- The role of the farnesoid X receptor in kidney health and disease: a potential therapeutic target in kidney diseases. [Review]Exp Mol Med. 2023 Feb 03 [Online ahead of print]EM
- The prevalence of kidney diseases has been increasing worldwide due to the aging population and has results in an increased socioeconomic burden as well as increased morbidity and mortality. A deep understanding of the mechanisms underlying the physiological regulation of the kidney and the pathogenesis of related diseases can help identify potential therapeutic targets. The farnesoid X receptor …
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- The kidney-brain pathogenic axis in severe falciparum malaria. [Review]Trends Parasitol. 2023 Feb 01 [Online ahead of print]TP
- Severe falciparum malaria is a medical emergency and a leading cause of death and neurodisability in endemic areas. Common complications include acute kidney injury (AKI) and cerebral malaria, and recent studies have suggested links between kidney and brain dysfunction in Plasmodium falciparum infection. Here, we review these new findings and present the hypothesis of a pivotal pathogenic crossta…
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- Association Between Proton Pump Inhibitor Exposure and Acute Kidney Injury After Cardiac Surgery. [Journal Article]Mayo Clin Proc. 2023 Feb; 98(2):266-277.MC
- CONCLUSIONS: Preoperative PPI exposure may be a modifiable risk factor for AKI among patients undergoing cardiac surgery.
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- The in-silico evaluation of important GLUT9 residue for uric acid transport based on renal hypouricemia type 2. [Journal Article]Chem Biol Interact. 2023 Feb 01 [Online ahead of print]CB
- Uric acid is the end product of purine metabolism. Uric acid transporters in the renal proximal tubule plays a key role in uric acid transport. Functional abnormalities in these transporters could lead to high or low levels of uric acid in the blood plasma, known as hyperuricemia and hypouricemia, respectively. GLUT9 has been reported as a key transporter for uric acid reuptake in renal proximal …
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- Shorter door-to-balloon time, better long-term clinical outcomes in ST-segment elevation myocardial infarction patients: J-MINUET Substudy. [Journal Article]J Cardiol. 2023 Jan 31 [Online ahead of print]JC
- CONCLUSIONS: Shorter DTB time was associated with better long-term clinical outcomes in STEMI patients treated with PPCI in contemporary clinical practice. Further efforts to shorten DTB time are recommended to improve long-term clinical outcomes in STEMI patients.
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- Lineage Tracing and Single-Nucleus Multiomics Reveal Novel Features of Adaptive and Maladaptive Repair after Acute Kidney Injury. [Journal Article]J Am Soc Nephrol. 2023 Jan 13 [Online ahead of print]JA
- CONCLUSIONS: Analysis of genome organization and gene activity with single-cell resolution using lineage tracing and single-nucleus multiomics offers new insight into the regulation of renal injury repair. Weeks to months after mild-to-moderate IRI, maladaptive PTCs persist with an aberrant epigenetic landscape, and PTCs exhibit an altered transcriptional profile even following adaptive repair.
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- Identification of AGXT2, SHMT1, and ACO2 as important biomarkers of acute kidney injury by WGCNA. [Journal Article]PLoS One. 2023; 18(2):e0281439.Plos
- Acute kidney injury (AKI) is a serious and frequently observed disease associated with high morbidity and mortality. Weighted gene co-expression network analysis (WGCNA) is a research method that converts the relationship between tens of thousands of genes and phenotypes into the association between several gene sets and phenotypes. We screened potential target genes related to AKI through WGCNA …
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- Transplant Renal Vein Thrombosis Rescued in a Pediatric Patient Using Suction Thrombectomy. [Journal Article]Tex Heart Inst J. 2023 Jan 01; 50(1)TH
- Renal vein thrombosis after kidney transplant is a rare but potentially graft-threatening event. As sequelae of this complication can range from brief acute kidney injury to total graft failure, it is necessary to maintain close clinical observation postoperatively. If posttransplant renal vein thrombosis does occur, recanalization may be attempted with mechanical thrombectomy, suction thrombecto…
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- Renal control of life-threatening malarial anemia. [Journal Article]Cell Rep. 2023 Feb 02; 42(2):112057.CR
- Iron recycling prevents the development of anemia under homeostatic conditions. Whether iron recycling was co-opted as a defense strategy to prevent the development of anemia in response to infection is unclear. We find that in severe Plasmodium falciparum malaria, the onset of life-threatening anemia is associated with acute kidney injury (AKI), irrespective of parasite load. Using a well-establ…
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- Door-to-furosemide time and clinical outcomes in acute heart failure. [Journal Article]Eur J Emerg Med. 2023 Feb 01 [Online ahead of print]EJ
- Acute heart failure (AHF) is one of the main causes of unplanned hospitalization in patients >65 years of age and is associated with adverse outcomes in this population. Observational studies suggest that intravenous diuretic therapy given in the first hour of presentation for AHF was associated with favorable outcomes. To study the short-term prognostic associations of the timing of intravenous …
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- Targeting a Single Codon to Rescue Septic Acute Kidney Injury. [Journal Article]J Am Soc Nephrol. 2023 Feb 01; 34(2):179-181.JA
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- Nivolumab-induced autoimmune diabetes mellitus presenting as diabetic ketoacidosis in a patient with metastatic mucosal melanoma. [Journal Article]J Oncol Pharm Pract. 2023 Feb 03 [Online ahead of print]JO
- CONCLUSIONS: Development of type 1 diabetes with the use of immune checkpoint inhibitors has been increasingly reported in the literature. The exact mechanism for autoimmune diabetes precipitated by nivolumab is yet to be elucidated. Patient education about the symptoms of diabetes and regular glucose monitoring cannot be overemphasized. Testing for antibodies against glutamic acid decarboxylase 65, insulin receptors, and islet cells may also prove useful. Human leukocyte antigen DQ and DR haplotyping prior to immune checkpoint inhibitor treatment might help determine susceptibility toward developing type 1 diabetes, and provide opportunities for earlier recognition, intervention, and possibly prevention.
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- Greater Impact of Living Donation Than HLA Mismatching in Short-Term Renal Allograft Survival. [Journal Article]Cureus. 2023 Jan; 15(1):e34427.C
- CONCLUSIONS: In our cohort, the level of HLA MM increased the risk of AR independently of donor type. Considering short graft survival, our results support the advantage of living donor vs deceased donor even with an increased HLA MM. However, its effect on long-term graft survival remains to be settled, emphasizing the need for further studies on this matter.
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- Heat Stroke Leading to a Fatal Outcome. [Case Reports]Cureus. 2023 Jan; 15(1):e33226.C
- Heat stroke (HS) can cause several physiological changes in the body. In its most severe form, it can cause multi-organ failure including encephalopathy, circulatory shock, liver failure, renal failure, disseminated intravascular coagulation, and rhabdomyolysis among others. HS is a preventable condition; however, it can be life-threatening in severe forms. We present a case of HS in a 54-year-ol…
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- [A Case Report of Subcutaneous Nodular Fat Necrosis Caused by Obstructive Pancreatitis Due to IPMN]. [Journal Article]Gan To Kagaku Ryoho. 2022 Dec; 49(13):1765-1767.GT
- A 72-year-old man underwent hemodialysis because of end-stage renal failure. The patient often suffered acute pancreatitis and was diagnosed with main duct type intraductal papillary mucinous neoplasm(IPMN). Moreover, skin erythema with pain occurred and was treated as cellulitis using antibiotics; however, the skin lesions did not improve. Skin pathological findings indicated subcutaneous nodula…
- Contemporary in-hospital and long-term prognosis of patients with acute ST-elevation myocardial infarction depending on renal function: a retrospective analysis. [Journal Article]BMC Cardiovasc Disord. 2023 Feb 02; 23(1):62.BC
- CONCLUSIONS: CKD is a frequent co-morbidity in patients with STEMI and is associated with a worse prognosis especially in advanced stages. Guideline-recommended therapies in patients with STEMI and CKD are still underused.
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- Atorvastatin reduces contrast media-induced pyroptosis of renal tubular epithelial cells by inhibiting the TLR4/MyD88/NF-κB signaling pathway. [Journal Article]BMC Nephrol. 2023 Feb 02; 24(1):25.BN
- CONCLUSIONS: Atorvastatin can attenuate CI-AKI through increasing the activity of MEG-treated renal tubular epithelial cells, relieving cell injury, as well as inhibiting pyroptosis and inflammation. More importantly, the mechanism was achieved by inhibiting the TLR4//MyD88/NF-κB signaling pathway.
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- Acute kidney injury and delayed methotrexate clearance in an adult patient with Philadelphia chromosome-positive acute lymphoblastic leukaemia treated with imatinib. [Journal Article]Eur J Hosp Pharm. 2023 Feb 02 [Online ahead of print]EJ
- A female patient in her early 30s was treated with imatinib and high-dose methotrexate (HD-MTX) for Philadelphia chromosome-positive acute lymphoblastic leukaemia. The patient developed delayed MTX clearance and grade 3 acute kidney injury characterised by elevated creatinine (114% increase from baseline). After intensified calcium folinate rescue therapy and hydration, the MTX serum level was ap…
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- Association of Body Mass Index and Acute Kidney Injury Incidence and Outcome: A Systematic Review and Meta-Analysis. [Review]J Ren Nutr. 2023 Jan 30 [Online ahead of print]JR
- This study aims to provide pooled estimates for the incidence of AKI in overweight, obese and normal BMI patients and to assess impact of BMI on mortality and CKD rates. We conducted literature search using online databases to analyse outcomes of BMI. This meta-analysis included 22 studies. Compared to normal BMI, underweight, overweight or obese patients had higher risk of having AKI. Underweigh…
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- Smokeless Tobacco Use is Associated with Worse Outcomes Following Total Knee Arthroplasty. [Journal Article]J Arthroplasty. 2023 Jan 30 [Online ahead of print]JA
- CONCLUSIONS: Smokeless tobacco use is associated with higher rates of both medical and joint complications following primary TKA. However, smoking is associated with higher risk for complications than smokeless tobacco use.
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- Incidence, predictors, clinical outcomes, and economic burden of recurrent acute kidney injury: a retrospective cohort study. [Journal Article]Curr Med Res Opin. 2023 Feb 02 [Online ahead of print]CM
- CONCLUSIONS: Recurrent AKI is associated with an increased mortality and health expenditures. Higher discharge SCr levels at index admission, and chronic comorbidities are associated with higher likelihood of AKI recurrence.
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- Fatal multisystem inflammatory syndrome in a 78-year-old adult after severe COVID-19 pneumonia during 2022 Omicron variant epidemic in Shanghai, China. [Journal Article]J Infect Public Health. 2023 Jan 11; 16(3):418-421.JI
- Multisystem inflammatory syndrome adult type (MIS-A) is a rare type of post-acute COVID-19 syndrome which more frequently occurred in younger population. Here we present a 78-year-old Chinese female, the oldest case reported, diagnosed with MIS-A who had severe SARS-CoV-2 infection. She was diagnosed with severe COVID-19 and experienced an unexpected sudden hemodynamic collapse in the recovery pe…
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- Cytoplasmic HMGB1 induces renal tubular ferroptosis after ischemia/reperfusion. [Journal Article]Int Immunopharmacol. 2023 Jan 31; 116:109757.II
- As a damage-associated molecular pattern molecule, high-mobility group box 1 (HMGB1) is well-studied and is released from injured tubular epithelial cells to trigger cell death. However, the role of intracellular HMGB1 induced cell death during acute kidney injury (AKI) is poorly understood. We showed that cytosolic HMGB1 induced ferroptosis by binding to acyl-CoA synthetase long-chain family mem…
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- Society for Cardiovascular Angiography and Interventions Shock Classification to Stratify Outcomes of Extracorporeal Membrane Oxygenation. [Journal Article]ASAIO J. 2022 Oct 13 [Online ahead of print]AJ
- We applied the Society for Cardiovascular Angiography and Interventions (SCAI) schema to cardiogenic shock (CS) patients treated with venoarterial extracorporeal membrane oxygenation (VA-ECMO) to assess performance in this high acuity group of patients. Records of adult patients receiving VA-ECMO for CS at our institution from 01/2015 to 12/2019 were reviewed. Post-cardiotomy and noncardiogenic s…
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- Is Low-Titer Group O Whole Blood Truly a Universal Blood Product? [Journal Article]J Am Coll Surg. 2022 Nov 28 [Online ahead of print]JA
- CONCLUSIONS: LTOWB appears to be a safe product for universal use across all blood groups. Group B recipients arrive with worse physiologic values associated with hemorrhagic shock whether receiving LTOWB or standard component products.
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- Effect of Glutamine Administration After Cardiac Surgery on Kidney Damage in Patients at High Risk for Acute Kidney Injury: A Randomized Controlled Trial. [Journal Article]Anesth Analg. 2022 Nov 29 [Online ahead of print]A&A
- CONCLUSIONS: Glutamine significantly decreased markers of kidney damage in cardiac surgery patients at high risk for AKI. Future trials have to be performed to investigate whether the administration of glutamine might be able to reduce the occurrence of AKI after cardiac surgery.
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- Activated 4-Factor Prothrombin Complex Concentrate as a Hemostatic Adjunct for Neonatal Cardiac Surgery: A Propensity Score-Matched Cohort Study. [Journal Article]Anesth Analg. 2022 Dec 02 [Online ahead of print]A&A
- CONCLUSIONS: We found that the use of a4FPCC as a hemostatic adjunct for post-CPB bleeding in neonatal cardiac surgery was associated with a decrease in mean total blood products transfused after CPB without an increased rate of 7- or 30-day postoperative thromboembolism. Our findings suggest that a4FPCCs can be considered as part of a hemostasis pathway for refractory bleeding in neonatal cardiac surgery.
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- Trends of Hepatocellular Carcinoma (HCC) Inpatients Mortality and Financial Burden From 2011 to 2017: A Nationwide Analysis. [Journal Article]J Clin Gastroenterol. 2022 Dec 12 [Online ahead of print]JC
- CONCLUSIONS: HCC-related admissions continue to be on the rise. HCC mortality has decreased across the years with earlier diagnoses and advances in therapy. However, we observed a significant increase in financial burden on health care with increasing in-hospital costs, a finding that needs to be verified in prospective trials.
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- Renal scintigraphy to predict persistent renal failure after acute kidney injury: an observational study. [Journal Article]J Nephrol. 2023 Feb 02 [Online ahead of print]JN
- CONCLUSIONS: Conventional renal scintigraphy can identify patients at high risk of PRF with a high specificity but a low sensitivity. New parameters, with comparable diagnostic abilities can be obtained within three minutes of injection.
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- The incidence and risk factors for acute kidney injury in patients treated with immune checkpoint inhibitors. [Journal Article]Anticancer Drugs. 2022 Dec 19 [Online ahead of print]AD
- CONCLUSIONS: In this study, we observed AKI development under ICIs in almost one in five patients with cancer. The increased AKI rates in CKD, hypoalbuminemia or RAAS inhibitor use pointed out a need for better onco-nephrology collaboration and efforts to improve the nutritional status of ICI-treated patients.
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