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Unbound Medicine.
(A hydroCort)
83,475 results
  • Immune checkpoint inhibitor-mediated hypophysitis: no place like home. [Journal Article]
    Clin Med (Lond). 2023 Jan; 23(1):81-84.Cooksley T, Knight T, … Adam S
  • Ambulatory emergency care forms a fundamental part of the strategy of trying to ensure safe and sustainable acute care services. Immune checkpoint inhibitor(ICI)-mediated hypophysitis is an important life-threatening complication of therapy. Patients presenting with clinical features and findings consistent with ICI-mediated hypophysitis were considered in the current study. In the absence of sev…
  • Reporting of Social Determinants of Health in Pediatric Sepsis Studies. [Journal Article]
    Pediatr Crit Care Med. 2023 Jan 25 [Online ahead of print]Menon K, Sorce LR, … Pediatric Sepsis Definition Taskforce are as follows
  • CONCLUSIONS: We found overall low reporting of SDOH and marked variability in categorizations and definitions of SDOH variables. Consistent and standardized reporting of SDOH in pediatric sepsis studies is needed to understand the role these factors play in the development and severity of sepsis, to compare and extrapolate study results between settings and to implement policies aimed at improving socioeconomic conditions related to sepsis.
  • Influence of sex on the requirement for and outcomes following late postnatal corticosteroid treatment. [Journal Article]
    Eur J Pediatr. 2023 Jan 24 [Online ahead of print]Lee R, Kostina E, … Greenough A
  • There remains a disparity between the outcomes of male and female prematurely born infants. Our aim was to assess the influence of sex on the requirement for late (> 7 days) postnatal corticosteroid (PNS) treatment and the outcomes following treatment. A retrospective whole population study of infants born at less than 28 weeks of gestation in all neonatal units in England between 2014 and 2018. …
  • ACTH-independent production of 11-oxygenated androgens and glucocorticoids in an adrenocortical adenoma. [Case Reports]
    Eur J Endocrinol. 2022 Dec 01; 187(6):K39-K45.Kitamura T, Blinder AR, … Tagami T
  • CONCLUSIONS: Due to its rarity, biochemical and histologic characteristics of androgen and glucocorticoid co-secreting adrenocortical adenomas are largely unknown. Herein, we report a case of adrenocortical adenoma that caused marked hyperandrogenemia and mild autonomous cortisol secretion. In this study, we investigated serum steroid profiles using liquid chromatography-tandem mass spectrometry (LC-MS/MS) and histologic characteristics of the resected tumor. LC-MS/MS revealed highly elevated levels of 11-oxygenated androgens which have not been well studied in adrenal tumors. The expression patterns of steroidogenic enzymes determined by immunohistochemistry supported the results of steroid profiling and suggested the capacity of the tumor cells to produce 11-oxygenated androgens. Measurement of 11-oxygenated steroids should facilitate a better understanding of androgen-producing adrenocortical neoplasms.
  • [Steroid profiling characteristics in pediatrc adrenal diseases]. [Journal Article]
    Probl Endokrinol (Mosk). 2022 Nov 03; 68(6):110-120.Yanar EA, Makazan NV, … Peterkova VA
  • CONCLUSIONS: Results of our study steroid profiling can be used as additional differential diagnosis method in patients with adrenocortical adenomas with or without hormonal hyperproduction (ACTH-independent Cushing syndrome and incidentaloma). Further studies are needed to identify steroid markers for subtyping pediatric adrenal diseases.
  • Evaluation of hydrocortisone as a strain-dependent growth-regulator of Porphyromonasgingivalis. [Journal Article]
    Anaerobe. 2023 Jan 18; 80:102698.Klomp T, Jahr H, … Conrads G
  • CONCLUSIONS: HC could reduce the incubation time when isolating P. gingivalis from clinical samples and could boost low biomass cultivations especially during their lag-phase. The growth-modulating effect might be via modulation of virulence factors/quorum sensing gene expression or by reactive oxygen species(ROS)-capturing during early stages of bacterial growth. Further experiments are necessary to explain the mechanism behind our observations.
  • Adrenal Dysfunction in Mitochondrial Diseases. [Review]
    Int J Mol Sci. 2023 Jan 06; 24(2)Corkery-Hayward M, Metherell LA
  • Cortisol is central to several homeostatic mechanisms including the stress and immune response. Adrenal insufficiency and impaired cortisol production leads to severe, potentially fatal disorders. Several fundamental stages of steroidogenesis occur within the mitochondria. These dynamic organelles not only contribute ATP for steroidogenesis, but also detoxify harmful by-products generated during …
  • The Role of Glucocorticoids in Breast Cancer Therapy. [Review]
    Curr Oncol. 2022 Dec 25; 30(1):298-314.Mitre-Aguilar IB, Moreno-Mitre D, … Mendoza-Almanza G
  • Glucocorticoids (GCs) are anti-inflammatory and immunosuppressive steroid molecules secreted by the adrenal gland and regulated by the hypothalamic-pituitary-adrenal (HPA) axis. GCs present a circadian release pattern under normal conditions; they increase their release under stress conditions. Their mechanism of action can be via the receptor-independent or receptor-dependent pathway. The recept…
  • Treatment of Hydatidiform Mole Suspected to COVID 19. [Case Reports]
    Adv Biomed Res. 2022; 11:105.Azarkish F, Rigiyousefabadi S, … Kashani ZA
  • The aim of this study was to report a case of the treatment of hydatidiform mole in Coronavirus pandemic in Iranshahr. A 17-year-old primiparous woman with gestational age of 14 weeks presented with unilateral leg swelling and sudden abdominal distension beginning in the night before referring to the health center. In the abdominal examination of the patient by a healthcare provider, the baby's h…
  • Cephradine-Induced Toxic Epidermal Necrolysis: A Case Report of Treatment With Etanercept. [Case Reports]
    Cureus. 2022 Dec; 14(12):e32657.Hubail R, Alnajjar L, Al Awadhi A
  • Toxic epidermal necrolysis (TEN) is a rare yet life-threatening severe cutaneous adverse reaction (SCAR) to various causative agents, including medications, vaccinations, infections, and malignancies, in addition to some other uncommon external stimuli. TEN is characterized by the sudden appearance of generalizeddusky erythematous targetoid macules with a purpuric center, which coalesces to form …
  • Effect of different odors on the fighting behavior of weaning piglets after merging into a large pen. [Journal Article]
    Anim Sci J. 2023; 94(1):e13809.Zhao W, Yang N, … Jiang Q
  • In intensive pig production, the fighting behavior of weaning piglets after merging pens is relatively common. Fighting behavior not only easily causes injury in pigs but also affects the production performance of pigs. To reduce fighting behavior in farms, this study aimed to explore the possible effect of odorous substances on piglet fighting behavior after merging into a large pen. Six differe…
  • Adrenal Insufficiency in Peroxisomal Disorders: a Single Institution Case Series. [Case Reports]
    Horm Res Paediatr. 2023 Jan 17 [Online ahead of print]Gagnon C, Hurst ACE, Ashraf AP
  • CONCLUSIONS: Primary adrenal insufficiency is common in patients with peroxisomal disorder. Based on our data, patients with the compound heterozygous PEX1 pathogenic variants of exon 13 (c.2097dupT and c.2528G>A) tend to have adrenal insufficiency. Aldosterone deficiency, though rare, can occur in PD.
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