- A quality-by-design eco-friendly UV-HPLC method for the determination of four drugs used to treat symptoms of common cold and COVID-19. [Journal Article]Sci Rep. 2023 Jan 28; 13(1):1616.SR
- An optimization approach based on full factorial design was employed for developing an HPLC-UV method for simultaneous determination of a quaternary mixture used for the treatment of symptoms related to common cold and COVID-19. The quaternary mixture is composed of paracetamol, levocetirizine dihydrochloride, phenylephrine hydrochloride and ambroxol hydrochloride. The developed technique is a gr…
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- Characterization of childhood exposure to environmental contaminants using stool in a semi-urban middle-class cohort from eastern Canada. [Journal Article]Environ Res. 2023 Jan 25 [Online ahead of print]ER
- Children are exposed to various environmental organic and inorganic contaminants with effects on health outcomes still largely unknown. Many matrices (e.g., blood, urine, nail, hair) have been used to characterize exposure to organic and inorganic contaminants. The sampling of feces presents several advantages; it is non-invasive and provides a direct evaluation of the gut microbiome exposure to …
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- Mera: A scalable high throughput automated micro-physiological system. [Journal Article]SLAS Technol. 2023 Jan 25 [Online ahead of print]ST
- There is an urgent need for scalable Microphysiological Systems (MPS's)1 that can better predict drug efficacy and toxicity at the preclinical screening stage. Here we present Mera, an automated, modular and scalable system for culturing and assaying microtissues with interconnected fluidics, inbuilt environmental control and automated image capture. The system presented has multiple possible flu…
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- Is L-PRF an effective hemostatic agent in single tooth extractions? A cohort study on VKA and DOAC patients. [Journal Article]Clin Oral Investig. 2023 Jan 28 [Online ahead of print]CO
- CONCLUSIONS: The use of L-PRF resulted in limited mild late post-operative bleedings without the need of medical intervention.
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- Long-Lived States Provide Insights from NMR into the β-Cyclodextrin Drug Assemblies. [Journal Article]J Phys Chem A. 2023 Jan 27 [Online ahead of print]JP
- In the last two decades, extending spin memory in NMR has been used for several purposes. Long-lived states (LLS) or singlet states are one of the first spin memory enhancement techniques used. LLS have the potential to extract structural information and intra- and intermolecular interactions of complex systems other than studying slow phenomenon. The motional regime of β-cyclodextrin (β-CD) drug…
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- Self-medication in Primary Dysmenorrhea among Undergraduate Students in a Medical College: A Descriptive Cross-sectional Study. [Journal Article]
- CONCLUSIONS: The prevalence of self-medication practice in primary dysmenorrhea among undergraduate students was lower when compared to similar studies done in similar settings.
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- Self-assembled FGF21 nanoparticles alleviate drug-induced acute liver injury. [Journal Article]
- Acetaminophen (N-acetyl-p-aminophenol, APAP) is a common antipyretic agent and analgesic. An overdose of APAP can result in acute liver injury (ALI). Oxidative stress and inflammation are central to liver injury. N-acetylcysteine (NAC), a precursor of glutathione, is used commonly in clinical settings. However, the window of NAC treatment is limited, and more efficacious alternatives must be foun…
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- Is Paracetamol Better than Diclofenac Sodium in Management of Postoperative Pain and Edema Following Major Maxillofacial Surgeries? [Journal Article]
- Paracetamol is an optimal non-opioid analgesic and holds considerable advantages over NSAIDs in managing post-operative pain. Literature to date doesn't provide substantial documentation of it's efficacy and safety in major oral and maxillofacial surgeries. The study is designed to compare the effectiveness of intravenous paracetamol with diclofenac sodium for controlling post-operative pain and …
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- Internuclear distance measurements between 1H and 14N in multi-component rigid solids at fast MAS. [Journal Article]J Magn Reson. 2023 Jan 18; 348:107378.JM
- 1H-14N internuclear distances are readily and accurately measured using the symmetry-based phase-modulated resonance-echo saturation-pulse double-resonance (PM-S-RESPDOR) method in rigid solids. The fraction curve, (S0 - S')/S0, is represented by a single variable of a 1H-14N heteronuclear dipolar coupling, where S0 and S' are the PM-S-RESPDOR signal intensity with and without 14N PM saturation p…
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- Caveolin-1 ameliorates acetaminophen-aggravated inflammatory damage and lipid deposition in non-alcoholic fatty liver disease via the ROS/TXNIP/NLRP3 pathway. [Journal Article]Int Immunopharmacol. 2023 Jan; 114:109558.II
- The overuse of acetaminophen (APAP) may cause more severe hepatotoxicity in patients with non-alcoholic fatty liver disease (NAFLD). Caveolin-1 (CAV1), is an essential regulator of metabolic function, which can alleviate liver damage by scavenging reactive oxygen species (ROS). Evidence suggests that the NOD-like receptor family pyrin domain-containing 3 (NLRP3) -mediated pyroptosis is involved i…
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- Reducing Opioid Overprescribing through Procedure-specific Prescribing Guidelines. [Journal Article]Plast Reconstr Surg Glob Open. 2023 Jan; 11(1):e4776.PR
- CONCLUSIONS: A procedure-specific prescribing model is a straight-forward intervention to promote safer opioid-prescribing practices in plastic surgery. Its usage in clinical practice may lead to more appropriate opioid prescribing.
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- Does Pain Medication Influence Outcomes in Elderly People seeking care for Back Pain? BACE Cohort study. [Journal Article]Eur J Pain. 2023 Jan 25 [Online ahead of print]EJ
- CONCLUSIONS: In the present study, although patients who de-escalated or stopped analgesic had less pain and disability, pain medication overall does not result in better outcomes in older people with back pain.
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- Repeat dose steroid in high pain responders after total knee arthroplasty - A study protocol. [Journal Article]Acta Anaesthesiol Scand. 2023 Jan 25 [Online ahead of print]AA
- CONCLUSIONS: The data from this study will provide evidence for the effect of a repeated dose of dexamethasone as an analgesic adjuvant in patients undergoing total knee arthroplasty with a high risk of postoperative pain.
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- Analgesia in Postoperative Adult Strabismus Patients. [Journal Article]J Pediatr Ophthalmol Strabismus. 2023 Jan-Feb; 60(1):e5-e7.JP
- This survey of pediatric ophthalmic surgeons on analgesia for postoperative adult strabismus patients indicates that 65% prescribed acetaminophen and/or nonsteroidal anti-inflammatory drugs (NSAIDs), and 12% to 16% prescribed opioids. Most surgeons reported reasonable control of pain regardless of analgesia. Acetaminophen and/or NSAIDs may adequately control pain, although certain circumstances m…
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- Migraine treatment in pregnancy: A survey of comfort and treatment practices of women's healthcare providers. [Journal Article]Headache. 2023 Jan 25 [Online ahead of print]H
- CONCLUSIONS: This survey of women's healthcare providers revealed varying levels of comfort regarding migraine management during pregnancy, and highlights the need for additional education regarding migraine treatment safety data during pregnancy.
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- Pharmaceutical toxicity is a common pattern of inpatient acute poisonings in Birjand City, East of Iran. [Journal Article]
- Information on the pattern of acute poisonings in hospitals of Birjand city, Iran, is limited. This study aimed to address this knowledge gap by examining the admissions in a major poisoning center in eastern Iran. This cross-sectional study included patients admitted to the Imam Reza Hospital in Birjand over 12 months. Medical records of the poisoned patients were reviewed, and the study variabl…
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- Risk of COVID-19 Diagnosis and Hospitalisation in Patients with Osteoarthritis or Back Pain Treated with Ibuprofen Compared to Other NSAIDs or Paracetamol: A Network Cohort Study. [Journal Article]
- CONCLUSIONS: In patients with osteoarthritis or back pain, we found no differential risks of incident COVID-19 diagnosis or COVID-19 hospitalisation for ibuprofen users compared with other ns-NSAIDs, COX-2i or paracetamol. Our findings support regulatory recommendations that NSAIDs, including ibuprofen, should be prescribed as indicated in the same way as before the COVID-19 pandemic, especially for those who rely on ibuprofen or NSAIDs to manage chronic arthritis or musculoskeletal pain symptoms.
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- eAn effective and stability-indicating method development and optimization utilizing the Box-Behnken Design for the simultaneous determination of Acetaminophen, Caffeine, and Aspirin in Tablets Formulation. [Journal Article]Biomed Chromatogr. 2023 Jan 24 [Online ahead of print]BC
- Analytical techniques must be sensitive, specific, and accurate in order to assess the active pharmaceutical ingredients in pharmaceutical dosage forms. The Quality by Design (QbD) application has proven to be a practical method for magnifying HPLC operations. This article discusses the successfully developed QbD-based stability-indicative LC method for evaluating acetaminophen, caffeine, and asp…
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- Developmental changes in the extent of drug binding to rat plasma proteins. [Journal Article]
- Binding of therapeutics to proteins in blood plasma is important in influencing their distribution as it is their free (unbound) form that is able to cross cellular membranes to enter tissues and exert their actions. The concentration and composition of plasma proteins vary during pregnancy and development, resulting in potential changes to drug protein binding. Here, we describe an ultrafiltrati…
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- [Extrapulmonary tuberculosis: a difficult therapeutic approach]. [Case Reports]Dtsch Med Wochenschr. 2023 Feb; 148(3):112-115.DM
- CONCLUSIONS: Toxic hepatitis is a possible severe complication of anti-Tb-treatment. A critical evaluation of patients' medication and soon initiation of anti -Tb-treatment is necessary. Especially in patients coming from high tb-incidence regions with history of poor general condition and persisting fever the diagnosis of extrapulmonary tuberculosis and bone marrow infiltration should be taken into account.
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- Oral NSAIDs vs. Other Oral Analgesic Agents for Acute Soft Tissue Injury. [Journal Article]Am Fam Physician. 2023 Jan; 107(1):23-24.AF
- Deliberate Self-Poisoning: Real-Time Characterization of Suicidal Habits and Toxidromes in the Food and Drug Administration Adverse Event Reporting System. [Journal Article]
- CONCLUSIONS: Worldwide coverage of the FAERS complements existing knowledge about DSP and may drive tailored prevention measures to timely address the DSP phenomenon and prevent intentional suicides.
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- Retracted: Comparison between Ibuprofen and Acetaminophen in the Treatment of Infectious Fever in Children: A Meta-Analysis. [Retraction of Publication]
- [This retracts the article DOI: 10.1155/2022/1794258.].
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- Dextromethorphan improves locomotor activity and decreases brain oxidative stress and inflammation in an animal model of acute liver failure. [Journal Article]
- CONCLUSIONS: The effect of dextromethorphan on oxidative stress and inflammation seems to be a major mechanism for its neuroprotective properties in HE. Based on these data DXM could be applied as an effective pharmacological option against HE-associated brain injury.
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- A novel humanized Chi3l1 blocking antibody attenuates acetaminophen-induced liver injury in mice. [Journal Article]
- Acetaminophen (APAP) overdose is a leading cause of acute liver injury in the USA. The chitinase 3-like-1 (Chi3l1) protein contributes to APAP-induced liver injury (AILI) by promoting hepatic platelet recruitment. Here, we report the development of a Chi3l1-targeting antibody as a potential therapy for AILI. By immunizing a rabbit successively with the human and mouse Chi3l1 proteins, we isolated…
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- Prevalence of and factors associated with unmanageable pain levels in people with knee or hip osteoarthritis: a cross-sectional population-based study. [Journal Article]
- CONCLUSIONS: Two-thirds of people with HKOA in Portugal have poor management of their pain levels. Clinical and lifestyle factors, that are highly presented in individuals with HKOA, are associated with unmanageable pain. Our results highlighting the need for further research and implementation of effective interventions to improve pain, function and quality of life in people with HKOA.
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- Continuous operation of fungal wheel reactor based on solid-state fermentation for the removal of pharmaceutical and personal care products. [Journal Article]J Environ Manage. 2023 Jan 20; 331:117316.JE
- Wood-rotting fungi and their enzymatic systems represent promising biocatalysts for the removal of pharmaceuticals and personal care products (PPCPs) from wastewater. We designed a fungal wheel reactor (FWR) based on solid-state fermentation (SSF) of Trametes versicolor and a lignocellulosic substrate, which was used as an immobilization carrier for fungal biomass and the sole initial nutrient so…
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- Intravenous Hydromorphone Versus Intravenous Acetaminophen for Older Adult Patients: More to Think About. [Letter]Ann Emerg Med. 2023 Feb; 81(2):246-247.AE
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- Development of a newly designed biosensor using multi-walled carbon nanotubes (MWCNTs) with gold nanoparticles (AuNPs) in the presence of acetaminophen for detection of Escherichia coli. [Journal Article]Arch Microbiol. 2023 Jan 21; 205(2):70.AM
- Escherichia coli is one of the main indicators in the quality control of water, pharmaceuticals, and other samples. Compared with the time-consuming and high prices of the classical methods, with their high risks in the case of insensitive, contamination and offline detections, biosensors have long been a fast and accurate approach for identifying different bacteria. The present study reports the…
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