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1,511 results
  • Impact of Rabeprazole on APO-Dabigatran Exposure in Healthy Volunteers. [Journal Article]
    CJC Open. 2023 Jan; 5(1):1-7.Chan N, Wheeler M, … Eikelboom J
  • CONCLUSIONS: When APO-dabigatran is administered with rabeprazole, the exposure to dabigatran is reduced by about 30%, which is similar to the level observed with Pradaxa when it was co-administered with a proton pump inhibitor. However, the finding that one-third of participants had a > 50% reduction in exposure is concerning, and it highlights the need for caution in patients who have, or are at risk of, reduced gastric acidity.
  • Proton Pump Inhibitors and Bone Health: An Update Narrative Review. [Review]
    Int J Mol Sci. 2022 09 14; 23(18)Lespessailles E, Toumi H
  • Proton pump inhibitors (PPIs) are an antacid drug often used in acid-related disorders. They decrease acid secretion in the stomach by blocking an enzyme called H+/K+ ATPase which controls acid production. Introduced to the market in 1989, their use has increased rapidly worldwide and they are now among the top 10 most prescribed drugs in the United States. As of 2015, the FDA has already approve…
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