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(Acute renal failure)
74,040 results
  • Improving Translation from Preclinical Studies to Clinical Trials in Acute Kidney Injury. [Journal Article]
  • NNephron 2018 May 23; :1-5
  • Fiorentino M, Kellum JA
  • CONCLUSIONS: Preclinical models of AKI should closely mimic the complexity of human AKI, considering the importance of several comorbidities in determining the clinical course and outcomes in the human disease. Moreover, studies should test novel interventions in models where AKI is already established, instead of focusing only at primary prevention. AKI definitions and endpoints in animal studies should be similar to those applied in clinical studies; in particular, AKI biomarkers should be implemented to guide patient selection for clinical trials and monitor intervention efficacy. In this scenario, cell-cycle arrest biomarkers have been widely investigated as AKI predictors in both preclinical and clinical studies and they serve as useful tools for future interventional studies. A better understanding of human AKI through a large collection of biological samples and kidney biopsies and omics applications, and an iterative relationship between preclinical and clinical studies are critical steps to improve future preclinical models and clinical trials. Finally, given the great variability in clinical manifestation of AKI, a strong collaboration between research centers and industry is recommended. Key messages: Several methodological issues have hampered the translation of basic research findings in clinical studies, and overcoming these obstacles is necessary to achieve success.
  • A dual role of miR-22 in rhabdomyolysis-induced acute kidney injury (AKI). [Journal Article]
  • APActa Physiol (Oxf) 2018 May 23; :e13102
  • Mathia S, Rudigier LJ, … Fähling M
  • CONCLUSIONS: miR-22 is a HIF repressor constitutively expressed in the adult kidney, and up-regulated in AKI. Specific inhibition of miR-22 is efficient in vivo, and profoundly affects renal gene expression in health and disease, including up-regulation of HIF. However, the net effect on rhabdomyolysis-induced AKI outcome is neutral or even negative. This article is protected by copyright. All rights reserved.
  • Prevention of dehydration in hospital patients. [Journal Article]
  • BJBr J Nurs 2018 May 24; 27(10):565-569
  • Shells R, Morrell-Scott N
  • Dehydration is widely linked to increased risk of mortality in patients who are acutely unwell, and it also increases the risk of further illness. Despite being recognised nationwide as a cause for c...
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