Try the Free App:
Prime PubMed app for iOS iPhone iPad
Prime PubMed app for Android
Prime PubMed is provided
free to individuals by:
Unbound Medicine.
5,082 results
  • Unique effect of clozapine on adenosine A2A-dopamine D2 receptor heteromerization. [Journal Article]
    Biomed Pharmacother. 2023 Feb 01; 160:114327.Valle-León M, Casajuana-Martin N, … Ciruela F
  • The striatal dopamine D2 receptor (D2R) is generally accepted to be involved in positive symptoms of schizophrenia and is a main target for clinically used antipsychotics. D2R are highly expressed in the striatum, where they form heteromers with the adenosine A2A receptor (A2AR). Changes in the density of A2AR-D2R heteromers have been reported in postmortem tissue from patients with schizophrenia…
  • Cariprazine - an Alternative Treatment for Clozapine-resistant Schizophrenia? [Case Reports]
    Clin Psychopharmacol Neurosci. 2023 Feb 28; 21(1):202-206.Montgomery A, Rogowska M, Dratcu L
  • Treatment-resistant schizophrenia (TRS) poses a significant therapeutic challenge in psychiatric practice. Clozapine is recognized as a treatment of choice in TRS but is not always effective in alleviating patients' symptoms. Additionally, clozapine therapy is associated with multiple side effects and monitoring requirements that often limit its use and negatively affect patients' compliance with…
  • Korean Medication Algorithm Project for Bipolar Disorder 2022: Comparisons with Other Treatment Guidelines. [Review]
    Clin Psychopharmacol Neurosci. 2023 Feb 28; 21(1):32-48.Jeong JH, Bahk WM, … Kim MD
  • The objective of this study was to compare recommendations of the Korean Medication Algorithm Project for Bipolar Disorder 2022 (KMAP-BP 2022) with other recently published guidelines for treating bipolar disorder. We reviewed a total of six recently published global treatment guidelines and compared treatment recommendation of the KMAP-BP 2022 with those of other guidelines. For initial treatmen…
  • Oculogyric Crisis after Initiation of Aripiprazole: A Case Report of an Active Duty Service Member. [Case Reports]
    Case Rep Psychiatry. 2023; 2023:9440028.Hadler NL, Roh YA, Nissan DA
  • CONCLUSIONS: Aripiprazole-induced acute dystonia, specifically OGC, is a rare potential adverse effect of aripiprazole. Risk factors include male gender, young age, use of typical antipsychotics, and initiation or uptitration of an antipsychotic. Even though atypical antipsychotics including aripiprazole are associated with lower risk for extrapyramidal symptoms, the possibility of oculogyric dystonia merits close monitoring especially in young, male, and drug naive patients. Anticholinergic agents such as diphenhydramine can treat symptoms of acute dystonia.
  • Recurrent Catatonia: Infection and Immunity in an Idiopathic Illness. [Case Reports]
    J Psychiatr Pract. 2023 01 01; 29(1):82-89.Tiwari S, Akyuz E, Das A
  • Catatonia can be associated with multiple physical and mental illnesses, and idiopathic catatonia is a well-recognized clinical entity. Here we report a case of recurrent idiopathic catatonia with underlying immunologic abnormalities, with an emphasis on etiological hypotheses. An 18-year-old female with mild learning disability, dyspraxia, autoimmune hypothyroidism, and nonceliac gluten intolera…
  • Autism Spectrum Disorder: A Review. [Review]
    JAMA. 2023 01 10; 329(2):157-168.Hirota T, King BH
  • CONCLUSIONS: ASD affects approximately 2.3% of children aged 8 years and approximately 2.2% of adults in the US. First-line therapy consists of behavioral interventions, while co-occurring psychiatric conditions, such as anxiety or aggression, may be treated with specific behavioral therapy or medication.
  • Drug-Induced Gambling Disorder: Epidemiology, Neurobiology, and Management. [Review]
    Pharmaceut Med. 2023 Jan; 37(1):37-52.Wolfschlag M, Håkansson A
  • Problematic gambling has been suggested to be a possible consequence of dopaminergic medications used mainly in neurological conditions, i.e. pramipexole and ropinirole, and possibly by one antipsychotic compound, aripiprazole. Patients with Parkinson's disease, restless legs syndrome and other conditions potentially treated with dopamine agonists, as well as patients treated for psychotic disord…
  • Impact of membrane lipid polyunsaturation on dopamine D2 receptor ligand binding and signaling. [Journal Article]
    Mol Psychiatry. 2023 Jan 06 [Online ahead of print]Jobin ML, De Smedt-Peyrusse V, … Trifilieff P
  • Increasing evidence supports a relationship between lipid metabolism and mental health. In particular, the biostatus of polyunsaturated fatty acids (PUFAs) correlates with some symptoms of psychiatric disorders, as well as the efficacy of pharmacological treatments. Recent findings highlight a direct association between brain PUFA levels and dopamine transmission, a major neuromodulatory system i…
  • The Role of Total White Blood Cell Count in Antipsychotic Treatment for Patients with Schizophrenia. [Journal Article]
    Curr Neuropharmacol. 2023 Jan 04 [Online ahead of print]Zhang Y, Tao S, … Li
  • CONCLUSIONS: TWBCc is affected by certain antipsychotics among patients with schizophrenia, with decreases observed following short-term, but increases following long-term treatment. TWBCc is predictive of drug response, with lower TWBCc predicting better responses to antipsychotics. It also mediates the effects of certain metabolic measures on improvement of negative symptoms. This.
  • Recognising side effects of antipsychotics in children with intellectual disabilities. [Case Reports]
    BMJ Case Rep. 2023 Jan 04; 16(1)Lee J, Shepperd R, … Anand G
  • Risperidone and aripiprazole are increasingly used for behavioural indications in children and adolescents with intellectual disabilities, including autism. Although there are some reports in literature, the side effect profile in this population remains poorly defined and there is a need to raise awareness among clinicians across specialties. We present two patients with significant intellectual…
  • Evidence-Based Use of Atypical Antipsychotics in the Care of Children and Adolescents. [Journal Article]
    J Psychosoc Nurs Ment Health Serv. 2023 Jan; 61(1):8-11.Ramos-Marcuse F, Kverno K
  • Atypical antipsychotics are increasingly used to treat children and adolescents with a variety of mental and behavioral symptoms, despite restrictive U.S. Food and Drug Administration indications. A recent taskforce advocates for a symptom-based approach to atypical antipsychotic use, rather than by diagnosis alone. Cautious prescribing of atypical antipsychotics should only take place after care…
  • Two-Injection Start Regimen of Long-Acting Aripiprazole in 133 Patients With Schizophrenia. [Journal Article]
    J Clin Psychopharmacol. 2023 Jan-Feb 01; 43(1):35-38.Cuomo A, Aguglia E, … Italian Clinical Psychopharmacology Working Group
  • CONCLUSIONS: The coadministration of 2 injections of 400 mg aripiprazole and 20 mg oral aripiprazole was not associated with safety concerns beyond those reported after a single injection followed by 14 days of orally administered aripiprazole. Our results should be interpreted with caution, due to the limited sample size and to the retrospective design of the study.
New Search Next