- Advances in patents related to intrapocket technology for the management of periodontitis. [Review]
- Increased prevalence of oral diseases such as gingivitis, periodontitis and dental caries has become major health issue worldwide. Such growing incidence of periodontitis has directly affected the development of drug delivery systems and growth of the market. Since the infections are limited to periodontal pockets or oral cavity, localized intrapocket drug delivery will be more beneficial than co…
- Control of periodontal infections: a randomized controlled trial I. The primary outcome attachment gain and pocket depth reduction at treated sites. [Randomized Controlled Trial]
- CONCLUSIONS: Patients receiving adjunctive therapies generally exhibited improved CAL gain and/or PPD reduction when compared with the outcome of SRP alone. Only additive, not synergistic effects of the various adjunctive therapies were observed.
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- Antibiotic resistance profile of the subgingival microbiota following systemic or local tetracycline therapy. [Randomized Controlled Trial]
- CONCLUSIONS: Local or systemically administered tetracycline results in transitory selection of subgingival species intrinsically resistant to this drug. Although the percentage of sites harboring periodontal pathogens resistant to tetracycline were quite elevated in this population, both therapies were effective in reducing their prevalence over time.
- Debridement and local application of tetracycline-loaded fibres in the management of persistent periodontitis: results after 12 months. [Randomized Controlled Trial]
- CONCLUSIONS: SRP plus TE fibres gave the greatest advantage in the treatment of periodontal persistent lesions at least 12 months following treatment.
- The use of tetracycline fibres in the treatment of generalised aggressive periodontitis: clinical and microbiological findings. [Controlled Clinical Trial]
- The purpose of the present study was to evaluate the effects of tetracycline fibres (TCF) as an adjunct to scaling in the treatment of generalised aggressive periodontitis and to compare the effects with mechanical treatment only. Ten patients, 24-39 years old referred for treatment to the Department of Preventive Dentistry, Periodontology and Implant Biology, Aristotle University of Thessaloniki…
- Periodontal therapy using local delivery of antimicrobial agents. [Meta-Analysis]
- Antimicrobial agents, systemic and/or local, are thought by some to be effective agents for treating periodontal infections. Here the authors determine the costs and benefits of local delivery agents for treating periodontal disease. Applying this cost-benefit analysis to patient care, however, will depend upon a clinician's expertise and a patient's value system.
- Local antibiotic therapy guided by microbiological diagnosis. [Journal Article]
- CONCLUSIONS: Therapy with tetracycline fibers guided by microbiological diagnosis effectively reduced P. gingivalis and A. actinomycetemcomitans locally, but was unable to completely eradicate the target organisms. Additional systemic antibiotic therapy further reduced P. gingivalis and A. actinomycetemcomitans. The observed persistence patterns suggest that reemergence of A. actinomycetemcomitans was due to recolonization, whereas the strikingly reproducible local reemergence of P. gingivalis in some sites indicated failed eradication.
- Locally delivered antimicrobials in periodontal treatment. [Journal Article]J Indiana Dent Assoc. 2002 Summer; 81(2):10-4.JI
- The management of periodontal diseases has included both non-surgical and surgical treatment options. Non-surgical treatment traditionally has referred to the role of mechanical instrumentation of the root surface with either scalers or curettes. However, the introduction of locally delivered anti-microbial medications, which can be placed directly into a periodontal pocket, has provided the prac…
- Release of tetracycline hydrochloride from electrospun poly(ethylene-co-vinylacetate), poly(lactic acid), and a blend. [Journal Article]
- Electrospun fiber mats are explored as drug delivery vehicles using tetracycline hydrochloride as a model drug. The mats were made either from poly(lactic acid) (PLA), poly(ethylene-co-vinyl acetate) (PEVA), or from a 50:50 blend of the two. The fibers were electrospun from chloroform solutions containing a small amount of methanol to solubilize the drug. The release of the tetracycline hydrochlo…
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- Local delivery of antimicrobials: a new era in the treatment of adult periodontitis. [Review]
- This article discusses the principles, products, and techniques currently available for local delivery of antimicrobials in the treatment of adult periodontitis. Four principles provide the scientific basis for the treatment of periodontitis: it is caused by bacteria; it cannot be cured, but it can be controlled; clinicians cannot remove all the plaque and calculus; and periodontitis reinfects. T…
- Release kinetics of 25% tetracycline hydrochloride-loaded ethylene vinyl acetate fibers. [Journal Article]
- In situ release kinetics of 25% tetracycline-loaded fibers (Actisite) were evaluated in this study. 1 cm precut tetracycline fibers were removed from periodontal pockets (>5 mm) of 24 patients. Fibers were maintained at their site for 1, 3, 7, 10 and 12 days. Remaining biologically active tetracycline on the fibers was determined by agar diffusion inhibition assay. Inhibition zones induced by fib…
- Neutral proteases in crevicular fluid as an indicator for periodontal treatment intervention. [Journal Article]
- To longitudinally determine if early therapeutic intervention, based on a positive neutral protease activity (NPA) assay score could effectively arrest the progress of periodontal disease destruction.
- Local antimicrobial therapies in periodontal disease. [Review]
- Periodontal therapy has the primary aim of halting periodontal disease progression. Clinical trials over the years have indicated that meticulous scaling and root planing in conjunction with a patient's proper plaque control can arrest periodontitis, but this therapy is not always completely effective and thus adjunctive therapies need to be considered. Local delivery of antibacterial agents into…
- Locally delivered antibiotics in periodontics. [Journal Article]Compend Contin Educ Dent. 2001 Sep; 22(9):748, 752-5.CC
- Treatment of peri-implantitis by local delivery of tetracycline. Clinical, microbiological and radiological results. [Journal Article]
- The purpose of this study was to investigate the clinical, microbiological and radiological effects of peri-implantitis therapy by local delivery of tetracycline. In 25 partially edentulous patients, 30 implants with radiographic evidence of circumferential bone loss, and peri-implant probing depths > or =5 mm were treated with polymeric tetracycline HCl-containing fibers. Clinical and microbial …
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- PCR monitoring for tetracycline resistance genes in subgingival plaque following site-specific periodontal therapy. A preliminary report. [Journal Article]
- CONCLUSIONS: These results complement earlier studies of tet resistance and demonstrate the efficacy of PCR monitoring for the appearance of specific resistance genes during and after antibiotic therapy.
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- [A biocompatibility study and the effects of slow-release antibiotic materials in the treatment of periodontal disease. I. The biocompatibility of cellulose acetate charged with 25% tetracycline hydrochloride. A clinical and scanning microscopic study of a case]. [Case Reports]Minerva Stomatol. 1998 Oct; 47(10):553-7.MS
- A clinical and microscopical (SEM) investigation has been carried out on the biocompatibility of cellulose acetate fiber tetracycline with 25% of tetracycline hydrochloride (Actisite R). A subject with advanced periodontal disease was selected and a pocket of 8 mm of PD was chosen. A segment of fiber was inserted into the pocket for 8 days. After removal, PD and GI clinical parameters were detect…
- Evaluation of tetracycline fiber therapy with digital image analysis. [Journal Article]
- The aims of the present study were to assess radiographically the effects of scaling/root planing combined with antibiotic therapy using tetracycline fibers (TCF): (I) on alveolar bone density and linear descriptors and (II) on supracrestal soft tissue density. 19 subjects with generalized adult periodontitis (with at least 20 teeth present, at least 4 teeth with pockets >4 mm and bleeding upon c…
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- Patient selection and clinical applications of periodontal tetracycline fibers. [Case Reports]Gen Dent. 1998 Jan-Feb; 46(1):58-61.GD
- With the introduction of Actisite (tetracycline hydrochloride) periodontal fiber therapy, controlled drug delivery of tetracycline into the periodontal pocket has become a clinical reality. An important factor in the success of this treatment option is the selection of suitable candidates according to specific patient selection criteria proposed by the author in this article. Case reports describ…
- Clinical response to local delivery of tetracycline in relation to overall and local periodontal conditions. [Randomized Controlled Trial]
- The purpose of this study was to determine the clinical response to local delivery of tetracycline in relation to clinical and microbiological conditions of the other teeth. 4 deep pockets were monitored in 19 subjects with multiple deep periodontal lesions and high counts of P. gingivalis. In 9 patients (LT) only 2 of the selected lesions were treated by placement of tetracycline fibers (Actisit…
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- Use of the polymeric matrix as internal standard for quantitation of in vivo delivery of tetracycline HCl from Actisite tetracycline fiber during periodontal treatment. [Journal Article]
- Actisite (tetracycline hydrochloride) periodontal fiber is a 23 cm monofilament containing 12.7 mg tetracycline HCl homogeneously dispersed in a polymer. This product is indicated as an adjunct to scaling and root planing to reduce pocket depth and bleeding on probing in patients with adult periodontitis. The sustained-release system, placed in the periodontal pocket for 10 d, releases the antibi…
- Topographic distribution of black-pigmenting anaerobes before and after periodontal treatment by local delivery of tetracycline. [Journal Article]
- The purpose of this study was to determine the distribution of black-pigmenting Gram-negative bacteria in the dentition of 10 adult periodontitis patients before and after treatment by local delivery of tetracycline. The subjects were selected based on a screening for high counts of Porphyromonas gingivalis and multiple deep pockets. Subgingival microbial samples were taken from the mesial and di…
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- Life on a string: development of the tetracycline fiber delivery system. [Historical Article]Technol Health Care. 1996 Sep; 4(3):269-82.TH
- Development of new drug therapy is difficult for large companies and almost unheard of by individuals. This autobiographical account of the development of the tetracycline fiber delivery system for periodontal therapy (Actisite) relates experiences of a scientist between 1976 and 1994 which lead to FDA approval. In this account, the author acknowledges some of the key people, companies and instit…
- The effect of tetracycline fiber therapy on beta-glucuronidase and interleukin-1 beta in crevicular fluid. [Journal Article]
- Treatment with the tetracycline HCL-containing (Actisite infinity) fiber has been shown to improve clinical measures of periodontitis, as well as reduce the number of sites infected with putative periodontal pathogens. In this study, we examined the effect of the tetracycline fiber on biochemical mediators of the host's inflammatory response in gingival crevicular fluid (GCF). The total amount of…
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- Treating periodontal diseases with tetracycline-impregnated fibers: data and controversies. [Review]Compend Contin Educ Dent. 1995 May; 16(5):448-55; quiz 456.CC
- This article addresses the use of tetracycline-impregnated fibers in the treatment of periodontal diseases. Clinical and microbiologic data are reviewed to provide pragmatic guidelines for fiber use. In addition, controversial issues associated with the labeling of Actisite, the potential of developing antibiotic-resistant strains, and the benefits of systemic vs local drug delivery are discussed…
- Actisite (tetracycline hydrochloride periodontal fiber) not a product for the pediatric dentist. [Journal Article]J Clin Pediatr Dent. 1995 Winter; 19(2):147.JC
- Fiber-enhanced periodontal therapy: an era of ultra-enhancement. [News]Dent Today. 1994 Oct; 13(10):22, 24, 26 passim.DT
- Actisite (tetracycline hydrochloride periodontal fiber): a critique. [Clinical Trial]Periodontal Clin Investig. 1994 Fall; 16(2):5-7.PC
- Long-term effect of tetracycline fibers on recurrent lesions in periodontal maintenance patients. [Clinical Trial]Periodontal Clin Investig. 1994 Spring; 16(1):8-13.PC
- Thirty-one patients with chronic adult periodontitis participated in this long-term private practice study. Sixty-one sites with moderate (4-6 mm, n = 21) or deep (> or = 7 mm, n = 40) periodontal pockets and bleeding on probing were treated with an antibiotic-releasing fiber, Actisite (Periodontal Therapeutic System) (tetracycline hydrochloride). Scaling/root planing (SRP) was performed on all t…