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1,268 results
  • Safe use of proton pump inhibitors in patients with cirrhosis. [Journal Article]
  • BJBr J Clin Pharmacol 2018 Apr 24
  • Weersink RA, Bouma M, … Borgsteede SD
  • CONCLUSIONS: We suggest using esomeprazole, omeprazole or rabeprazole in patients with CTP A or B cirrhosis and only esomeprazole in patients with CTP C. Pharmacokinetic changes are also important to consider when prescribing PPIs to vulnerable, cirrhotic patients.
  • Evaluating the Effect of Six Proton Pump Inhibitors on the Antiplatelet Effects of Clopidogrel. [Journal Article]
  • JSJ Stroke Cerebrovasc Dis 2018; 27(6):1582-1589
  • Przespolewski ER, Westphal ES, … Gengo FM
  • CONCLUSIONS: These data do not demonstrate a significant interaction between common individual PPIs and clopidogrel in healthy volunteers who respond to clopidogrel alone. This adds data to a growing body of evidence indicating that the addition of a PPI may have a weak effect on clopidogrel's antiplatelet properties, and may only be relevant in specific clinical circumstances.
  • LC-MS/MS bioassay of four proton pump inhibitors. [Journal Article]
  • JCJ Chromatogr B Analyt Technol Biomed Life Sci 2018 Feb 15; 1076:61-69
  • Elkady EF, Fouad MA, Jaadan BM
  • A new validated bio-analytical LC-MS/MS method was developed for the simultaneous extraction and determination of four proton pump inhibitors: esomeprazole, lansoprazole, pantoprazole and rabeprazole...
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