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32,932 results
  • Mera: A scalable high throughput automated micro-physiological system. [Journal Article]
    SLAS Technol. 2023 Jan 25 [Online ahead of print]Cliffe FE, Madden C, … Lyons M
  • There is an urgent need for scalable Microphysiological Systems (MPS's)1 that can better predict drug efficacy and toxicity at the preclinical screening stage. Here we present Mera, an automated, modular and scalable system for culturing and assaying microtissues with interconnected fluidics, inbuilt environmental control and automated image capture. The system presented has multiple possible flu…
  • Long-Lived States Provide Insights from NMR into the β-Cyclodextrin Drug Assemblies. [Journal Article]
    J Phys Chem A. 2023 Jan 27 [Online ahead of print]Gangwar U, Singh B, Kurur ND
  • In the last two decades, extending spin memory in NMR has been used for several purposes. Long-lived states (LLS) or singlet states are one of the first spin memory enhancement techniques used. LLS have the potential to extract structural information and intra- and intermolecular interactions of complex systems other than studying slow phenomenon. The motional regime of β-cyclodextrin (β-CD) drug…
  • Self-assembled FGF21 nanoparticles alleviate drug-induced acute liver injury. [Journal Article]
    Front Pharmacol. 2022; 13:1084799.Huang Z, Wang H, … Zhao Y
  • Acetaminophen (N-acetyl-p-aminophenol, APAP) is a common antipyretic agent and analgesic. An overdose of APAP can result in acute liver injury (ALI). Oxidative stress and inflammation are central to liver injury. N-acetylcysteine (NAC), a precursor of glutathione, is used commonly in clinical settings. However, the window of NAC treatment is limited, and more efficacious alternatives must be foun…
  • Internuclear distance measurements between 1H and 14N in multi-component rigid solids at fast MAS. [Journal Article]
    J Magn Reson. 2023 Jan 18; 348:107378.Ogaeri Y, Suzuki N, … Nishiyama Y
  • 1H-14N internuclear distances are readily and accurately measured using the symmetry-based phase-modulated resonance-echo saturation-pulse double-resonance (PM-S-RESPDOR) method in rigid solids. The fraction curve, (S0 - S')/S0, is represented by a single variable of a 1H-14N heteronuclear dipolar coupling, where S0 and S' are the PM-S-RESPDOR signal intensity with and without 14N PM saturation p…
  • Analgesia in Postoperative Adult Strabismus Patients. [Journal Article]
    J Pediatr Ophthalmol Strabismus. 2023 Jan-Feb; 60(1):e5-e7.Rho J, Gannon E, … Hoehn ME
  • This survey of pediatric ophthalmic surgeons on analgesia for postoperative adult strabismus patients indicates that 65% prescribed acetaminophen and/or nonsteroidal anti-inflammatory drugs (NSAIDs), and 12% to 16% prescribed opioids. Most surgeons reported reasonable control of pain regardless of analgesia. Acetaminophen and/or NSAIDs may adequately control pain, although certain circumstances m…
  • Developmental changes in the extent of drug binding to rat plasma proteins. [Journal Article]
    Sci Rep. 2023 Jan 23; 13(1):1266.Qiu F, Dziegielewska KM, … Saunders NR
  • Binding of therapeutics to proteins in blood plasma is important in influencing their distribution as it is their free (unbound) form that is able to cross cellular membranes to enter tissues and exert their actions. The concentration and composition of plasma proteins vary during pregnancy and development, resulting in potential changes to drug protein binding. Here, we describe an ultrafiltrati…
  • [Extrapulmonary tuberculosis: a difficult therapeutic approach]. [Case Reports]
    Dtsch Med Wochenschr. 2023 Feb; 148(3):112-115.Lüers A
  • CONCLUSIONS: Toxic hepatitis is a possible severe complication of anti-Tb-treatment. A critical evaluation of patients' medication and soon initiation of anti -Tb-treatment is necessary. Especially in patients coming from high tb-incidence regions with history of poor general condition and persisting fever the diagnosis of extrapulmonary tuberculosis and bone marrow infiltration should be taken into account.
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