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Unbound Medicine.
(Acrocyanosis)
468 results
  • Vascular complications in 305 severely ill patients with COVID-19: a cohort study. [Journal Article]
    Sao Paulo Med J. 2022 Dec 19 [Online ahead of print]Correia RM, Santos BC, … Nakano LCU
  • CONCLUSIONS: Vascular complications in critically ill COVID-19 patients are common (23.6%) and can be closely related to the mortality rate (56.3%) until 30 days after ICU admission. Macrovascular complications have direct implications for mortality, which is the main outcome of the management of COVID-19.
  • Cold AIHA and the best treatment strategies. [Journal Article]
    Hematology Am Soc Hematol Educ Program. 2022 12 09; 2022(1):90-95.Despotovic JM, Kim TO
  • Cold-reactive autoimmune hemolytic anemia (AIHA) is rare among the hemolytic anemias. It results when 1 of a variety of processes causes the generation of immunoglobulin M (IgM) autoantibodies against endogenous erythrocytes, resulting in complement activation and predominantly intravascular hemolysis. Cold AIHA is typically a primary lymphoproliferative disorder with marrow B-cell clones produci…
  • Secondary Acrocyanosis in a Paraplegic Patient With Spinal Cord Injury. [Case Reports]
    Cureus. 2022 Sep; 14(9):e29420.Ruiz-Rodríguez JF, Fernández-de Thomas RJ, De Jesus O
  • Secondary acrocyanosis after spinal cord injury is extremely rare. We describe a case with secondary acrocyanosis in a complete T12 paraplegic patient. A 41-year-old man with complete T12 paraplegia after a gunshot wound to the thoracic spine 20 years prior presented with a four-month history of bilateral foot bluish discoloration precipitated when he sat with his legs down, improving rapidly aft…
  • Case Report: Artifactual Hypoglycemia: A Condition That Should Not Be Forgotten. [Case Reports]
    Front Endocrinol (Lausanne). 2022; 13:951377.Amaral S, Palha A, … Silva-Nunes J
  • CONCLUSIONS: Artifactual hypoglycemia has been described in various conditions including Raynaud's phenomenon, peripheral arterial disease, Eisenmenger syndrome, acrocyanosis, or hypothermia. With this case report, we want to reinforce the importance of being aware of this diagnosis to prevent anxiety, unnecessary treatment, and diagnostic tests.
  • [Functional vascular acrosyndromes]. [Review]
    Inn Med (Heidelb). 2022 Jun; 63(6):591-600.Klein-Weigel P, Ruttloff A, … Richter JG
  • Vascular acrosyndromes are characterized by sparse, uniform clinical manifestations and a variety of possible pathomechanisms. The present article focuses on the functional entities. Raynaud phenomenon is based on cold- or stress-induced vasospasms of acral arteries. It is defined by the color changes of the skin, in the typical case white-blue-red (tricolore). The long fingers are most commonly …
  • [Paroxysmal vascular acrosyndromes: Practical approach to diagnosis and management]. [Journal Article]
    Rev Med Interne. 2022 Oct; 43(10):596-602.Senet P
  • Paroxysmal vascular acrosyndromes are related to a peripheral vasomotor disorder and presented as paroxysmal color changes of the fingers. They include primary Raynaud's phenomenon (RP), which is the most common, secondary RP and erythermalgia. They are to be distinguished from non-paroxysmal acrosyndromes such as acrocyanosis and chilblains, which are very frequent and often associated with RP, …
  • Part II Cutaneous Manifestations of Peripheral Vascular Disease. [Review]
    J Am Acad Dermatol. 2022 Apr 30 [Online ahead of print]Raja A, Karch J, … Vashi N
  • In this Part 2 of a 2-part continuing medical education series, we review the epidemiology of peripheral vascular disease, its association with cutaneous symptoms, and the diagnosis and evaluation of cutaneous features of vascular disorders. As peripheral vascular disease becomes more prevalent globally, it is essential for dermatologists to become competent at accurately recognizing and diagnosi…
  • Ethylmalonic encephalopathy masquerading as meningococcemia. [Journal Article]
    Cold Spring Harb Mol Case Stud. 2022 02; 8(2)Horton A, Hong KM, … Fahey M
  • Ethylmalonic encephalopathy (MIM #602473) is a rare autosomal recessive metabolic condition caused by biallelic variants in ETHE1 (MIM #608451), characterized by global developmental delay, infantile hypotonia, seizures, and microvascular damage. The microvascular changes result in a pattern of relapsing spontaneous diffuse petechiae and purpura, positional acrocyanosis, and pedal edema, hemorrha…
  • [Acrocyanosis as the first manifestation of orthostatic postural tachycardia syndrome in two adolescents]. [Case Reports]
    Arch Argent Pediatr. 2021 12; 119(6):e639-e642.Gimeno Sánchez I, Granados Ruiz MÁ, … Prieto Tato LM
  • Acrocyanosis triggered by standing position as the main sign of postural orthostatic tachycardia (POTS) is little known but well described in scientific literature. In pediatric age, POTS is defined as orthostatic intolerance that is accompanied by an excessive increase in heart rate without arterial hypotension. We present two clinical reports of teenagers who were admitted in the Emergency Depa…
  • Raynaud Phenomenon and Other Vasospastic Disorders. [Review]
    Cardiol Clin. 2021 Nov; 39(4):583-599.Casanegra AI, Shepherd RF
  • Vasospastic disorders are prevalent in the general population and can affect individuals of any age. Primary (or idiopathic) vasospastic disorders often have a benign course; treatment focuses on the control of symptoms. Secondary vasospastic disorders occur owing to an underlying condition and have an increased risk of complications, including tissue loss and digital ulcerations; treatment shoul…
  • Long-term Outcome of Chilblains Associated with SARS-CoV-2. [Journal Article]
    Acta Derm Venereol. 2021 Dec 13; 101(12):adv00614.Poizeau F, Barbarot S, … Dupuy A
  • Numerous cases of chilblains have been observed in the course if the COVID-19 pandemic. The aims of this study were to provide comprehensive follow-up data for patients reporting chilblains, and to determine the risk factors for incomplete recovery. Patients referred to 5 hospitals in France between March and May 2020 for chilblains were surveyed on December 2020. A teleconsultation was offered. …
  • Patient characteristics in tardive COVID-19 pseudoperniosis: a case series of 16 patients. [Journal Article]
    Clin Exp Dermatol. 2022 Feb; 47(2):399-403.Ganatra B, Amarnani R, … Bunker CB
  • CONCLUSIONS: Unlike acute PP, TCPP has a protracted and delayed presentation that is typically associated with profound acrocyanosis. Patients with TCPP represent a new phenomenon that is part of the post-COVID-19 syndrome, with risk factors and pathophysiology that are not yet fully understood. Our data indicate that likely predisposing factors for developing TCPP include young age, a preceding history of cold intolerance and an arachnodactyloid phenotype. Anorexia, connective tissue disorders or sickle cell trait may also predispose to TCPP. In addition, low titre antinuclear antibody positivity, the presence of cryoglobulins, or low complement levels may represent further risk factors. Finally, prolonged low temperatures are also likely to be contributing to the symptoms.
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