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542,989 results
  • Effects of Vitamin D supplementation or deficiency on metabolic phenotypes in mice of different sexes. [Journal Article]
    J Steroid Biochem Mol Biol. 2023 Jan 25 [Online ahead of print]Hu T, Ren L, … An Z
  • Vitamin D is a steroid hormone precursor that was initially recognized for its important roles in calcium-phosphate homeostasis and bone health. However, the resent prevalence of vitamin D deficiency has highlighted its non-skeletal function, such as its important role in regulating endogenous metabolism. The aim of the present study was to examine the roles of vitamin D supplementation or defici…
  • Lactobacillus acidophilus regulates abnormal serotonin availability in experimental ulcerative colitis. [Journal Article]
    Anaerobe. 2023 Jan 25 [Online ahead of print]Hizay A, Dag K, … Keles-Celik N
  • CONCLUSIONS: In our study, it was observed that the amount of serotonin in the intestinal tissue increased excessively with ulcerative colitis. In addition, L.acidophilus has been found to reduce the abnormally increased amount of serotonin in the colon tissue, as well as reduce the inflammation in the intestinal tissue that occurs with ulcerative colitis. With our findings, it is predicted that probiotic application can be used as a treatment option in ulcerative colitis.
  • Roxadustat and its failure: A comparative dynamic study. [Journal Article]
    J Mol Graph Model. 2023 Jan 21; 120:108422.Gul K, Zaman N, Azam SS
  • Roxadustat, a small-molecule inhibitor of hypoxia-inducible factor prolyl hydroxylase domain 2 (HIF-PHD2) has been recently overruled by the American Food and Drug Administration (FDA) in Phase 3 clinical trials. This study provides insights into the dynamics of Roxadustat with PHD2 and proposes two FDA-approved drugs; Pemetrexed and Valrubicin to treat chronic kidney disease (CKD). Role of chemi…
  • A Biomimetic Lubricating Nanosystem with Responsive Drug Release for Osteoarthritis Synergistic Therapy. [Journal Article]
    Adv Healthc Mater. 2023 Jan 28 [Online ahead of print]Li C, Gong P, … Liu Z
  • Osteoarthritis (OA) is associated with lubrication failure of articular cartilage and severe inflammatory response of joint capsule. Synergistic therapy combining joint lubrication and anti-inflammation emerges as a novel treatment of OA. In this study, bioinspired by ultra-low friction of natural articular synovial fluid and mussel adhesion chemistry, a biomimetic nanosystem with dual functions …
  • The effect of DNA repair gene variants on COVID-19 disease: susceptibility, severity, and clinical course. [Journal Article]
    Nucleosides Nucleotides Nucleic Acids. 2023 Jan 28 [Online ahead of print]Senkal N, Serin I, … Kose M
  • Oxidative stress (OS), which leads to DNA damage, plays a role in the pathogenesis of Coronavirus disease 2019 (COVID-19). We aimed to evaluate the role of DNA repair gene variants [X-ray repair cross complementing 4 (XRCC4) rs28360071, rs6869366, and X-ray cross-complementary gene 1 (XRCC1) rs25487] in susceptibility to COVID-19 in a Turkish population. We also evaluated its effect on the clinic…
  • PRKN/parkin-mediated mitophagy is induced by the probiotics Saccharomyces boulardii and Lactococcus lactis. [Journal Article]
    Autophagy. 2023 Jan 28 [Online ahead of print]Hawrysh PJ, Gao J, … McQuibban GA
  • Mitochondrial impairment is a hallmark feature of neurodegenerative disorders, such as Parkinson disease, and PRKN/parkin-mediated mitophagy serves to remove unhealthy mitochondria from cells. Notably, probiotics are used to alleviate several symptoms of Parkinson disease including impaired locomotion and neurodegeneration in preclinical studies and constipation in clinical trials. There is some …
  • Topical ocular delivery of nanoparticles with epoetin beta in Wistar Hannover rats. [Journal Article]
    Sci Rep. 2023 Jan 27; 13(1):1559.Silva B, Gonçalves LM, … Delgado E
  • Topical instillation of drugs targeting the posterior ocular segment is an expanding area of research. Chitosan and hyaluronic acid have remarkable mucoadhesive properties and potentially enhance pre-corneal retention time after topical instillation. Bearing this in mind, we explored the possibility of delivering epoetin beta (EPOβ) to the posterior segment of the eye in a chitosan-hyaluronic aci…
  • Caffeic acid protects against atherosclerotic lesions and cognitive decline in ApoE-/- mice. [Journal Article]
    J Pharmacol Sci. 2023 Feb; 151(2):110-118.Sun R, Wu T, … Chen J
  • Caffeic acid has been indicated to benefit cholesterol balance, but the effect of pure caffeic acid on atherosclerosis in vivo has not been tested. Given that atherosclerosis and Alzheimer's disease share common features including distracted lipid balance and chronic inflammation, the concurrent effects of caffeic acid on atherosclerotic lesions and cognitive decline were explored here by using t…
  • Antioxidants: Structure-activity of plant polyphenolics. [Journal Article]
    Vitam Horm. 2023; 121:395-411.Rammohan A, Zyryanov GV, … Manjula K
  • The excessive accumulation of reactive oxygen species (ROS)/free radicals can lead to abnormal oxidation of biomolecules such as proteins, lipids, fats, carbohydrates and nucleic acids in human organisms. Accordingly, endogenous oxidative stress induces the progressive development of various chronic diseases like rheumatoid arthritis, cancers, cardiovascular risks, diabetes, digestive ulcers, hyp…
  • The adenoviral E4orf3/4 is a regulatory polypeptide with cell transforming properties in vitro. [Journal Article]
    Tumour Virus Res. 2023 Jan 25; 15:200254.Ip WH, Bertzbach LD, … Dobner T
  • The human adenovirus species C type 5 (HAdV-C5) early region 4 (E4) encodes several distinct polypeptides, defined as E4orf1 to E4orf6/7 according to the order and arrangement of the corresponding open reading frames (ORFs). All E4 gene products operate through a complex network of interactions with key viral and cellular regulatory proteins involved in transcription, apoptosis, cell cycle contro…
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