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27,630 results
  • Safety profile of anesthetic modalities during laser treatment for retinopathy of prematurity: a systematic review. [Review]
    J Perinatol. 2023 Jan 28 [Online ahead of print]Gavriilidou A, Seliniotaki AK, … Mataftsi A
  • CONCLUSIONS: Significant heterogeneity among studies precludes direct comparisons and generalizability of the results. No specific anesthetic modality for treatment of ROP with laser photocoagulation was shown to be superior in terms of safety. Well-designed studies are required to establish the optimal anesthetic approach, considering that laser photocoagulation still remains one of the main therapeutic modalities for ROP.
  • Novel Receptor-Binding-Based Assay for the Detection of Opioids in Human Urine Samples. [Journal Article]
    Anal Chem. 2023 Jan 27 [Online ahead of print]Bergerhoff M, Moosmann B
  • Consumption of opioids is a growing global health problem. The gold standard for drugs of abuse screening is immunochemical assays. However, this method comes with some disadvantages when screening for a wide variety of opioids. Detection of the binding of a compound at the human μ-opioid receptor (MOR) offers a promising alternative target. Here, we set up a urine assay to allow for detection of…
  • Assessment of Opioid-Induced Immunomodulation in Experimental and Clinical Sepsis. [Journal Article]
    Crit Care Explor. 2023 Jan; 5(1):e0849.Bissell BD, Sturgill JL, … Starr ME
  • CONCLUSIONS: Minimal alterations in cytokines were seen with opioid exposure during clinical sepsis. In a preclinical model, opioid exposure during sepsis was associated with ineffective bacterial clearance upon secondary infection. Further studies are warranted to evaluate the immunomodulatory role of opioids and their implications, especially in the post-sepsis period.
  • Immunotherapeutic Strategies for Treating Opioid Use Disorder and Overdose. [Journal Article]
    Expert Opin Investig Drugs. 2023 Jan 25 [Online ahead of print]Luba R, Martinez S, … Comer SD
  • Development and implementation of effective treatments for opioid use disorder (OUD) and prevention of overdose are urgent public health needs. Though existing medications for OUD (MOUD) are effective, barriers to initiation and retention in treatment persist. Therefore, development of novel treatments, especially those that may complement existing treatments, is needed.
  • North Carolina pharmacists' willingness to sell fentanyl test strips: a survey study. [Journal Article]
    Harm Reduct J. 2023 Jan 24; 20(1):10.Marley GT, Ostrach B, Carpenter D
  • CONCLUSIONS: North Carolina community pharmacists are willing to engage in various behaviors related to FTS sales and distribution. Most pharmacists were interested in receiving FTS training, which should be created to address pharmacist-reported barriers to FTS sales. Pharmacist distribution of FTS could increase access to FTS at the community level and has the potential to change drug use behavior and reduce overdose deaths.
  • Assessment of abuse potential of carfentanil. [Journal Article]
    Addict Biol. 2023 Feb; 28(2):e13265.Wei J, Lai M, … Di B
  • Carfentanil, as a fentanyl analogue, is a potent synthetic opioid. It has been controlled in many countries, and its emergence has been highlighted by many recent reports. However, although discriminative stimulus effects of carfentanil in rats had been reported, its abuse potential has not been fully evaluated. In this study, we evaluated the abuse potential of carfentanil via the tests of condi…
  • Opioid-related deaths in Ontario correctional facilities and penitentiaries (2009-2019). [Journal Article]
    Forensic Sci Med Pathol. 2023 Jan 23 [Online ahead of print]Button L, Williams AS, … Woodall KL
  • The opioid crisis is a significant public health issue in North America that began in the 1990s with opioid-related deaths increasing each year. Although studies have been published regarding the incidence of opioid-related deaths in the general population, there is limited information regarding deaths in the prison population. To investigate the impact of the opioid epidemic in this vulnerable p…
  • A Novel Inpatient Buprenorphine Induction Program for Adolescents With Opioid Use Disorder. [Journal Article]
    Hosp Pediatr. 2023 Jan 23 [Online ahead of print]Trope LA, Stemmle M, … Congdon JL
  • CONCLUSIONS: These results provide promising preliminary evidence of the feasibility of inpatient buprenorphine induction for adolescents with OUD. Given the public health urgency and severe shortage of adolescent access to MOUD, these results prompt consideration of broader clinical implementation and research to facilitate rapid expansion of access to evidence-based OUD care.
  • A Pharmacogenetic Precision Medicine Approach to Analgesia and Sedation Optimization in Critically Ill Adults. [Review]
    Pharmacotherapy. 2023 Jan 20 [Online ahead of print]Dzierba A, Stollings JL, Devlin JW
  • Precision medicine is a growing field in critical care. Research increasingly demonstrated pharmacogenomic variability to be an important determinant of analgesic and sedative drug response in the intensive care unit (ICU). Genome-wide association and candidate gene finding studies suggest analgesic and sedatives tailored to an individual's genetic makeup, environmental adaptations, in addition t…
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