- Co-delivery of gemcitabine and paclitaxel plus NanoCpG empowers chemoimmunotherapy of postoperative "cold" triple-negative breast cancer. [Journal Article]Bioact Mater. 2023 Jul; 25:61-72.BM
- Triple-negative breast cancer (TNBC) due to lack of clear target and notorious "cold" tumor microenvironment (TME) is one of the most intractable and lethal malignancies. Tuning "cold" TME into "hot" becomes an emerging therapeutic strategy to TNBC. Herewith, we report that integrin-targeting micellar gemcitabine and paclitaxel (ATN-mG/P, ATN sequence: Ac-PhScNK-NH2) cooperating with polymersomal…
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- Discriminative accuracy of the A/T/N scheme to identify cognitive impairment due to Alzheimer's disease. [Journal Article]Alzheimers Dement (Amst). 2023 Jan-Mar; 15(1):e12390.AD
- The optimal combination of amyloid-β/tau/neurodegeneration (A/T/N) biomarker profiles for the diagnosis of Alzheimer's disease (AD) dementia is unclear.
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- Complete mitochondrial genome data and phylogenetic analysis of the Great Marquis, Bassarona dunya (Doubleday, 1848) (Lepidoptera: Nymphalidae: Limenitidinae) from Malaysia. [Journal Article]Mitochondrial DNA B Resour. 2023; 8(1):167-171.MD
- The Great Marquis or Bassarona dunya is a butterfly species commonly found in the tropical regions of Asia, America, and Africa. This butterfly is a member of the subfamily Limenitidinae and the classification within this subfamily has been unstable. Here, we report the first complete mitochondrial genome (mitogenome) of B. dunya sampled from Malaysia. The mitogenome is 15,242 bp long, comprising…
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- Euthyroid sick syndrome and its association with complications of type 1 diabetes mellitus onset. [Journal Article]
- CONCLUSIONS: ESS is associated with T1DM onset severity and spontaneously disappears. ESS delayed the recovery from AKI.
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- Phylogenomics including the newly sequenced mitogenomes of two moths (Noctuoidea, Erebidae) reveals Ischyja manlia (incertae sedis) as a member of subfamily Erebinae. [Journal Article]Genetica. 2023 Jan 28 [Online ahead of print]G
- We sequenced the mitogenomes of two Erebid species, namely Ischyja manlia (Cramer, 1776) and Rusicada privata (Walker, 1865) to analyse the phylogenetic relationship and to establish the taxonomic position of incertae sedis members of the family Erebidae. The two circular genomes of I. manlia and R. privata were 15,879 bp and 15,563 bp long, respectively. The gene order was identical, containing …
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- Lower semantic fluency scores and a phonemic-over-semantic advantage predict abnormal CSF P-tau181 levels in Aβ + patients within the Alzheimer's disease clinical spectrum. [Journal Article]Neurol Sci. 2023 Jan 27 [Online ahead of print]NS
- CONCLUSIONS: SVF and the SPD are able to predict tauopathy across the AD spectrum, thus supporting their status of valid, and sufficiently specific, cognitive markers of AD.
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- Are we facing an increasing surgical demand for high myopic traction maculopathies? A 12-year study from Hong Kong. [Journal Article]
- CONCLUSIONS: We observe an increase in the number of surgically operated MTM. This follows the trend of the global rise in the prevalence of myopia and baby boomers entering retirement.
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- Characterization of the complete mitochondrial genome sequence of Smerinthus caecus (Lepidoptera: Sphingidae). [Journal Article]
- In this study, we sequenced and analyzed the complete mitogenome of Smerinthus caecus Ménétriés, 1857. The mitogenome of S. caecus is a circular structure, and 15,363 bp long in size and encodes 13 protein-coding genes (PCGs), two ribosomal RNA genes (rRNAs), 22 transfer RNA genes (tRNAs), and a control region (CR). An extremely high AT bias of 79.2% was found in the nucleotide composition of mit…
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- The mitochondrial genome of Dendroctonus rufipennis (Kirby, 1837) (Coleoptera: Curculionidae: Scolytinae) and its phylogenetic analyses. [Journal Article]
- The mitogenome of Dendroctonus rufipennis is a circular molecule of 16,547 bp which consists of 13 protein-coding genes (PCGs), 22 transfer RNA genes, two ribosomal RNA genes, and a control region (GenBank accession no. NC_063906). All of 13 PCGs initiate with the standard start codon of ATN. Most PCGs used the typical stop codon 'TAA' or 'TAG', only nad5 terminated with incomplete stop codon (TA…
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- The Synergic Effect of AT(N) Profiles and Depression on the Risk of Conversion to Dementia in Patients with Mild Cognitive Impairment. [Journal Article]
- Few studies have addressed the impact of the association between Alzheimer's disease (AD) biomarkers and NPSs in the conversion to dementia in patients with mild cognitive impairment (MCI), and no studies have been conducted on the interaction effect of these two risk factors. AT(N) profiles were created using AD-core biomarkers quantified in cerebrospinal fluid (CSF) (normal, brain amyloidosis, …
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- Trade for Food Security: The Stability of Global Agricultural Trade Networks. [Journal Article]
- Global food production is facing increasing uncertainties under climate change and the coronavirus pandemic, provoking challenges and severe concerns to national food security. The role of global agricultural trade in bridging the imbalance between food supply and demand has come to the fore. However, the impact of multifaceted and dynamic factors, such as trade policies, national relations, and …
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- Complete Mitochondrial Genome of Scolytoplatypodini Species (Coleoptera: Curculionidae: Scolytinae) and Phylogenetic Implications. [Journal Article]
- The complete mitochondrial genomes (mitogenomes) of beetles in the tribe Scolytoplatypodini (genus Scolytoplatypus) were sequenced and annotated. These included Scolytoplatypus raja (15,324 bp), Scolytoplatypus sinensis (15,394 bp), Scolytoplatypus skyliuae (15,167 bp), and Scolytoplatypus wugongshanensis (15,267 bp). The four mitogenomes contained 37 typical genes, including 13 protein-coding ge…
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- ATN GRADING SYSTEM IN A DOME-SHAPED MACULA AND RIDGE-SHAPED MACULA HIGHLY MYOPIC COHORT. [Journal Article]Ophthalmologica. 2023 Jan 18 [Online ahead of print]O
- CONCLUSIONS: DSM group showed more Bruch´s membrane defects and a greater stage of the atrophy component, based on the ATN grading system, compared with RSM group. As Bruch´s membrane may have biomechanical properties in terms of strength, the defects found around the macula, added to the major atrophic component, may be a cause of a local relaxation that induce a central bulge forming the dome.
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- Role of Enlarged Perivascular Space in the Temporal Lobe in Cerebral Amyloidosis. [Journal Article]Ann Neurol. 2023 Jan 18 [Online ahead of print]AN
- CONCLUSIONS: Investigating the burden and topographic distribution of EPVS including T-EPVS may be useful for predicting amyloid status, indicating that impaired perivascular drainage may contribute to cerebral amyloidosis. This article is protected by copyright. All rights reserved.
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- The complete mitochondrial genome and novel gene arrangement in Nesodiprion zhejiangensis Zhou & Xiao (Hymenoptera: Diprionidae). [Journal Article]Funct Integr Genomics. 2023 Jan 18; 23(1):41.FI
- The complete mitochondrial genome (mitogenome) of the sawfly, Nesodiprion zhejiangensis Zhou & Xiao, was sequenced, assembled, and deposited in GenBank (Accession Number: OM501121). The 15,660 bp N. zhejiangensis mitogenome encodes for 2 ribosomal RNAs (rrnL and rrnS), 22 transfer RNAs (tRNAs), 13 protein-coding genes (PCGs), and an AT-rich region of 450 bp in length. The nucleotide composition i…
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- Tau as a biomarker of cognitive impairment and neuropsychiatric symptom in Alzheimer's disease. [Journal Article]
- The A/T/N research framework has been proposed for the diagnosis and prognosis of Alzheimer's disease (AD). However, the spatial distribution of ATN biomarkers and their relationship with cognitive impairment and neuropsychiatric symptoms (NPS) need further clarification in patients with AD. We scanned 83 AD patients and 38 cognitively normal controls who independently completed the mini-mental s…
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- Fluid biomarkers in Alzheimer's disease. [Review]Adv Clin Chem. 2023; 112:249-281.AC
- Alzheimer's disease (AD) characterization has progressed from being indexed using clinical symptomatology followed by neuropathological examination at autopsy to in vivo signatures using cerebrospinal fluid (CSF) biomarkers and positron emission tomography. The core AD biomarkers reflect amyloid-β plaques (A), tau pathology (T) and neurodegeneration (N), following the ATN schedule, and are now be…
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- The mitochondrial genome of Binodoxys acalephae (Hymenoptera: Braconidae) with unique gene rearrangement and phylogenetic implications. [Journal Article]Mol Biol Rep. 2023 Jan 13 [Online ahead of print]MB
- CONCLUSIONS: The arrangement of mitochondrial genes and the phylogenetic relationships among nine Braconidae subfamilies were constructed better to understand the diversity and evolution of Aphidiinae mitogenomes.
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- Comparative mitochondrial genomics and phylogenetics for species of the snakehead genus Channa Scopoli, 1777 (Perciformes: Channidae). [Journal Article]Gene. 2023 Jan 07; 857:147186.GENE
- The family Channidae, members of which are commonly known as snakehead fish, includes 53 Channa species and three Parachanna species. In this study, we characterized mitochondrial genomes (mitogenomes) of five Channa species (C. andrao, C. bleheri, C. ornatipinnis, C. pulchra, and C. stewartii) for the first time. We compared the mitogenomes with the mitogenomes of 11 other Channidae fish. The ne…
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- Neuropsychological Assessment in the Distinction Between Biomarker Defined Frontal-Variant of Alzheimer's Disease and Behavioral-Variant of Frontotemporal Dementia. [Journal Article]J Alzheimers Dis. 2023 Jan 03 [Online ahead of print]JA
- CONCLUSIONS: In patients with an early prominent frontal profile, a higher impairment in attention and visuo-spatial functions, signaling additional right hemisphere fronto-parietal dysfunction, point towards a diagnosis of fvAD-dementia and may be useful in clinical practice.
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- Revisiting the Phylogenetic Relationship and Evolution of Gargarini with Mitochondrial Genome (Hemiptera: Membracidae: Centrotinae). [Journal Article]
- In this study, we newly sequenced and analyzed the complete mitochondrial genomes of five genera and six species in Gargarini: Antialcidas floripennae, Centrotoscelus davidi, Kotogargara minuta, Machaerotypus stigmosus, Tricentrus fulgidus, and Tricentrus gammamaculatus. The mitochondrial genomes contain 13 protein-coding genes, two ribosomal RNA genes, 22 transfer RNA genes, and a contr…
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- The first complete mitochondrial genome sequences for Ulidiidae and phylogenetic analysis of Diptera. [Journal Article]Mol Biol Rep. 2023 Jan 06 [Online ahead of print]MB
- CONCLUSIONS: The phylogenetic relationship of T. sintenisi based on the mitogenome is consistent with the traditional morphological taxonomy, according to which T. sintenisi belongs to the family Otitidae, which is closely related to the family Muscidae.
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- Complete chloroplast genomes and comparative analysis of Ligustrum species. [Journal Article]
- In this study, we assembled and annotated the chloroplast (cp) genomes of four Ligustrum species, L. sinense, L. obtusifolium, L. vicaryi, and L. ovalifolium 'Aureum'. Including six other published Ligustrum species, we compared various characteristics such as gene structure, sequence alignment, codon preference, and nucleic acid diversity, and performed positive-selection genes screening and phy…
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- Eighteen mitochondrial genomes of Syrphidae (Insecta: Diptera: Brachycera) with a phylogenetic analysis of Muscomorpha. [Journal Article]
- In this study, 18 mitochondrial genomes (mitogenomes) of Syrphidae were sequenced. These mitogenomes ranged from 15,648 to 16,405 bp and contained 37 genes that were similar to those from other Syrphidae species. Most protein-coding genes (PCGs) started with a standard ATN codon and ended with TAA/G. All transfer RNAs (tRNAs) could be folded into the cloverleaf secondary structure except tRNA-Ser…
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- Effects of geometric individualisation of a human spine model on load sharing: neuro-musculoskeletal simulation reveals significant differences in ligament and muscle contribution. [Journal Article]Biomech Model Mechanobiol. 2023 Jan 05 [Online ahead of print]BM
- In spine research, two possibilities to generate models exist: generic (population-based) models representing the average human and subject-specific representations of individuals. Despite the increasing interest in subject specificity, individualisation of spine models remains challenging. Neuro-musculoskeletal (NMS) models enable the analysis and prediction of dynamic motions by incorporating a…
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- Surgical management of atypical trigeminal neuralgia secondary to tentorial meningioma: 2D video. [Case Reports]
- CONCLUSIONS: The postoperative period was excellent, without any neurological deficit. The patient consented with publication of her images and videos.
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- Dynamic changes of CSF clusterin levels across the Alzheimer's disease continuum. [Journal Article]
- CONCLUSIONS: Our results indicated that there are differences levels of CSF clusterin in different stages of AD pathology. The CSF clusterin level decreased at the early stage are related to abnormal Aβ pathology; and the increased levels are associated with tau pathology and neurodegeneration.
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- Assessment of perfusion deficit with early phases of [18F]PI-2620 tau-PET versus [18F]flutemetamol-amyloid-PET recordings. [Journal Article]Eur J Nucl Med Mol Imaging. 2022 Dec 27 [Online ahead of print]EJ
- CONCLUSIONS: The early perfusion phases of [18F]PI-2620 tau- and [18F]flutemetamol-amyloid-PET are roughly equivalent indices of perfusion defect indicative of regional and lobar neuronal injury in patients with various neurodegenerative diseases. As such, either tracer may serve for two diagnostic channels by assessment of amyloid/tau status and neuronal activity.
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- Brain-derived tau: a novel blood-based biomarker for Alzheimer's disease-type neurodegeneration. [Journal Article]
- Blood-based biomarkers for amyloid beta and phosphorylated tau show good diagnostic accuracies and agreements with their corresponding CSF and neuroimaging biomarkers in the amyloid/tau/neurodegeneration [A/T/(N)] framework for Alzheimer's disease. However, the blood-based neurodegeneration marker neurofilament light is not specific to Alzheimer's disease while total-tau shows lack of correlation…
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- Hippocampal subfield volumetry in corticobasal syndrome of diverse underlying pathologies. [Journal Article]J Neurol. 2022 Dec 24 [Online ahead of print]JN
- CONCLUSIONS: CBS-AD and amnestic AD patients exhibit comparable, and significantly greater hippocampal atrophy compared to CBS-nAD patients. Hippocampal subfield volumetry in CBS is indicative of an AD underlying pathology.
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