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Unbound Medicine.
(Acute promyelocytic leukemia)
11,880 results
  • Poison With a Purpose: A Case Report on Arsenic Cardiotoxicity and Obesity. [Case Reports]
    Cureus. 2022 Dec; 14(12):e33185.Nachtigal EA, Doan TN
  • Acute promyelocytic leukemia (APL) is a form of leukemia in which there is an arrest of the maturation of the myeloid lineage at the promyelocyte stage. Although there is high early mortality due to coagulopathy, APL is now a curable disease with the use of arsenic trioxide (ATO) and all-trans-retinoic acid (ATRA). Arsenic is weight-based for the treatment of APL, and many toxicities are dose-dep…
  • Differentiation syndrome in patients with acute promyelocytic leukemia. [Case Reports]
    Clin Case Rep. 2023 Jan; 11(1):e6697.Elamin NH, Rashid F, … Yassin MA
  • A 48-year-old male diagnosed with acute promyelocytic leukemia (APL) started on all-trans-retinoic acid and arsenic trioxide, developed typical symptoms of differentiation syndrome, and improved dramatically on steroids. Hence, any APL patient started on chemotherapy, needs to be monitored closely for developing differentiation syndrome and to start steroid upon suspicion.
  • Understanding Quality of Life in Patients With Acute Leukemia, a Global Survey. [Journal Article]
    J Patient Cent Res Rev. 2023 Winter; 10(1):21-30.Pemberton-Whiteley Z, Nier S, … Bradley J
  • CONCLUSIONS: Findings indicated key factors, particularly age, gender, and socioeconomic state, that clinicians responsible for the care of patients with acute leukemia should be aware of when designing support strategies. The importance of social functioning in relation to patient QoL also should be included in considerations.
  • Acute Promyelocytic Leukemia with Rare Genetic Aberrations: A Report of Three Cases. [Case Reports]
    Genes (Basel). 2022 12 23; 14(1)Liu G, Liu L, … Li X
  • Acute promyelocytic leukemia (APL) is a unique subtype of acute myeloid leukemia (AML) that is characterized by the PML::RARA fusion or, more rarely, a variant RARA translocation. While APL can be clinically suspected, diagnosis of APL requires genetic confirmation. Targeted therapy such as all-trans-retinoic acid (ATRA) and arsenic trioxide (ATO) has dramatically improved the prognosis of APL pa…
  • Fever of Unknown Origin and Multidrug Resistant Organism Colonization in AML Patients. [Journal Article]
    Mediterr J Hematol Infect Dis. 2023; 15(1):e2023013.Guarnera L, Trotta GE, … Del Principe MI
  • CONCLUSIONS: In our experience, MDRO colonization is a frequent and difficult-to-eradicate condition that can arise at all stages of treatment. Prompt discharge of patients as soon as clinical conditions allow could limit the spread of MDRO. In addition, the appropriate use of antibiotics, especially in the case of FUO, and the contraction of hospitalization length, when feasible, are measures to tackle the further spread of MDRO.
  • Immunophenotypic characterization of acute leukemias in Bahia, Brazil. [Journal Article]
    Einstein (Sao Paulo). 2023; 21:eAO0117.Santos MMD, Santos ASD, … Torres AJL
  • CONCLUSIONS: Significant differences were found as to several antigens when comparing adults and children, and these findings may contribute to future studies correlating the phenotypic profile to genetic characteristics and therapeutic response, including specific antigen therapies, which may be better targeted.
  • Electrochemical Biosensors in the Diagnosis of Acute and Chronic Leukemias. [Review]
    Cancers (Basel). 2022 Dec 26; 15(1)Allegra A, Petrarca C, … Gangemi S
  • Until now, morphological assessment with an optical or electronic microscope, fluorescence in situ hybridization, DNA sequencing, flow cytometry, polymerase chain reactions, and immunohistochemistry have been employed for leukemia identification. Nevertheless, despite their numerous different vantages, it is difficult to recognize leukemic cells correctly. Recently, the electrochemical evaluation…
  • Acute myeloid leukemia: challenges for diagnosis and treatment in Latin America. [Review]
    Hematology. 2023 Dec; 28(1):2158015.Gómez-De León A, Demichelis-Gómez R, … Rego EM
  • CONCLUSIONS: Disparities in access to technologies, supportive care capacity, and availability of novel agents and HSCT hinder results in our region, reflecting barriers common to other LMICs. Recent developments in the diagnosis and treatment of this disease must be implemented through education, collaborative clinical research, and advocacy to improve outcomes.
  • In silico mechanisms of arsenic trioxide-induced cardiotoxicity. [Journal Article]
    Front Physiol. 2022; 13:1004605.Li Y, Wan R, … Zhang H
  • It has been found that arsenic trioxide (ATO) is effective in treating acute promyelocytic leukemia (APL). However, long QT syndrome was reported in patients receiving therapy using ATO, which even led to sudden cardiac death. The underlying mechanisms of ATO-induced cardiotoxicity have been investigated in some biological experiments, showing that ATO affects human ether-à-go-go-related gene (hE…
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