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24,036 results
  • Pharmaceutical administration for severe hypertension during pregnancy: Network meta-analysis. [Systematic Review]
    Front Pharmacol. 2022; 13:1092501.Deng NJ, Xian-Yu CY, … Zhang C
  • Aims: To evaluate the efficacy of different pharmacologic treatment for severe hypertension during pregnancy. Methods: Two reviewers searched Ovid MEDLINE, Ovid EMbase, and the Cochrane Library for randomized clinical trials from the establishment of the database to 15 July 2021 that were eligible for inclusion and analyzed the pharmaceuticals used for severe hypertension in pregnancy. Results: 2…
  • Phenomenological analysis of simple ion channel block in large populations of uncoupled cardiomyocytes. [Journal Article]
    Math Med Biol. 2023 Jan 23 [Online ahead of print]Simitev RD, Al Dawoud A, … Smith GL
  • Current understanding of arrhythmia mechanisms and design of anti-arrhythmic drug therapies hinges on the assumption that myocytes from the same region of a single heart have similar, if not identical, action potential waveforms and drug responses. On the contrary, recent experiments reveal significant heterogeneity in uncoupled healthy myocytes both from different hearts as well as from identica…
  • Ambroxol-enhanced ciliary beating via voltage-gated Ca2+ channels in mouse airway ciliated cells. [Journal Article]
    Eur J Pharmacol. 2023 Feb 15; 941:175496.Saito D, Suzuki C, … Nakahari T
  • Ambroxol (ABX) facilitates the mucociliary clearance (MC) by enhancing ciliary beating in airways. In this study, we focused on airway ciliary beating enhanced by ABX. However, little is known about the ABX-stimulated Ca2+ signalling activating airway ciliary beating. Airway ciliated cells isolated from mice lungs were observed by a high-speed video microscope, and the activities of beating cilia…
  • Deletion of Notch3 Impairs Contractility of Renal Resistance Vessels Due to Deficient Ca2+ Entry. [Journal Article]
    Int J Mol Sci. 2022 Dec 16; 23(24)Helle F, Hultström M, … Chatziantoniou C
  • Notch3 plays an important role in the differentiation and development of vascular smooth muscle cells. Mice lacking Notch3 show deficient renal autoregulation. The aim of the study was to investigate the mechanisms involved in the Notch3-mediated control of renal vascular response. To this end, renal resistance vessels (afferent arterioles) were isolated from Notch3-/- and wild-type littermates (…
  • Postpartum medical management of hypertension and risk of readmission for hypertensive complications. [Journal Article]
    J Hypertens. 2023 Feb 01; 41(2):351-355.Lovgren T, Connealy B, … D Dahlke J
  • CONCLUSIONS: The risk of postpartum readmission for hypertensive complication was reduced by 65% when patients were discharged on nifedipine monotherapy and 56% with combined nifedipine and labetalol treatment when compared with no treatment. Patients discharged on labetalol monotherapy were nearly six times as likely to be readmitted for hypertensive complications when compared with patients on nifedipine monotherapy.
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