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29 results
  • Advances in patents related to intrapocket technology for the management of periodontitis. [Review]
    Recent Pat Drug Deliv Formul. 2015; 9(2):129-45.Yadav SK, Khan G, Mishra B
  • Increased prevalence of oral diseases such as gingivitis, periodontitis and dental caries has become major health issue worldwide. Such growing incidence of periodontitis has directly affected the development of drug delivery systems and growth of the market. Since the infections are limited to periodontal pockets or oral cavity, localized intrapocket drug delivery will be more beneficial than co…
  • Periodontal therapy using local delivery of antimicrobial agents. [Meta-Analysis]
    Dent Clin North Am. 2002 Oct; 46(4):665-77, viii.Niederman R, Abdelshehid G, Goodson JM
  • Antimicrobial agents, systemic and/or local, are thought by some to be effective agents for treating periodontal infections. Here the authors determine the costs and benefits of local delivery agents for treating periodontal disease. Applying this cost-benefit analysis to patient care, however, will depend upon a clinician's expertise and a patient's value system.
  • Local antibiotic therapy guided by microbiological diagnosis. [Journal Article]
    J Clin Periodontol. 2002 Aug; 29(8):743-9.Mombelli A, Schmid B, … Lang NP
  • CONCLUSIONS: Therapy with tetracycline fibers guided by microbiological diagnosis effectively reduced P. gingivalis and A. actinomycetemcomitans locally, but was unable to completely eradicate the target organisms. Additional systemic antibiotic therapy further reduced P. gingivalis and A. actinomycetemcomitans. The observed persistence patterns suggest that reemergence of A. actinomycetemcomitans was due to recolonization, whereas the strikingly reproducible local reemergence of P. gingivalis in some sites indicated failed eradication.
  • Locally delivered antimicrobials in periodontal treatment. [Journal Article]
    J Indiana Dent Assoc. 2002 Summer; 81(2):10-4.John V, Phillips G
  • The management of periodontal diseases has included both non-surgical and surgical treatment options. Non-surgical treatment traditionally has referred to the role of mechanical instrumentation of the root surface with either scalers or curettes. However, the introduction of locally delivered anti-microbial medications, which can be placed directly into a periodontal pocket, has provided the prac…
  • Local delivery of antimicrobials: a new era in the treatment of adult periodontitis. [Review]
    Compend Contin Educ Dent. 1999; 20(4 Suppl):13-8; quiz 34-5.Killoy WJ
  • This article discusses the principles, products, and techniques currently available for local delivery of antimicrobials in the treatment of adult periodontitis. Four principles provide the scientific basis for the treatment of periodontitis: it is caused by bacteria; it cannot be cured, but it can be controlled; clinicians cannot remove all the plaque and calculus; and periodontitis reinfects. T…
  • Release kinetics of 25% tetracycline hydrochloride-loaded ethylene vinyl acetate fibers. [Journal Article]
    Periodontal Clin Investig. 1999; 21(1):6-9.Demirel K, Yalçin F, … Altas K
  • In situ release kinetics of 25% tetracycline-loaded fibers (Actisite) were evaluated in this study. 1 cm precut tetracycline fibers were removed from periodontal pockets (>5 mm) of 24 patients. Fibers were maintained at their site for 1, 3, 7, 10 and 12 days. Remaining biologically active tetracycline on the fibers was determined by agar diffusion inhibition assay. Inhibition zones induced by fib…
  • Local antimicrobial therapies in periodontal disease. [Review]
    Ann R Australas Coll Dent Surg. 2000 Oct; 15:57-60.Kinane DF
  • Periodontal therapy has the primary aim of halting periodontal disease progression. Clinical trials over the years have indicated that meticulous scaling and root planing in conjunction with a patient's proper plaque control can arrest periodontitis, but this therapy is not always completely effective and thus adjunctive therapies need to be considered. Local delivery of antibacterial agents into…
  • Evaluation of tetracycline fiber therapy with digital image analysis. [Journal Article]
    J Clin Periodontol. 1998 Sep; 25(9):737-45.Fourmousis I, Tonetti MS, … Brägger U
  • The aims of the present study were to assess radiographically the effects of scaling/root planing combined with antibiotic therapy using tetracycline fibers (TCF): (I) on alveolar bone density and linear descriptors and (II) on supracrestal soft tissue density. 19 subjects with generalized adult periodontitis (with at least 20 teeth present, at least 4 teeth with pockets >4 mm and bleeding upon c…
  • Patient selection and clinical applications of periodontal tetracycline fibers. [Case Reports]
    Gen Dent. 1998 Jan-Feb; 46(1):58-61.Latner L
  • With the introduction of Actisite (tetracycline hydrochloride) periodontal fiber therapy, controlled drug delivery of tetracycline into the periodontal pocket has become a clinical reality. An important factor in the success of this treatment option is the selection of suitable candidates according to specific patient selection criteria proposed by the author in this article. Case reports describ…
  • Life on a string: development of the tetracycline fiber delivery system. [Historical Article]
    Technol Health Care. 1996 Sep; 4(3):269-82.Goodson JM
  • Development of new drug therapy is difficult for large companies and almost unheard of by individuals. This autobiographical account of the development of the tetracycline fiber delivery system for periodontal therapy (Actisite) relates experiences of a scientist between 1976 and 1994 which lead to FDA approval. In this account, the author acknowledges some of the key people, companies and instit…
  • The effect of tetracycline fiber therapy on beta-glucuronidase and interleukin-1 beta in crevicular fluid. [Journal Article]
    J Clin Periodontol. 1996 Sep; 23(9):816-22.Lamster IB, Pullman JR, … Grbic JT
  • Treatment with the tetracycline HCL-containing (Actisite infinity) fiber has been shown to improve clinical measures of periodontitis, as well as reduce the number of sites infected with putative periodontal pathogens. In this study, we examined the effect of the tetracycline fiber on biochemical mediators of the host's inflammatory response in gingival crevicular fluid (GCF). The total amount of…
  • Treating periodontal diseases with tetracycline-impregnated fibers: data and controversies. [Review]
    Compend Contin Educ Dent. 1995 May; 16(5):448-55; quiz 456.Greenstein G
  • This article addresses the use of tetracycline-impregnated fibers in the treatment of periodontal diseases. Clinical and microbiologic data are reviewed to provide pragmatic guidelines for fiber use. In addition, controversial issues associated with the labeling of Actisite, the potential of developing antibiotic-resistant strains, and the benefits of systemic vs local drug delivery are discussed…
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