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Unbound Medicine.
(Achalasia)
9,553 results
  • Optimal surgical approaches for esophageal epiphrenic diverticulum: literature review and our experience. [Journal Article]
    Clin J Gastroenterol. 2023 Feb 01 [Online ahead of print]Sato Y, Tanaka Y, … Matsuhashi N
  • Esophageal epiphrenic diverticulum is a rare condition usually secondary to a primary esophageal motility disorder. Although epiphrenic diverticulum may be treated by thoracoscopic and laparoscopic management, the optimal surgical approach have not been established. We successfully treated a left epiphrenic diverticulum along with achalasia and paraesophageal hernia by a planned combination of th…
  • Post-POEM Contrast-Enhanced Swallow Study: Is It Always Necessary? [Journal Article]
    J Gastrointest Surg. 2023 Jan 31 [Online ahead of print]Szydlo Shein G, Elazary R, … Mintz Y
  • CONCLUSIONS: The study findings suggest that performing routine contrast-enhanced swallow studies on all patients is not necessary following POEM, as leaks can be screened for by clinical or laboratory abnormalities. Herein, we propose an algorithm based on objective measurable findings for the selection of patients who should undergo CESS.
  • Achalasia: investigation and management. [Review]
    Br J Hosp Med (Lond). 2023 Jan 02; 84(1):1-9.Slim N, Williamson JM
  • Achalasia, characterised by the absence of peristalsis and failure of relaxation of the lower oesophageal sphincter, is an uncommon degenerative condition that results in dysphagia. If left untreated it can lead to aspiration, oesophageal perforation, oesophagitis and malnutrition. It has a range of immune, allergic, viral and genetic aetiological causes. Successful diagnosis relies on the use of…
  • TYPE II ACHALASIA WITH SUBSEQUENT RECOVERY OF ESOPHAGEAL MOTILITY - POEM. [Journal Article]
    Rev Esp Enferm Dig. 2023 Jan 23 [Online ahead of print]Maderuelo González E, Relea Pérez L, Herreros de Tejada A
  • CONCLUSIONS: Achalasia is an esophageal motor disorder characterized by incomplete relaxation of the lower esophageal sphincter and a complete absence of peristalsis in the esophageal body. The cause of the absence of motility is the loss of the inhibitory neurons of the myenteric plexus, but the accurate etiopathogenesis is still unknown. Therefore, there is no curative treatment and all therapeutic options are symptomatic, aimed to relieve the obstruction of the EGJ. POEM is the newest method. Absence of motility of the esophageal body in patients with achalasia was believed to be irreversible. Nevertheless, more and more studies describe a partial recovery of motility observed in manometry after POEM, especially in type II Achalasia. The exact pathophysiological mechanism of this recovery is still unknown.
  • Updates in the Field of Submucosal Endoscopy. [Review]
    Life (Basel). 2022 Dec 30; 13(1)Maehata T, Sato Y, … Tateishi K
  • Submucosal endoscopy (third-space endoscopy) can be defined as an endoscopic procedure performed in the submucosal space. This procedure is novel and has been utilized for delivery to the submucosal space in a variety of gastrointestinal diseases, such as a tumor, achalasia, gastroparesis, and subepithelial tumors. The main submucosal endoscopy includes peroral endoscopic myotomy, gastric peroral…
  • Impact of Hypermannosylation on the Structure and Functionality of the ER and the Golgi Complex. [Journal Article]
    Biomedicines. 2023 Jan 06; 11(1)Franzka P, Schüler SC, … Hübner CA
  • Proteins of the secretory pathway undergo glycosylation in the endoplasmic reticulum (ER) and the Golgi apparatus. Altered protein glycosylation can manifest in serious, sometimes fatal malfunctions. We recently showed that mutations in GDP-mannose pyrophosphorylase A (GMPPA) can cause a syndrome characterized by alacrima, achalasia, mental retardation, and myopathic alterations (AAMR syndrome). …
  • Dysphagia in Children, Do Not Blame Eosinophils Too Quickly. [Case Reports]
    Children (Basel). 2022 Dec 28; 10(1)Debourdeau A, Gonzalez JM, … Vitton V
  • Dysphagia in children is a relatively frequent symptom in childhood, and the main causes are congenital and linked to ear-nose-throat etiologies. However, non-congenital esophageal dysphagia is less common, and the main cause in such cases is eosinophilic esophagitis (EoE). When there is no response to a well-conducted treatment, with normalization of histology, the diagnosis of EoE must then be …
  • Probability of additional intervention and long-term follow-up of esophagomyotomy. [Journal Article]
    Surg Endosc. 2023 Jan 19 [Online ahead of print]Rasmussen M, Ward MA, … Leeds SG
  • CONCLUSIONS: Our results for both LHM and POEM emphasize the importance of long-term follow-up in patients with an esophageal motility disorder. We have found that patients undergoing LHM are more likely to have a post-operative intervention as well as a higher rate of repeat myotomy than POEM. With both interventions, a greater change in Eckardt score decreased the likelihood of reintervention.
  • Submucosal endoscopy: the present and future. [Review]
    Clin Endosc. 2023 Jan; 56(1):23-37.Nabi Z, Reddy DN
  • Submucosal endoscopy or third-space endoscopy utilizes the potential space between the mucosal and muscularis layers of the gastrointestinal tract to execute therapeutic interventions for various diseases. Over the last decade, endoscopic access to the submucosal space has revolutionized the field of therapeutic endoscopy. Submucosal endoscopy was originally used to perform endoscopic myotomy in …
  • Downexpression of miR-200c-3p Contributes to Achalasia Disease by Targeting the PRKG1 Gene. [Journal Article]
    Int J Mol Sci. 2022 Dec 30; 24(1)Micale L, Fusco C, … Latiano A
  • Achalasia is an esophageal smooth muscle motility disorder with unknown pathogenesis. Taking into account our previous results on the downexpression of miR-200c-3p in tissues of patients with achalasia correlated with an increased expression of PRKG1, SULF1, and SYDE1 genes, our aim was to explore the unknown biological interaction between these genes and human miR-200c-3p and if this relation co…
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