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(Ademetionine)
8,844 results
  • Study of the accumulation and distribution of arsenic species and association with arsenic toxicity in rats after 30 days of oral realgar administration. [Journal Article]
  • JEJ Ethnopharmacol 2018 Oct 29
  • Yi Y, Gao SR, … Shen-Ji
  • CONCLUSIONS: After a single oral administration, the distribution and elimination of realgar in blood were slow, whereas it was rapidly absorbed and distributed in the liver, kidney and brain. Therefore, we recommend that realgar should not frequently used on a daily basis. Because the administration of a large dose of realgar did not display significant toxicity, we believe that the continuous administration of realgar for 30 days is safe in rats. In addition, hematology, biochemistry, and electrolyte levels and ECG should be monitored during realgar treatment. The accumulation and distribution of As species after 30 days of oral administration of realgar revealed that DMA and MMA are the main end products of As metabolism. Realgar-induced hepatotoxicity may be related to the accumulation of DMA and As(III). In addition, we speculate that nephrotoxicity and neurotoxicity may occur when DMA accumulates to a certain high level.
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