- GSH-PEGylated liposomal methylprednisolone in comparison to free methylprednisolone: slow release characteristics and prolonged lymphocyte depression in a first-in-human study. [Journal Article]
- BJBr J Clin Pharmacol 2018 Jan 31
- CONCLUSIONS: 2B3-201 is considered safe, with no clinically relevant changes in (CNS) safety parameters and no serious adverse events. In addition, 2B3-201 shows a long plasma half-life and prolonged immunosuppressive effects.
- Lessons learned from administration of high-dose methylprednisolone sodium succinate for acute pediatric spinal cord injuries. [Journal Article]
- JNJ Neurosurg Pediatr 2017; 20(6):567-574
- CONCLUSIONS: High-dose MPSS for ASCI was not delivered to pediatric patients according to protocol with a high degree of reliability. Patients receiving steroids for pediatric ASCI were significantly more likely to experience complications than patients not receiving steroids. The findings presented, including complications of steroid use, support removal of high-dose MPSS as a treatment option for pediatric ASCI.
- Patient med TBE förbättrades snabbt vid behandling med kortison - Evidens saknas dock för värdet av immunmodulerande terapi. [Case Reports]
- LLakartidningen 2017 Jun 16; 114
- Rapid improvement of tick-borne encephalitis after treatment with corticosteroids Tick-borne encephalitis (TBE) is a viral disease transmitted by ticks. The virus is divided into three subtypes named...
Rapid improvement of tick-borne encephalitis after treatment with corticosteroids Tick-borne encephalitis (TBE) is a viral disease transmitted by ticks. The virus is divided into three subtypes named Western, Siberian and Far Eastern TBE virus (TBEV). Western TBEV is endemic in parts of Europe and Sweden and typically causes a biphasic illness with influenza-like symptoms followed by neurological symptoms ranging from mild meningitis to severe meningoencephalitis and death. Despite an effective vaccine, TBE is increasing in Sweden and Europe. The pathogenesis of TBE is poorly understood; direct infection of neurons as well as immunological reactions mediated by T-cells have been implicated. In some endemic areas, such as Lithuania, patients with TBE are given corticosteroids based on the clinical experience that it results in rapid improvement. However, existing retrospective studies have failed to show beneficial effects of corticosteroids compared to symptomatic treatment in patients with TBE. This case report describes how an elderly man with meningoencephalitis and cranial nerve palsy due to TBE rapidly improved after administration of high dose corticosteroids.
- [A particular type of cicatricial Pemphigoid with unique IgA deposit]. [Case Reports]
- PAPan Afr Med J 2017; 26:136
- Cicatricial Pemphigoid is a subepithelial bullous dermatosis which essentially involves the mucous membranes with cicatricial evolution We report the case of a 66-year old patient hospitalized with e...
Cicatricial Pemphigoid is a subepithelial bullous dermatosis which essentially involves the mucous membranes with cicatricial evolution We report the case of a 66-year old patient hospitalized with erosive gingivitis associated with dysphagia, dyspnea and blurred vision. Dermatologic examination showed erosive lesions involving the palate and the pharynx. Ophthalmologic examination showed symblepharons, ectropion and bilateral cataract. Gingival biopsy revealed a necrotic detachment of the buccal epithelium. Direct immunofluorescence showed linear IgA deposit at the dermo-epidermal junction. Indirect immunofluorescence test was negative. The diagnosis of cicatricial pemphigoid was confirmed. Esophagogastroduodenoscopy objectified double stenosis of the esophagus. Nasopharyngeal and bronchial endoscopy showed ulceration of the epiglottis, hypopharynx, pharynx and bronchial tree. The patient was treated with Solumedrol bolus corresponding to 0.5mg/kg/day prednisone associated with 100mg/day disulone. The patient showed a favorable early clinical outcome complicated because of the aggravation of dysphagia and esophageal stenosis after 2 months. Our case study is singular due to the occurrence of a cicatricial pemphigoid in a male patient with a serious clinical picture due to lesions extending to conjunctival, oral, nasal, esophageal and bronchial mucous membranes associated with direct immunofluorescence only showing IgA deposit.
- Anaphylaxie induite par des médicaments. [Journal Article]
- SDSwiss Dent J 2017; 127(4):324-325
- Anaphylaxis is defined as a serious allergic or hypersensitivity reaction in the most cases as a result of an IgE-mediated allergic reaction that is rapid in onset and may cause death. Common trigger...
Anaphylaxis is defined as a serious allergic or hypersensitivity reaction in the most cases as a result of an IgE-mediated allergic reaction that is rapid in onset and may cause death. Common triggers are foods, insect stings, and medications. The medical treatment includes, epinephrine, glucocorticoids, antihistamines and inhaled bronchodilators, with the aim to prevent progression to life-threatening respiratory and/or cardiovascular symptoms.
- Acute transverse myelitis in a pediatric patient. [Case Reports]
- AJAm J Emerg Med 2017; 35(7):1034.e3-1034.e4
- A Rare and Fatal Case of Viral Encephalitis in an Immunocompetent Host. [Case Reports]
- AJAm J Med Sci 2017; 353(2):194-195
- Ocular Surface Epithelial Atypia Mimicking Squamous Neoplasia in Association With Ulcerative Colitis. [Case Reports]
- CCornea 2017; 36(4):502-505
- CONCLUSIONS: Severe ocular surface epithelial atypia resembling OSSN may be seen in association with UC.
- Nicolau Syndrome. [Case Reports]
- AIArch Iran Med 2017; 20(1):60-64
- A 23 year-old man was admitted to the hospital with chief complaints of pain, edema and spasm of the left lower limb, as well as mottling of dorsal and plantar aspects of the foot. One week before t...
A 23 year-old man was admitted to the hospital with chief complaints of pain, edema and spasm of the left lower limb, as well as mottling of dorsal and plantar aspects of the foot. One week before the current admission, he was treated with oral co-amoxiclave and intramuscular penicillin 6.3.3. Immediately after the third injection, he experienced burning and yellowish discoloration at the site of the injection wich then progressed to his leg and foot. Pain, significant edema, spasm and mottling occurred within 30 minutes of the injection. The patient was referred to the hospital after 36 hours from the beginning of the symptoms. Color Doppler sonography revealed no impairment in the lower extremity flow and the common femoral artery, superficial femoral, popliteal, dorsalis pedis and posterior tibialis arteries were normal. Superficial probe sonography detected mild effusion in the left ankle without collection.
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- Double trouble: tPA-induced angioedema. [Case Reports]
- PMPostgrad Med J 2017; 93(1096):103-104