- Safety profile of anesthetic modalities during laser treatment for retinopathy of prematurity: a systematic review. [Review]J Perinatol. 2023 Jan 28 [Online ahead of print]JP
- CONCLUSIONS: Significant heterogeneity among studies precludes direct comparisons and generalizability of the results. No specific anesthetic modality for treatment of ROP with laser photocoagulation was shown to be superior in terms of safety. Well-designed studies are required to establish the optimal anesthetic approach, considering that laser photocoagulation still remains one of the main therapeutic modalities for ROP.
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- Pre-hospital analgesia in pediatric trauma and critically ill patients: An analysis of a German air rescue service. [Journal Article]Scand J Trauma Resusc Emerg Med. 2023 Jan 28; 31(1):5.SJ
- CONCLUSIONS: German emergency physicians achieved a sufficient pain therapy in pediatric patients with a NRS > 4 after trauma. In case of non-trauma, the pain management by the emergency physicians is restrained and less successful. The most common analgesic medications administered were ketamine and fentanyl, followed by piritramide.
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- Novel Receptor-Binding-Based Assay for the Detection of Opioids in Human Urine Samples. [Journal Article]Anal Chem. 2023 Jan 27 [Online ahead of print]AC
- Consumption of opioids is a growing global health problem. The gold standard for drugs of abuse screening is immunochemical assays. However, this method comes with some disadvantages when screening for a wide variety of opioids. Detection of the binding of a compound at the human μ-opioid receptor (MOR) offers a promising alternative target. Here, we set up a urine assay to allow for detection of…
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- Using Evidence to Inform Legislation Aimed at Curbing Fentanyl Deaths. [Journal Article]JAMA Health Forum. 2023 Jan 06; 4(1):e225202.JH
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- Precipitated opioid withdrawal after buprenorphine administration in patients presenting to the emergency department: A case series. [Journal Article]
- CONCLUSIONS: Cases of adverse outcomes after buprenorphine administration in the ED and hospital meet criteria for PW, although some cases may have represented protracted opioid withdrawal. Further investigation into the incidence, risk factors, management of PW as well as patient perspectives is needed to expand and sustain the use of buprenorphine in EDs and hospitals.
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- Ketamine Compared with Fentanyl for Surgical Abortion: A Randomized Controlled Trial. [Journal Article]Obstet Gynecol. 2023 Jan 01; 141(1):227.OG
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- Ketamine Compared With Fentanyl for Surgical Abortion: A Randomized Controlled Trial. [Journal Article]Obstet Gynecol. 2023 Jan 01; 141(1):226.OG
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- Predictive models for fentanyl dose requirement and postoperative pain using clinical and genetic factors in patients undergoing major breast surgery. [Journal Article]Pain. 2022 Nov 09 [Online ahead of print]PAIN
- Fentanyl exhibits interindividual variability in its dose requirement due to various nongenetic and genetic factors such as single nucleotide polymorphisms (SNPs). This study aims to develop and cross-validate robust predictive models for postoperative fentanyl analgesic requirement and other related outcomes in patients undergoing major breast surgery. Data regarding genotypes of 10 candidate SN…
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- Intraoperative use of the machine learning-derived nociception level monitor results in less pain in the first 90 min after surgery. [Journal Article]Front Pain Res (Lausanne). 2022; 3:1086862.FP
- In this pooled analysis of two randomized clinical trials, intraoperative opioid dosing based on the nociception level-index produced less pain compared to standard care with a difference in pain scores in the post-anesthesia care unit of 1.5 (95% CI 0.8-2.2) points on an 11-point scale. The proportion of patients with severe pain was lower by 70%. Severe postoperative pain remains a significant …
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- Assessment of Opioid-Induced Immunomodulation in Experimental and Clinical Sepsis. [Journal Article]Crit Care Explor. 2023 Jan; 5(1):e0849.CC
- CONCLUSIONS: Minimal alterations in cytokines were seen with opioid exposure during clinical sepsis. In a preclinical model, opioid exposure during sepsis was associated with ineffective bacterial clearance upon secondary infection. Further studies are warranted to evaluate the immunomodulatory role of opioids and their implications, especially in the post-sepsis period.
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- Immunotherapeutic Strategies for Treating Opioid Use Disorder and Overdose. [Journal Article]Expert Opin Investig Drugs. 2023 Jan 25 [Online ahead of print]EO
- Development and implementation of effective treatments for opioid use disorder (OUD) and prevention of overdose are urgent public health needs. Though existing medications for OUD (MOUD) are effective, barriers to initiation and retention in treatment persist. Therefore, development of novel treatments, especially those that may complement existing treatments, is needed.
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- Comparison between intermittent epidural bolus of levobupivacaine 0.125% and ropivacaine 0.2% with fentanyl as adjuvant for combined spinal epidural technique in labor analgesia: A double blinded prospective study. [Randomized Controlled Trial]Ann Afr Med. 2023 Jan-Mar; 22(1):88-93.AA
- CONCLUSIONS: Ropivacaine produces an early onset of analgesia than levobupivacaine but levobupivacaine had significantly prolonged analgesia compared to ropivacaine. Both drugs were found to be safe for labor analgesia. Maternal satisfaction and fetal outcome were similar with both the drugs.
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- Immediate release fentanyl in general practices: Mostly off-label prescribing. [Journal Article]
- CONCLUSIONS: IRFs are not prescribed frequently in Dutch general practices. However, when prescribed, a relatively large portion of patients received an off-label prescription.
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- North Carolina pharmacists' willingness to sell fentanyl test strips: a survey study. [Journal Article]
- CONCLUSIONS: North Carolina community pharmacists are willing to engage in various behaviors related to FTS sales and distribution. Most pharmacists were interested in receiving FTS training, which should be created to address pharmacist-reported barriers to FTS sales. Pharmacist distribution of FTS could increase access to FTS at the community level and has the potential to change drug use behavior and reduce overdose deaths.
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- Assessment of abuse potential of carfentanil. [Journal Article]Addict Biol. 2023 Feb; 28(2):e13265.AB
- Carfentanil, as a fentanyl analogue, is a potent synthetic opioid. It has been controlled in many countries, and its emergence has been highlighted by many recent reports. However, although discriminative stimulus effects of carfentanil in rats had been reported, its abuse potential has not been fully evaluated. In this study, we evaluated the abuse potential of carfentanil via the tests of condi…
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- Fentanyl Drives Startling Increases in Adolescent Overdose Deaths. [Journal Article]JAMA. 2023 Jan 24; 329(4):280-281.JAMA
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- Strategies to Reduce Harm: An Expert Panel Discussion on the Fentanyl Crisis. [Journal Article]Perm J. 2023 Jan 24 [Online ahead of print]PJ
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- Opioid-related deaths in Ontario correctional facilities and penitentiaries (2009-2019). [Journal Article]
- The opioid crisis is a significant public health issue in North America that began in the 1990s with opioid-related deaths increasing each year. Although studies have been published regarding the incidence of opioid-related deaths in the general population, there is limited information regarding deaths in the prison population. To investigate the impact of the opioid epidemic in this vulnerable p…
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- Phase II study comparing nasal pressure monitoring with capnography during invasive endoscopic procedures: a single-center, single-arm trial. [Clinical Trial, Phase II]
- Nasal pressure signal is commonly used to evaluate obstructive sleep apnea. This study aimed to assess its safety for respiratory monitoring during sedation. A total of 45 adult patients undergoing sedation with propofol and fentanyl for invasive endoscopic procedures were enrolled. While both nasal pressure and capnograph signals were continuously recorded, only the nasal pressure signal was dis…
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- Re: Re: Transdermal fentanyl patch versus standard analgesia in postoperative oral submucous fibrosis patients: A triple blinded, randomised control trial. [Letter]Br J Oral Maxillofac Surg. 2023 Jan 10 [Online ahead of print]BJ
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- Comparing the Effects of Low-Dose Ketamine, Fentanyl, and Morphine on Hemorrhagic Tolerance and Analgesia in Humans. [Journal Article]Prehosp Emerg Care. 2023 Jan 23 [Online ahead of print]PE
- Hemorrhage is a leading cause of preventable battlefield and civilian trauma deaths. Ketamine, fentanyl, and morphine are recommended analgesics for use in the prehospital (i.e., field) setting to reduce pain. However, it is unknown whether any of these analgesics reduce hemorrhagic tolerance in humans. We tested the hypothesis that fentanyl (75 µg) and morphine (5 mg), but not ketamine (20 mg), …
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- HCN-Channel-Dependent Hyperexcitability of the Layer V Pyramidal Neurons in IL-mPFC Contributes to Fentanyl-Induced Hyperalgesia in Male Rats. [Journal Article]Mol Neurobiol. 2023 Jan 23 [Online ahead of print]MN
- Opioids are often first-line analgesics in pain therapy. However, prolonged use of opioids causes paradoxical pain, termed "opioid-induced hyperalgesia (OIH)." The infralimbic medial prefrontal cortex (IL-mPFC) has been suggested to be critical in inflammatory and neuropathic pain processing through its dynamic output from layer V pyramidal neurons. Whether OIH condition induces excitability chan…
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- Positive Preemptive Analgesia Effectiveness of Pregabalin Combined with Celecoxib in Total Knee Arthroplasty: A Prospective Controlled Randomized Study. [Randomized Controlled Trial]
- CONCLUSIONS: The preemptive analgesia regimen of pregabalin combined with celecoxib had positive effects on improving acute pain and reducing the cumulative dose of opioids after TKA. This trial is registered with ChiCTR2100041595.
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- Extended access to fentanyl vapor self-administration leads to addiction-like behaviors in mice: Blood chemokine/cytokine levels as potential biomarkers. [Journal Article]
- Rodent models are useful for understanding the mechanisms that underlie opioid addiction, but most preclinical studies have focused on rewarding and consummatory aspects of opioids without components of dependence-induced escalation of drug taking or seeking. We characterized several opioid-related behaviors in mice using a model of vaporized fentanyl self-administration. Male and female C57BL/6J…
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- A Novel Inpatient Buprenorphine Induction Program for Adolescents With Opioid Use Disorder. [Journal Article]Hosp Pediatr. 2023 Jan 23 [Online ahead of print]HP
- CONCLUSIONS: These results provide promising preliminary evidence of the feasibility of inpatient buprenorphine induction for adolescents with OUD. Given the public health urgency and severe shortage of adolescent access to MOUD, these results prompt consideration of broader clinical implementation and research to facilitate rapid expansion of access to evidence-based OUD care.
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- Characterization of early versus late opioid iatrogenic withdrawal syndrome in critically ill children transitioning from fentanyl -infusions to methadone. [Journal Article]J Opioid Manag. 2023 Jan-Feb; 19(1):43-56.JO
- CONCLUSIONS: The majority developed opioid IWS, with most developing early IWS, despite methadone initiation. Future studies should evaluate the optimal methadone dosing and overlap time to prevent opioid IWS.
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- Transdermal fentanyl patch in long term post operative pain management for oral submucous fibrosis: to be or not to be? Re: Transdermal fentanyl patch versus standard analgesia in postoperative oral submucous fibrosis patients: A triple blinded, randomised control trial. [Letter]Br J Oral Maxillofac Surg. 2023 Jan 10 [Online ahead of print]BJ
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- A Pharmacogenetic Precision Medicine Approach to Analgesia and Sedation Optimization in Critically Ill Adults. [Review]Pharmacotherapy. 2023 Jan 20 [Online ahead of print]P
- Precision medicine is a growing field in critical care. Research increasingly demonstrated pharmacogenomic variability to be an important determinant of analgesic and sedative drug response in the intensive care unit (ICU). Genome-wide association and candidate gene finding studies suggest analgesic and sedatives tailored to an individual's genetic makeup, environmental adaptations, in addition t…
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- Clarifying 'safer supply' to enrich policy discussions. [Editorial]Addiction. 2023 Jan 20 [Online ahead of print]A
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