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83 results
  • Dermatology: how to manage acne in skin of colour. [Review]
    Drugs Context. 2022; 11Chiang C, Ward M, Gooderham M
  • Acne vulgaris is a prevalent dermatological condition worldwide but is especially challenging to treat in individuals with skin of colour (SOC). Corresponding to Fitzpatrick skin phototypes III-VI, people of African, Asian, Middle Eastern and Hispanic ethnicity are considered to have SOC. With the additional risk of postinflammatory hyperpigmentation (PIH) as a consequence of inflammatory acne or…
  • The road to biologics in patients with hidradenitis suppurativa: a nationwide drug utilization study. [Journal Article]
    Br J Dermatol. 2022 10; 187(4):523-530.Ring HC, Yao Y, … Egeberg A
  • CONCLUSIONS: Patients with HS who receive biologic therapy have long preceding treatment histories with multiple drug classes and treatment series, many of which are supported by relatively weak evidence in HS. Delay in the initiation of biologic therapy may represent a missed opportunity to prevent disease progression. What is already known about this topic? The treatment journey leading to biologic therapy in patients with HS has not previously been investigated. What does this study add? Our data from 225 patients with HS illustrate that patients who receive biologic therapy have long preceding treatment histories with multiple drug classes and treatment series, many of which are supported by relatively weak evidence in HS.
  • Therapeutic Options for the Treatment of Darier's Disease: A Comprehensive Review of the Literature. [Review]
    J Cutan Med Surg. 2022 May-Jun; 26(3):280-290.Hanna N, Lam M, … Lynde CW
  • Darier's disease (also known as keratosis follicularis or dyskeratosis follicularis) is an autosomal dominant inherited disorder which manifests as hyperkeratotic greasy papules in the first or second decade of life. Aside from symptom management and behavioral modifications to avoid triggers, there are currently no validated treatments for Darier's disease (DD). However, a variety of treatments …
  • Challenges and Solutions in Oral Isotretinoin in Acne: Reflections on 35 Years of Experience. [Journal Article]
    Clin Cosmet Investig Dermatol. 2019; 12:943-951.Bettoli V, Guerra-Tapia A, … Piquero-Martín J
  • Acne vulgaris affects more than 80% of adolescents and young adults and forms a substantial proportion of the dermatologist's and general practitioner's caseload. Severity of symptoms varies but may result in facial scarring and psychological repercussions. Oral isotretinoin is highly effective but can only be prescribed by specialists. Side effects are recognized and mostly predictable, ranging …
  • Premature ventricular contractions associated with isotretinoin use. [Case Reports]
    An Bras Dermatol. 2016 Nov-Dec; 91(6):820-821.Alan S, Ünal B, Yildirim A
  • Isotretinoin has been considered a unique drug for acne treatment. However, it is associated with numerous adverse effects. Isotretinoin can trigger premature ventricular contractions. This report describes a 33-year-old-woman who presented with palpitations for 1 week while undergoing 1-month isotretinoin treatment for mild-moderate facial acne. An electrocardiogram and Holter monitoring showed …
  • Isotretinoin: controversies, facts, and recommendations. [Review]
    Expert Rev Clin Pharmacol. 2016 Nov; 9(11):1435-1442.Bauer LB, Ornelas JN, … Alikhan A
  • Since it was introduced to the market by Hoffman-La Roche (Roche) in 1982, isotretinoin has remained the most effective treatment for severe and recalcitrant acne. However, it has also been surrounded by controversy due to its teratogenicity and inconsistent associations with depression, suicidality, inflammatory bowel disease, increases in lipid levels, and elevated transaminases. Areas covered:…
  • Large-scale survey to describe acne management in Brazilian clinical practice. [Journal Article]
    Clin Cosmet Investig Dermatol. 2015; 8:571-7.Seité S, Caixeta C, Towersey L
  • CONCLUSIONS: This survey illustrates that Brazilian dermatologists employ complex treatment regimens to manage acne, choosing systemic drugs, particularly isotretinoin, even in some cases of grade I acne, and heavily prescribe antibiotics. Because complex regimens are harder for patients to comply with, this result notably raises the question of adherence, which is a key factor in successful treatment.
  • Isotretinoin and inflammatory bowel disease: trial lawyer misuse of science and FDA warnings. [Editorial]
    Am J Gastroenterol. 2014 Apr; 109(4):570-1.Tenner S
  • Based on the Food and Drug Administration Adverse Event Reporting System (FAERS), the FDA and Hoffman La Roche issued warnings of a possible causal association between isotretinoin and inflammatory bowel disease. While scientists studied the association, trial lawyers used the courts to award large sums of money to plaintiffs despite the absence of clear scientific evidence of a causal effect. In…
  • Are we underdosing acne patients with generic isotretinoin? [Journal Article]
    Dermatol Online J. 2013 Jan 15; 19(1):12.Mutizwa MM, Sheinbein DM
  • With Roche's withdrawl of Accutane from the U.S. market in 2009, isotretinoin has only been available in its generic form. Many clinicians fail to realize that for approval by the U.S. Food and Drug Administration, a generic medication must have a bioequivalence between 80 percent and 125 percent of that of the innovator product. This potential variability in bioavailability between branded and g…
  • [An investigational study of acne treatment in France]. [Journal Article]
    Ann Dermatol Venereol. 2012 Oct; 139(10):611-6.Seité S, Rougier A, Dréno B
  • CONCLUSIONS: This study demonstrated the complexity of management of acne patients by dermatologists, particularly in the case of mild to severe acne. Most notably, such therapeutic complexity raises the question of compliance, a key factor in successful treatment.
  • Isotretinoin use and the risk of inflammatory bowel disease: a population-based cohort study. [Journal Article]
    J Invest Dermatol. 2013 Apr; 133(4):907-12.Alhusayen RO, Juurlink DN, … Canadian Drug Safety and Effectiveness Research Network
  • Limited evidence suggests that isotretinoin may be associated with inflammatory bowel disease (IBD). To explore this association, we conducted a retrospective population-based cohort study in British Columbia, Canada, among participants who were newly treated with isotretinoin or topical acne medications. The entire population of untreated provincial residents aged 12-29 years served as the refer…
  • Isotretinoin: state of the art treatment for acne vulgaris. [Journal Article]
    J Dtsch Dermatol Ges. 2010 Mar; 8 Suppl 1:S47-59.Ganceviciene R, Zouboulis CC
  • Summary Isotretinoin (13-cis retinoic acid) is the most potent known inhibitor of sebum production. The multiple modes of action for isotretinoin, including suppression of sebaceous gland activity, normalization of the pattern of keratinization within the sebaceous gland follicle, inhibition of inflammation, reduction of growth of Propionibacterium acnes in a secondary manner and, as currently sh…
  • Isotretinoin (13-cis-retinoic acid)-associated premature ventricular contractions. [Case Reports]
    Turk J Pediatr. 2009 Jul-Aug; 51(4):387-8.Kiliç E, Sahin M, … Ozer S
  • Isotretinoin (13-cis-retinoic acid), a synthetic vitamin A derivative, is used to treat a wide variety of dermatologic conditions including severe acne. Isotretinoin can trigger premature ventricular contractions (PVCs). We describe a 17-year-old boy who presented with PVCs on electrocardiogram during isotretinoin (Roaccutane, Roche) treatment for nodular facial acne. Presence of documented PVCs …
  • Isotretinoin: is there any arrhythmic effect? [Journal Article]
    Int J Dermatol. 2008 Feb; 47(2):195-7.Selcoki Y, Gorpelioglu C, … Akcay A
  • Oral isotretinoin is currently the most effective therapy for acne, but is associated with numerous adverse effects. To investigate the cardiac effects of isotretinoin, acne patients receiving isotretinoin for 6 months were studied. Methods Twenty-six patients with acne vulgaris were enrolled in the study. The patients were treated with a dose of 0.8 mg/kg/day of isotretinoin (Roaccutane, Hoffman…
  • CD69 on CD56+ NK cells and response to chemoimmunotherapy in metastatic melanoma. [Journal Article]
    Eur J Clin Invest. 2007 Nov; 37(11):887-96.Konjević G, Jović V, … Spuzić I
  • CONCLUSIONS: The dynamics of the increase in CD69 early activation antigen expression on CD56+ NK cells is systematic and serial with the increase being significantly higher on day six of the first cycle in group B patients with clinical response, compared to those without, indicating possible predictive value of CD69 expression for clinical response to chemoimmunotherapy.
  • [Isotretinoin: compliance with recommendations in childbearing women]. [Journal Article]
    Ann Dermatol Venereol. 2005 May; 132(5):415-23.Bensouda-Grimaldi L, Jonville-Béra AP, … les Centres Régionaux de Pharmacovigilance
  • CONCLUSIONS: Despite 3 successive isotretinoin prescription and issue recommendations strengthening in childbearing women, pregnancies can't be totally avoided. Bad compliance concerns the prescription and/or an incomplete or not understood information by the patient who does not scrupulously apply the care and contraception agreement. However, this study does not allow to assess the proportion of issued prescriptions despite their non-accordance with the licence criteria. The National Commission of Pharmacovigilance did not like to limit isotretinoin prescription to dermatologists only. It estimates that the administrative authority must intensify information by dermatologists, general practitioners and pharmacists, about measures to take to avoid an exposure to isotretinoin during pregnancy.
  • Polar hysteria: an expression of hypervitaminosis A. [Historical Article]
    Am J Ther. 2004 Nov-Dec; 11(6):507-16.O'Donnell J
  • Isotretinoin (Accutane) is a drug closely related to the chemical structure of Vitamin A. The pharmacology and toxicology of these two retinoids is similar enough to warrant comparison. Accutane is a powerful drug which its manufacturer, Roche, indicates is limited for severe recalcitrant nodular acne. This potency is also reflected in Accutane's well-known ability to produce severe birth defects…
  • Isotretinoin use and subsequent depression and suicide: presenting the evidence. [Review]
    Am J Clin Dermatol. 2003; 4(7):493-505.Hull PR, D'Arcy C
  • The growing number of reported cases of depression and suicide associated with isotretinoin (a retinoid receptor agonist) use in patients with acne has prompted concern among dermatologists, patients, and their relatives and has triggered new warnings from regulators including depression-related, patient-informed consent forms. In establishing a cause-effect relationship, it is useful to judiciou…
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