- Drugs and Lactation Database (LactMed): Amphetamine [BOOK]Drugs and Lactation Database (LactMed). National Library of Medicine (US): Bethesda (MD)BOOK
- In dosages prescribed for medical indications, some evidence indicates that amphetamine does not affect nursing infants adversely. The effect of amphetamine in milk on the neurological development of the infant has not been well studied. Large dosages of amphetamine might interfere with milk production, especially in women whose lactation is not well established. Breastfeeding is generally discou…
- Posterior Reversible Encephalopathy Syndrome With Visual Disturbances in an Adolescent After Overdose With Adderall XR: A Case Report. [Journal Article]J Neuroophthalmol. 2022 Oct 03 [Online ahead of print]JN
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- Case Report: Successful Intravenous Lipid Emulsion Therapy for Canine Amphetamine Toxicosis. [Case Reports]
- A 4-year-old, female-spayed, mixed breed dog, weighing 24.2 kg, was presented for acute ingestion of ~12.3 mg/kg of Adderall XRⓇ, an extended-release amphetamine medication. In dogs, the oral median lethal dose for amphetamines ranges anywhere from 9-11 mg/kg to 20-27 mg/kg. On presentation, the patient was agitated, tachycardic and hypertensive. Initial treatment was instituted with intravenous …
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- Using drug knowledgebase information to distinguish between look-alike-sound-alike drugs. [Journal Article]
- CONCLUSIONS: Drug indications data from a drug knowledgebase can discriminate between many LASA drugs.
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- A Single-Dose, Two-Way Crossover, Open-Label Bioequivalence Study of an Amphetamine Extended-Release Oral Suspension in Healthy Adults. [Randomized Controlled Trial]J Atten Disord. 2020 02; 24(3):414-419.JA
- Objective: The purpose of this study was to compare the pharmacokinetics of a new extended-release amphetamine oral suspension (AMP XR-OS) with a standard extended-release mixed amphetamine salts product, Adderall XR®. Method: In this single-dose, open-label, randomized, two-period, two-treatment crossover study, 42 healthy adult volunteers received 15 mL of AMP XR-OS in one period and a 30 mg Ad…
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- Improving viable low cost generic medication prescription rate in primary care pediatric practice. [Journal Article]
- The pediatric clinics of the Michigan State University College of Human Medicine (MSU-CHM) consist of academic pediatricians serving two clinics with a patient population of 5200. The internal quality measures published by the MSU health team had consistently indicated our generic medications prescription rate to be very low, with an average of about 21% for the years 2009, 2010, and 2011. There …
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- Stimulant use following the publicity of cardiovascular safety and the introduction of patient medication guides. [Journal Article]
- CONCLUSIONS: The first signal of stimulant CV safety concerns was followed by varying responses depending on the outcome measure used, suggesting that patients and physicians responded at different times after the publicity of safety concerns. Clinical consequences of the changes are uncertain. Copyright © 2015 John Wiley & Sons, Ltd.
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- Nonmedical use of prescription ADHD stimulant medications among adults in a substance abuse treatment population: early findings from the NAVIPPRO surveillance system. [Journal Article]
- CONCLUSIONS: Prescription stimulant NMU was low compared with other prescription medications among individuals assessed for substance abuse problems, with little difference among specific products.
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- Attention-deficit/hyperactivity disorder stimulant medication reaction masquerading as chronic cough. [Case Reports]Ann Allergy Asthma Immunol. 2013 Aug; 111(2):82-3.AA
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- Atypical coupling between posterior regions of the default mode network in attention-deficit/hyperactivity disorder: a pharmaco-magnetoencephalography study. [Journal Article]
- CONCLUSIONS: Adults with ADHD exhibit hyper- and hypoconnectivity between regions of the DMN during rest, which were suppressed after stimulant medication administration.
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- Nonmedical Use and Diversion of ADHD Stimulants Among U.S. Adults Ages 18-49: A National Internet Survey. [Journal Article]
- CONCLUSIONS: NMU of ADHD prescription stimulants were low compared with other prescription medications. While prevalence of NMU was higher for immediate-release than extended-release ADHD medications, absolute rates for prescription stimulants were low.
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- Acute, sustained chorea in children after supratherapeutic dosing of amphetamine-derived medications. [Case Reports]
- Amphetamine-derived medications are being prescribed with increasing frequency to younger pediatric patients to treat attention deficit hyperactivity disorder. Although choreiform movements were reported in adults with amphetamine abuse and in those under therapeutic treatment for attention deficit hyperactivity disorder, previous literature concerning the pediatric population is spare. We descri…
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- Motor skills of children newly diagnosed with Attention Deficit Hyperactivity Disorder prior to and following treatment with stimulant medication. [Journal Article]
- Motor difficulties are common in children with Attention Deficit Hyperactivity Disorder (ADHD). Although preliminary evidence has suggested that methylphenidate can improve the motor skills in children with ADHD and Developmental Coordination Disorder (DCD), the effect of stimulant medication on motor performance in children newly diagnosed with ADHD with or without motor impairment remains uncle…
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- Not acute myocardial infarction in a teenager due to Adderall XR. [Letter]
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- Acute myocardial infarction in a teenager due to Adderall XR. [Case Reports]
- Adderall XR is commonly prescribed for children and adolescents with attention deficit/hyperactivity disorder. We present a case of a 15-year-old male who suffered a myocardial infarction after starting Adderall XR. Patient was otherwise in good health with no previous cardiac abnormalities. Cardiac catheterization was normal, and etiology was presumed to be secondary to acute vasospasm. The pati…
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- Blue toes after stimulant therapy for pediatric attention deficit hyperactivity disorder. [Case Reports]
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- The mixed amphetamine salt extended release (Adderall XR, Max-XR) as an adjunctive to SSRIS or SNRIS in the treatment of adult ADHD patients with comorbid partially responsive generalized anxiety: an open-label study. [Clinical Trial]
- To examine the changes in partially responsive anxiety symptoms utilizing adjunctive treatment with the mixed amphetamine salt extended release (Adderall XR, MAX-XR) in the treatment of adult ADHD patients, with comorbid refractory anxiety. Consenting adult patients (n = 32) with confirmed diagnosis of generalized anxiety (GA) and comorbid (ADHD) participated in this open-label study. All patient…
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- Chronic low dose Adderall XR down-regulates cfos expression in infantile and prepubertal rat striatum and cortex. [Journal Article]
- We previously reported that treatment of prepubertal male rats with low, injected or oral, doses of methylphenidate stimulated cfos, fosB and arc expression in many areas of the developing brain. In the present study our objective was to determine whether the widely prescribed psychostimulant Adderall XR (ADD) exerted similar effects in infantile and prepubertal rat brain. We report here, for the…
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- Re: Myocardial infarction associated with Adderall XR and alcohol use in a young man. [Case Reports]
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- An update on central nervous system stimulant formulations in children and adolescents with attention-deficit/hyperactivity disorder. [Review]
- CONCLUSIONS: Stimulants are effective medications to treat the symptoms of ADHD. The multiple available dosage forms allow for individualization of treatment.
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- Myocardial infarction associated with adderall XR and alcohol use in a young man. [Case Reports]
- Adderall, consisting of a mixture of amphetamine salts and dextroamphetamine salts, is a prescription drug for attention deficit/hyperactivity disorder (ADHD) and narcolepsy. Labeled or unlabeled use of Adderall is gaining popularity among young children and college students. Although it is rare, Adderall use is associated with myocardial infarction and even sudden death. We report a case of a yo…
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- Using long-acting stimulants: does it change ADHD treatment outcome? [Journal Article]
- CONCLUSIONS: Long-acting stimulant formulations have dramatically changed the landscape of ADHD practice.
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- Commentary: Concerns With the Suspension of Adderall XR. [Journal Article]Can Child Adolesc Psychiatr Rev. 2005 May; 14(2):39.CC
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- The impact of the withdrawal of Adderall XR (long-acting mixed amphetamine salts) from the Canadian market on paediatric patients and their families. [Journal Article]
- CONCLUSIONS: Of the 53 (43%) completed questionnaires, 89% of respondents indicated that they were concerned when informed of the withdrawal, while 58% indicated that they were frightened. Despite the concerns, only a modest degree of anger was expressed. Thirty per cent of respondents reported anger directed at Health Canada, 24% reported anger directed at the manufacturer, while no caregiver reported anger directed at their physician. Only three families (5.7%) indicated a decrease in confidence in the physician following the event. Fifty-eight per cent indicated a willingness to resume taking Adderall XR, if it was deemed safe by Health Canada. These results offer insight into patient and family perspectives following an unexpected medication recall. While caregivers were generally concerned and often frightened by this event, the present data do not suggest that the parent-physician relationship was greatly affected.
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- Methylphenidate and amphetamine do not induce cytogenetic damage in lymphocytes of children with ADHD. [Randomized Controlled Trial]
- CONCLUSIONS: Earlier findings of methylphenidate-induced chromosomal changes in children were not replicated in this study. These results add to the accumulating evidence that therapeutic levels of methylphenidate do not induce cytogenetic damage in humans. Furthermore, our results indicate that amphetamine-based products do not pose a risk for cytogenetic damage in children.
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- Special issues in the diagnosis and treatment of ADHD in adolescents. [Review]
- Attention-deficit/hyperactivity disorder (ADHD) is a common disorder among adolescents but can be a challenge to diagnose in this population for several reasons. Obvious symptoms of hyperactivity and impulsivity are displayed less frequently than in younger children. Direct observation by potential raters is more limited because adolescents spend less time with parents and usually have multiple t…
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- Attention-deficit/hyperactivity disorder in adults: evidence-based recommendations for management. [Review]
- Attention-deficit/hyperactivity disorder (ADHD) is associated with impairments in educational, occupational, neuropsychological, and social functioning in adults. Successful diagnosis and treatment of the disorder in adults can be a challenge because recent and integrative clinical guidelines are lacking and diagnostic criteria are based on making a retrospective diagnosis of childhood-onset ADHD…
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- ECGs before stimulants in children. [Journal Article]Med Lett Drugs Ther. 2008 Jul 28; 50(1291):60.ML
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- Abuse of medications employed for the treatment of ADHD: results from a large-scale community survey. [Journal Article]
- CONCLUSIONS: The risks for abuse of prescription and illicit stimulants are elevated among individuals being treated in an ADHD clinic. Prescription agents used most often are those with pharmacologic and pharmacokinetic characteristics that provide a rapid high. This suggests that long-acting stimulant preparations that have been developed for the treatment of ADHD may have lower abuse potential than short-acting formulations.
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- Rebound effects with long-acting amphetamine or methylphenidate stimulant medication preparations among adolescent male drivers with attention-deficit/hyperactivity disorder. [Randomized Controlled Trial]
- This study investigated whether OROS methylphenidate (OROS MPH, Concerta) or extended-release mixed amphetamine salts (se-AMPH ER, Adderall XR) were associated with worsening of driving performance, or drug rebound, relative to placebo 16-17 hours post-ingestion. Nineteen male adolescent drivers aged 17-19 with attention-deficit/hyperactivity disorder (ADHD) were compared on a virtual reality dri…
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