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Unbound Medicine.
(Acute myelocytic myelogenous leukemia AML )
1,618 results
  • Anti-Leukemic Activity of Brassica-Derived Bioactive Compounds in HL-60 Myeloid Leukemia Cells. [Journal Article]
    Int J Mol Sci. 2022 Nov 02; 23(21)Núñez-Sánchez MÁ, Martínez-Sánchez MA, … Ruiz-Alcaraz AJ
  • Acute myeloid leukemia (AML) is a cancer of the myeloid blood cells mainly treated with chemotherapy for cancer remission, but this non-selective treatment also induces numerous side effects. Investigations with bioactive compounds from plant-derived foods against cancer have increased in the last years because there is an urgent need to search for new anti-leukemic agents possessing higher effic…
  • Quercetin induces autophagy-associated death in HL-60 cells through CaMKKβ/AMPK/mTOR signal pathway. [Journal Article]
    Acta Biochim Biophys Sin (Shanghai). 2022 Sep 25; 54(9):1244-1256.Xiao J, Zhang B, … Nie D
  • Acute myeloid leukemia (AML) is one of the most common malignancies of the hematopoietic progenitor cell in adults. Quercetin has gained recognition over the years because of its anti-cancer effect with minimal toxicity. Herein, we aim to investigate the anti-leukemia mechanism of quercetin and to decipher the signaling pathway of quercetin in HL-60 leukemic cells. We observed that quercetin indu…
  • Targeting FHL1 impairs cell proliferation and differentiation of acute myeloid leukemia cells. [Journal Article]
    Biochem Cell Biol. 2022 08 01; 100(4):301-308.Liu Y, Li H, … Fan S
  • The four and a half LIM domains 1 (FHL1) is considered to play important roles in tumors. This study aims to investigate the role and precise mechanisms of FHL1 in acute myeloid leukemia (AML). Here, we found that FHL1 was highly expressed in AML. CCK8, flow cytometry, and Western blot analysis of cell cycle-related proteins showed that overexpression of FHL1 promoted proliferation and accelerate…
  • WTIP upregulates FOXO3a and induces apoptosis through PUMA in acute myeloid leukemia. [Journal Article]
    Cell Death Dis. 2021 12 20; 13(1):18.Zhu Y, Tong X, … Lu X
  • Acute myeloid leukemia (AML) is an aggressive and heterogeneous clonal hematologic malignancy for which novel therapeutic targets and strategies are required. Emerging evidence suggests that WTIP is a candidate tumor suppressor. However, the molecular mechanisms of WTIP in leukemogenesis have not been explored. Here, we report that WTIP expression is significantly reduced both in AML cell lines a…
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