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Unbound Medicine.
(Acute lymphoblastic lymphocytic leukemia ALL )
34,250 results
  • Enhancing CAR-T cell functionality in a patient-specific manner. [Journal Article]
    Nat Commun. 2023 Jan 31; 14(1):506.Zhang DKY, Adu-Berchie K, … Mooney DJ
  • Patient responses to autologous CD19 chimeric antigen receptor (CAR) T-cell therapies are limited by insufficient and inconsistent cellular functionality. Here, we show that controlling the precise level of stimulation during T-cell activation to accommodate individual differences in the donor cells will dictate the functional attributes of CAR-T cell products. The functionality of CAR-T cell pro…
    Harefuah. 2023 Jan; 162(1):57-63.Elitzur S, Izraeli S
  • Acute lymphoblastic leukemia (ALL) is the most common childhood malignancy, constituting approximately 25% of childhood cancers. In recent decades, survival rates have improved dramatically, from approximately 10% in the 1960's to over 90% today. This tremendous achievement has been accomplished through collaborative randomized clinical trials, with progressive evolution of highly efficient, risk…
  • Cdc73 protects Notch-induced T-cell leukemia cells from DNA damage and mitochondrial stress. [Preprint]
    bioRxiv. 2023 Jan 22Melnick A, McCarter A, … Chiang MY
  • Activated Notch signaling is highly prevalent in T-cell acute lymphoblastic leukemia (T-ALL) but pan-Notch inhibitors were toxic in clinical trials. To find alternative ways to target Notch signals, we investigated Cell division cycle 73 (Cdc73), which is a Notch cofactor and component of transcriptional machinery, a potential target in T-ALL. While we confirmed previous work that CDC73 interacts…
  • The case of T-ALL presenting with NK phenotype after COVID-19 vaccination. [Case Reports]
    Pathol Res Pract. 2023 Jan 15; 242:154310.Yanagida E, Kubota A, … Murayama T
  • NK-lymphoblastic leukemia/lymphoma (NK-LL) is an extremely rare hematopoietic tumor consisting of natural killer (NK) precursor cells, and their lineage overlaps with T-cells, making it challenging to diagnose. COVID-19 vaccination is recommended for people with a risk of aggravation such as cancer-bearing patients, including hematopoietic tumors. We present a 55-year-old man who had cervical lym…
  • Health utility of children with acute lymphoblastic leukemia in China. [Journal Article]
    Front Public Health. 2022; 10:1069336.Wang W, Dong Y, … Cai J
  • CONCLUSIONS: This is the first study that measured health utility of children with pALL in China. Mean health utility scores increased from induction to maintenance. These provided important utility estimates that help inform future health economic models. The phrasing of "School work/homework" in CHU9D-CHN could be further improved. More efforts are needed to design and implement specific interventions targeting at the dimension "able to join in activities" for enhancing HRQoL of children with pALL in China.
  • Notch Partners in the Long Journey of T-ALL Pathogenesis. [Review]
    Int J Mol Sci. 2023 Jan 10; 24(2)Toribio ML, González-García S
  • T-cell acute lymphoblastic leukemia (T-ALL) is an aggressive hematological disease that arises from the oncogenic transformation of developing T cells during T-lymphopoiesis. Although T-ALL prognosis has improved markedly in recent years, relapsing and refractory patients with dismal outcomes still represent a major clinical issue. Consequently, understanding the pathological mechanisms that lead…
  • Do CAR-T and Allogeneic Stem Cell Transplant Both Have a Place in Lymphoid Neoplasms? [Review]
    Int J Mol Sci. 2023 Jan 05; 24(2)Martino M, Canale FA, … Allegra A
  • Allogeneic stem cell transplantation (allo-SCT) represented the first immunotherapy to treat hematologic malignancies: it has been considered as a cure for the disease and never as an approach to extend the life of patients. The success of allo-SCT derives both from the ability to treat patients with intensive chemoradiotherapy and from the potent graft-versus-leukemia effects mediated by donor i…
  • Prognostic Role of CD200 in Acute Lymphoblastic Leukemia Patients. [Journal Article]
    Diagnostics (Basel). 2023 Jan 16; 13(2)Khalil M, Elsharkawy N, … Ayoub MA
  • CONCLUSIONS: This study showed that CD200 expression was expressed in 100% of the patients. Correlations between CD200 expression and different laboratory data of patients revealed that there was an impact of CD200 on different diagnostic findings. After the follow-up of the patients, we found that the use of PRISM function of the software could add value to the detection of minimal residual disease.
  • Lineage switch of acute myeloid leukemia to T-Cell acute lymphoblastic leukemia - A unique case report. [Case Reports]
    Indian J Pathol Microbiol. 2023 Jan-Mar; 66(1):191-195.Jamil SF, Sharma U, … Bansal S
  • "Lineage switch" is term described when leukemic cells on relapse exhibit a new phenotype, where losses of one lineage defining markers with simultaneous gain of another lineage defining markers occur. Relapse of acute leukemia is although a very common event, lineage switch occurs and reported very rarely in such cases. The pathogenesis involved in this phenomenon remains unclear; however plasti…
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