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5,843 results
  • A dissection of SARS‑CoV2 with clinical implications (Review). [Journal Article]
    Int J Mol Med. 2020 Aug; 46(2):489-508.Stancioiu F, Papadakis GZ, … Tsatsakis A
  • We are being confronted with the most consequential pandemic since the Spanish flu of 1918‑1920 to the extent that never before have 4 billion people quarantined simultaneously; to address this global challenge we bring to the forefront the options for medical treatment and summarize SARS‑CoV2 structure and functions, immune responses and known treatments. Based on literature and our own experien…
  • Human hepatic in vitro models reveal distinct anti-NASH potencies of PPAR agonists. [Journal Article]
    Cell Biol Toxicol. 2020 Jul 01 [Online ahead of print]Boeckmans J, Natale A, … Rodrigues RM
  • Non-alcoholic steatohepatitis (NASH) is a highly prevalent, chronic liver disease characterized by hepatic lipid accumulation, inflammation, and concomitant fibrosis. Up to date, no anti-NASH drugs have been approved. In this study, we reproduced key NASH characteristics in vitro by exposing primary human hepatocytes (PHH), human skin stem cell-derived hepatic cells (hSKP-HPC), HepaRG and HepG2 c…
  • Current and Future Treatments in the Fight Against Non-Alcoholic Fatty Liver Disease. [Review]
    Cancers (Basel). 2020 Jun 28; 12(7)Smeuninx B, Boslem E, Febbraio MA
  • Obesity is recognised as a risk factor for many types of cancers, in particular hepatocellular carcinoma (HCC). A critical factor in the development of HCC from non-alcoholic fatty liver disease (NAFLD) is the presence of non-alcoholic steatohepatitis (NASH). Therapies aimed at NASH to reduce the risk of HCC are sparse and largely unsuccessful. Lifestyle modifications such as diet and regular exe…
  • Molecular Mechanisms of Cardiomyocyte Death in Drug-Induced Cardiotoxicity. [Review]
    Front Cell Dev Biol. 2020; 8:434.Ma W, Wei S, … Li W
  • Homeostatic regulation of cardiomyocytes plays a crucial role in maintaining the normal physiological activity of cardiac tissue. Severe cardiotoxicity results in cardiac diseases including but not limited to arrhythmia, myocardial infarction and myocardial hypertrophy. Drug-induced cardiotoxicity limits or forbids further use of the implicated drugs. Such drugs that are currently available in th…
  • Antenatal PPARγ Agonist Pioglitazone Stimulates Fetal Lung Maturation Equally in Males and Females. [Journal Article]
    Am J Physiol Lung Cell Mol Physiol. 2020 Jun 24 [Online ahead of print]Lee C, Sakurai R, … Rehan VK
  • Antenatal steroids (ANS) accelerate fetal lung maturation and reduce the incidence of respiratory distress syndrome. However, sex-specificity, i.e., being less effective in males, and potential long-term neurodevelopmental sequelae, particularly with repeated courses, remain significant limitations. The differential sex response to ANS is likely mediated via the inhibitory effect of fetal androge…
  • UPR modulation of host immunity by P. aeruginosa in cystic fibrosis. [Journal Article]
    Clin Sci (Lond). 2020 Jun 15 [Online ahead of print]Bedi B, Lin KC, … Sadikot RT
  • Cystic fibrosis (CF) is a progressive multi organ autosomal recessive disease with devastating impact on the lungs caused by derangements of the cystic fibrosis transmembrane conductance regulator (CFTR) gene. Morbidity and mortality are caused by the triad of impaired mucociliary clearance, microbial infections and chronic inflammation. P. aeruginosa is a main respiratory pathogen in individuals…
    J Pharm Biomed Anal. 2020 May 22; 188:113311.Sarcan ET, Tas A, … Hekimoglu B
  • X-ray is used in several areas for analysis, imaging, sterilisation and security. X-ray machines are increasingly used in the entrance of the airports, shopping centres, etc. for security purposes. Therefore, human beings and belongings are frequently exposed to X-ray by transiting these checkpoints at various sites such as airports, shopping centres etc. This study aims is to investigate the X-r…
  • Chronic Granulomatous Disease: a Comprehensive Review. [Review]
    Clin Rev Allergy Immunol. 2020 Jun 10 [Online ahead of print]Yu HH, Yang YH, Chiang BL
  • Chronic granulomatous disease (CGD) is a primary immunodeficiency of phagocyte function due to defective NADPH oxidase (phox). Compared with the common types of CYBB/gp91phox, NCF1/p47phox, and CYBA/p22phox deficiency, NCF4/p40phox deficiency is a mild and atypical form of CGD without invasive bacterial or fungal infections. It can be diagnosed using serum-opsonized E.coli as a stimulus in dihydr…
  • Nonalcoholic Fatty Liver Disease: An Important Consideration for Primary Care Providers in Hawai'i. [Journal Article]
    Hawaii J Health Soc Welf. 2020 Jun 01; 79(6):180-186.Pattison RJ, Esteban JP, … Kuwada SK
  • Non-alcoholic fatty liver disease (NAFLD) is the most common cause of chronic liver disease worldwide. NAFLD is a broad term for both non-alcoholic fatty liver (NAFL), which describes simple fatty liver without inflammation, and non-alcoholic steatohepatitis (NASH), the more severe phenotype with hepatocellular inflammation. The population of Hawai'i is particularly vulnerable to the NAFLD and ob…
  • Portuguese-Brazilian evidence-based guideline on the management of hyperglycemia in type 2 diabetes mellitus. [Review]
    Diabetol Metab Syndr. 2020; 12:45.Bertoluci MC, Salles JEN, … Leitão CB
  • CONCLUSIONS: In non-pregnant adults, the recommended HbA1c target is below 7%. Higher levels are recommended in frail older adults and patients at higher risk of hypoglycemia. Lifestyle modification is recommended at all phases of treatment. Metformin is the first choice when HbA1c is 6.5-7.5%. When HbA1c is 7.5-9.0%, dual therapy with metformin plus an SGLT2i and/or GLP-1RA (first-line antidiabetic agents, AD1) is recommended due to cardiovascular and renal benefits. If an AD1 is unaffordable, other antidiabetic drugs (AD) may be used. Triple or quadruple therapy should be considered when HbA1c remains above target. In patients with clinical or subclinical atherosclerosis, the combination of one AD1 plus metformin is the recommended first-line therapy to reduce cardiovascular events and improve blood glucose control. In stable heart failure with low ejection fraction (< 40%) and glomerular filtration rate (eGFR) > 30 mL/min/1.73 m2, metformin plus an SGLT-2i is recommended to reduce cardiovascular mortality and heart failure hospitalizations and improve blood glucose control. In patients with diabetes-associated chronic kidney disease (CKD) (eGFR 30-60 mL/min/1.73 m2 or eGFR 30-90 mL/min/1.73 m2 with albuminuria > 30 mg/g), the combination of metformin and an SGLT2i is recommended to attenuate loss of renal function, reduce albuminuria and improve blood glucose control. In patients with severe renal failure, insulin-based therapy is recommended to improve blood glucose control. Alternatively, GLP-1RA, DPP4i, gliclazide MR and pioglitazone may be considered to reduce albuminuria. In conclusion, the current evidence supports individualizing anti-hyperglycemic treatment for T2DM.
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