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11,315 results
  • Optimum timing of antithymocyte globulin in relation to adoptive regulatory T cell therapy. [Journal Article]
    Am J Transplant. 2023 Jan; 23(1):84-92.Muckenhuber M, Mucha J, … Wekerle T
  • Reducing the recipient's T cell repertoire is considered to increase the efficacy of regulatory T cell (Treg) therapy. This necessitates timing the administration of antithymocyte globulin (ATG) early enough before adoptive cell therapy (ACT) so that residual serum ATG does not deplete the transferred Tregs. The optimum time point in this regard has not been defined. Herein, we report the effects…
  • Vacuolar Processing Enzymes in Plant Programmed Cell Death and Autophagy. [Review]
    Int J Mol Sci. 2023 Jan 07; 24(2)Wleklik K, Borek S
  • Vacuolar processing enzymes (VPEs) are plant cysteine proteases that are subjected to autoactivation in an acidic pH. It is presumed that VPEs, by activating other vacuolar hydrolases, are in control of tonoplast rupture during programmed cell death (PCD). Involvement of VPEs has been indicated in various types of plant PCD related to development, senescence, and environmental stress responses. A…
  • Prolonged use of eltrombopag in patients with severe aplastic anemia in the real world. [Journal Article]
    Clin Exp Med. 2023 Jan 16 [Online ahead of print]Li R, Wang N, … Li J
  • Eltrombopag (EPAG) can improve the efficacy of immunosuppressive therapy (IST) consisting of antithymocyte immunoglobulin (ATG) and cyclosporin in severe aplastic anemia (SAA) patients. This study explored whether patients with SAA could benefit from continuous usage of EPAG beyond 6 months.Seventy-four treatment-naive Chinese patients with SAA were administrated with rabbit ATG-based IST plus EP…
  • Graphene oxide nanoarchitectures in cancer biology: Nano-modulators of autophagy and apoptosis. [Review]
    J Control Release. 2023 Jan 19; 354:503-522.Taheriazam A, Abad GGY, … Hushmandi K
  • Nanotechnology is a growing field, with many potential biomedical applications of nanomedicine for the treatment of different diseases, particularly cancer, on the horizon. Graphene oxide (GO) nanoparticles can act as carbon-based nanocarriers with advantages such as a large surface area, good mechanical strength, and the capacity for surface modification. These nanostructures have been extensive…
  • The therapeutic potential of arctigenin against multiple human diseases: A mechanistic review. [Review]
    Phytomedicine. 2023 Feb; 110:154647.Wang G, Ge L, … Chen L
  • CONCLUSIONS: Inhibition of PI3K/AKT pathway and activation of AMPK signaling play the pivotal roles in the therapeutic effects of ATG. PI3K/AKT and AMPK signaling widely link to other signaling pathways, modulating various biological processes such as anti-inflammation, anti-oxidative stress, anti-fibrosis, anti-ER stress, anti-steatosis and pro-apoptosis, which constitute the curative mechanisms of ATG against multiple human diseases.
  • Autophagy and longevity: Evolutionary hints from hyper-longevous mammals. [Review]
    Front Endocrinol (Lausanne). 2022; 13:1085522.Locatelli AG, Cenci S
  • Autophagy is a fundamental multi-tasking adaptive cellular degradation and recycling strategy. Following its causal implication in age-related decline, autophagy is currently among the most broadly studied and challenged mechanisms within aging research. Thanks to these efforts, new cellular nodes interconnected with this phylogenetically ancestral pathway and unexpected roles of autophagy-associ…
  • Betulinic acid may modulate autophagy in renal cell carcinoma cells. [Journal Article]
    Bratisl Lek Listy. 2023; 124(2):104-108.Atas MN, Ertugrul B, … Ergen A
  • CONCLUSIONS: In our preliminarily study, it was concluded that the role of autophagy may differ in renal cell carcinoma cells depending on their origin and that the effects of betulinic acid on autophagy in these cells may vary accordingly (Fig. 4, Ref. 40). Text in PDF Keywords: betulinic acid, autophagy, kidney, cancer, cell.
  • Lipid kinase PIK3C3 maintains healthy brown and white adipose tissues to prevent metabolic diseases. [Journal Article]
    Proc Natl Acad Sci U S A. 2023 Jan 03; 120(1):e2214874120.Song W, Postoak JL, … Van Kaer L
  • Adequate mass and function of adipose tissues (ATs) play essential roles in preventing metabolic perturbations. The pathological reduction of ATs in lipodystrophy leads to an array of metabolic diseases. Understanding the underlying mechanisms may benefit the development of effective therapies. Several cellular processes, including autophagy and vesicle trafficking, function collectively to maint…
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