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Unbound Medicine.
(Abdominal aortic aneurysm)
33,321 results
  • Effect of rheological models on pulsatile hemodynamics in a multiply afflicted descending human aortic network. [Journal Article]
    Comput Methods Biomech Biomed Engin. 2023 Jan 28 [Online ahead of print]Kumar S, Kumar BVR, … Shankar O
  • In the cardiovascular diseased (CVD) conditions, it is essential to choose a suitable rheological model for capturing the correct physics behind the hemodynamic in the multiply afflicted diseased arterial network. This study investigates the effect of blood rheology on hemodynamics in a blood vessel with abdominal aortic aneurysm (AAA) and right internal iliac stenosis (RIIAS). A model with AAA a…
  • Unique case of abdominal aortic aneurysm causing obstructive jaundice and duodenal obstruction. [Journal Article]
    J R Coll Physicians Edinb. 2023 Jan 28 [Online ahead of print]Ur Rahman A, Joseph C, … Gazal K
  • Obstruction of the duodenum by an abdominal aortic aneurysm (AAA) (aortoduodenal syndrome) has rarely been reported. It presents with symptoms of upper gastrointestinal (GI) tract obstruction. Obstructive jaundice caused by an AAA is also extremely rare and requires high clinical suspicion. We present a unique case with informed consent of an elderly gentleman who presented with both rare present…
  • Macrophage elastase derived from adventitial macrophages modulates aortic remodeling. [Journal Article]
    Front Cell Dev Biol. 2022; 10:1097137.Chen Y, Yang X, … Fan J
  • Abdominal aortic aneurysm (AAA) is pathologically characterized by intimal atherosclerosis, disruption and attenuation of the elastic media, and adventitial inflammatory infiltrates. Although all these pathological events are possibly involved in the pathogenesis of AAA, the functional roles contributed by adventitial inflammatory macrophages have not been fully documented. Recent studies have re…
  • The impact of race on outcomes following ruptured abdominal aortic aneurysm repair. [Journal Article]
    J Vasc Surg. 2023 Jan 23 [Online ahead of print]Li B, Ayoo K, … Roche-Nagle G
  • CONCLUSIONS: This study identified racial differences in demographic, clinical, and procedural characteristics for patients undergoing rAAA repair. In particular, the door-to-intervention time for Black patients of 2.8 hours does not meet the Society for Vascular Surgery recommendation of 90 minutes. Despite these differences, 8-year mortality is similar for Black and White patients. These differences should be further investigated and there are opportunities to improve rAAA care for Black patients.
  • Mechanosignals in abdominal aortic aneurysms. [Review]
    Front Cardiovasc Med. 2022; 9:1021934.Lowis C, Ramara Winaya A, … Ramkhelawon B
  • Cumulative evidence has shown that mechanical and frictional forces exert distinct effects in the multi-cellular aortic layers and play a significant role in the development of abdominal aortic aneurysms (AAA). These mechanical cues collectively trigger signaling cascades relying on mechanosensory cellular hubs that regulate vascular remodeling programs leading to the exaggerated degradation of t…
  • Homeostatic, Non-Canonical Role of Macrophage Elastase in Vascular Integrity. [Journal Article]
    Circ Res. 2023 Jan 24 [Online ahead of print]Salarian M, Ghim M, … Sadeghi MM
  • CONCLUSIONS: An MMP-12 deficiency/complement activation/NETosis pathway compromises aortic integrity, which predisposes to adverse vascular remodeling and abdominal aortic aneurysm rupture. Considering these new findings, the role of macrophage MMP-12 in vascular homeostasis demands re-evaluation of MMP-12 function in diverse settings.
  • Frailty Amongst Veterans Undergoing Abdominal Aortic Aneurysm Repair. [Journal Article]
    Ann Vasc Surg. 2023 Jan 20 [Online ahead of print]Chen AJ, Yeh SL, … O'Connell JB
  • CONCLUSIONS: Our findings demonstrate that frailty is associated with higher rates of adverse outcomes in open repair compared to EVAR. Patients who underwent open repair had higher rates of wound dehiscence, surgical site infection, and pneumonia, compared to those undergoing endovascular repair. Frailty was associated with larger AAA diameter in the EVAR cohort and longer operative times, with higher frequency of postoperative pneumonia in the OAR cohort. Frailty is a strong risk factor that should be considered in the management of aortic aneurysms.
  • Iliac Branch Devices in the Repair of Ruptured Aorto-iliac Aneurysms: A Multicenter Study. [Journal Article]
    J Endovasc Ther. 2023 Jan 22 [Online ahead of print]Karelis A, Sonesson B, … Dias NV
  • CONCLUSIONS: This multicenter study demonstrates that ruptured aortoiliac aneurysms do not necessarily require mandatory occlusion of hypogastric arteries. Iliac branch devices are shown to be a valid alternative in highly selected cases, with good midterm results, even if reinterventions are required in a significant proportion of patients.
  • The Contemporary Impact of Body Mass Index on Open Aortic Aneurysm Repair. [Journal Article]
    J Vasc Surg. 2023 Jan 19 [Online ahead of print]Bellamkonda KS, Scali ST, … Stone DH
  • CONCLUSIONS: Both low (<18.5) and high (>34) BMI were associated with increased oAAA mortality in current practice. Despite the perception that obesity confers substantial surgical risk during oAAA, diminished BMI was associated with a 3-fold increase in 30-day and 1-year mortality. It appears that BMI extremes are distinct proxies for differential clinical phenotypes and should inform risk stratification for oAAA repair.
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