- Pharmacological Treatments for Congenital Myasthenic Syndromes Caused by COLQ Mutations. [Journal Article]Curr Neuropharmacol. 2023 Jan 26 [Online ahead of print]CN
- CONCLUSIONS: (1) β-adrenergic agonist therapy is the first pharmacological strategy for treating CMS with COLQ mutations. (2) AChEIs should be avoided in patients with CMS with COLQ mutations.
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- Electron beam degradation of the cardiovascular drug salbutamol: Mechanisms and degradation pathways. [Journal Article]Chemosphere. 2023 Jan 23 [Online ahead of print]C
- With the increasing incidence and mortality of cardiovascular diseases, high consumption of the cardiovascular drug salbutamol (SAL) has made this compound an emerging pollutant in natural water and a challenge for traditional wastewater treatment. In this paper, an efficient advanced oxidation process was used to degrade SAL by electron beam (EB) irradiation. The results revealed that 100 mg L-1…
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- "As-needed" inhaled corticosteroids for patients with asthma. [Journal Article]J Allergy Clin Immunol Pract. 2023 Jan 23 [Online ahead of print]JA
- Prevention of severe asthma exacerbations is a primary management goal for asthma across the severity spectrum. Inhaled corticosteroids (ICS) decrease the risk of asthma exacerbations, but patient adherence to ICS-containing medications as a daily maintenance therapy is poor, and many patients overuse short-acting beta2-agonist relievers; both are associated with increased risk of severe exacerba…
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- Bronchodilator response after two methods of salbutamol nebulization in asthmatic children. [Journal Article]
- CONCLUSIONS: Salbutamol inhaled from BAN results in a better bronchodilator response than twice the nominal dose of this drug inhaled from CON, which is due to the absence of drug loss during the expiratory phase and therefore greater pulmonary deposition.
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- Effectiveness and Safety of Albuterol Solutions with and without Benzalkonium Chloride. [Journal Article]Respir Care. 2023 Jan 20 [Online ahead of print]RC
- Introduction: Continuous aerosolized β2-agonist, namely albuterol, is the most commonly used therapy for critical asthma. Benzalkonium chloride is a preservative present in some formulations of aerosolized albuterol solutions that can induce bronchospasm by itself. Recent studies have shown that inhalation of albuterol containing benzalkonium chloride might induce unintended bronchoconstriction a…
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- Phase diagrams of PEG1000,1500,2000,4000,6000 + lithium citrate + water ATPSs, and the partitioning of salbutamol at T = 298.15 K. [Journal Article]
- Salbutamol is a drug used to treat the pulmonary diseases by ameliorate the medium and large airways in the lungs. Partitioning of salbutamol drug on the aqueous two-phase systems (ATPSs) of PEG1000,1500,2000,4000,6000 + trilithium citrate + water was determined at T = 298.15 K. The effect of molecular mass of polymer (MMP) on the binodal and tie-line compositions were studied. Results showed tha…
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- An analysis of prehospital pediatric medication dosing errors after implementation of a state-wide EMS pediatric drug dosing reference. [Journal Article]Prehosp Emerg Care. 2023 Jan 18 [Online ahead of print]PE
- CONCLUSIONS: Medications administered to prehospital pediatric patients continue to demonstrate dosing errors despite pediatric dosing reference implementation. Although there have been improvements in error rates in asthma medications, the overall error rate has increased. Continued work to build patient safety strategies to reduce pediatric medication dosing errors by EMS is needed.
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- THE ICS/FORMOTEROL RELIEVER THERAPY REGIMEN IN ASTHMA: A REVIEW. [Journal Article]J Allergy Clin Immunol Pract. 2023 Jan 10 [Online ahead of print]JA
- The Global Initiative for Asthma (GINA) recommends that low dose inhaled corticosteroid (ICS)/formoterol is preferred to short-acting beta2-agonists (SABA's) as reliever therapy in adolescents and adults with asthma, across the range of asthma severity. This recommendation represents the most fundamental change in asthma management for many decades. In this commentary, we review the rationale for…
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- Protein superglue inspired in-situ one-step site-specific immobilization of beta2-adrenoceptor and its application in bioactive compound screening from Cortex Magnoliae Officinalis. [Journal Article]J Chromatogr A. 2023 Jan 06; 1690:463780.JC
- The platforms based on immobilization of transmembrane proteins have become an effective way to study drug-protein interaction and identify new leads for drug discovery. Herein, we exploited the protein superglue (i.e. SpyTag-SpyCatcher chemistry) for site-specific, oriented, and in-situ one-step beta2-adrenoceptor (β2-AR) immobilization. SpyCatcher was used as a fusion tag at the C-terminal of β…
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- Early-Onset Ventilator-Associated Pneumonia in Pediatric Severe Traumatic Brain Injury. [Journal Article]Neurocrit Care. 2023 Jan 12 [Online ahead of print]NC
- CONCLUSIONS: Ventilator-associated pneumonia occurs commonly in children with severe TBI, with rates of 27-41%, depending on CDC-defined VAP or clinical VAP. The discrepancy between clinical VAP and CDC-defined VAP further illustrates the need for a standardized definition for VAP. Although most interventions were not associated with VAP, nebulized 3% saline and albuterol were associated with reduced incidence of VAP; future investigation is needed to determine whether mucolytic agents can decrease the rate of VAP in children with severe TBI.
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- Patient and Operative Factors Predict Risk of Discretionary Prolonged Postoperative Mechanical Ventilation in a Broad Surgical Cohort. [Journal Article]Anesth Analg. 2022 Oct 13 [Online ahead of print]A&A
- CONCLUSIONS: DPPMV was uncommon in this broad surgical cohort but could be accurately predicted using readily available patient-specific and operative factors. These results may be useful for preoperative risk stratification, postoperative resource allocation, and clinical trial planning.
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- PURA syndrome: Neuromuscular junction manifestations with potential therapeutic implications. [Letter]Neuromuscul Disord. 2022 Nov 04 [Online ahead of print]ND
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- Step-in step-down approach in the management of bronchial asthma in adolescents and adults. [Journal Article]
- CONCLUSIONS: We conclude that step-in step-down approach is a more robust and safer approach for control of asthma.
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- Assessment and management of asthma exacerbations in an emergency department unit. [Journal Article]Allergol Immunopathol (Madr). 2023; 51(1):74-76.AI
- CONCLUSIONS: PRAM is a reliable tool that can be used effectively to estimate the asthma exacerbation severity.
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- Activation of β-Adrenoceptors Promotes Lipid Droplet Accumulation in MCF-7 Breast Cancer Cells via cAMP/PKA/EPAC Pathways. [Journal Article]
- Physiologically, β-adrenoceptors are major regulators of lipid metabolism, which may be reflected in alterations in lipid droplet dynamics. β-adrenoceptors have also been shown to participate in breast cancer carcinogenesis. Since lipid droplets may be seen as a hallmark of cancer, the present study aimed to investigate the role of β-adrenoceptors in the regulation of lipid droplet dynamics in MC…
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- Lung Derecruitment in the Allergic Asthma of Obesity: Evidence from an Anatomically Based Inverse Model. [Journal Article]J Appl Physiol (1985). 2023 Jan 05 [Online ahead of print]JA
- The increase in asthma associated with the obesity epidemic cannot simply be due to airway hyperresponsiveness from chronic lung compression because chronic lung compression is a feature of obesity in general. We therefore sought to investigate what other factors might be at play in the impaired lung function seen in obese individuals with asthma. We measured respiratory system impedance in four …
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- Temperature cycling-induced formation of crystalline coatings. [Journal Article]Int J Pharm. 2022 Dec 31; 632:122577.IJ
- The surface of particles is the hotspot of interaction with their environment and is therefore a major target for particle engineering. Particles with tailored coatings are greatly desired for a range of different applications. Amorphous coatings applied via film coating or microencapsulation have frequently been described in the pharmaceutical context and usually result in homogeneous surfaces. …
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- [β-arrestin2 recruitment by β-adrenergic receptor agonists and antagonists]. [Journal Article]Sheng Li Xue Bao. 2022 Dec 25; 74(6):993-1004.SL
- A large number of β-adrenergic receptor (β-AR) agonists and antagonists are widely used in the treatment of cardiovascular diseases and other diseases. Nonetheless, it remains unclear whether these commonly used β-AR drugs can activate downstream β- arrestin-biased signaling pathways. The objective of this study was to investigate β-arrestin2 recruitment effects of β-AR agonists and antagonists t…
- Use of Drugs Considering Route of Administration on Drug Prescription Pattern for Bronchial Asthma in a Tertiary Level Hospital. [Journal Article]Mymensingh Med J. 2023 Jan; 32(1):73-75.MM
- Bronchial asthma is one of the much known long-term respiratory conditions. Incidence is increasing, in developing countries like Bangladesh. Cross-sectional type of observational study was carried out over one year (July 2017 to June 2018) in the department of Pharmacology with collaboration of the department of Respiratory Medicine and Medicine, Mymensingh Medical College and Hospital, Mymensin…
- Comparative Efficacy of Levosalbutamol and Racemic Salbutamol in the Treatment of Acute Exacerbation of Asthma. [Randomized Controlled Trial]Mymensingh Med J. 2023 Jan; 32(1):10-17.MM
- Asthma is a major noncommunicable disease (NCD), affecting both children and adults, and is the most common chronic disease among children. It is common in all ages and the prevalence is increasing in most countries, especially among children as because of urbanization. Multiple therapeutic modalities are available for management of acute asthma. The commonly used formulation is Racemic Salbutamo…
- The prevalence of bronchodilator responsiveness of the small airway (using mid-maximal expiratory flow) in COPD - a retrospective study. [Journal Article]
- CONCLUSIONS: BDR in the SA (evaluated by MMEF) is common in COPD, and it is also feature seen in all patients with BDR in FEV1. Even in the absence of BDR in FEV1, BDR in MMEF is detected in some patients with COPD, potentially identifying a subgroup of patients who may benefit from different treatment strategies.
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- Optimising intravenous salbutamol in children: a phase 2 study. [Journal Article]Arch Dis Child. 2022 Dec 29 [Online ahead of print]AD
- CONCLUSIONS: A paediatric PKPD model for salbutamol is described. An infusion of 0.5 µg/kg/min after bolus achieves effective bronchodilation. Higher rates are associated with greater tachycardia and hyperglycaemia.
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- Assay validation for vilanterol and its metabolites in human urine with application for doping control analysis. [Journal Article]Drug Test Anal. 2022 Dec 29 [Online ahead of print]DT
- A bioanalytical method for detecting the ultra-long-acting beta2 -agonist (U-LABA), inhaled vilanterol and its metabolites, GSK932009 and GW630200, in urine was developed to potentially monitor permitted therapeutic versus prohibited supratherapeutic use in sport. The World Anti-Doping Agency (WADA) has established urinary concentration thresholds for beta2 -agonists salbutamol and formoterol. Th…
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- Amorphicity and Aerosolization of Soluplus-Based Inhalable Spray Dried Powders. [Journal Article]
- Soluplus is a polymer that has been explored to prepare nanocomposites for pulmonary drug delivery and is non-toxic. However, its aerosolization attributes when spray-dried have not been investigated. Hence, this work aimed to investigate the aerosol performance of soluplus-based spray-dried powders. In addition, the potential use of leucine to improve the aerosolization of such particles was als…
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- Diagnostic and Prognostic Risk Assessment of Heat Shock Protein HSPA1B rs2763979 Gene Variant in Asthma. [Journal Article]
- Given the significant role the heat shock protein Hsp70 plays in modulating cellular homeostasis in several chronic inflammatory disorders, the genetic variation of the inducible HSP70 (HSPA1B) gene may impact protein expression and disease phenotype. The HSPA1B rs2763979 variant has been associated with multiple inflammatory scenarios, but no previous studies have explored its association with a…
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- Unconventional interactions of the TRPV4 ion channel with beta-adrenergic receptor ligands. [Journal Article]
- The transient receptor potential vanilloid 4 (TRPV4) ion channel is present in different tissues including those of the airways. This channel is activated in response to stimuli such as changes in temperature, hypoosmotic conditions, mechanical stress, and chemicals from plants, lipids, and others. TRPV4's overactivity and/or dysfunction has been associated with several diseases, such as skeletal…
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- Investigation on the molecular, electronic and spectroscopic properties of rosmarinic acid: an intuition from an experimental and computational perspective. [Journal Article]J Biomol Struct Dyn. 2022 Dec 22 [Online ahead of print]JB
- Various drugs such as corticosteroids, salbutamol, and β2 agonist are available for the treatment of asthma an inflammatory disease and its symptoms, although the ingredient and the mode of action of these drugs are not clearly elucidated. Hence this research aimed at carrying out improved scientific research with respect to the use of natural product rosmarinic acid which poses minima, side effe…
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- Children with Near-Fatal Asthma: The Use of Inhaled Volatile Anesthetics and Extracorporeal Membrane Oxygenation. [Journal Article]Pediatr Allergy Immunol Pulmonol. 2022 12; 35(4):170-173.PA
- Background and Purpose: The use of extracorporeal membrane oxygenation (ECMO) has been described for near-fatal asthma that continues to be refractory despite maximal medical therapy. Methods: Patients admitted to the pediatric intensive care unit at Texas Children's Hospital from 2012 to 2020 with the diagnosis of asthma who were supported on ECMO or isoflurane were included in the study. Patien…
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- No-shaking and shake-fire delays affect respirable dose for suspension but not solution pMDIs. [Journal Article]Int J Pharm. 2023 Jan 25; 631:122478.IJ
- It has long been accepted that suspension pressurized metered-dose inhalers (pMDIs) must be shaken if a correct dose is to be delivered, if not, it will usually be higher than the label claim. The purpose of this work was to investigate the influence of the device being unshaken, shaken and after a period of delay in pMDI actuation on the Fine Particle Mass (<5 µm), Extra Fine Particle Mass (<2 µ…
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- Potential Mechanisms Between HF and COPD: New Insights From Bioinformatics. [Review]Curr Probl Cardiol. 2022 Dec 15; 48(3):101539.CP
- Heart failure (HF) and chronic obstructive pulmonary disease (COPD) are closely related in clinical practice. This study aimed to investigate the co-genetic characteristics and potential molecular mechanisms of HF and COPD. HF and COPD datasets were downloaded from gene expression omnibus database. After identifying common differentially expressed genes (DEGs), the functional analysis highlighted…
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