- Trace element zinc and skin disorders. [Review]Front Med (Lausanne). 2022; 9:1093868.FM
- Zinc is a necessary trace element and an important constituent of proteins and other biological molecules. It has many biological functions, including antioxidant, skin and mucous membrane integrity maintenance, and the promotion of various enzymatic and transcriptional responses. The skin contains the third most zinc in the organism. Zinc deficiency can lead to a range of skin diseases. Except f…
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- Change in Cutibacterium acnes phylotype abundance and improvement of clinical parameters using a new dermocosmetic product containing Myrtus communis and Celastrol enriched plant cell culture extracts in patients with acne vulgaris. [Journal Article]J Eur Acad Dermatol Venereol. 2023 Mar; 37 Suppl 2:20-25.JE
- CONCLUSIONS: This study showed that the application of a new dermocosmetic product containing M. communis and Celastrol-enriched plant cell culture extracts was linked to a change in the C. acnes phylotype abundance and an improvement in acne severity.
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- Recent advances in understanding inflammatory acne: Deciphering the relationship between Cutibacterium acnes and Th17 inflammatory pathway. [Review]J Eur Acad Dermatol Venereol. 2023 Mar; 37 Suppl 2:3-11.JE
- Acne vulgaris is a common chronic inflammatory skin disease of the pilosebaceous units. Four factors contribute to acne: hyperseborrhea and dysseborrhea, follicular hyperkeratinisation, skin microbiome dysbiosis and local immuno-inflammation. Recent key studies have highlighted a better understanding of the important role of Cutibacterium acnes (C. acnes) in the development of acne. Three major f…
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- Modulation of allergic contact dermatitis via gut microbiota modified by diet, vitamins, probiotics, prebiotics, and antibiotics. [Review]Pharmacol Rep. 2023 Feb 02 [Online ahead of print]PR
- Allergic contact dermatitis is one of the most common recorded occupational diseases. There are many different substances that the skin comes into contact with on a daily basis and that can cause ACD, e.g., preservatives, surfactants, and antimicrobial agents. The development of a mouse model of ACD has provided insight into the immune mechanisms involved. Drugs used in the treatment of skin dise…
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- Microneedling in Combination With 15% Trichloroacetic Acid Peel Versus 25% Pyruvic Acid Peel in the Treatment of Acne Scars. [Randomized Controlled Trial]Dermatol Surg. 2023 Feb 01; 49(2):155-160.DS
- CONCLUSIONS: In our study, the combination modality showed early reduction in rolling and boxcar compared with icepick scars. These peels led to improvement in overall texture of the skin, hence more patient satisfaction. On comparing ECCA, a significant difference was not observed.
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- Can hidradenitis suppurativa patients classify their lesions by means of a digital lesion identification scheme? [Journal Article]J Dtsch Dermatol Ges. 2023 01; 21(1):27-32.JD
- CONCLUSIONS: HS-patients demonstrate high willingness to share their experiences and data. Therefore, a self-assessment scheme, as the developed LISAI, can be a valuable tool to enrich patient surveys with the identification of lesion types, for instance as a basis for phenotyping.
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- Comparisons of Four Acne Grading Systems Recommended in China, Korea, and Japan. [Journal Article]
- CONCLUSIONS: IIGS and AGS exhibited great correlation with KAGS and JAGS and were highly reliable.
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- Comedogenic lupus: a rare variant of chronic cutaneous lupus erythematosus - case series. [Journal Article]An Bras Dermatol. 2023 Jan 25 [Online ahead of print]AB
- CONCLUSIONS: Dermatologists should be aware of acneiform conditions with poor response to the usual treatment. Early diagnosis and treatment reduce the risk of unaesthetic scars.
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- Evaluation of the safety and efficacy of a fractional picosecond 1064 nm laser for post-acne erythema in adult Chinese patients. [Journal Article]Skin Res Technol. 2023 Jan; 29(1):e13274.SR
- CONCLUSIONS: Treatment with fractional 1064 nm picosecond Nd:YAG laser is effective and safe for PAE of Chinese patients.
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- Photodynamic therapy treats acne by altering the composition of the skin microbiota. [Journal Article]Skin Res Technol. 2023 Jan; 29(1):e13269.SR
- CONCLUSIONS: The skin microbial composition changes after PDT treatment. PDT is an effective method for the treatment of severe acne.
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- Association Between Acne Vulgaris and Body Mass Index in Adult Population: A Tertiary Hospital-Based Retrospective Study in Riyadh, Saudi Arabia. [Journal Article]Cureus. 2022 Dec; 14(12):e32867.C
- Acne vulgaris (AV) is the common form of acne, characterized by a polymorphic eruption of inflammatory non-papules, pustules, nodules, blackheads, and whiteheads. Acne was eighth among the top 10 disorders in terms of prevalence in 2010. The objective of this study was to see if there was any association between acne vulgaris and BMI in the young adult population.
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- A Comparative Clinical and Laboratory Study of Adolescent and Adult Acne in Iraqi Women. [Journal Article]
- Background Acne vulgaris is a common chronic inflammatory disease of the pilosebaceous units associated with long-term sequelae and complications. Currently, acne in women is classified into adolescent and post-adolescent forms. However, comparative studies evaluating the clinical and laboratory parameters across various age groups in women with acne are lacking. The aim of the study is to compar…
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- Whole-genome sequencing, annotation, and biological characterization of a novel Siphoviridae phage against multi-drug resistant Propionibacterium acne. [Journal Article]
- Antibiotics-resistant Propionibacterium acne (P. acne) causes severe acne vulgaris, serious public health, and psychological threat. A new lytic bacteriophage (phage), φPaP11-13, infecting P. acne, was isolated from the sewage management center of Xinqiao Hospital. It can form transparent plaque with diameters of 1.0 ~ 5.0 mm on the double-layer agar plate, indicating a robust lytic ability again…
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- Optimal blue light irradiation conditions for the treatment of acne vulgaris in a mouse model. [Journal Article]J Photochem Photobiol B. 2023 Feb; 239:112651.JP
- CONCLUSIONS: In conclusion, blue light could control severe dermatologic inflammatory responses; therefore, it can be used to irradiate AV with high inflammation levels on a daily basis until improvement is observed. In addition, porphyrin, a metabolite of Cutibacterium acnes, and reactive oxygen species generated by the surrounding skin tissue may have essential roles in AV treatment.
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- Release of Tretinoin Solubilized in Microemulsion from Carbopol and Xanthan Gel: In Vitro versus Ex Vivo Permeation Study. [Journal Article]
- CONCLUSIONS: The results confirm the benefit of TRE solubilization in ME due to its bioavailability from the tested dermal formulations.
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- Exploring the Synergistic Effect of Bergamot Essential Oil with Spironolactone Loaded Nano-Phytosomes for Treatment of Acne Vulgaris: In Vitro Optimization, In Silico Studies, and Clinical Evaluation. [Journal Article]
- The foremost target of the current work was to formulate and optimize a novel bergamot essential oil (BEO) loaded nano-phytosomes (NPs) and then combine it with spironolactone (SP) in order to clinically compare the efficiency of both formulations against acne vulgaris. The BEO-loaded NPs formulations were fabricated by the thin-film hydration and optimized by 32 factorial design. NPs' assessment…
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- Stabilization of Acne Vulgaris-Associated Microbial Dysbiosis with 2% Supramolecular Salicylic Acid. [Journal Article]
- Facial microbiota dysbiosis is an important factor in causing acne vulgaris. The present study aimed to analyze the effect of 2% Supramolecular Salicylic Acid (SSA) on acne-associated facial bacteria. In the current study, 30 acne vulgaris patients (treated with 2% SSA for eight weeks) and ten volunteers with no facial acne were selected. Samples from acne patients (before and after treatment) an…
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- Insulin Resistance and Acne: The Role of Metformin as Alternative Therapy in Men. [Review]
- The association between acne and insulin resistance has not been investigated as thoroughly in males as it has been in women, despite the fact that in adult men, acne prevalence has grown. On the face, sebaceous glands produce and secrete sebum, which lubricates the skin and protects it from friction. Metformin, an insulin-sensitizing medication, may modify the association between acne vulgaris a…
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- Prevalence and Self-Medication for Acne among Students of Health-Related Science Colleges at King Saud University in Riyadh Region Saudi Arabia. [Journal Article]
- Background and Objectives: In Saudi Arabia, Acne vulgaris is a very predominant ailment among adolescents, especially female university students, and self-medication has become a trend to manage this condition. To determine the prevalence of Acne vulgaris among health care students and to access the scenario of its self-medication in light of students' knowledge, attitude, and practice towards it…
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- Phototherapy as a Treatment for Dermatological Diseases, Cancer, Aesthetic Dermatologic Conditions and Allergenic Rhinitis in Adult and Paediatric Medicine. [Review]
- The development of light-emitting diodes (LEDs) has led to an increase in the use of lighting regimes within medicine particularly as a treatment for dermatological conditions. New devices have demonstrated significant results for the treatment of medical conditions, including mild-to-moderate acne vulgaris, wound healing, psoriasis, squamous cell carcinoma in situ (Bowen's disease), basal cell c…
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- Microbiomes in Acne Vulgaris and Their Susceptibility to Antibiotics in Indonesia: A Systematic Review and Meta-Analysis. [Review]
- Hot and humid countries such as Indonesia have a higher prevalence of acne vulgaris (AV). The activity of skin microbes, not only Cutibacterium acnes, contribute to the formation of AV. Topical and oral antibiotics are routinely prescribed to treat AV. As antimicrobial resistance rates increase globally, there are concerns about decreased efficacy. This study intends to systematically evaluate th…
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- Effect of Sarecycline on the Acne Symptom and Impact Scale and Concerns in Moderate-to-Severe Truncal Acne in Open-Label Pilot Study. [Journal Article]
- Truncal acne is common, and the psychosocial burden may be underestimated as patients most often complain of facial acne. The Acne Symptom and Impact Scale (ASIS) is a 17-item patient-reported outcome (PRO) measure designed to assess the signs and impacts of acne vulgaris. ASIS has previously been validated in a prospective, non-interventional study as a reliable PRO instrument for facial acne. I…
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- A Post Hoc Analysis of Efficacy Data on Sarecycline in Hispanics with Acne from Two Phase 3, Multicenter, Randomized, Double-Blind, Placebo-Controlled Clinical Trials. [Journal Article]
- Sarecycline is a novel, narrow-spectrum, third generation tetracycline class antibiotic approved by the Food and Drug Administration (FDA) for the treatment of moderate-to-severe acne in patients ages nine and older. Recently, focus has increased on whether treatment responses differ in acne in skin of color. Here, we aimed to analyze the efficacy of using sarecycline in Hispanics. We report pool…
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- Long-term oral antibiotic use in people with acne vulgaris in UK primary care: a drug utilization study. [Journal Article]Br J Dermatol. 2022 Dec 13 [Online ahead of print]BJ
- CONCLUSIONS: Further work is needed to understand the consequences of using antibiotics for shorter periods than recommended. Suboptimal treatment duration may result in reduced clinical effectiveness or repeated exposures, potentially contributing to antimicrobial resistance.
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- How is oral isotretinoin prescribed for the treatment of acne vulgaris? Results from a UK Dermatology Clinical Trials Network (UKDCTN) and British Dermatological Nursing Group (BDNG) survey of health professionals. [Journal Article]Clin Exp Dermatol. 2023 Jan 20; 48(1):20-23.CE
- We undertook a survey of UK healthcare professionals through the UK Dermatology Clinical Trials Network and British Dermatological Nursing Group to understand clinicians' routine practice of prescribing oral isotretinoin for treatment of acne vulgaris. We also wanted to understand clinicians' experiences and views on prescribing low daily dose regimens. Overall, the survey showed that clinicians …
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- Network Pharmacology and Experimental Validation to Explore the Molecular Mechanisms of Compound Huangbai Liquid for the Treatment of Acne. [Journal Article]
- CONCLUSIONS: This study revealed the multiple active components, multiple targets, and multiple pathways of CHL in the treatment of acne, which provided a new perspective for the study of the mechanism of traditional Chinese medicine in the treatment of acne.
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- Effects of metformin on clinical, hormonal and relevant gene expression parameters in patients of acne - an observational study. [Journal Article]Clin Exp Dermatol. 2023 Jan 19 [Online ahead of print]CE
- CONCLUSIONS: Metformin monotherapy led to significant clinical improvement in acne, possibly by reducing testosterone, inhibiting FoxO1 and reducing lipid synthesis by decreasing the expression of lipogenic genes.
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- Acne vulgaris: navigating the NICE recommendations for specialist referral, patient expectations, and the isotretinoin product licence. [Journal Article]Clin Exp Dermatol. 2023 Jan 19 [Online ahead of print]CE
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- Prevalence of acne in Taiwan: A 13-year population-based retrospective study. [Journal Article]J Dermatol. 2023 Jan 18 [Online ahead of print]JD
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- Sleep quality, circadian preferences, and mood among patients with acne vulgaris: a case-control study. [Journal Article]Sleep Breath. 2023 Jan 18 [Online ahead of print]SB
- CONCLUSIONS: Acne is highly associated with poor sleep and mood. Dermatologists are advised to attend closely to the psychological impact of acne. Improvements in sleep and mood may benefit the treatment of acne.
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