- A quality-by-design eco-friendly UV-HPLC method for the determination of four drugs used to treat symptoms of common cold and COVID-19. [Journal Article]Sci Rep. 2023 Jan 28; 13(1):1616.SR
- An optimization approach based on full factorial design was employed for developing an HPLC-UV method for simultaneous determination of a quaternary mixture used for the treatment of symptoms related to common cold and COVID-19. The quaternary mixture is composed of paracetamol, levocetirizine dihydrochloride, phenylephrine hydrochloride and ambroxol hydrochloride. The developed technique is a gr…
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- Gancao Nourishing-Yin decoction combined with methotrexate in treatment of aging CIA mice: a study based on DIA proteomic analysis. [Journal Article]Chin Med. 2023 Jan 28; 18(1):9.CM
- CONCLUSIONS: Aging aggravated joints damage in CIA, which probably due to metabolic changes rather than more severe inflammation. GCNY showed significant effects in the ERA mice model especially when integrated with MTX to obtain a synergic action.
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- Detection and genetic analysis of porcine circovirus-like virus in pigs with diarrhea between 2016 and 2021 in Henan and Shanxi provinces of China. [Journal Article]Arch Virol. 2023 Jan 28; 168(2):76.AV
- Porcine circovirus-like virus (PCLV) is a recently discovered virus that may be associated with diarrhea in pigs. To investigate the epidemic profile and genetic characteristics of this virus, 175 clinical samples (141 intestinal samples, 17 blood samples, and 17 fecal samples) were collected from diseased piglets during outbreaks of diarrhea from 33 pig farms in 19 cities of Henan and Shanxi pro…
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- [Exosomes secreted from human umbilical cord mesenchymal stem cells promote pancreatic ductal adenocarcinoma growth by transferring miRNAs]. [Journal Article]Zhonghua Zhong Liu Za Zhi. 2023 Jan 23; 45(1):50-55.ZZ
- Objective: To observe the effects of exosomes derived from human umbilical cord mesenchymal stem cells on the proliferation and invasion of pancreatic cancer cells, and to analyze the contents of exosomes and explore the mechanisms affecting pancreatic cancer cells. Methods: Exosomes extracted from human umbilical cord mesenchymal stem cells were added to pancreatic cancer cells BxPC3, Panc-1 and…
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- Effects of Vitamin D supplementation or deficiency on metabolic phenotypes in mice of different sexes. [Journal Article]J Steroid Biochem Mol Biol. 2023 Jan 25 [Online ahead of print]JS
- Vitamin D is a steroid hormone precursor that was initially recognized for its important roles in calcium-phosphate homeostasis and bone health. However, the resent prevalence of vitamin D deficiency has highlighted its non-skeletal function, such as its important role in regulating endogenous metabolism. The aim of the present study was to examine the roles of vitamin D supplementation or defici…
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- Small-Size Ti3C2Tx MXene Nanosheets Coated with Metal-Polyphenol Nanodots for Enhanced Cancer Photothermal Therapy and Anti-Inflammation. [Journal Article]Acta Biomater. 2023 Jan 25 [Online ahead of print]AB
- As a controllable, simple method with few side effects, near-infrared (NIR) light-based photothermal therapy (PTT) has been proven an effective cancer therapeutic approach. However, PTT-induced inflammation is a potential negative factor. And the overexpressed heat shock proteins (HSPs) by cancer cells can protect them from hyperthermia during PTT. In this work, small-size Ti3C2Tx MXene nanosheet…
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- Colloidal stability and aggregation behavior of CdS colloids in aquatic systems: Effects of macromolecules, cations, and pH. [Journal Article]Sci Total Environ. 2023 Jan 25 [Online ahead of print]ST
- Redox-dynamic environments such as river floodplains and paddy fields have been demonstrated to be important sources of CdS colloids. To date, the aggregation kinetics of CdS colloids had not yet been studied, and the structure and properties of macromolecules on the interaction between different macromolecules and CdS colloids, as well as the aggregation behavior of CdS colloids are unclear. Thi…
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- Lactobacillus acidophilus regulates abnormal serotonin availability in experimental ulcerative colitis. [Journal Article]Anaerobe. 2023 Jan 25 [Online ahead of print]A
- CONCLUSIONS: In our study, it was observed that the amount of serotonin in the intestinal tissue increased excessively with ulcerative colitis. In addition, L.acidophilus has been found to reduce the abnormally increased amount of serotonin in the colon tissue, as well as reduce the inflammation in the intestinal tissue that occurs with ulcerative colitis. With our findings, it is predicted that probiotic application can be used as a treatment option in ulcerative colitis.
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- Roxadustat and its failure: A comparative dynamic study. [Journal Article]J Mol Graph Model. 2023 Jan 21; 120:108422.JM
- Roxadustat, a small-molecule inhibitor of hypoxia-inducible factor prolyl hydroxylase domain 2 (HIF-PHD2) has been recently overruled by the American Food and Drug Administration (FDA) in Phase 3 clinical trials. This study provides insights into the dynamics of Roxadustat with PHD2 and proposes two FDA-approved drugs; Pemetrexed and Valrubicin to treat chronic kidney disease (CKD). Role of chemi…
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- Ameliorative Effects of Thunbergia erecta L. Leaves Against the Initiation of Hepatocarcinogenesis Induced by Diethylnitrosamine in the Rat Model. [Journal Article]Appl Biochem Biotechnol. 2023 Jan 28 [Online ahead of print]AB
- Thunbergia erecta L. contains cytotoxic and liver-protective compounds. Thunbergia erecta L. leaves were macerated in 70% aqueous ethanol, then fractionated with ethyl acetate (9.3 g) and butanol (12.7 g), and attenuated Den-induced liver cancer in a Wistar rat experimental model. Ethyl acetate and butanol fractions were chromatographed using column chromatography and solid-phase extraction (SPE)…
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- Expression of pro-inflammatory cytokines (IL-6 & IL-18) exacerbate the risk of diabetic nephropathy in the Pakistani population. [Journal Article]Mol Biol Rep. 2023 Jan 28 [Online ahead of print]MB
- CONCLUSIONS: The present study implicates that increased expression of IL-6 and decreased of IL-18 was associated with development of DN in Pakistani population.
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- Toxicity bioassay and sub-lethal effects of profenofos-based insecticide on behavior, biochemical, hematological, and histopathological responses in Grass carp (Ctenopharyngodon idella). [Journal Article]Ecotoxicology. 2023 Jan 28 [Online ahead of print]E
- Profenofos (organophosphate) is among the major toxicant polluting freshwater bodies, exerting a significant effect on fish health. The LC50 value of Profenofos (PRO) was resolved in Grass carp (Ctenopharyngodon idella) with average body weight (55.82 ± 5.42 g) and determined the 96 h LC50 value as 7.2 µg/L for the assay. Twenty-one-day exposures to 1.8 µg/ L and 3.6 µg/ L doses were conducted to…
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- Discovery of Biologically Optimized Polymyxin Derivatives Facilitated by Peptide Scanning and In Situ Screening Chemistry. [Journal Article]J Am Chem Soc. 2023 Jan 28 [Online ahead of print]JA
- Peptides can be converted to highly active compounds by introducing appropriate substituents on the suitable amino acid residue. Although modifiable residues in peptides can be systematically identified by peptide scanning methodologies, there is no practical method for optimization at the "scanned" position. With the purpose of using derivatives not only for scanning but also as a starting point…
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- A Biomimetic Lubricating Nanosystem with Responsive Drug Release for Osteoarthritis Synergistic Therapy. [Journal Article]Adv Healthc Mater. 2023 Jan 28 [Online ahead of print]AH
- Osteoarthritis (OA) is associated with lubrication failure of articular cartilage and severe inflammatory response of joint capsule. Synergistic therapy combining joint lubrication and anti-inflammation emerges as a novel treatment of OA. In this study, bioinspired by ultra-low friction of natural articular synovial fluid and mussel adhesion chemistry, a biomimetic nanosystem with dual functions …
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- The effect of DNA repair gene variants on COVID-19 disease: susceptibility, severity, and clinical course. [Journal Article]Nucleosides Nucleotides Nucleic Acids. 2023 Jan 28 [Online ahead of print]NN
- Oxidative stress (OS), which leads to DNA damage, plays a role in the pathogenesis of Coronavirus disease 2019 (COVID-19). We aimed to evaluate the role of DNA repair gene variants [X-ray repair cross complementing 4 (XRCC4) rs28360071, rs6869366, and X-ray cross-complementary gene 1 (XRCC1) rs25487] in susceptibility to COVID-19 in a Turkish population. We also evaluated its effect on the clinic…
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- PRKN/parkin-mediated mitophagy is induced by the probiotics Saccharomyces boulardii and Lactococcus lactis. [Journal Article]Autophagy. 2023 Jan 28 [Online ahead of print]A
- Mitochondrial impairment is a hallmark feature of neurodegenerative disorders, such as Parkinson disease, and PRKN/parkin-mediated mitophagy serves to remove unhealthy mitochondria from cells. Notably, probiotics are used to alleviate several symptoms of Parkinson disease including impaired locomotion and neurodegeneration in preclinical studies and constipation in clinical trials. There is some …
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- Functionality of the bacteriocin sakacin G produced by Lactobacillus curvatus ACU-1 on cooked sausages under industrial conditions. [Journal Article]Lett Appl Microbiol. 2023 Jan 27 [Online ahead of print]LA
- Biopreservation is an alternative to prevent the growth of pathogens and reduce microbial spoilage in food, based on the use of microorganisms and/or their metabolic products. The objective of this study was to determine the optimal mode of application and the effectiveness of cell-free supernatant (CFS) from Lactobacillus curvatus ACU-1, containing sakacin G, in Vienna-type sausages to control L…
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- N-methyl-D-aspartic acid receptor 2A functionalized stationary phase: A reliable method for pursuing potential ligands against Alzheimer's disease from natural products. [Journal Article]CNS Neurosci Ther. 2023 Jan 27 [Online ahead of print]CN
- CONCLUSIONS: In the present study, we developed a reliable method for the rapid identification of NMDA-2A ligands from natural products, which may be used as a platform for new drug discovery to generate high-quality drug candidates.
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- Reduced digestion of circulating genomic DNA in systemic sclerosis patients with the DNASE1L3 R206C variant. [Journal Article]Rheumatology (Oxford). 2023 Jan 27 [Online ahead of print]R
- CONCLUSIONS: Our results confirm that circulating gDNA is a physiologic DNASE1L3 substrate and show that its digestion is reduced in SSc patients with the DNASE1L3 R206C variant.
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- Supplementation with sesame oil suppresses genotoxicity, hepatotoxicity and enterotoxicity induced by sodium arsenite in rats. [Journal Article]Lipids Health Dis. 2023 Jan 27; 22(1):14.LH
- CONCLUSIONS: Our data indicated that SSO protected the liver, colon and bone marrow potentially via anti-inflammatory and anti-apoptotic activities. The data suggest that sesame oil has potential therapeutic applications against chemical toxicities induced by arsenic.
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- Topical ocular delivery of nanoparticles with epoetin beta in Wistar Hannover rats. [Journal Article]Sci Rep. 2023 Jan 27; 13(1):1559.SR
- Topical instillation of drugs targeting the posterior ocular segment is an expanding area of research. Chitosan and hyaluronic acid have remarkable mucoadhesive properties and potentially enhance pre-corneal retention time after topical instillation. Bearing this in mind, we explored the possibility of delivering epoetin beta (EPOβ) to the posterior segment of the eye in a chitosan-hyaluronic aci…
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- Comparative proteomic analysis identified proteins and the phenylpropanoid biosynthesis pathway involved in the response to ABA treatment in cotton fiber development. [Journal Article]Sci Rep. 2023 Jan 27; 13(1):1488.SR
- Abscisic acid (ABA) is a plant hormone that plays an important role in cotton fiber development. In this study, the physiological changes and proteomic profiles of cotton (Gossypium hirsutum) ovules were analyzed after 20 days of ABA or ABA inhibitor (ABAI) treatment. The results showed that compared to the control (CK), the fiber length was significantly decreased under ABA treatment and increas…
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- Effect of salinity on ccmfn gene RNA editing of mitochondria in wild barley and uncommon types of RNA editing. [Journal Article]Funct Integr Genomics. 2023 Jan 27; 23(1):50.FI
- The primary function of mitochondria is cellular respiration and energy production. Cytochrome C complex is an essential complex that transports electrons in the respiratory chain between complex III and complex IV. One of this complex's main subunits is CcmFN, which is believed to be crucial for holocytochrome assembly. In wild-type plant Hordeum vulgare subsp. spontaneum, four ccmfn cDNAs are s…
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- Impact of antithrombotic therapy on acute and delayed intracranial haemorrhage and evaluation of the need of short-term hospitalisation based on CT findings after mild traumatic brain injury: experience from an oral and maxillofacial surgery unit. [Journal Article]Eur J Trauma Emerg Surg. 2023 Jan 27 [Online ahead of print]EJ
- CONCLUSIONS: According to our experience, antithrombotic therapy does not increase the rate of ICH after mTBI. A GCS of < 15, loss of consciousness, amnesia, headache, dizziness, and nausea are indicators of higher ICH risk. A second CT scan is more effective in patients with secondary neurological deterioration. Initial CT findings were not clinically relevant and should not indicate in-hospital observation.
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- Caffeic acid protects against atherosclerotic lesions and cognitive decline in ApoE-/- mice. [Journal Article]J Pharmacol Sci. 2023 Feb; 151(2):110-118.JP
- Caffeic acid has been indicated to benefit cholesterol balance, but the effect of pure caffeic acid on atherosclerosis in vivo has not been tested. Given that atherosclerosis and Alzheimer's disease share common features including distracted lipid balance and chronic inflammation, the concurrent effects of caffeic acid on atherosclerotic lesions and cognitive decline were explored here by using t…
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- Antioxidants: Structure-activity of plant polyphenolics. [Journal Article]Vitam Horm. 2023; 121:395-411.VH
- The excessive accumulation of reactive oxygen species (ROS)/free radicals can lead to abnormal oxidation of biomolecules such as proteins, lipids, fats, carbohydrates and nucleic acids in human organisms. Accordingly, endogenous oxidative stress induces the progressive development of various chronic diseases like rheumatoid arthritis, cancers, cardiovascular risks, diabetes, digestive ulcers, hyp…
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- The adenoviral E4orf3/4 is a regulatory polypeptide with cell transforming properties in vitro. [Journal Article]Tumour Virus Res. 2023 Jan 25; 15:200254.TV
- The human adenovirus species C type 5 (HAdV-C5) early region 4 (E4) encodes several distinct polypeptides, defined as E4orf1 to E4orf6/7 according to the order and arrangement of the corresponding open reading frames (ORFs). All E4 gene products operate through a complex network of interactions with key viral and cellular regulatory proteins involved in transcription, apoptosis, cell cycle contro…
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- Characterization of imidacloprid-induced hepatotoxicity and its mechanisms based on a metabolomic approach in Xenopus laevis. [Journal Article]Sci Total Environ. 2023 Jan 24; 869:161794.ST
- The toxic effects of imidacloprid are attracting increased concern because of its widespread use in agriculture and its persistence in the aquatic environment. Imidacloprid bioaccumulates and triggers various morphological and behavioral responses in amphibians, but the toxic effects and mechanism of imidacloprid in amphibians remain uncertain. In this study, the acute toxicity and chronic effect…
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- Microplastics decrease the toxicity of cadmium to methane production from anaerobic digestion of sewage sludge. [Journal Article]Sci Total Environ. 2023 Jan 24 [Online ahead of print]ST
- Microplastics (MPs) and Cd have been proven to inhibit methane production from anaerobic digestion of sewage sludge. However, the published studies mainly focused on their single inhibition. This cannot reflect the real-world situations where MPs and Cd co-exist. This study therefore aims to reveal the combined effect of MPs and Cd on anaerobic digestion of sewage sludge. Experimental results sho…
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- Curative anti-typhoid effect of Detarium microcarpum Guill. & Perr. (Leguminosae) hydroethanolic extract root bark based-on in vivo and molecular docking analyses. [Journal Article]J Ethnopharmacol. 2023 Jan 24 [Online ahead of print]JE
- CONCLUSIONS: These results demonstrate potent anti-typhoid activities of the hydroethanolic of Detarium microcarpum root bark extract through antioxidant properties and high inhibitory affinity of its compounds on some bacterial key enzymes that justify its use as traditional medicine to typhoid fever.
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