liver function in patients with early breast cancer. Methods: A retrospective cohort study was conducted to include 4 318 patients with early breast cancer who received adjuvant endocrine therapy in Department of Breast Surgery, Peking Union Medical College Hospital from January 1, 2013 to December 31, 2021. All the patients…
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- Factors Associated with Liver Fibrosis in Chinese Patients with Type 2 Diabetes Mellitus and Non-Alcoholic Fatty Liver Disease. [Journal Article]
- CONCLUSIONS: For T2DM patients combined with NAFLD, older age, higher SBP, higher ALT, higher GGT, lower LDL, and lower PLT were relevant factors for LF.
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- Protective effect of dendropanoxide against cadmium-induced hepatotoxicity via anti-inflammatory activities in Sprague-Dawley rats. [Journal Article]Toxicol Mech Methods. 2023 Jan 30 [Online ahead of print]TM
- Cadmium (Cd) accumulates in the body through contaminated foods or water and causes pathological damage to the liver via oxidative stress and inflammatory reactions. This study was conducted to explore the effects of dendropanoxide (DPx) on Cd-induced hepatotoxicity in rats. Sprague-Dawley (SD) rats were injected with CdCl2 (7 mg/kg body weight) intraperitoneally for 14 days for the induction of …
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- Systematic Analysis of the Mechanism of Polygoni Multiflori Caulis in Improving Depressive Disorder in Mice via Network Pharmacology Combined with Ultra-High Performance Liquid Chromatography Coupled with Quadrupole Exactive Orbitrap Mass Spectrometer. [Journal Article]Comb Chem High Throughput Screen. 2023 Jan 30 [Online ahead of print]CC
- CONCLUSIONS: PMC is a relatively safe antidepressant herbal medicine with its potential mechanism involving multiple compounds, targets, and pathways.
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- Mu opioid receptor alleviated ferroptosis in hepatic ischemia reperfusion injury via the HIF-1α/KCNQ1OT1 axis. [Journal Article]Am J Physiol Cell Physiol. 2023 Jan 30 [Online ahead of print]AJ
- CONCLUSIONS: MOR alleviated ferroptosis in HIRI via the HIF-1α/KCNQ1OT1 axis.
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- InP/ZnS quantum dots cause liver damage in rare minnow (Gobiocypris rarus) larvae. [Journal Article]Comp Biochem Physiol C Toxicol Pharmacol. 2023 Jan 27 [Online ahead of print]CB
- InP/ZnS quantum dots (QDs) are widely used in biomedical imaging and light-emitting component manufacturing industries, but there are few studies on their biological toxicity. In this study, we conducted experiments with rare minnow larvae and found that InP/ZnS QDs can cause liver damage. InP/ZnS QDs appeared only in the intestine of larvae and were not enriched in other parts of the larvae. The…
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- Phosphoethanolamine cytidyltransferase ameliorates mitochondrial function and apoptosis in hepatocytes in T2DM in vitro. [Journal Article]J Lipid Res. 2023 Jan 27 [Online ahead of print]JL
- Liver function indicators are often impaired in patients with type 2 diabetes mellitus (T2DM), who present higher concentrations of aspartate aminotransferase (AST), alanine aminotransferase (ALT), and gamma-glutamyl transferase (GGT) than individuals without diabetes. However, the mechanism of liver injury in patients with T2DM has not been clearly elucidated. In this study, we performed a lipid…
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- The mitigative effect of lotus root (Nelumbo nucifera Gaertn) extract on acute alcoholism through activation of alcohol catabolic enzyme, reduction of oxidative stress, and protection of liver function. [Journal Article]
- CONCLUSIONS: The results of the current study showed that the methanolic extract of lotus root had the highest activation rate of ethanol dehydrogenase. Network pharmacology results suggest that lotus root extract may play a role in the treatment of alcoholism by regulating signaling pathways, such as neuroactive ligand-receptor interactions, as well as biological processes, such as regulation of secretion, regulation of ion transport, response to lipopolysaccharides, and response to alcohol. Animal experiments confirmed the therapeutic effect of lotus root on acute alcoholism mechanistically through activation of alcohol catabolic enzyme, reduction of oxidative stress and protection of liver function.
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- Deficiency of NLR family member NLRC5 alleviates alcohol induced hepatic injury and steatosis by enhancing autophagy of hepatocytes. [Journal Article]Toxicol Appl Pharmacol. 2023 Jan 26; 461:116406.TA
- Steatosis is regarded as an early response of the liver to excessive alcohol consumption, which ultimately results in alcoholic liver disease (ALD). Hepatocytes are the primary drivers of the pathological process known as hepatic damage and steatosis, which is characterized by significant fat accumulation and an abundance of fat vacuoles. NLRs, a family member of pattern recognition receptors, ha…
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- Hepatoprotective Effect of Morin Hydrate in Type 2 Diabetic Wistar Rats Exposed to Diesel Exhaust Particles. [Journal Article]Appl Biochem Biotechnol. 2023 Jan 28 [Online ahead of print]AB
- Studies have shown that exposure to air pollutants such as diesel exhaust particles (DEP) exacerbate diabetes complications. Morin hydrate (MH), a plant bioflavonoid, provides hepatoprotection due to its diverse pharmacological properties. This study examines the hepatoprotective effects of MH in Wistar rats with type 2 diabetes exposed to diesel exhaust (DE). Procured male Wistar rats (n = 60) w…
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- Toxicity bioassay and sub-lethal effects of profenofos-based insecticide on behavior, biochemical, hematological, and histopathological responses in Grass carp (Ctenopharyngodon idella). [Journal Article]Ecotoxicology. 2023 Jan 28 [Online ahead of print]E
- Profenofos (organophosphate) is among the major toxicant polluting freshwater bodies, exerting a significant effect on fish health. The LC50 value of Profenofos (PRO) was resolved in Grass carp (Ctenopharyngodon idella) with average body weight (55.82 ± 5.42 g) and determined the 96 h LC50 value as 7.2 µg/L for the assay. Twenty-one-day exposures to 1.8 µg/ L and 3.6 µg/ L doses were conducted to…
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- Changes in the content of Puerarin-PLGA nanoparticles in mice under the influence of alcohol and analysis of their antialcoholism. [Journal Article]J Appl Biomater Funct Mater. 2023 Jan-Dec; 21:22808000221148100.JA
- To observe the metabolic changes and antialcoholic effect of Puerarin-PLGA nanoparticles (PUE-NP) in mice. PUE-NP was prepared and characterized by particle size distribution and morphology. The mouse models with acute alcoholism were established to observe their behavioral changes after alcohol poisoning. The expressions of biologically active enzymes such as CRE, BUN, AST, ALT in serum and SOD …
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- Supplementation with sesame oil suppresses genotoxicity, hepatotoxicity and enterotoxicity induced by sodium arsenite in rats. [Journal Article]
- CONCLUSIONS: Our data indicated that SSO protected the liver, colon and bone marrow potentially via anti-inflammatory and anti-apoptotic activities. The data suggest that sesame oil has potential therapeutic applications against chemical toxicities induced by arsenic.
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- Effects of acute heat stress on haemato-biochemical parameters, oxidative resistance ability, and immune responses of hybrid yellow catfish (pelteobagrus fulvidraco × P. vachelli) juveniles. [Journal Article]Vet Res Commun. 2023 Jan 28 [Online ahead of print]VR
- This study investigated the effect of heat stress on the physiological parameters, oxidation resistance ability and immune responses in juvenile hybrid yellow catfish. Heat stress group exposed to 35 °C and control to 28 °C. Blood and liver were sampled at different hours' post-exposure. Results showed that red blood cell (RBC), white blood cell (WBC) counts, Hemoglobin (HGB) levels and hematocri…
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- Effect of high-pathogenicity island (HPI) on TGF-β1/Smad3 pathway in mouse model of E. coli strains causing diarrhea in calf. [Journal Article]Res Vet Sci. 2022 Sep 22; 156:1-6.RV
- CONCLUSIONS: The study concludes that E. coli HPI induced and enhanced the over expression of TGF-β1/Smad3 pathway and ultimately caused pathological anomalies.
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- Liver injury on admission linked to worse outcomes in COVID-19: an analysis of 14,138 patients. [Journal Article]
- CONCLUSIONS: Routine liver chemistry testing should be implemented and used for risk stratification at the time of COVID-19 diagnosis.
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- The Effects of Sunitinib in Healthy and Cisplatin-Induced Rats. [Journal Article]Chem Biodivers. 2023 Jan 26 [Online ahead of print]CB
- Sunitinib is a multitargeted kinase inhibitor that inhibits many receptor tyrosine kinases and has been used in the treatment of gastrointestinal stromal tumors, metastatic renal cell carcinoma, and pancreatic neuroendocrine tumors. In this study, the effects of sunitinib given to rats, both alone and after stress with cisplatin, were investigated. The animals were divided into four groups - (1) …
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- Curcumin-resveratrol nano-formulation counteracting hyperammonemia in rats. [Journal Article]Metab Brain Dis. 2023 Jan 25 [Online ahead of print]MB
- Malnutrition and low dietary protein intake could be risk factors for developing peripheral and central hyperammonemia, especially in pediatrics. Both curcumin and resveratrol proved to be effective against several hepatic and cerebral injuries. They were reported to be beneficial in lowering circulating ammonia levels, yet both are known for their low bioavailability. The use of pharmaceutical n…
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- Hypertransaminasemia in cancer patients receiving immunotherapy and immune-based combinations: the MOUSEION-05 study. [Review]Cancer Immunol Immunother. 2023 Jan 25 [Online ahead of print]CI
- CONCLUSIONS: According to our results, ICIs monotherapy and immune-based combinations were associated with higher risk of all-grade and grade 3-4 hypertransaminasemia. Monitoring liver function should be recommended in cancer patients treated with ICIs monotherapy or immune-based combination, and in case of underlying liver disease, a careful risk-benefit assessment appears as a mandatory need.
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- Protective effect of omega-3 polyunsaturated fatty acids on sepsis via the AMPK/mTOR pathway. [Journal Article]
- CONCLUSIONS: ω-3 PUFAs ameliorated sepsis development by activating the AMPK/mTOR pathway, serving as a potent therapeutic agent for sepsis. Further in vivo studies may validate potential clinical use.
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