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25,893 results
  • Cinnamic acid and lactobionic acid based nanoformulations as a potential antiamoebic therapeutics. [Journal Article]
    Exp Parasitol. 2023 Jan 25 [Online ahead of print]Akbar N, Kawish M, … Siddiqui R
  • Acanthamoeba castellanii causes granulomatous amoebic encephalitis, an uncommon but severe brain infection and sight-threatening Acanthamoeba keratitis. Most of the currently used anti-amoebic treatments are not always effective, due to persistence of the cyst stage, and recurrence can occur. Here in this study we synthesize cinnamic acid and lactobionic acid-based magnetic nanoparticles (MNPs) u…
  • Cu(II)-Triggered Ion Channel Properties of a 2,2'-Bipyridine-Modified Amphotericin B. [Journal Article]
    ACS Appl Bio Mater. 2023 Jan 28 [Online ahead of print]Komaki K, Kasuya S, … Koshiyama T
  • The development of stimuli-responsive synthetic channels that open and close in response to physical and chemical changes in the surrounding environment has attracted attention because of their potential bioapplications such as sensing, drug release, antibiotics, and molecular manipulation tools to control membrane transport in cells. Metal coordination is ideal as a stimulus for stimuli-responsi…
  • Invasive fungal infection by Peziza ostracoderma in an immunocompromised patient. [Case Reports]
    Med Mycol Case Rep. 2023 Mar; 39:26-30.Kinch A, Furebring M, … Hallböök H
  • We report for the first time a case of disseminated infection caused by Peziza ostracoderma, a mold not previously associated with invasive infections in humans. P. ostracoderma occurs in natural and sterilized soil and may cause hypersensitivity pneumonitis in greenhouse workers. The immunocompromised patient presented with neutropenic fever that did not respond to broad-spectrum antibiotics and…
  • Prevention of acquired invasive fungal infection with decontamination regimen in mechanically ventilated ICU patients: a pre/post observational study. [Journal Article]
    Infect Dis (Lond). 2023 Jan 24 [Online ahead of print]Massart N, Reizine F, … Fillatre P
  • CONCLUSIONS: Acquired fungal infection is a rare event, but accounts for a large proportion of ICU-acquired infections. Our study showed a preventive effect of decontamination against acquired fungal infection, especially candidemia.Take home messageAcquired fungal infection (AFI) incidence is close to 4% in mechanically ventilated patients without antifungal prophylaxis (3% for pulmonary aspergillosis and 1% for candidemia).Aspergillosis accounts for 14% of ventilator-associated pneumonia and candidemia for 9% of acquired bloodstream infections.Immunocompromised patients, those infected with SARS-COV 2 or influenza virus, males and patients admitted during the fall season are at higher risk of AFI.Mechanically ventilated patients receiving multiple site decontamination (MSD) have a lower risk of AFI.
  • C-reactive protein interacts with amphotericin B liposomes and its potential clinical consequences. [Journal Article]
    Clin Chem Lab Med. 2023 Jan 25 [Online ahead of print]Delanghe JR, Himpe J, … Verbeke F
  • CONCLUSIONS: In vitro experiments are suggestive of a complexation between CRP and liposomes in plasma. Interpretation of CRP values following administration of AmBisome® might be impaired due to this complexation. In vivo formation of complexes between liposomes and CRP might contribute, or even lead, to intravascular microembolisation. Similar effects have been described following the administration of Intralipid® and other phosphocholine-containing liposomes.
  • Off-label treatments as potential accelerators in the search for the ideal antifungal treatment of cryptococcosis. [Review]
    Future Microbiol. 2023 Jan 23 [Online ahead of print]Alves V, Araújo GR, Frases S
  • Cryptococcosis is an opportunistic mycosis that mainly affects immunosuppressed patients. The treatment is a combination of three antifungal agents: amphotericin B, 5-flucytosine and fluconazole. However, these drugs have many disadvantages, such as high nephrotoxicity, marketing bans in some countries and fungal resistance. One of the solutions to find possible new drugs is pharmacological repos…
  • Cerebral mucormycosis masquerading as brain metastasis from lung cancer: A case report. [Case Reports]
    Heliyon. 2023 Jan; 9(1):e12761.Cai Y, Wu Q, … Liu Z
  • We report a rare case of concurrent pulmonary and cerebral mucormycosis initially misdiagnosed as a metastatic tumor. A 66-year-old man with a complaint of progressive right-sided limb weakness for 3 days. Head MRI showed a left parietal occupying lesion with severe edema, and a chest CT scan showed a parenchymal mass with speculation and pleural invasion in his left lung. The patient was initial…
  • Study of Clinicoepidemiology and Surgical Complications in Acute Invasive Fungal Rhinosinusitis. [Journal Article]
    Indian J Otolaryngol Head Neck Surg. 2023 Jan 13 [Online ahead of print]Chaurpagar R, Chiplunkar B, … Athawale N
  • To study clinicoepidemiology and surgical complications in acute invasive fungal rhinosinusitis. Retrospective observational study carried in GMC Akola from February 2021 to April 2022. Detailed history and clinical examination, nasal endoscopic biopsy or swab for KOH and fungal culture was taken. CECT/MRI PNS + Orbit + Brain was done. All patients underwent surgery and tissue sample send for his…
  • Anti-fungal therapy: An overview for maxillofacial surgeons in post-covid-19 fungal infections. [Review]
    Natl J Maxillofac Surg. 2022 Sep-Dec; 13(3):330-336.Datarkar A, Bhawalkar A, … Walkey D
  • India is well known as the diabetes "capital" of the world but now it is also becoming the mucormycosis "capital" of the world. Indian Council of Medical Research has formed an "Evidence-Based Advisory in The Time of COVID-19 on Screening, Diagnosis, and Management of Mucormycosis." As per this advisory, an oral and maxillofacial surgeon forms an integral part of the team dedicated to fight this …
  • Mysterious alarming mucormycosis: Anesthetic challenges in a series of four cases. [Case Reports]
    Natl J Maxillofac Surg. 2022 Sep-Dec; 13(3):471-474.Neville JF, Jayanthi A, … Rath A
  • The sudden epidemic of mucormycosis amid COVID-19 pandemic has significantly challenged our understanding of the disease while affecting the whole medical and surgical management. Overzealous use of steroids in the management of covid-19 and uncontrolled diabetes mellitus has resulted in a tremendous rise in mucormycosis cases further burdening the already strained health care infrastructure and …
  • Blastomycosis: A Review of Mycological and Clinical Aspects. [Review]
    J Fungi (Basel). 2023 Jan 14; 9(1)Linder KA, Kauffman CA, Miceli MH
  • Blastomycosis is caused by a thermally dimorphic fungus that thrives in moist acidic soil. Blastomyces dermatitidis is the species responsible for most infections in North America and is especially common in areas around the Great Lakes, the St. Lawrence Seaway, and in several south-central and southeastern United States. Other Blastomyces species have more recently been discovered to cause disea…
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