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10,132 results
  • Screening for small molecule inhibitors of SAH nucleosidase using an SAH riboswitch. [Journal Article]
    Anal Biochem. 2023 Jan 19 [Online ahead of print]Sadeeshkumar H, Balaji A, … Breaker RR
  • Due to the emergence of multidrug resistant pathogens, it is imperative to identify new targets for antibiotic drug discovery. The S-adenosylhomocysteine (SAH) nucleosidase enzyme is a promising target for antimicrobial drug development due to its critical functions in multiple bacterial processes including recycling of toxic byproducts of S-adenosylmethionine (SAM)-mediated reactions and produci…
  • Revisiting One-Carbon Metabolites in Human Breast Milk: Focus on S-Adenosylmethionine. [Journal Article]
    Nutrients. 2023 Jan 05; 15(2)Lerin C, Collado MC, … Bottiglieri T
  • Breastfeeding is the gold standard for early nutrition. Metabolites from the one-carbon metabolism pool are crucial for infant development. The aim of this study is to compare the breast-milk one-carbon metabolic profile to other biofluids where these metabolites are present, including cord and adult blood plasma as well as cerebrospinal fluid. Breast milk (n = 142), cord blood plasma (n = 23), m…
  • 3-(Adenosylthio)benzoic Acid Derivatives as SARS-CoV-2 Nsp14 Methyltransferase Inhibitors. [Journal Article]
    Molecules. 2023 Jan 12; 28(2)Bobileva O, Bobrovs R, … Jaudzems K
  • SARS-CoV-2 nsp14 guanine-N7-methyltransferase plays an important role in the viral RNA translation process by catalyzing the transfer of a methyl group from S-adenosyl-methionine (SAM) to viral mRNA cap. We report a structure-guided design and synthesis of 3-(adenosylthio)benzoic acid derivatives as nsp14 methyltransferase inhibitors resulting in compound 5p with subnanomolar inhibitory activity …
  • Mining an O-methyltransferase for de novo biosynthesis of physcion in Aspergillus nidulans. [Journal Article]
    Appl Microbiol Biotechnol. 2023 Jan 17 [Online ahead of print]Yao Y, Yang E, … Liu G
  • Physcion is one of natural anthraquinones, registered as a novel plant-derived fungicide due to its excellent prevention of plant disease. However, the current production of physcion via plant extraction limits its yield promotion and application. Here, a pair of polyketide synthases (PKS) in emodin biosynthesis were used as probes to mining the potential O-methyltransferase (OMT) responsible for…
  • Novel strategies to reverse chemoresistance in colorectal cancer. [Review]
    Cancer Med. 2023 Jan 16 [Online ahead of print]Ma SC, Zhang JQ, … Li L
  • Colorectal cancer (CRC) is a common gastrointestinal malignancy with high morbidity and fatality. Chemotherapy, as traditional therapy for CRC, has exerted well antitumor effect and greatly improved the survival of CRC patients. Nevertheless, chemoresistance is one of the major problems during chemotherapy for CRC and significantly limits the efficacy of the treatment and influences the prognosis…
  • Functional Diversification and Structural Origins of Plant Natural Product Methyltransferases. [Review]
    Molecules. 2022 Dec 21; 28(1)Lashley A, Miller R, … Salim V
  • In plants, methylation is a common step in specialized metabolic pathways, leading to a vast diversity of natural products. The methylation of these small molecules is catalyzed by S-adenosyl-l-methionine (SAM)-dependent methyltransferases, which are categorized based on the methyl-accepting atom (O, N, C, S, or Se). These methyltransferases are responsible for the transformation of metabolites i…
  • Structures and mechanisms of tRNA methylation by METTL1-WDR4. [Journal Article]
    Nature. 2023 Jan; 613(7943):383-390.Ruiz-Arroyo VM, Raj R, … Nam Y
  • Specific, regulated modification of RNAs is important for proper gene expression1,2. tRNAs are rich with various chemical modifications that affect their stability and function3,4. 7-Methylguanosine (m7G) at tRNA position 46 is a conserved modification that modulates steady-state tRNA levels to affect cell growth5,6. The METTL1-WDR4 complex generates m7G46 in humans, and dysregulation of METTL1-W…
  • Abnormal methylation caused by folic acid deficiency in neural tube defects. [Review]
    Open Life Sci. 2022; 17(1):1679-1688.Cao R, Xie J, Zhang L
  • Neural tube closure disorders, including anencephaly, spina bifida, and encephalocele, cause neural tube defects (NTDs). This congenital disability remained not only a major contributor to the prevalence of stillbirths and neonatal deaths but also a significant cause of lifelong physical disability in surviving infants. NTDs are complex diseases caused by multiple etiologies, levels, and mechanis…
  • Elucidating the Kinetic Mechanism of Human METTL16. [Journal Article]
    Biochemistry. 2023 Jan 17; 62(2):494-506.Breger K, Brown JA
  • Methyltransferase-like protein 16 (METTL16) is one of four catalytically active, S-adenosylmethionine (SAM)-dependent m6A RNA methyltransferases in humans. Well-known methylation targets of METTL16 are U6 small nuclear RNA (U6 snRNA) and the MAT2A mRNA hairpins; however, METTL16 binds to other RNAs, including the 3' triple helix of the metastasis-associated lung adenocarcinoma transcript 1 (MALAT…
  • Plant homocysteine, a methionine precursor and plant's hallmark of metabolic disorders. [Review]
    Front Plant Sci. 2022; 13:1044944.Sobieszczuk-Nowicka E, Arasimowicz-Jelonek M, … Floryszak-Wieczorek J
  • Homocysteine (Hcy) is a sulfur-containing non-proteinogenic amino acid, which arises from redox-sensitive methionine metabolism. In plants, Hcy synthesis involves both cystathionine β-lyase and S-adenosylhomocysteine hydrolase activities. Thus, Hcy itself is crucial for de novo methionine synthesis and S-adenosylmethionine recycling, influencing the formation of ethylene, polyamines, and nicotian…
  • Circ-ERC2 Is Involved in Melatonin Synthesis by Regulating the miR-125a-5p/MAT2A Axis. [Journal Article]
    Int J Mol Sci. 2022 Dec 07; 23(24)Guo HX, Zheng Y, … Yuan B
  • The circadian rhythm of melatonin secretion in the pineal gland is highly conserved in vertebrates. Melatonin levels are always elevated at night. Acetylserotonin O-methyltransferase (ASMT) is the last enzyme in the regulation of melatonin biosynthesis (N-acetyl-5-hydroxytryptamine-melatonin). S-adenosylmethionine (SAM) is an important methyl donor in mammals and can be used as a substrate for th…
  • The Role of the m6A RNA Methyltransferase METTL16 in Gene Expression and SAM Homeostasis. [Review]
    Genes (Basel). 2022 12 08; 13(12)Mermoud JE
  • The RNA methylation of adenosine at the N6-position (m6A) has attracted significant attention because of its abundance and dynamic nature. It accounts for more than 80% of all RNA modifications present in bacteria and eukaryotes and regulates crucial aspects of RNA biology and gene expression in numerous biological processes. The majority of m6A found in mammals is deposited by a multicomponent c…
  • Decipher the molecular evolution and expression patterns of Cupin family genes in oilseed rape. [Journal Article]
    Int J Biol Macromol. 2023 Feb 01; 227:437-452.Hu F, Ye Z, … Cao J
  • Cupin proteins are involved in plant growth and development as well as in response to various stresses. Here, a total of 173 Cupin genes were identified in Brassica napus, and their molecular evolution and expression patterns were analyzed. These genes were classified into ten groups. Motif and exon-intron structure indicated a high degree of conservation within each group during evolution. BnaCu…
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