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8,694 results
  • Mechanisms of MAFG Dysregulation in Cholestatic Liver Injury and Development of Liver Cancer. [Journal Article]
  • GGastroenterology 2018 May 04
  • Liu T, Yang H, … Lu SC
  • CONCLUSIONS: Expression of MAFG increases in cells and tissues with cholestasis, as well as in human cholangiocarcinoma and HCC specimens; high expression levels correlate with tumor progression and reduced survival time. SAMe and UDCA reduce expression of MAFG in response to cholestasis, by shared and distinct mechanisms. OCA induces MAFG expression, cancer cell proliferation, and growth of xenograft tumors in mice.
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