- Open Surgery for Abdominal Aortic Aneurysm: 980 Consecutive Patient Outcomes from a High-Volume Centre in the United Kingdom. [Journal Article]Vasc Endovascular Surg. 2023 Jan 30 [Online ahead of print]VE
- CONCLUSIONS: Our data confirm that open surgery for AAA can be performed in large volume centres quite safely. Elective and Emergency surgery does affect early 30 day mortality but does not influence long-term outcome.
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- INKILN is a novel long noncoding RNA promoting vascular smooth muscle inflammation via scaffolding MKL1 and USP10. [Preprint]bioRxiv. 2023 Jan 09B
- CONCLUSIONS: These findings elucidate an important pathway of VSMC inflammation involving an INKILN /MKL1/USP10 regulatory axis. Human BAC Tg mice offer a novel and physiologically relevant approach for investigating human-specific lncRNAs under vascular disease conditions.
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- Hyperuricemia exacerbates abdominal aortic aneurysm formation through the URAT1/ERK/MMP-9 signaling pathway. [Journal Article]BMC Cardiovasc Disord. 2023 Jan 30; 23(1):55.BC
- CONCLUSIONS: We have provided human evidence that hyperuricemia exacerbates AAA formation. In addition, our murine experimental evidence suggests that hyperuricemia exacerbates AAA formation and reveals that the URAT1/ERK1/2/ROS/MMP-9 pathway is among the pathways activated by uric acid in HASMCs.
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- The Impact of a Limited Field-of-View on Computed Hemodynamics in Abdominal Aortic Aneurysms: Evaluating the Feasibility of Completing Ultrasound Segmentations with Parametric Geometries. [Journal Article]Ann Biomed Eng. 2023 Jan 28 [Online ahead of print]AB
- To improve abdominal aortic aneurysm (AAA) rupture risk assessment, a large, longitudinal study on AAA hemodynamics and biomechanics is necessary, using personalized fluid-structure interaction (FSI) modeling. 3-dimensional, time-resolved ultrasound (3D+t US) is the preferred image modality to obtain the patient-specific AAA geometry for such a study, since it is safe, affordable and provides tem…
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- Interleukin-38 suppresses abdominal aortic aneurysm formation in mice by regulating macrophages in an IL1RL2-p38 pathway-dependent manner. [Journal Article]Physiol Rep. 2023 Jan; 11(2):e15581.PR
- Macrophages play crucial roles in abdominal aortic aneurysm (AAA) formation through the inflammatory response and extracellular matrix degradation; therefore, regulating macrophages may suppress AAA formation. Interleukin-38 (IL-38) is a member of the IL-1 family, which binds to IL-36 receptor (IL1RL2) and has an anti-inflammation effect. Because macrophages express IL1RL2, we hypothesized that I…
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- Effect of rheological models on pulsatile hemodynamics in a multiply afflicted descending human aortic network. [Journal Article]Comput Methods Biomech Biomed Engin. 2023 Jan 28 [Online ahead of print]CM
- In the cardiovascular diseased (CVD) conditions, it is essential to choose a suitable rheological model for capturing the correct physics behind the hemodynamic in the multiply afflicted diseased arterial network. This study investigates the effect of blood rheology on hemodynamics in a blood vessel with abdominal aortic aneurysm (AAA) and right internal iliac stenosis (RIIAS). A model with AAA a…
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- Unique case of abdominal aortic aneurysm causing obstructive jaundice and duodenal obstruction. [Journal Article]J R Coll Physicians Edinb. 2023 Jan 28 [Online ahead of print]JR
- Obstruction of the duodenum by an abdominal aortic aneurysm (AAA) (aortoduodenal syndrome) has rarely been reported. It presents with symptoms of upper gastrointestinal (GI) tract obstruction. Obstructive jaundice caused by an AAA is also extremely rare and requires high clinical suspicion. We present a unique case with informed consent of an elderly gentleman who presented with both rare present…
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- Additional Aortic Coverage With Off The Shelf, Multibranched Endograft Compared With Custom-Made Devices For Endovascular Repair of Pararenal Abdominal Aortic Aneurysm. [Journal Article]Eur J Vasc Endovasc Surg. 2023 Jan 24 [Online ahead of print]EJ
- CONCLUSIONS: Despite not requiring customisation time, OTS endografts for the treatment of p-AAA lead to a more extensive healthy aortic coverage, as well as an average sacrifice of 2.5 additional segmental arteries, in comparison with CMDs. When compared with OTS devices, CMDs appear to limit the extent of unnecessary aortic coverage and the theoretical subsequent risk of spinal cord ischaemia.
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- Use of Secondary Iliac Branch Devices after Previous Endovascular Abdominal and Thoraco-Abdominal Aortic Aneurysm Repair†. [Journal Article]Eur J Vasc Endovasc Surg. 2023 Jan 24 [Online ahead of print]EJ
- CONCLUSIONS: Secondary IBD after EVAR is a safe and effective procedure with high technical success and low complication rates. The technique of choice to revascularise the IIA seems to not affect early and follow up results. Long term durability of IBD repair is acceptable with low rates of IIA re-interventions.
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- Macrophage elastase derived from adventitial macrophages modulates aortic remodeling. [Journal Article]
- Abdominal aortic aneurysm (AAA) is pathologically characterized by intimal atherosclerosis, disruption and attenuation of the elastic media, and adventitial inflammatory infiltrates. Although all these pathological events are possibly involved in the pathogenesis of AAA, the functional roles contributed by adventitial inflammatory macrophages have not been fully documented. Recent studies have re…
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- Effects of cardiac function alterations on the risk of postoperative thrombotic complications in patients receiving endovascular aortic repair. [Journal Article]
- Introduction: Chronic heart disease (CHD) is a common comorbidity of patients receiving endovascular aneurysm repair (EVAR) for abdominal aortic aneurysms (AAA). The explicit relationship between ventricular systolic function and EVAR complication of thrombotic events is unknown. Methods: In this study, we proposed a three-dimensional numerical model coupled with the lumped-elements heart model, …
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- Comparative analysis of thoracic and abdominal aortic aneurysms across the segment and species at the single-cell level. [Journal Article]
- Introduction: Aortic aneurysm is a life-threatening disease resulted from progressive dilatation of the aorta, which can be subdivided into thoracic and abdominal aortic aneurysms. Sustained subcutaneous angiotensin II infusion can induce aortic aneurysms in mice. However, the relevance of using angiotensin II induction model to study aneurysm disease and the degree of commonality between species…
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- The impact of race on outcomes following ruptured abdominal aortic aneurysm repair. [Journal Article]J Vasc Surg. 2023 Jan 23 [Online ahead of print]JV
- CONCLUSIONS: This study identified racial differences in demographic, clinical, and procedural characteristics for patients undergoing rAAA repair. In particular, the door-to-intervention time for Black patients of 2.8 hours does not meet the Society for Vascular Surgery recommendation of 90 minutes. Despite these differences, 8-year mortality is similar for Black and White patients. These differences should be further investigated and there are opportunities to improve rAAA care for Black patients.
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- Local and global distensibility assessment of abdominal aortic aneurysms in vivo from probe tracked 2D ultrasound images. [Journal Article]Front Med Technol. 2022; 4:1052213.FM
- Rupture risk estimation of abdominal aortic aneurysm (AAA) patients is currently based on the maximum diameter of the AAA. Mechanical properties that characterize the mechanical state of the vessel may serve as a better rupture risk predictor. Non-electrocardiogram-gated (non-ECG-gated) freehand 2D ultrasound imaging is a fast approach from which a reconstructed volumetric image of the aorta can …
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- Single-cell transcriptome in silico analysis reveals conserved regulatory programs in macrophages/monocytes of abdominal aortic aneurysm from multiple mouse models and human. [Journal Article]Front Cardiovasc Med. 2022; 9:1062106.FC
- Abdominal aortic aneurysm (AAA) is a life-threatening disease and there is currently a lack of effective treatment to prevent it rupturing. ScRNA-seq studies of AAA are still lacking. In the study, we analyzed the published AAA scRNA-seq datasets from the mouse elastase-induced model, CaCl2 treatment model, Ang II-induced model and human by using bioinformatic approaches and in silico analysis. A…
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- Mechanosignals in abdominal aortic aneurysms. [Review]Front Cardiovasc Med. 2022; 9:1021934.FC
- Cumulative evidence has shown that mechanical and frictional forces exert distinct effects in the multi-cellular aortic layers and play a significant role in the development of abdominal aortic aneurysms (AAA). These mechanical cues collectively trigger signaling cascades relying on mechanosensory cellular hubs that regulate vascular remodeling programs leading to the exaggerated degradation of t…
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- Administration of anti-inflammatory M2 macrophages suppresses progression of angiotensin II-induced aortic aneurysm in mice. [Journal Article]
- Aortic aneurysm (AA) is a vascular disorder characterized pathologically by inflammatory cell invasion and extracellular matrix (ECM) degradation. It is known that regulation of the balance between pro-inflammatory M1 macrophages (M1Ms) and anti-inflammatory M2 macrophages (M2Ms) plays a pivotal role in AA stabilization. We investigated the effects of M2M administration in an apolipoprotein E-def…
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- Artificial Intelligence Outperforms Kaplan-Meier Analyses Estimating Survival after Elective Treatment of Abdominal Aortic Aneurysms. [Journal Article]Eur J Vasc Endovasc Surg. 2023 Jan 21 [Online ahead of print]EJ
- CONCLUSIONS: N-MTLR outperforms KM for the entire post-operative follow up time. This N-MTLR model has the potential to render more precise patient specific survival estimates, and establish survival differences between subgroups of patients that KM is unable to detect, demonstrated here for different age groups.
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- Homeostatic, Non-Canonical Role of Macrophage Elastase in Vascular Integrity. [Journal Article]Circ Res. 2023 Jan 24 [Online ahead of print]CircR
- CONCLUSIONS: An MMP-12 deficiency/complement activation/NETosis pathway compromises aortic integrity, which predisposes to adverse vascular remodeling and abdominal aortic aneurysm rupture. Considering these new findings, the role of macrophage MMP-12 in vascular homeostasis demands re-evaluation of MMP-12 function in diverse settings.
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- Frailty Amongst Veterans Undergoing Abdominal Aortic Aneurysm Repair. [Journal Article]Ann Vasc Surg. 2023 Jan 20 [Online ahead of print]AV
- CONCLUSIONS: Our findings demonstrate that frailty is associated with higher rates of adverse outcomes in open repair compared to EVAR. Patients who underwent open repair had higher rates of wound dehiscence, surgical site infection, and pneumonia, compared to those undergoing endovascular repair. Frailty was associated with larger AAA diameter in the EVAR cohort and longer operative times, with higher frequency of postoperative pneumonia in the OAR cohort. Frailty is a strong risk factor that should be considered in the management of aortic aneurysms.
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- Simultaneous hybrid repair of symptomatic femoral, iliac, and abdominal aortic aneurysms. [Journal Article]Vascular. 2023 Jan 23 [Online ahead of print]V
- CONCLUSIONS: This report supports the role of utilizing multiple hybrid operative techniques to best repair the respective aneurysm in a single operation, with favorable patient outcomes.
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- ADAR1 Non-Editing Function in Macrophage Activation and Abdominal Aortic Aneurysm. [Journal Article]Circ Res. 2023 Jan 23 [Online ahead of print]CircR
- CONCLUSIONS: Macrophage ADAR1 promotes aneurysm formation in both mouse and human arteries through a novel mechanism, that is, Drosha protein degradation, which inhibits the processing of microRNAs targeting NF-kB signaling and thus elicits macrophage-mediated vascular inflammation in AAA.
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- Anatomical feasibility of fenestrated stent graft to treat complex abdominal aortic aneurysms from a Korean single institute database. [Journal Article]
- CONCLUSIONS: Z-FEN was applicable to 33.3% of the juxtarenal AAA patients. As recent studies confirm, the effectiveness and safety of fenestrated EVAR, Z-FEN can be an option for AAA patients with short aortic neck.
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- Deep-learning method for fully automatic segmentation of the abdominal aortic aneurysm from computed tomography imaging. [Journal Article]
- Abdominal aortic aneurysm (AAA) is one of the leading causes of death worldwide. AAAs often remain asymptomatic until they are either close to rupturing or they cause pressure to the spine and/or other organs. Fast progression has been linked to future clinical outcomes. Therefore, a reliable and efficient system to quantify geometric properties and growth will enable better clinical prognoses fo…
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- Efficacy and safety of prophylactic intraoperative sac embolization in EVAR for abdominal aortic aneurysm: A meta-analysis. [Review]
- CONCLUSIONS: EVAR combined with sac embolization effectively reduces the incidence of type II endoleak and the reintervention rate without enhancing the operation time. Therefore, more high-quality studies are still needed for validation due to the limited amount and quality of included literature.
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- High-Strength Injectable Hydrogel into Perivascular Interstitial Space Enhances Arterial Adventitial Stress. [Journal Article]Langmuir. 2023 Jan 23 [Online ahead of print]L
- Injectable hydrogels with strong mechanical properties have significant potential for biomedical applications, including the development of electronic skin, intelligent medical robots, as well as tissue engineering. In this study, we report on an injectable hydrogel with notable tensile strength and adhesion properties, achieved through cross-linking thiol-terminated four-arm poly (ethylene glyco…
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- Iliac Branch Devices in the Repair of Ruptured Aorto-iliac Aneurysms: A Multicenter Study. [Journal Article]J Endovasc Ther. 2023 Jan 22 [Online ahead of print]JE
- CONCLUSIONS: This multicenter study demonstrates that ruptured aortoiliac aneurysms do not necessarily require mandatory occlusion of hypogastric arteries. Iliac branch devices are shown to be a valid alternative in highly selected cases, with good midterm results, even if reinterventions are required in a significant proportion of patients.
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- Reassessing the Role of Sarcopenia for Predicting Long-Term Survival After Abdominal Aortic Aneurysm Repair. [Journal Article]World J Surg. 2023 Jan 22 [Online ahead of print]WJ
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- The Contemporary Impact of Body Mass Index on Open Aortic Aneurysm Repair. [Journal Article]J Vasc Surg. 2023 Jan 19 [Online ahead of print]JV
- CONCLUSIONS: Both low (<18.5) and high (>34) BMI were associated with increased oAAA mortality in current practice. Despite the perception that obesity confers substantial surgical risk during oAAA, diminished BMI was associated with a 3-fold increase in 30-day and 1-year mortality. It appears that BMI extremes are distinct proxies for differential clinical phenotypes and should inform risk stratification for oAAA repair.
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- The Independent Impact of Peripheral Arterial Disease on Mortality in Nonagenarians and Centenarians Who Were Treated in an Intensive Care Unit: A Consecutive Cohort of 1 108 Patients. [Journal Article]Eur J Vasc Endovasc Surg. 2023 Jan 19 [Online ahead of print]EJ
- CONCLUSIONS: One out of four critically ill nonagenarians and centenarians in an ICU in Germany had PAD. PAD was associated with both higher short and long term mortality while its impact outweighed higher age. Future studies should address this increasingly important population beyond 89 years of age.
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