- Experimental Treatment of a Suspected Case of Mycetoma Based on Dot-in-Circle Sign. [Journal Article]
- IJIran J Med Sci 2018; 43(5):564-566
- Major Infectious Diseases [BOOK]
- BOOKThe International Bank for Reconstruction and Development / The World Bank: Washington (DC)
- The neglected tropical diseases (NTDs) affect more than 1 billion of the poorest and most marginalized people of the world. These infections are a consequence of the environmental and socioeconomic c...
The neglected tropical diseases (NTDs) affect more than 1 billion of the poorest and most marginalized people of the world. These infections are a consequence of the environmental and socioeconomic conditions in which the poor live, and the ill health and disability they cause are a primary factor locking the poor into poverty. They are diseases of the most neglected people who live in countries that lack the basic resources to control them. Yet this chapter demonstrates that the tools to end this neglect already exist, and that there are compelling economic arguments that ending these diseases would be one of the most cost-effective of global public health programs. The NTD concept was developed to draw attention to this opportunity that was overlooked by the Millennium Development Goals (MDGs). At least 18 diseases are recognized as NTDs by World Health Assembly resolutions; the latest addition is mycetoma (WHO 2013, 2016). The World Health Organization (WHO) has set specific targets for control, elimination, and eradication of a subset of these diseases (table 17.1). These are the NTDs that we focus on in this chapter. The end of NTDs is now firmly embedded within the Sustainable Development Goals (SDGs) for 2030, under target 3.3, reflecting the promise to “leave no one behind.” This chapter reaffirms the case that NTDs account for a significant and unfairly distributed global disease burden, cost-effective interventions exist to reduce that burden, these interventions are affordable, and they are good investments in universal health coverage and social protection. It builds on the second edition of the Disease Control Priorities (DCP2) project (Hotez and others 2006) with new data and analysis. It also takes into account new strategies and tools that have been introduced since 2006 and the increasingly ambitious elimination and eradication targets for individual diseases that have emerged since 2012, including the unprecedented donation by the pharmaceutical industry under the London Declaration of more than a billion medicines annually to treat nine of the most important NTDs. Finally, it helps provide a longer-term perspective on SDG target 3.3 and the 2030 goals. This chapter is structured around three key NTD interventions, rather than individual NTDs, in recognition of the increasingly integrated delivery of interventions to the poorest, most remote, and otherwise most marginalized communities of the world. These interventions are as follows: Preventive chemotherapy by mass drug administration. Innovative and intensified disease management. Vector ecology and management. For simplicity of analysis, we focus on a subset of the NTDs recognized by the WHO. We do not provide a full analysis of veterinary public health interventions against zoonotic NTDs or of water, sanitation, and hygiene (WASH). These conditions are beyond the scope of this chapter, but WASH is addressed in chapter 9 in volume 7 of the third edition of Disease Control Priorities (Hutton and Chase 2017). Chapter 13 in volume 8 (Bundy and others 2017) discusses mass deworming programs, and chapter 29 (Ahuja and others 2017) in volume 8 analyzes the economics of such programs.
- Prone transradial catheterization for combined single-session endovascular and percutaneous interventions: approach, technical success, safety, and outcomes in 15 patients. [Journal Article]
- DIDiagn Interv Radiol 2018; 24(5):276-282
- CONCLUSIONS: PTRA is a safe and feasible method for performing combined arterial and posterior approach percutaneous interventions without the need for repositioning.
- Nocardiosis in Sudan: Current Situation and Future Perspective. [Journal Article]
- IDInfect Disord Drug Targets 2018 Sep 12
- CONCLUSIONS: Since the description of Nocardia by Edmond Nocard in 1888, it started to be well known worldwide, In Sudan, however, the awareness regarding this bacteria is still below the level, and is only due to the end of the fifty.
- Enteroparasitosis infections among renal transplant recipients in Khartoum state, Sudan 2012-2013. [Journal Article]
- BRBMC Res Notes 2018 Aug 29; 11(1):621
- Renal transplantation procedure markedly increased over the past few decades. The risk of harboring parasitic diseases may affect transplant recipients during life expectancy. We aimed in this study ...
Renal transplantation procedure markedly increased over the past few decades. The risk of harboring parasitic diseases may affect transplant recipients during life expectancy. We aimed in this study to determine the enteroparasitosis frequency among renal transplant recipients in Khartoum state, Sudan. A case-control hospital-based study performed between November 2012 and May 2013, on 300 renal transplant recipients attending Sudanese Kidney Association hospital in Khartoum state, Sudan, along with 300 normal healthy individuals matching the case in age and sex. Stool samples were collected for parasitological studies.
- Pedal Fungal Mass in the Midwest. [Journal Article]
- JAJ Am Podiatr Med Assoc 2018; 108(4):334-339
- Mycetoma cases are predominantly found in tropical regions and are a rare finding in the United States. These masses that are fungal or bacterial in origin can result in significant destruction of so...
Mycetoma cases are predominantly found in tropical regions and are a rare finding in the United States. These masses that are fungal or bacterial in origin can result in significant destruction of soft tissue and bone. We present a case of a patient who emigrated from Mexico to Indianapolis. He presented with a soft-tissue mass that was excised and ultimately found to be a eumycetoma of the hallux of his left foot. Successful treatment included surgical resection in combination with postoperative terbinafine, which was pulse dosed to decrease its impact on hepatic function.
- Image Gallery: Actinomycetoma caused by Gordonia terrae in an immunocompetent woman. [Letter]
- BJBr J Dermatol 2018; 179(2):e90
- Mycetoma: a clinical dilemma in resource limited settings. [Review]
- ACAnn Clin Microbiol Antimicrob 2018 Aug 10; 17(1):35
- CONCLUSIONS: Since delay in visiting health facility results into gruesome complication, early presentation, recognition and initiation of appropriate choice of regimen is helpful in reducing complications. The clinical overview of mycetoma and the suggested algorithm may enhance suspicion and possibly increase recognition of mycetoma in the community and further guide in differentiation of eumycetoma from actinomycetoma. There is an urgent need for research funding for mycetoma, a disease plagued by severe physical disabilities and social stigma leading to isolation.
- VNTR confirms the heterogeneity of Madurella mycetomatis and is a promising typing tool for this mycetoma causing agent. [Journal Article]
- MMMed Mycol 2018 Jul 31
- The neglected tropical disease mycetoma is a chronic granulomatous inflammatory and infectious disease affecting various body parts. The most common causative agent is the fungus Madurella mycetomati...
The neglected tropical disease mycetoma is a chronic granulomatous inflammatory and infectious disease affecting various body parts. The most common causative agent is the fungus Madurella mycetomatis. In order to study the genetic diversity of this fungus and to monitor any potential outbreaks, a good typing method that can be used in endemic settings is needed. Previous typing methods developed were not discriminative and not easy to perform in resource-limited laboratories. Variable-Number-Tandem-Repeat (VNTR) typing overcomes these difficulties and further enables interlaboratory data comparison. Therefore, in this study we developed a VNTR method for typing M. mycetomatis. Six tandem-repeats were identified in the genome of M. mycetomatis isolate MM55 using an online tandem repeats software. The variation in these repeats was determined by PCR and gel-electrophoresis on DNA obtained from 81 M. mycetomatis isolates obtained from patients. These patients originated from Sudan, Mali, Peru, and India. The 81 isolates were divided into 14 genotypes which separated into two main clusters with seven and five subdivisions, respectively. VNTR typing confirms the heterogeneity of M. mycetomatis strains and can be used to study the epidemiology of M. mycetomatis. The results presented in this article are made fully available to the scientific community on request from the Eumycetoma Working Group. We hope that this open resource approach will bridge scientific community working with mycetoma from all around the world and lead to a deeper understanding of M. mycetomatis.
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- The painless combination of anatomically contoured titanium plates and porcine dermal collagen patch for chest wall reconstruction. [Journal Article]
- JTJ Thorac Dis 2018; 10(5):2890-2897
- CONCLUSIONS: Our early experience indicates that the combination of the MatrixRib system and Permacol patch for chest wall reconstruction is safe and feasible with promising results in terms of anatomical restoration of the chest wall mechanics, infection and pain.