- In Vitro α-Amylase and α-Glucosidase Inhibitory Activity of Green Seaweed Halimeda tuna Extract from the Coast of Lhok Bubon, Aceh. [Journal Article]
- Seaweed belongs to marine biota and contains nutrients and secondary metabolites beneficial for health. This study aimed to determine the antidiabetic activity of extracts and fractions of green seaweed Halimeda tuna. The H. tuna sample was extracted with the maceration method using methanol and then partitioned using ethyl acetate and water to obtain ethyl acetate and water fractions. The methan…
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- Degradation of alkane hydrocarbons by Priestia megaterium ZS16 and sediments consortia with special reference to toxicity and oxidative stress induced by the sediments in the vicinity of an oil refinery. [Journal Article]Chemosphere. 2023 Jan 16; 317:137886.C
- Petroleum hydrocarbon is a critical ecological issue with impact on ecosystems through bioaccumulation. It poses significant risks to human health. Due to the extent of alkane hydrocarbon pollution in some environments, biosurfactants are considered as a new multifunctional technology for the efficient removal of petroleum-based contaminants. To this end, Yamuna river sediments were collected at …
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- An ultralong-acting tenofovir ProTide nanoformulation achieves monthslong HBV suppression. [Journal Article]
- Treatment of chronic hepatitis B virus (HBV) requires lifelong daily therapy. However, suboptimal adherence to the existing daily therapy has led to the need for ultralong-acting antivirals. A lipophilic and hydrophobic ProTide was made by replacing the alanyl isopropyl ester present in tenofovir alafenamide (TAF) with a docosyl phenyl alanyl ester, now referred to as M1TFV. NM1TFV and nanoformul…
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- Therapeutic efficacy of n-Docosanol against velogenic Newcastle disease virus infection in domestic chickens. [Journal Article]Front Microbiol. 2022; 13:1049037.FM
- CONCLUSIONS: Our findings suggest n-docosanol as a promising remedy in the control strategy of Newcastle disease in the poultry industry.
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- Analysis of docosanol using GC/MS: Method development, validation, and application to ex vivo human skin permeation studies. [Journal Article]
- Docosanol is the only US Food and Drug Administration (FDA) approved over-the-counter topical product for treating recurrent oral-facial herpes simplex labialis. Validated analytical methods for docosanol are required to demonstrate the bioequivalence of docosanol topical products. A gas chromatography/selected ion monitoring mode mass spectrometry (GC/SIM-MS) method was developed and validated f…
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- A polydimethylsiloxane/deep eutectic solvent sol-gel thin film sorbent and its application to solid-phase microextraction of parabens. [Journal Article]Anal Chim Acta. 2022 Apr 15; 1202:339666.AC
- A novel, efficient and reproducible thin-film solid-phase microextraction method using the polydimethylsiloxane/deep eutectic solvent sol-gel as coating material was developed for preconcentration of parabens from environmental samples. New sorbent materials consisting of polydimethylsiloxane with nine new synthesized deep eutectic solvents were prepared by the sol-gel method, and these materials…
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- The Effect of Vegetable Oil Composition on the Structural Properties of Oleogels Based on Behenyl Alcohol/Behenic Acid Oleogelator System. [Journal Article]J Cosmet Sci. 2021 Jul-Aug; 72(4):399-417.JC
- Recently, we described that the weight ratio (R) between behenyl alcohol (BO) and behenic acid (BA) in sunflower oil effects the textural and structural properties of the oleogel system. One R (7:3) was found as optimal since it led to an enhancement of the oleogel properties for both the hardness and the stability in terms of oil-binding capacity. However, what remains unknown is the effect of o…
- Development of novel thin-film solid-phase microextraction materials based on deep eutectic solvents for preconcentration of trace amounts of parabens in surface waters. [Journal Article]J Sep Sci. 2022 Apr; 45(7):1374-1384.JS
- A green and sensitive thin-film solid-phase microextraction method based on deep eutectic solvent was developed that enables simultaneous isolation, preconcentration, and determination of parabens in surface waters. Six new deep eutectic solvents were synthesized and used directly to prepare thin-film coatings on a stainless steel mesh support. Among the compounds obtained, the highest efficiency…
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- Diffusion of volatile organics and water in the epicuticular waxes of petunia petal epidermal cells. [Journal Article]
- Plant cuticles are a mixture of crystalline and amorphous waxes that restrict the exchange of molecules between the plant and the atmosphere. The multicomponent nature of cuticular waxes complicates the study of the relationship between the physical and transport properties. Here, a model cuticle based on the epicuticular waxes of Petunia hybrida flower petals was formulated to test the effect of…
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- Suppression of Thiol-Dependent Antioxidant System and Stress Response in Methicillin-Resistant Staphylococcus aureus by Docosanol: Explication Through Proteome Investigation. [Journal Article]
- The present study was aimed to investigate the effect of docosanol on the protein expression profile of methicillin-resistant Staphylococcus aureus (MRSA). Thus, two-dimensional gel electrophoresis coupled with MALDI-TOF MS technique was utilized to identify the differentially regulated proteins in the presence of docosanol. A total of 947 protein spots were identified from the intracellular prot…
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- Relative humidity regimes modify epicuticular wax metabolism and fruit properties during Navelate orange conservation in an ABA-dependent manner. [Journal Article]
- Relative humidity (RH) during conservation and the chemical composition of epicuticular wax layer are factors that determine fruit quality and weight loss. This study investigates the influence of RH on the epicuticular wax metabolism during citrus fruit storage, and how it is affected by abscisic acid (ABA). Low RH conditions increased alcohols and fatty acids abundance, mainly due to accumulati…
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- Current Drugs to Treat Infections with Herpes Simplex Viruses-1 and -2. [Review]
- Herpes simplex viruses-1 and -2 (HSV-1 and -2) are two of the three human alphaherpesviruses that cause infections worldwide. Since both viruses can be acquired in the absence of visible signs and symptoms, yet still result in lifelong infection, it is imperative that we provide interventions to keep them at bay, especially in immunocompromised patients. While numerous experimental vaccines are u…
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- Binary Mixtures of Some Active Pharmaceutical Ingredients with Fatty Alcohols-The Criteria of Successful Eutectic Formation and Dissolution Improvement. [Journal Article]
- Pharmaceutical eutectics are solid mixtures, where the crystals of active pharmaceutical ingredients (APIs) are finely divided in the phase-separated microstructures. The size reduction makes the eutectic formation a viable option to improve the dissolution rate of the poorly soluble APIs. In the present study, ibuprofen, naproxen, and sorafenib were investigated in terms of their phase behaviors…
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- An Alternative Treatment for Vaginal Cuff Wart: a Case Report. [Case Reports]
- Human papillomavirus (HPV) has been directly related to acuminate warts and cervical cancer, the second most common neoplasia among women. Given the lack of treatment against the virus itself, many medications have been utilised, mainly aiming in modifying the host's immunological response. We present the case of a 54 years old postmenopausal patient with a history of vaginal cuff wart and HPV pe…
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- Inhibition of biofilm and biofilm-associated virulence factor production in methicillin-resistant Staphylococcus aureus by docosanol. [Journal Article]
- Antimicrobial resistance is a major public health concern in infection control. Hence, a multi-pronged approach is necessary to curb the severity of infections. The present study entails the identification of docosanol (fatty alcohol) from Streptomyces as a novel antibiofilm agent which can target the virulence factors of MRSA. Results showed that docosanol as a potent antibiofilm agent and found…
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- Policosanol profiles and adenosine 5'-monophosphate-activated protein kinase (AMPK) activation potential of Korean wheat seedling extracts according to cultivar and growth time. [Journal Article]
- Policosanols is a health promoting aliphatic alcohol known as lipid-lowing agent. To enable maximising the functional properties of wheat, this research investigates the policosanol profiles and adenosine 5'-monophosphate-activated protein kinase (AMPK) activation potential of Korean wheat seedlings according to cultivars and growth times. GC-MS revealed six policosanols that differed markedly in…
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- Effect of the ratio between behenyl alcohol and behenic acid on the oleogel properties. [Journal Article]
- In oleogel food systems (based on the mixture between stearic acid and stearyl alcohol) the strong effect of the weight ratio (R) between these two components on the textural and structural properties is well described. The effect of R for other fatty acids and fatty alcohols is less explored. Moreover, they do not show an enhancement of the oleogel properties for specific R. The effect of R on t…
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- Muscle extract of Arothron immaculatus regulates the blood glucose level and the antioxidant system in high-fat diet and streptozotocin induced diabetic rats. [Journal Article]
- In the present study pufferfish, Arothron immaculatus muscle methanol extract (AIME) was used to evaluate the antidiabetic activity against the high-fat diet (HFD) in streptozotocin (STZ) induced diabetic rat models. Initially, the In vitro antioxidant activity of the different muscle extract was evaluated which showed that AIME has higher efficiency to scavenge the free radicals. The animal stud…
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- Increasing jojoba-like wax ester production in Saccharomyces cerevisiae by enhancing very long-chain, monounsaturated fatty acid synthesis. [Journal Article]
- CONCLUSIONS: Changing the FA profile of the yeast S. cerevisiae towards very long-chain monounsaturated FAs is possible by combined overexpression of endogenous and heterologous enzymes derived from various sources (e.g. a marine copepod or plants). This strategy was used to produce jojoba-like WEs in S. cerevisiae and can potentially be extended towards other commercially interesting products derived from very long-chain FAs.
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- Antiviral drugs for varicella-zoster virus and herpes simplex virus infections. [Review]Med Lett Drugs Ther. 2018 Sep 24; 60(1556):153-157.ML
- Painful Oral Lesions. [Review]
- Painful oral vesiculoerosive diseases (OVD) include lichen planus, pemphigus vulgaris, mucous membrane pemphigoid, erythema multiforme, and recurrent aphthous stomatitis. OVD lesions have an immunopathic cause. Treatment is aimed at reducing the immunologic and the following inflammatory response. The mainstay of OVD management is topical or systemic corticosteroids to include topical triamcinolo…
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- Hypoglycemic Efficacy of Docking Selected Natural Compounds against α-Glucosidase and α-Amylase. [Journal Article]
- The inhibition of α-glucosidase and α-amylase is a clinical strategy for the treatment of type II diabetes, and herbal medicines have been reported to credibly alleviate hyperglycemia. Our previous study has reported some constituents from plant or herbal sources targeted to α-glucosidase and α-amylase via molecular docking and enzymatic measurement, but the hypoglycemic potencies in cell system …
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- Synthesis of bioactive compounds from vermicast isolated actinomycetes species and its antimicrobial activity against human pathogenic bacteria. [Journal Article]
- The present study was aimed to evaluate the antimicrobial activities of bioactive compounds synthesized from vermicast isolated actinomycetes species. Specifically, the synthesized bioactive compounds were evaluated for their antimicrobial activity against selected Gram + ve and Gram - ve human pathogenic bacteria including Staphylococcus aureus, Bacillus circulans, Bacillus subtilis, Pseudomonas…
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- Enhanced long-chain fatty alcohol oxidation by immobilization of alcohol dehydrogenase from S. cerevisiae. [Journal Article]
- This work reports on the oxidation of long-chain aliphatic alcohols catalyzed by a stabilized alcohol dehydrogenase from S. cerevisiae (yeast alcohol dehydrogenase (YADH)). In particular, the oxidation of the fatty alcohol tetracosanol (C24H50O) to yield lignoceric acid (C23H47COOH) was studied. The immobilization of YADH onto glyoxyl agarose supports crosslinked with a polymer (polyethylenimine)…
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- Anti-HIV activity of southern African plants: Current developments, phytochemistry and future research. [Review]
- CONCLUSIONS: An investigation of the plants from southern Africa with ethnobotanical use for the treatment of HIV, management of HIV or HIV-related symptoms, therefore provide a very good analysis of the major assays employed and the anti-viral compounds and compound groups identified. The similarity in identified anti-viral compounds worldwide should support the progression from in vitro studies to in vivo testing in development of affordable and effective anti-HIV agents for countries with high infection and mortality rates due to HIV/AIDS.
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- Intracellular imaging of docosanol in living cells by coherent anti-Stokes Raman scattering microscopy. [Journal Article]
- Docosanol is an over-the-counter topical agent that has proved to be one of the most effective therapies for treating herpes simplex labialis. However, the mechanism by which docosanol suppresses lesion formation remains poorly understood. To elucidate its mechanism of action, we investigated the uptake of docosanol in living cells using coherent anti-Stokes Raman scattering microscopy. Based on …
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- Metabolic engineering of Saccharomyces cerevisiae for production of very long chain fatty acid-derived chemicals. [Journal Article]
- Production of chemicals and biofuels through microbial fermentation is an economical and sustainable alternative for traditional chemical synthesis. Here we present the construction of a Saccharomyces cerevisiae platform strain for high-level production of very-long-chain fatty acid (VLCFA)-derived chemicals. Through rewiring the native fatty acid elongation system and implementing a heterologous…
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- Topical antiviral and antifungal medications in pregnancy: a review of safety profiles. [Review]
- Medications should be employed with caution in women of childbearing age who are pregnant or considering pregnancy. Compared to oral or parenteral agents, topical medications have limited systemic absorption and are deemed safer. However, their safety profile must be assessed cautiously due to the limited available data. In this article, we aggregate human and animal studies to provide recommenda…
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- Rational Vehicle Design Ensures Targeted Cutaneous Steroid Delivery. [Journal Article]
- CONCLUSIONS: Formulation-6/DFD-01 had the optimal balance of betamethasone retention in the skin, with low systemic absorption. This designed vehicle ensured retention of the corticosteroid in skin layers to maximize local efficacy while minimizing potential for hypothalamic-pituitary-adrenal suppression.
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- Phytochemicals from the Bark of Rhamnus caroliniana. [Journal Article]
- Rhamnus caroliniana (Rhamnaceae), or Carolina buckthorn, is a plant commonly found in the southeastern United States that was used in Cherokee traditional medicine. To date, there have been no reports on the phytochemical constituents of R. caroliniana. The bark of R. caroliniana was collected and extracted with chloroform. The crude chloroform extract was subjected to preparative column chromato…