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14,141 results
  • Electron beam degradation of the cardiovascular drug salbutamol: Mechanisms and degradation pathways. [Journal Article]
    Chemosphere. 2023 Jan 23 [Online ahead of print]Shao H, Ren Y, … Xu G
  • With the increasing incidence and mortality of cardiovascular diseases, high consumption of the cardiovascular drug salbutamol (SAL) has made this compound an emerging pollutant in natural water and a challenge for traditional wastewater treatment. In this paper, an efficient advanced oxidation process was used to degrade SAL by electron beam (EB) irradiation. The results revealed that 100 mg L-1…
  • "As-needed" inhaled corticosteroids for patients with asthma. [Journal Article]
    J Allergy Clin Immunol Pract. 2023 Jan 23 [Online ahead of print]Cardet JC, Papi A, Reddel H
  • Prevention of severe asthma exacerbations is a primary management goal for asthma across the severity spectrum. Inhaled corticosteroids (ICS) decrease the risk of asthma exacerbations, but patient adherence to ICS-containing medications as a daily maintenance therapy is poor, and many patients overuse short-acting beta2-agonist relievers; both are associated with increased risk of severe exacerba…
  • Effectiveness and Safety of Albuterol Solutions with and without Benzalkonium Chloride. [Journal Article]
    Respir Care. 2023 Jan 20 [Online ahead of print]Al-Subu AM, Friestrom E, … Bogenschutz MC
  • Introduction: Continuous aerosolized β2-agonist, namely albuterol, is the most commonly used therapy for critical asthma. Benzalkonium chloride is a preservative present in some formulations of aerosolized albuterol solutions that can induce bronchospasm by itself. Recent studies have shown that inhalation of albuterol containing benzalkonium chloride might induce unintended bronchoconstriction a…
  • THE ICS/FORMOTEROL RELIEVER THERAPY REGIMEN IN ASTHMA: A REVIEW. [Journal Article]
    J Allergy Clin Immunol Pract. 2023 Jan 10 [Online ahead of print]Beasley R, Bruce P, … Hatter L
  • The Global Initiative for Asthma (GINA) recommends that low dose inhaled corticosteroid (ICS)/formoterol is preferred to short-acting beta2-agonists (SABA's) as reliever therapy in adolescents and adults with asthma, across the range of asthma severity. This recommendation represents the most fundamental change in asthma management for many decades. In this commentary, we review the rationale for…
  • Early-Onset Ventilator-Associated Pneumonia in Pediatric Severe Traumatic Brain Injury. [Journal Article]
    Neurocrit Care. 2023 Jan 12 [Online ahead of print]Gahagen RE, Beardsley AL, … Friedman ML
  • CONCLUSIONS: Ventilator-associated pneumonia occurs commonly in children with severe TBI, with rates of 27-41%, depending on CDC-defined VAP or clinical VAP. The discrepancy between clinical VAP and CDC-defined VAP further illustrates the need for a standardized definition for VAP. Although most interventions were not associated with VAP, nebulized 3% saline and albuterol were associated with reduced incidence of VAP; future investigation is needed to determine whether mucolytic agents can decrease the rate of VAP in children with severe TBI.
  • Lung Derecruitment in the Allergic Asthma of Obesity: Evidence from an Anatomically Based Inverse Model. [Journal Article]
    J Appl Physiol (1985). 2023 Jan 05 [Online ahead of print]Bates JHT, Kaminsky DA, … Dixon AE
  • The increase in asthma associated with the obesity epidemic cannot simply be due to airway hyperresponsiveness from chronic lung compression because chronic lung compression is a feature of obesity in general. We therefore sought to investigate what other factors might be at play in the impaired lung function seen in obese individuals with asthma. We measured respiratory system impedance in four …
  • Temperature cycling-induced formation of crystalline coatings. [Journal Article]
    Int J Pharm. 2022 Dec 31; 632:122577.Zellnitz-Neugebauer S, Lanzinger M, … Neugebauer P
  • The surface of particles is the hotspot of interaction with their environment and is therefore a major target for particle engineering. Particles with tailored coatings are greatly desired for a range of different applications. Amorphous coatings applied via film coating or microencapsulation have frequently been described in the pharmaceutical context and usually result in homogeneous surfaces. …
  • [β-arrestin2 recruitment by β-adrenergic receptor agonists and antagonists]. [Journal Article]
    Sheng Li Xue Bao. 2022 Dec 25; 74(6):993-1004.Wang YR, Cheng DQ, … Liu X
  • A large number of β-adrenergic receptor (β-AR) agonists and antagonists are widely used in the treatment of cardiovascular diseases and other diseases. Nonetheless, it remains unclear whether these commonly used β-AR drugs can activate downstream β- arrestin-biased signaling pathways. The objective of this study was to investigate β-arrestin2 recruitment effects of β-AR agonists and antagonists t…
  • Amorphicity and Aerosolization of Soluplus-Based Inhalable Spray Dried Powders. [Journal Article]
    Pharmaceutics. 2022 Nov 27; 14(12)Adhikari BR, Das SC
  • Soluplus is a polymer that has been explored to prepare nanocomposites for pulmonary drug delivery and is non-toxic. However, its aerosolization attributes when spray-dried have not been investigated. Hence, this work aimed to investigate the aerosol performance of soluplus-based spray-dried powders. In addition, the potential use of leucine to improve the aerosolization of such particles was als…
  • Unconventional interactions of the TRPV4 ion channel with beta-adrenergic receptor ligands. [Journal Article]
    Life Sci Alliance. 2023 Mar; 6(3)Benítez-Angeles M, Juárez-González E, … Rosenbaum T
  • The transient receptor potential vanilloid 4 (TRPV4) ion channel is present in different tissues including those of the airways. This channel is activated in response to stimuli such as changes in temperature, hypoosmotic conditions, mechanical stress, and chemicals from plants, lipids, and others. TRPV4's overactivity and/or dysfunction has been associated with several diseases, such as skeletal…
  • No-shaking and shake-fire delays affect respirable dose for suspension but not solution pMDIs. [Journal Article]
    Int J Pharm. 2023 Jan 25; 631:122478.D'Angelo D, Chierici V, … Buttini F
  • It has long been accepted that suspension pressurized metered-dose inhalers (pMDIs) must be shaken if a correct dose is to be delivered, if not, it will usually be higher than the label claim. The purpose of this work was to investigate the influence of the device being unshaken, shaken and after a period of delay in pMDI actuation on the Fine Particle Mass (<5 µm), Extra Fine Particle Mass (<2 µ…
  • Potential Mechanisms Between HF and COPD: New Insights From Bioinformatics. [Review]
    Curr Probl Cardiol. 2022 Dec 15; 48(3):101539.Wang A, Li Z, … Ma X
  • Heart failure (HF) and chronic obstructive pulmonary disease (COPD) are closely related in clinical practice. This study aimed to investigate the co-genetic characteristics and potential molecular mechanisms of HF and COPD. HF and COPD datasets were downloaded from gene expression omnibus database. After identifying common differentially expressed genes (DEGs), the functional analysis highlighted…
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