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(Addison's disease)
6,584 results
  • Coronary artery disease in a patient with Addison's disease: a case report and literature review. [Journal Article]
    BMC Cardiovasc Disord. 2023 Jan 29; 23(1):54.Zhao R, Luo S, … Xiong F
  • CONCLUSIONS: The combination of Addison's disease and coronary artery disease in one patient is rare. Addison's disease can induce inflammation and disorders of water and electrolyte metabolism, which may further accelerate the course of coronary artery disease. Meanwhile, the hypotension in Addison's disease may affect the coronary blood flow, which may result in an increased susceptibility to unstable angina in the presence of coronary stenosis. So, we should analyze comprehensively if the coronary artery disease progress rapidly.
  • Cardiotoxicity of Anti-Cancer Radiation Therapy: a Focus on Heart Failure. [Review]
    Curr Heart Fail Rep. 2023 Jan 24 [Online ahead of print]Ritter A, Quartermaine C, … Miller E
  • As the percentage of patients achieving long-term survival following treatment of their cancer grows, it is increasingly important to understand the long-term toxicities of cancer-directed treatment. In this review, we highlight the recent findings regarding radiation-induced cardiotoxicity across multiple disease sites, with a particular focus on heart failure.
  • Replication of association at the LPP and UBASH3A loci in a UK autoimmune Addison's disease cohort. [Journal Article]
    Eur J Endocrinol. 2023 Jan 10; 188(1)Howarth S, Sneddon G, … Pearce SHS
  • Autoimmune Addison's disease (AAD) arises from a complex interplay between multiple genetic susceptibility polymorphisms and environmental factors. The first genome wide association study (GWAS) with patients from Scandinavian Addison's registries has identified association signals at four novel loci in the genes LPP, SH2B3, SIGLEC5, and UBASH3A. To verify these novel risk loci, we performed a ca…
  • Virtual Community Engagement for Retention of Black Men in Clinical Research. [Journal Article]
    Am J Mens Health. 2023 Jan-Feb; 17(1):15579883221147767.Nolan TS, McKoy A, … Joseph JJ
  • Black American men have worse cardiovascular health compared with their White counterparts, yet are highly underrepresented in clinical trials. In 2020, Black men were recruited to participate in Black Impact, a community-based lifestyle intervention to increase cardiovascular health. Due to the research pause during the Coronavirus Disease (COVID-19) pandemic, a virtual community engagement (VCE…
  • Etiology, clinical characteristics and mortality among Indian patients with Addison's disease. [Journal Article]
    Endocr Connect. 2023 Jan 01 [Online ahead of print]Gunna S, Singh M, … Bhatia E
  • The etiology, presentation and mortality of patients with primary adrenal insufficiency (PAI) in developing countries may differ from economically developed nations. However, information in this regard is scanty. The aim of this study was to determine the etiology and compare the clinical characteristics and mortality in infectious and autoimmune causes of PAI in Indian patients. All eligible (n=…
  • Future directions for adrenal insufficiency: cellular transplantation and genetic therapies. [Journal Article]
    J Clin Endocrinol Metab. 2023 Jan 06 [Online ahead of print]Graves LE, Torpy DJ, … Clarke B
  • Primary adrenal insufficiency occurs in 1 in 5-7000 adults. Leading aetiologies are autoimmune adrenalitis in adults and congenital adrenal hyperplasia (CAH) in children. Oral replacement of cortisol is lifesaving, but poor quality of life, repeated adrenal crises and dosing uncertainty related to lack of a validated biomarker for glucocorticoid sufficiency, persists. Adrenocortical cell therapy …
  • The Benefits and Drawbacks of Staging Pelvic Pouches. [Review]
    Clin Colon Rectal Surg. 2022 Nov; 35(6):445-452.Addison P, Keshinro AO, Schwartzberg DM
  • Since the mid-20th century, physicians have searched for way to improve the lives of patients with ulcerative colitis (UC). Early attempts of curative resection left the patients with a permanent stoma with only primitive stoma appliances available. Gradually, stoma care improved and operations were devised to give the patient bowel continuity without the need for a permanent ostomy. As these ope…
  • Autoimmune Polyglandular Syndrome Type II: A Case Report. [Case Reports]
    Cureus. 2022 Nov; 14(11):e31641.Jamal H, LaLoggia M, Harjai N
  • Autoimmune polyglandular syndromes (APS) are polyendocrinopathies characterized by autoimmune dysfunction of multiple endocrine organs. We present the case of a 23-year-old male with a past medical history of autoimmune thyroiditis diagnosed seven months prior who presented with a chief complaint of six months of fatigue, shortness of breath, and weight loss. Physical exam was remarkable for glob…
  • Autoimmune polyendocrine syndrome II presenting paradoxically as Takotsubo cardiomyopathy: a case report and reappraisal of pathophysiology. [Journal Article]
    Egypt Heart J. 2022 Dec 13; 74(1):82.Batta A, Gupta AK, … Wander GS
  • CONCLUSIONS: Intricate relationship and interplay exist between the steroid hormones and catecholamines in the pathogenesis of TCM. Steroid hormones not only potentiate the actions of catecholamines, but they also regulate and channelize catecholaminergic actions preventing their deleterious effects on the cardiac tissue. Hence, both steroid deficiency and exogenous steroid replacement may precipitate TCM. Evidence from more such cases and larger perspective studies in future will further improve our understanding of this complex disease process and its myriad associations.
  • Genetic diversity fuels gene discovery for tobacco and alcohol use. [Journal Article]
    Nature. 2022 Dec; 612(7941):720-724.Saunders GRB, Wang X, … Vrieze S
  • Tobacco and alcohol use are heritable behaviours associated with 15% and 5.3% of worldwide deaths, respectively, due largely to broad increased risk for disease and injury1-4. These substances are used across the globe, yet genome-wide association studies have focused largely on individuals of European ancestries5. Here we leveraged global genetic diversity across 3.4 million individuals from fou…
  • [Hyperpigmentation reveals Addison's disease in a pregnant woman]. [Case Reports]
    Ugeskr Laeger. 2022 11 28; 184(48)Danielsen E, Hansen JF, … Worm D
  • A 31-year-old woman was admitted to the local department of endocrinology for control of known anti-TPO positive hypothyroidism during pregnancy. The clinician noticed a remarkable hyperpigmentation. Primary adrenal insufficiency was diagnosed and treatment with cortico- and mineralosteroids commenced. Diagnosis of primary adrenal insufficiency during pregnancy is challenging as many symptoms ove…
  • Insilico prediction and functional analysis of nonsynonymous SNPs in human CTLA4 gene. [Journal Article]
    Sci Rep. 2022 11 28; 12(1):20441.Irfan M, Iqbal T, … Bhatti A
  • The CTLA4 receptor is an immune checkpoint involved in the downregulation of T cells. Polymorphisms in this gene have been found to be associated with different diseases like rheumatoid arthritis, autosomal dominant immune dysregulation syndrome, juvenile idiopathic arthritis and autoimmune Addison's disease. Therefore, the identification of polymorphisms that have an effect on the structure and …
  • Narrative Review on the Effects of Oat and Sprouted Oat Components on Blood Pressure. [Review]
    Nutrients. 2022 Nov 11; 14(22)Liska DJ, Dioum E, … Mah E
  • Hypertension (HTN) is a major risk factor for cardiovascular disease (CVD) and cognitive decline. Elevations in blood pressure (BP) leading to HTN can be found in young adults with increased prevalence as people age. Oats are known to decrease CVD risk via an established effect of β-glucan on the attenuation of blood cholesterol. Many past studies on CVD and oats have also reported a decrease in …
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