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33,850 results
  • Systematic Comparison and Rational Design of Theophylline Riboswitches for Effective Gene Repression. [Journal Article]
    Microbiol Spectr. 2023 Jan 23 [Online ahead of print]Wang X, Fang C, … He J
  • Riboswitches are promising regulatory tools in synthetic biology. To date, 25 theophylline riboswitches have been developed for regulation of gene expression in bacteria. However, no one has systematically evaluated their regulatory effects. To promote efficient selection and application of theophylline riboswitches, we examined 25 theophylline riboswitches in Escherichia coli MG1655 and found th…
  • Theophylline Attenuates BLM-Induced Pulmonary Fibrosis by Inhibiting Th17 Differentiation. [Journal Article]
    Int J Mol Sci. 2023 Jan 05; 24(2)Park SJ, Hahn HJ, … Lee HJ
  • Idiopathic pulmonary fibrosis (IPF) is a chronic and refractory interstitial lung disease. Although there are two approved drugs for IPF, they were not able to completely cure the disease. Therefore, the development of new drugs is required for the effective treatment of IPF. In this study, we investigated the effect of theophylline, which has long been used for the treatment of asthma, on pulmon…
  • Knowledge and Attitude of Healthcare Practitioners Toward Therapeutic Drug Monitoring Practices in the Najran Region, Kingdom of Saudi Arabia. [Journal Article]
    Cureus. 2022 Dec; 14(12):e32214.Al Mutarid M, Alhossan A, … Almutarid QD
  • CONCLUSIONS: This study found that the majority of the healthcare professionals in Najran were aware of the TDM, particularly those with more than 10 years of professional experience. In addition, TDM service is not widely available in smaller hospitals in Najran. There is a need to conduct customized training programs for junior healthcare professionals, thus increasing the levels of awareness toward TDM. Future studies in Saudi Arabia can explore the role of clinical pharmacists in the provision of TDM services by assessing the clinical and economic outcomes of pharmacist interventions in TDM.
  • Pacemaker implantation for persistent sinus node dysfunction in a patient with COVID-19. [Case Reports]
    Clin Case Rep. 2023 Jan; 11(1):e6819.Ota T, Okajima K, … Onishi Y
  • A 46-year-old woman was admitted with coronavirus disease-2019 infection. Symptomatic sinus bradycardia occurred, followed by congestive heart failure. Therapeutics such as isoproterenol, theophylline, and cilostazol could not safely improve her symptoms. She underwent pacemaker implantation 53 days after admission. Atrial pacing remained was at 60% after 6 months.
  • Machine Learning Directed Aptamer Search from Conserved Primary Sequences and Secondary Structures. [Journal Article]
    ACS Synth Biol. 2023 Jan 20; 12(1):186-195.Perez Tobia J, Huang PJ, … Liu J
  • Computer-aided prediction of aptamer sequences has been focused on primary sequence alignment and motif comparison. We observed that many aptamers have a conserved hairpin, yet the sequence of the hairpin can be highly variable. Taking such secondary structure information into consideration, a new algorithm combining conserved primary sequences and secondary structures is developed, which combine…
  • Inhibition of uterine contractility by guanine-based purines in non-pregnant rats. [Journal Article]
    Naunyn Schmiedebergs Arch Pharmacol. 2022 Dec 21 [Online ahead of print]Zizzo MG, Cicio A, Serio R
  • Growing evidence pointed out that guanine-based purines are able to modulate smooth muscle contractile activity of blood vessels and gastrointestinal tract. Since, so far, possible guanine-based purine modulation of uterine musculature is unknown, the aim of the present study was to investigate in vitro, using organ bath technique, guanosine and guanine effects on spontaneous uterine contraction,…
  • The influence of input material properties on hot melt granules prepared using a counter-rotating batch mixer. [Journal Article]
    Pharm Dev Technol. 2022 Dec 30 [Online ahead of print]Pafiakis A, Armenante P, Gogos CG
  • CONCLUSIONS: This work highlighted that, firstly it is possible to measure plastic and frictional energy dissipation as product temperature. Secondly, granule growth and density were found to be proportional to the onset of polymer molecular mobility activated by the heat liberated from interparticle velocity differences via mechanical work (torque) required to move agglomerates through the mixer for the duration of each run.
  • [Preparation and in vitro evaluation of FDM 3D printed theophylline tablets with personalized dosage]. [Journal Article]
    Beijing Da Xue Xue Bao Yi Xue Ban. 2022 Dec 18; 54(6):1202-1207.Kaidierya A, Zhang RG, … Fan TY
  • CONCLUSIONS: Three different dosages of theophylline tablets were successfully prepared by FDM 3D printing technology in this study. The exploration may bring beneficial for the preparation of personalized dose preparations. We expect that with the development of 3D printing technology, FDM 3D printed personalized tablets can be used in the clinic as soon as possible to provide personalized treatment for patients.
  • A purine derivative, paraxanthine, promotes cysteine uptake for glutathione synthesis. [Journal Article]
    J Pharmacol Sci. 2023 Jan; 151(1):37-45.Matsumura N, Kinoshita C, … Aoyama K
  • Purine derivatives such as caffeine and uric acid have neuroprotective activities and are negatively correlated with the incidence of both Alzheimer's disease and Parkinson's disease. We have reported that an increment of intracellular glutathione (GSH) via cysteine uptake in neuronal cells is one of the mechanisms by which caffeine and uric acid confer neuroprotection. Here, we investigated whet…
  • Advances in riboswitch-based biosensor as food samples detection tool. [Review]
    Compr Rev Food Sci Food Saf. 2023 Jan; 22(1):451-472.Dong X, Qi S, … Wang Z
  • Food safety has always been a hot issue of social concern, and biosensing has been widely used in the field of food safety detection. Compared with traditional aptamer-based biosensors, aptamer-based riboswitch biosensing represents higher precision and programmability. A riboswitch is an elegant example of controlling gene expression, where the target is coupled to the aptamer domain, resulting …
  • COVID-19 loss of taste and smell: potential psychological repercussions. [Review]
    Pan Afr Med J. 2022; 43:38.Javed N, Ijaz Z, … Sheikh AB
  • The novel coronavirus (COVID-19) has become a cause for global concern. Apart from a multitude of symptoms, the virus is known for its ability to cause loss of taste and smell that can be irreversible in a few cases. In fact, even after recovery, post-covid syndrome can still lead to devastating outcomes, specifically with reference to loss of smell and taste. A number of mechanisms that have bee…
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