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Unbound Medicine.
(Actinic keratosis)
4,565 results
  • Shining Light on PDT and Actinic Keratosis. [Journal Article]
    J Drugs Dermatol. 2023 Feb 01; 22(2):226-227.Kalner S, Vergilis I
  • Photodynamic therapy (PDT) is a non-invasive treatment modality involving photosensitizers that are activated by absorption of visible light to initially form the excited singlet state, followed by transition to the long-lived excited triplet state.
  • Dermatoscopic finding of white circles in an invasive pigmented melanoma. [Letter]
    Australas J Dermatol. 2023 Jan 30 [Online ahead of print]Vasanthan R, Akay BN, … Rosendahl C
  • Dermatoscopic white circles, seen with both non-polarized and polarized dermatoscopy, are a known clue to actinic keratosis in a flat lesion and invasive squamous cell carcinoma in a raised lesion. We have not discovered a previous published example of this clue in a melanoma. We present a case report of a 70-year-old Australian male with a pigmented superficial spreading melanoma on the face, Br…
  • Wnt Signaling Pathways: From Inflammation to Non-Melanoma Skin Cancers. [Review]
    Int J Mol Sci. 2023 Jan 13; 24(2)Di Bartolomeo L, Vaccaro F, … Vaccaro M
  • Canonical and non-canonical Wnt signaling pathways are involved in cell differentiation and homeostasis, but also in tumorigenesis. In fact, an exaggerated activation of Wnt signaling may promote tumor growth and invasion. We summarize the most intriguing evidence about the role of Wnt signaling in cutaneous carcinogenesis, in particular in the pathogenesis of non-melanoma skin cancer (NMSC). Wnt…
  • Orobol, 3'-hydroxy-genistein, suppresses the development and regrowth of cutaneous SCC. [Journal Article]
    Biochem Pharmacol. 2023 Jan 16; 209:115415.Roh E, Kim JE, … Dong Z
  • Chronic solar ultraviolet exposure is a major risk factor for cutaneous squamous cell carcinoma (cSCC), which is the second most common type of skin cancer. Our previous data showed that total protein and phosphorylation levels of T-LAK cell-originated protein kinase (TOPK) were enhanced in solar-simulated light (SSL)-induced skin carcinogenesis and overexpressed in actinic keratosis (AK) and cSC…
  • Association of trichilemmal and basal cell carcinomas: a case report. [Case Reports]
    Pan Afr Med J. 2022; 43:89.Mekkaoui ME, Dani B, … Cherradi N
  • Proliferating trichilemmal tumor (PTT) is a benign tumor arising from the isthmic portion of the hair follicle. Malignant transformation in PPT is very rare and unusual. Indeed, only about sixty well-documented cases have been found in the English literature. We present here the case of a 72-year-old patient with an exceptional combination of malignant trichilemmal carcinoma and basal cell carcin…
  • Association between serum periostin levels and the severity of arsenic-induced skin lesions. [Journal Article]
    PLoS One. 2023; 18(1):e0279893.Khatun M, Siddique AE, … Hossain K
  • Arsenic is a potent environmental toxicant and human carcinogen. Skin lesions are the most common manifestations of chronic exposure to arsenic. Advanced-stage skin lesions, particularly hyperkeratosis have been recognized as precancerous diseases. However, the underlying mechanism of arsenic-induced skin lesions remains unknown. Periostin, a matricellular protein, is implicated in the pathogenes…
  • Pigmented Macules on the Head and Neck: A Systematic Review of Dermoscopy Features. [Review]
    Dermatol Pract Concept. 2022 Nov; 12(4):e2022194.Gouda G, Pyne J, Dicker T
  • CONCLUSIONS: Further studies are needed to determine the dermoscopic criteria for pigmented melanocytic and non-melanocytic lesions on the head and neck. Furthermore, there is a gap in the knowledge of site-specific dermoscopic features on specific sites, namely ears, nose, cheeks, scalp and neck which will also benefit from further studies.
  • Treatment of actinic keratosis: a systematic review. [Review]
    Arch Dermatol Res. 2022 Dec 01 [Online ahead of print]Worley B, Harikumar V, … Alam M
  • Treatment of actinic keratoses (AKs) can help lower the risk of eventual skin cancer and address field pre-cancerization. This review compares the different therapeutic options for actinic keratosis. Databases used include Medline, EMBASE, Web of Science and the Cochrane Library from inception to December 2019. Randomized control trials that were related to any approved or recognized treatment fo…
  • Tirbanibulin for Actinic Keratosis: Insights into the Mechanism of Action. [Review]
    Clin Cosmet Investig Dermatol. 2022; 15:2495-2506.Schlesinger T, Stockfleth E, … Berman B
  • Actinic keratosis (AK) is a common pre-neoplastic skin lesion constituted by uncontrolled proliferation of atypical keratinocytes that may evolve to squamous cell carcinoma. With global prevalence increasing, AK is expected to be the most common carcinoma of the skin. Tirbanibulin is a reversible tubulin polymerization inhibitor with potent anti-proliferative and anti-tumoral effects. In-vivo and…
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