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32,634 results
  • A descriptive systematic review of salivary TDM in neonates and infants. [Journal Article]
  • BJBr J Clin Pharmacol 2018 Feb 14
  • Hutchinson L, Sinclair M, … Callan B
  • CONCLUSIONS: There is significant potential for infantile saliva testing and in particular, for neutral and weakly acidic compounds. Of the properties investigated, pKa was the most influential with both logP and protein binding having little effect on this correlation. To conclude any compound with a pKa within physiological range (pH 6 - 8) should be considered with extra care, with the extraction and analysis method examined and optimized on a case-by-case basis.
  • High versus standard dose caffeine for apnoea: a systematic review. [Journal Article]
  • ADArch Dis Child Fetal Neonatal Ed 2018 Feb 07
  • Vliegenthart R, Miedema M, … Onland W
  • CONCLUSIONS: Although this review suggests that administering a higher dose of caffeine might enhance its beneficial effect on death or BPD, firm recommendations on the optimal caffeine dose cannot be given due to the low level of evidence. A large RCT is urgently needed to confirm or refute these findings and determine the optimal dose of caffeine.
  • DNP enhanced NMR with flip-back recovery. [Journal Article]
  • JMJ Magn Reson 2018 Jan 31; 288:69-75
  • Björgvinsdóttir S, Walder BJ, … Emsley L
  • DNP methods can provide significant sensitivity enhancements in magic angle spinning solid-state NMR, but in systems with long polarization build up times long recycling periods are required to optim...
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