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113 results
  • An ultralong-acting tenofovir ProTide nanoformulation achieves monthslong HBV suppression. [Journal Article]
    Sci Adv. 2022 Dec 23; 8(51):eade9582.Das S, Wang W, … Poluektova LY
  • Treatment of chronic hepatitis B virus (HBV) requires lifelong daily therapy. However, suboptimal adherence to the existing daily therapy has led to the need for ultralong-acting antivirals. A lipophilic and hydrophobic ProTide was made by replacing the alanyl isopropyl ester present in tenofovir alafenamide (TAF) with a docosyl phenyl alanyl ester, now referred to as M1TFV. NM1TFV and nanoformul…
  • Current Drugs to Treat Infections with Herpes Simplex Viruses-1 and -2. [Review]
    Viruses. 2021 06 25; 13(7)Sadowski LA, Upadhyay R, … Margulies BJ
  • Herpes simplex viruses-1 and -2 (HSV-1 and -2) are two of the three human alphaherpesviruses that cause infections worldwide. Since both viruses can be acquired in the absence of visible signs and symptoms, yet still result in lifelong infection, it is imperative that we provide interventions to keep them at bay, especially in immunocompromised patients. While numerous experimental vaccines are u…
  • An Alternative Treatment for Vaginal Cuff Wart: a Case Report. [Case Reports]
    Acta Medica (Hradec Kralove). 2020; 63(1):49-51.Psomiadou V, Iavazzo C, … Vorgias G
  • Human papillomavirus (HPV) has been directly related to acuminate warts and cervical cancer, the second most common neoplasia among women. Given the lack of treatment against the virus itself, many medications have been utilised, mainly aiming in modifying the host's immunological response. We present the case of a 54 years old postmenopausal patient with a history of vaginal cuff wart and HPV pe…
  • Effect of the ratio between behenyl alcohol and behenic acid on the oleogel properties. [Journal Article]
    J Colloid Interface Sci. 2020 Feb 15; 560:874-884.Callau M, Sow-Kébé K, … Fameau AL
  • In oleogel food systems (based on the mixture between stearic acid and stearyl alcohol) the strong effect of the weight ratio (R) between these two components on the textural and structural properties is well described. The effect of R for other fatty acids and fatty alcohols is less explored. Moreover, they do not show an enhancement of the oleogel properties for specific R. The effect of R on t…
  • Painful Oral Lesions. [Review]
    Dent Clin North Am. 2018 10; 62(4):597-609.Hargitai IA
  • Painful oral vesiculoerosive diseases (OVD) include lichen planus, pemphigus vulgaris, mucous membrane pemphigoid, erythema multiforme, and recurrent aphthous stomatitis. OVD lesions have an immunopathic cause. Treatment is aimed at reducing the immunologic and the following inflammatory response. The mainstay of OVD management is topical or systemic corticosteroids to include topical triamcinolo…
  • Anti-HIV activity of southern African plants: Current developments, phytochemistry and future research. [Review]
    J Ethnopharmacol. 2018 Jan 10; 210:133-155.Prinsloo G, Marokane CK, Street RA
  • CONCLUSIONS: An investigation of the plants from southern Africa with ethnobotanical use for the treatment of HIV, management of HIV or HIV-related symptoms, therefore provide a very good analysis of the major assays employed and the anti-viral compounds and compound groups identified. The similarity in identified anti-viral compounds worldwide should support the progression from in vitro studies to in vivo testing in development of affordable and effective anti-HIV agents for countries with high infection and mortality rates due to HIV/AIDS.
  • Topical antiviral and antifungal medications in pregnancy: a review of safety profiles. [Review]
    J Eur Acad Dermatol Venereol. 2017 Sep; 31(9):1440-1446.Patel VM, Schwartz RA, Lambert WC
  • Medications should be employed with caution in women of childbearing age who are pregnant or considering pregnancy. Compared to oral or parenteral agents, topical medications have limited systemic absorption and are deemed safer. However, their safety profile must be assessed cautiously due to the limited available data. In this article, we aggregate human and animal studies to provide recommenda…
  • Rational Vehicle Design Ensures Targeted Cutaneous Steroid Delivery. [Journal Article]
    J Clin Aesthet Dermatol. 2017 Feb; 10(2):12-19.Kircik L, Okumu F, … Sugarman J
  • CONCLUSIONS: Formulation-6/DFD-01 had the optimal balance of betamethasone retention in the skin, with low systemic absorption. This designed vehicle ensured retention of the corticosteroid in skin layers to maximize local efficacy while minimizing potential for hypothalamic-pituitary-adrenal suppression.
  • Phytochemicals from the Bark of Rhamnus caroliniana. [Journal Article]
    Nat Prod Commun. 2017 Mar; 12(3):403-406.Mekala AB, Satyal P, Setzer WN
  • Rhamnus caroliniana (Rhamnaceae), or Carolina buckthorn, is a plant commonly found in the southeastern United States that was used in Cherokee traditional medicine. To date, there have been no reports on the phytochemical constituents of R. caroliniana. The bark of R. caroliniana was collected and extracted with chloroform. The crude chloroform extract was subjected to preparative column chromato…
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