- Unique effect of clozapine on adenosine A2A-dopamine D2 receptor heteromerization. [Journal Article]Biomed Pharmacother. 2023 Feb 01; 160:114327.BP
- The striatal dopamine D2 receptor (D2R) is generally accepted to be involved in positive symptoms of schizophrenia and is a main target for clinically used antipsychotics. D2R are highly expressed in the striatum, where they form heteromers with the adenosine A2A receptor (A2AR). Changes in the density of A2AR-D2R heteromers have been reported in postmortem tissue from patients with schizophrenia…
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- Relationship Between Plasma Aripiprazole and Dehydroaripiprazole Concentrations and Prolactin Levels in Chinese Children and Adolescents. [Journal Article]J Child Adolesc Psychopharmacol. 2023 Feb 02 [Online ahead of print]JC
- Objective: To investigate the relationship between plasma aripiprazole (ARI) and its metabolite dehydroaripiprazole (DARI) concentrations and prolactin (PRL) levels in Chinese children and adolescents. Methods: This was a retrospective cross-sectional study and the data were collected at Beijing HuiLongGuan Hospital, a Beijing City owned psychiatric hospital, between January 1 and December 31, 20…
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- Aripiprazole Used to Treat Capgras Syndrome in an Adolescent Diagnosed With Autism. [Journal Article]Clin Neuropharmacol. 2022 Dec 27 [Online ahead of print]CN
- CONCLUSIONS: Aripiprazole seems to be an effective and well-tolerated antipsychotic drug in the treatment of CS accompanying autism.
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- Prolactin-Raising and Prolactin-Sparing Antipsychotic Drugs and the Risk of Fracture and Fragility Fracture in Patients With Schizophrenia, Dementia, and Other Disorders. [Meta-Analysis]J Clin Psychiatry. 2023 Jan 30; 84(1)JC
- Patients who require antipsychotic drug treatment are at increased risk of fractures, including osteoporosis-related fragility fractures, for reasons related to demographics, illness-related factors, and treatment-related factors. As examples, patients with dementia may be vulnerable to falls due to cognitive and psychomotor impairment, patients with schizophrenia may be vulnerable to injury rela…
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- Diagnosis and treatment of intractable idiopathic orofacial pain with attention-deficit/hyperactivity disorder. [Journal Article]
- Attention-deficit/hyperactivity disorder (ADHD) has been reported to be associated with primary chronic pain syndromes, such as fibromyalgia, migraine, and chronic low back pain. Although idiopathic orofacial pain (IOP) is classified as burning mouth syndrome or persistent idiopathic facial or dentoalveolar pain and as a primary chronic pain, the association between IOP and ADHD has not been inve…
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- The Sapap3-/- mouse reconsidered as a comorbid model expressing a spectrum of pathological repetitive behaviours. [Journal Article]
- Symptom comorbidity is present amongst neuropsychiatric disorders with repetitive behaviours, complicating clinical diagnosis and impeding appropriate treatments. This is of particular importance for obsessive-compulsive disorder (OCD) and Tourette syndrome. Here, we meticulously analysed the behaviour of Sapap3 knockout mice, the recent rodent model predominantly used to study compulsive-like be…
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- Efficacy of oral versus long-acting antipsychotic treatment in patients with early-phase schizophrenia in Europe and Israel: a large-scale, open-label, randomised trial (EULAST). [Journal Article]Lancet Psychiatry. 2023 Jan 27 [Online ahead of print]LP
- CONCLUSIONS: We found no substantial advantage for LAI antipsychotic treatment over oral treatment regarding time to discontinuation in patients with early-phase schizophrenia, indicating that there is no reason to prescribe LAIs instead of oral antipsychotics if the goal is to prevent discontinuation of antipsychotic medication in daily clinical practice.
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- Comparative effectiveness of long-acting injectable antipsychotics in patients with schizophrenia in Japan. [Journal Article]Schizophr Res. 2023 Jan 25; 252:300-308.SR
- CONCLUSIONS: Our study suggests that aripiprazole and paliperidone are superior to fluphenazine/haloperidol in the risk of psychiatric hospitalization and LAI discontinuation. Aripiprazole is superior to risperidone in the risk of LAI discontinuation.
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- Cariprazine - an Alternative Treatment for Clozapine-resistant Schizophrenia? [Case Reports]Clin Psychopharmacol Neurosci. 2023 Feb 28; 21(1):202-206.CP
- Treatment-resistant schizophrenia (TRS) poses a significant therapeutic challenge in psychiatric practice. Clozapine is recognized as a treatment of choice in TRS but is not always effective in alleviating patients' symptoms. Additionally, clozapine therapy is associated with multiple side effects and monitoring requirements that often limit its use and negatively affect patients' compliance with…
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- Effectiveness of Switching to Long-acting Injectable Aripiprazole in Patients with Recent-onset and Chronic Schizophrenia. [Journal Article]Clin Psychopharmacol Neurosci. 2023 Feb 28; 21(1):57-67.CP
- CONCLUSIONS: High rates of successful switching to LAI aripiprazole from other antipsychotics suggest its good tolerability and effectiveness. Improvements in psychopathology and social functioning were more evident in patients with recent- onset schizophrenia, and improvements in metabolic abnormalities were more prominent in patients with chronic schizophrenia.
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- Korean Medication Algorithm Project for Bipolar Disorder 2022: Comparisons with Other Treatment Guidelines. [Review]Clin Psychopharmacol Neurosci. 2023 Feb 28; 21(1):32-48.CP
- The objective of this study was to compare recommendations of the Korean Medication Algorithm Project for Bipolar Disorder 2022 (KMAP-BP 2022) with other recently published guidelines for treating bipolar disorder. We reviewed a total of six recently published global treatment guidelines and compared treatment recommendation of the KMAP-BP 2022 with those of other guidelines. For initial treatmen…
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- Macroscale EEG characteristics in antipsychotic-naïve patients with first-episode psychosis and healthy controls. [Journal Article]
- Electroencephalography in patients with a first episode of psychosis (FEP) may contribute to the diagnosis and treatment response prediction. Findings in the literature vary due to small sample sizes, medication effects, and variable illness duration. We studied macroscale resting-state EEG characteristics of antipsychotic naïve patients with FEP. We tested (1) for differences between FEP patient…
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- What Role for Long-Acting Injectable Antipsychotics in Managing Schizophrenia Spectrum Disorders in Children and Adolescents? A Systematic Review. [Systematic Review]Paediatr Drugs. 2023 Jan 20 [Online ahead of print]PD
- CONCLUSIONS: There are few studies assessing the use of LAIAs in adolescents with SSD. Overall, these treatments have suggested good effectiveness and acceptable safety and tolerability. However, we found no studies examining their use in children aged < 12 years. The problems and benefits linked to this type of antipsychotic formulation in the child and adolescent population require further study, ideally with prospective, controlled designs.
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- Oculogyric Crisis after Initiation of Aripiprazole: A Case Report of an Active Duty Service Member. [Case Reports]
- CONCLUSIONS: Aripiprazole-induced acute dystonia, specifically OGC, is a rare potential adverse effect of aripiprazole. Risk factors include male gender, young age, use of typical antipsychotics, and initiation or uptitration of an antipsychotic. Even though atypical antipsychotics including aripiprazole are associated with lower risk for extrapyramidal symptoms, the possibility of oculogyric dystonia merits close monitoring especially in young, male, and drug naive patients. Anticholinergic agents such as diphenhydramine can treat symptoms of acute dystonia.
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- Sonic hedgehog pathway as a new target of atypical antipsychotics: Revisiting of amisulpride and aripiprazole effects in a rat model of schizophrenia. [Journal Article]Life Sci. 2023 Jan 15; 316:121366.LS
- CONCLUSIONS: Amisulpride and/or aripiprazole have a favorable role in turning on Shh-pathway with subsequent beneficial cognitive and neurogenesis effects.
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- Recurrent Catatonia: Infection and Immunity in an Idiopathic Illness. [Case Reports]J Psychiatr Pract. 2023 01 01; 29(1):82-89.JP
- Catatonia can be associated with multiple physical and mental illnesses, and idiopathic catatonia is a well-recognized clinical entity. Here we report a case of recurrent idiopathic catatonia with underlying immunologic abnormalities, with an emphasis on etiological hypotheses. An 18-year-old female with mild learning disability, dyspraxia, autoimmune hypothyroidism, and nonceliac gluten intolera…
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- Global occurrence and aquatic hazards of antipsychotics in sewage influents, effluent discharges and surface waters. [Review]Environ Pollut. 2023 Jan 14; 320:121042.EP
- Despite increasing reports of pharmaceuticals in surface waters, aquatic hazard information remains limited for many contaminants, particularly for sublethal, chronic responses plausibly linked to molecular initiation events that are largely conserved across vertebrates. Here, we critically examined available refereed information on the occurrence of 67 antipsychotics in wastewater effluent and s…
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- Agonistic properties of a series of psychotropic drugs at 5-HT1A receptors in rat and human brain membranes determined by [35S]GTPγS binding assay. [Journal Article]Pharmacol Rep. 2023 Jan 13 [Online ahead of print]PR
- CONCLUSIONS: Our previous studies have raised the concept of a psychoactive drug group with a common pharmacological mechanism of action, i.e., 5-HT1A receptor agonism, consisting of perospirone, aripiprazole, ziprasidone, clozapine, quetiapine, nemonapride, and trazodone. The present study demonstrates the data indicating that brexpiprazole and probably vortioxetine are included in this drug group. Lurasidone and asenapine are excluded from this group.
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- Autism Spectrum Disorder: A Review. [Review]JAMA. 2023 01 10; 329(2):157-168.JAMA
- CONCLUSIONS: ASD affects approximately 2.3% of children aged 8 years and approximately 2.2% of adults in the US. First-line therapy consists of behavioral interventions, while co-occurring psychiatric conditions, such as anxiety or aggression, may be treated with specific behavioral therapy or medication.
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- Drug-Induced Gambling Disorder: Epidemiology, Neurobiology, and Management. [Review]
- Problematic gambling has been suggested to be a possible consequence of dopaminergic medications used mainly in neurological conditions, i.e. pramipexole and ropinirole, and possibly by one antipsychotic compound, aripiprazole. Patients with Parkinson's disease, restless legs syndrome and other conditions potentially treated with dopamine agonists, as well as patients treated for psychotic disord…
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- Impact of membrane lipid polyunsaturation on dopamine D2 receptor ligand binding and signaling. [Journal Article]Mol Psychiatry. 2023 Jan 06 [Online ahead of print]MP
- Increasing evidence supports a relationship between lipid metabolism and mental health. In particular, the biostatus of polyunsaturated fatty acids (PUFAs) correlates with some symptoms of psychiatric disorders, as well as the efficacy of pharmacological treatments. Recent findings highlight a direct association between brain PUFA levels and dopamine transmission, a major neuromodulatory system i…
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- The Role of Total White Blood Cell Count in Antipsychotic Treatment for Patients with Schizophrenia. [Journal Article]Curr Neuropharmacol. 2023 Jan 04 [Online ahead of print]CN
- CONCLUSIONS: TWBCc is affected by certain antipsychotics among patients with schizophrenia, with decreases observed following short-term, but increases following long-term treatment. TWBCc is predictive of drug response, with lower TWBCc predicting better responses to antipsychotics. It also mediates the effects of certain metabolic measures on improvement of negative symptoms. This.
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- Recognising side effects of antipsychotics in children with intellectual disabilities. [Case Reports]BMJ Case Rep. 2023 Jan 04; 16(1)BC
- Risperidone and aripiprazole are increasingly used for behavioural indications in children and adolescents with intellectual disabilities, including autism. Although there are some reports in literature, the side effect profile in this population remains poorly defined and there is a need to raise awareness among clinicians across specialties. We present two patients with significant intellectual…
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- Evidence-Based Use of Atypical Antipsychotics in the Care of Children and Adolescents. [Journal Article]J Psychosoc Nurs Ment Health Serv. 2023 Jan; 61(1):8-11.JP
- Atypical antipsychotics are increasingly used to treat children and adolescents with a variety of mental and behavioral symptoms, despite restrictive U.S. Food and Drug Administration indications. A recent taskforce advocates for a symptom-based approach to atypical antipsychotic use, rather than by diagnosis alone. Cautious prescribing of atypical antipsychotics should only take place after care…
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- Association between lean muscle mass and treatment-resistant late-life depression in the IRL-GRey randomized controlled trial. [Journal Article]Int Psychogeriatr. 2023 Jan 03 [Online ahead of print]IP
- CONCLUSIONS: As expected, older age and female sex were associated with lower lean muscle mass in TR-LLD. However, contrary to prior results in LLD, lean muscle mass was not associated with depression severity or outcome. This suggests that aripiprazole augmentation may be useful for TR-LLD, even in the presence of anomalous body composition.clinicaltrials.gov Identifier: NCT00892047.
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- Weight changes in people with early psychosis treated with oral or long-acting injectable aripiprazole. [Journal Article]Schizophr Res. 2023 Jan; 251:74-81.SR
- CONCLUSIONS: While aripiprazole is generally considered relatively benign in terms of weight, it still poses a significant risk especially for people with early psychosis. However the current study suggests that the risk may be lower in those treated with LAI than with Oral formulation, consolidating the clinical utility of LAI.
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- Parkinsonism Symptoms After Exposure to Low-Dose Aripiprazole. [Journal Article]J Clin Psychopharmacol. 2023 Jan-Feb 01; 43(1):69-70.JC
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- Two-Injection Start Regimen of Long-Acting Aripiprazole in 133 Patients With Schizophrenia. [Journal Article]J Clin Psychopharmacol. 2023 Jan-Feb 01; 43(1):35-38.JC
- CONCLUSIONS: The coadministration of 2 injections of 400 mg aripiprazole and 20 mg oral aripiprazole was not associated with safety concerns beyond those reported after a single injection followed by 14 days of orally administered aripiprazole. Our results should be interpreted with caution, due to the limited sample size and to the retrospective design of the study.
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- Comparative efficacy and acceptability of treatments for depressive symptoms in cognitive impairment: A systematic review and Bayesian network meta-analysis. [Systematic Review]
- CONCLUSIONS: Our NMAs indicated that non-pharmacological interventions were more efficacious and safe than pharmacological treatments for reducing depressive symptoms as well as improving cognitive impairment. Electrical current stimulation, aerobic exercise, and reminiscence therapy could be first recommended considering their beneficial performance on both depression and cognition. Hence, non-pharmacological treatments deserve more attention and extensive application and should at least be considered as an alternative or assistance in clinical settings.
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