- ATRA+ATO combination in APL - A commentary on "evolving of treatment paradigms and challenges in acute promyelocytic leukaemia: A real-world analysis of 1105 patients over the last three decades" by Teng-Fei et al. [Journal Article]Transl Oncol. 2023 Mar; 29:101620.TO
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- Refractory acute promyelocytic leukemia with PLZF/RARa rearrangement: a case report and literature review. [Journal Article]Anticancer Drugs. 2022 Dec 02 [Online ahead of print]AD
- Acute promyelocytic leukemia patients with PLZF-RARa rearrangement have no obvious differentiation-inducing effect on retinoic acid, have a poor response to traditional chemotherapy, and have poor overall prognosis. A case of acute promyelocytic leukemia with PLZF/RARa rearrangement reported in this article was treated with induction chemotherapy with arsenic trioxide combined with a new anthracy…
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- Poison With a Purpose: A Case Report on Arsenic Cardiotoxicity and Obesity. [Case Reports]
- Acute promyelocytic leukemia (APL) is a form of leukemia in which there is an arrest of the maturation of the myeloid lineage at the promyelocyte stage. Although there is high early mortality due to coagulopathy, APL is now a curable disease with the use of arsenic trioxide (ATO) and all-trans-retinoic acid (ATRA). Arsenic is weight-based for the treatment of APL, and many toxicities are dose-dep…
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- Biased Clonal Evolution in Acute Promyelocytic Leukemia through Imbalances Affecting the der(17) but Not the der(15) Chromosome: Report of Two Cases. [Case Reports]Cytogenet Genome Res. 2023 Feb 01 [Online ahead of print]CG
- Acute promyelocytic leukemia (APL) is characterized by the chromosomal translocation t(15;17)(q24;q21), raising two hybrid genes: PML::RARA and RARA::PML. There is a biased clonal evolution in APL since imbalances affecting the der(15) chromosome (the one that carries the transforming PML::RARA gene) have never been reported; instead, imbalances of the der(17), mainly in form of an ider(17)(q10),…
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- Differentiation syndrome in patients with acute promyelocytic leukemia. [Case Reports]
- A 48-year-old male diagnosed with acute promyelocytic leukemia (APL) started on all-trans-retinoic acid and arsenic trioxide, developed typical symptoms of differentiation syndrome, and improved dramatically on steroids. Hence, any APL patient started on chemotherapy, needs to be monitored closely for developing differentiation syndrome and to start steroid upon suspicion.
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- Circular RNA PVT1 regulates cell proliferation, migration and apoptosis by stabilizing c-Myc and its downstream target CXCR4 expression in acute myeloid leukemia. [Journal Article]Turk J Haematol. 2023 Jan 31 [Online ahead of print]TJ
- CONCLUSIONS: Our results showed that circPVT1 was highly expressed in AML patients and was related to shorter OS and RFS. CircPVT1 may exert an oncogenic role in THP-1 cells by stabilizing c-Myc protein expression and its downstream target CXCR4 expression. These data indicated that circPVT1 may be a promising therapeutic target for AML.
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- Understanding Quality of Life in Patients With Acute Leukemia, a Global Survey. [Journal Article]
- CONCLUSIONS: Findings indicated key factors, particularly age, gender, and socioeconomic state, that clinicians responsible for the care of patients with acute leukemia should be aware of when designing support strategies. The importance of social functioning in relation to patient QoL also should be included in considerations.
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- Case report: Identification of acute promyelocytic leukemia during osimertinib resistance followed by granulocyte colony-stimulating factor and pembrolizumab. [Case Reports]
- CONCLUSIONS: In general, patients undergoing EGFR-TKI combined with local radiotherapy should be concerned about their hematological assessment. If patients exhibit unrecoverable abnormalities in routine blood tests, a secondary nonsolid malignancy other than myelosuppression should be considered, and further lung cancer treatment should be discontinued.
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- Case report: Identification of a novel HNRNPC::RARG fusion in acute promyelocytic leukemia lacking RARA rearrangement. [Case Reports]
- Acute promyelocytic leukemia (APL) is a special subtype of acute myeloid leukemia (AML), 95% patients have PML-RARA fusion gene as a result of a reciprocal chromosomal translocation t(15;17)(q22; q21). The retinoic acid receptors (RARs) belong to nuclear hormone receptors which modulate the transcription of DNA elements. RARs have three isoforms: retinoic acid receptor alpha (RARA), retinoic acid…
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- [Childhood acute promyelocytic leukemia (APL) with TBL1XR1-RARB fusion: a case report]. [Case Reports]Zhonghua Xue Ye Xue Za Zhi. 2022 Aug 14; 43(8):699.ZX
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- The involvement and therapeutic potential of lncRNA Kcnq1ot1/miR-34a-5p/Sirt1 pathway in arsenic trioxide-induced cardiotoxicity. [Journal Article]
- CONCLUSIONS: The lncRNA Kcnq1ot1/miR-34a-5p/Sirt1 pathway is involved in ATO-induced cardiotoxicity. Propranolol can attenuate ATO-induced cardiotoxicity at least partially through the lncRNA Kcnq1ot1/miR-34a-5p/Sirt1 pathway. Combined administration with propranolol may be a new strategy for alleviating the cardiotoxicity of ATO.
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- Pyrrolidine Dithiocarbamate Enhances the Cytotoxic Effect of Arsenic Trioxide on Acute Promyelocytic Leukemia Cells. [Journal Article]Comb Chem High Throughput Screen. 2023 Jan 23 [Online ahead of print]CC
- CONCLUSIONS: In conclusion, PDTC enhances the cytotoxic effect of ATO on APL, and the mechanism is, at least in part, related to the promotion of ATO-induced degradation of PML-RARα fusion protein via forming a complex PDTC-ATO.
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- Novel indole retinoid derivative induces apoptosis and cell cycle arrest and modulates AKT and ERK signaling in HL-60 cells. [Journal Article]Fundam Clin Pharmacol. 2023 Jan 23 [Online ahead of print]FC
- Chemotherapy with targeted drugs is the first line therapy option for acute and chronic myeloid leukemia. However, hematopoietic stem cell transplantation may be used in high-risk patients or patients with failed responses to chemo drugs. Discovery and development of more effective new agents with lower side effects is the main aim of leukemia treatment. In this study, a novel retinoid compound w…
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- Oral ulcers and cutaneous rash as manifestations of differentiation syndrome in acute promyelocytic leukaemia. [Journal Article]Indian J Dermatol Venereol Leprol. 2022 Dec 07 [Online ahead of print]IJ
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- Acute Promyelocytic Leukemia with Rare Genetic Aberrations: A Report of Three Cases. [Case Reports]
- Acute promyelocytic leukemia (APL) is a unique subtype of acute myeloid leukemia (AML) that is characterized by the PML::RARA fusion or, more rarely, a variant RARA translocation. While APL can be clinically suspected, diagnosis of APL requires genetic confirmation. Targeted therapy such as all-trans-retinoic acid (ATRA) and arsenic trioxide (ATO) has dramatically improved the prognosis of APL pa…
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- Fever of Unknown Origin and Multidrug Resistant Organism Colonization in AML Patients. [Journal Article]
- CONCLUSIONS: In our experience, MDRO colonization is a frequent and difficult-to-eradicate condition that can arise at all stages of treatment. Prompt discharge of patients as soon as clinical conditions allow could limit the spread of MDRO. In addition, the appropriate use of antibiotics, especially in the case of FUO, and the contraction of hospitalization length, when feasible, are measures to tackle the further spread of MDRO.
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- Strange Bedfellows: NPM1 Mutations in Acute Promyelocytic Leukemia. [Letter]
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- Immunophenotypic characterization of acute leukemias in Bahia, Brazil. [Journal Article]
- CONCLUSIONS: Significant differences were found as to several antigens when comparing adults and children, and these findings may contribute to future studies correlating the phenotypic profile to genetic characteristics and therapeutic response, including specific antigen therapies, which may be better targeted.
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- Comorbidity burden and outcomes of older adults with acute promyelocytic leukemia: a National Cancer Database analysis of 2221 patients. [Journal Article]Leuk Lymphoma. 2023 Jan 11 [Online ahead of print]LL
- Association between comorbidity burden and patient outcomes has not been adequately investigated in acute promyelocytic leukemia (APL). We utilized the National Cancer Database to evaluate the association of the Charlson-Deyo Comorbidity Index (CCI) with one-month mortality and overall survival (OS) in adults ≥60 years with APL. One-month mortality was 16%, 24%, and 32%, and 3-year OS was 61%, 53…
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- Combined Application of Salinomycin and ATRA Induces Apoptosis and Differentiation of Acute Myeloid Leukemia Cells by Inhibiting WNT/β-catenin Pathway. [Journal Article]Anticancer Agents Med Chem. 2023 Jan 10 [Online ahead of print]AA
- CONCLUSIONS: S+RA induced differentiation by β-catenin-inhibition-mediated up-regulation of C/EBPs and PU.1 and suppression of c-Myc. S+RA triggered apoptosis through β-catenin-inhibition-regulated Δ ψ m collapse and caspase-3/7 activation. Taken together, our findings may provide novel therapeutic strategies for AML patients by targeting the WNT/β-catenin pathway.
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- Electrochemical Biosensors in the Diagnosis of Acute and Chronic Leukemias. [Review]
- Until now, morphological assessment with an optical or electronic microscope, fluorescence in situ hybridization, DNA sequencing, flow cytometry, polymerase chain reactions, and immunohistochemistry have been employed for leukemia identification. Nevertheless, despite their numerous different vantages, it is difficult to recognize leukemic cells correctly. Recently, the electrochemical evaluation…
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- Nicotinamide Mononucleotide Administration Prevents Doxorubicin-Induced Cardiotoxicity and Loss in Physical Activity in Mice. [Journal Article]
- Doxorubicin (Doxo) is a widely used antineoplastic drug with limited clinical application due to its deleterious dose-related side effects. We investigated whether nicotinamide mononucleotide (NMN) could protect against Doxo-induced cardiotoxicity and physical dysfunction in vivo. To assess the short- and long-term toxicity, two Doxo regimens were tested, acute and chronic. In the acute study, C5…
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- Effects of peripheral blood leukocyte count and tumor necrosis factor-alpha on early death in acute promyelocytic leukemia. [Journal Article]
- CONCLUSIONS: During induction treatment, cytotoxic chemotherapy may need to be initiated to reduce the risk of DS for APL patients with a low-intermediate risk WBC count ≥10 × 10^9/L on Day 5 or for all patients with a peak WBC count ≥16 × 10^9/L. Patients with WBC > 7 × 10^9/L on Day 3 have a higher risk of ED. Leukocyte proliferation is associated with TNF-α rather than IL-6, and TNF-α may be a potential biomarker for predicting ED.
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- Acute myeloid leukemia: challenges for diagnosis and treatment in Latin America. [Review]Hematology. 2023 Dec; 28(1):2158015.H
- CONCLUSIONS: Disparities in access to technologies, supportive care capacity, and availability of novel agents and HSCT hinder results in our region, reflecting barriers common to other LMICs. Recent developments in the diagnosis and treatment of this disease must be implemented through education, collaborative clinical research, and advocacy to improve outcomes.
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- Torque teno mini virus driven childhood acute promyelocytic leukemia: The third case report and sequence analysis. [Case Reports]
- In this manuscript, we report torque teno mini virus (TTMV) as a cause of acute promyelocytic leukemia (APL) lacking PML::RARA in a 3-year-old boy. Astolfi et al. firstly identified partial integration of the TTMV genome into RARA intron 2, which resulted in in-frame TTMV::RARA fusion in two APL-like pediatric cases without PML::RARA in November 2021. This fascinating report identified an unexpec…
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- In silico mechanisms of arsenic trioxide-induced cardiotoxicity. [Journal Article]
- It has been found that arsenic trioxide (ATO) is effective in treating acute promyelocytic leukemia (APL). However, long QT syndrome was reported in patients receiving therapy using ATO, which even led to sudden cardiac death. The underlying mechanisms of ATO-induced cardiotoxicity have been investigated in some biological experiments, showing that ATO affects human ether-à-go-go-related gene (hE…
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- A Novel Inclusion Body in Acute Promyelocytic Leukemia. [Journal Article]Turk J Haematol. 2022 Dec 30 [Online ahead of print]TJ
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