- Radical Resection Combined with Intestinal Autotransplantation for Locally Advanced Pancreatic Cancer after Neoadjuvant Therapy: A Report of 36 Consecutive Cases. [Journal Article]Ann Surg. 2023 Jan 24 [Online ahead of print]AnnS
- CONCLUSIONS: Our attempt suggests safety of this modality and may be clinically beneficial for highly-selected patients with PDAC. However, experience of multidisciplinary pancreatic cancer care and intestinal transplantation is warranted.
- Publisher Full Text (DOI)
- Pancreatic Cancer in Celiac Disease Patients-A Systematic Review and Meta-Analysis. [Review]
- CONCLUSIONS: The association between CD and PC is uncertain. However, the results of the current meta-analysis may indicate an increased risk of PC in the group of patients with CD and other cancers. Further multicenter studies are warranted.
- PMC Free PDF
- Clinical Features and Management of Small Bowel Masses Detected During Device-Assisted Enteroscopy: A Multi-Center Experience. [Journal Article]
- CONCLUSIONS: In this multi-center retrospective study we found that SBMLs are more likely to be sporadic than syndromic, medium in size and either pedunculated or submucosal. NETs and hamartomas predominated and symptoms, most commonly anemia, can be present for more than a year prior to diagnosis. Close to one half of lesions required either no further intervention or only endoscopic surveillance.
- PMC Free PDF
- Case report: Neurofibromatosis type 1 gastrointestinal stromal tumor and small bowel adenocarcinoma with a novel germline NF1 frameshift mutation. [Case Reports]
- A synchronous case of small bowel adenocarcinoma(SAB) is reported, accompanied with gastrointestinal stromal tumor(GIST),and gangliocytomain in an elderly woman with neurofibromatosis type 1 (NF-1). A 67-year-old female was hospitalized with the chief complaint of abdominal pain, the computed tomography scan indicated a large bowel mass. Multiple tumors were found in the small intestine, through …
- PMC Free PDF
- Familial Duodenal Somatostatinomatosis Not Associated With a Known Genetic Syndrome. [Journal Article]Pancreas. 2022 Sep 01; 51(8):1056-1060.P
- We report a father and his daughter who both had multiple somatostatinomas in the duodenal bulb without a known syndrome. The father, at age 68 years, was incidentally found to harbor 4 approximately 1.5-cm well-differentiated neuroendocrine tumors in the duodenal bulb. His preoperative somatostatin level was elevated. He underwent partial duodenectomy and regional lymph node dissection; one lymp…
- Publisher Full Text (DOI)
- Computed tomographic findings may be useful for differentiating small intestinal adenocarcinomas, lymphomas, and spindle cell sarcomas in dogs. [Journal Article]Vet Radiol Ultrasound. 2023 Jan 03 [Online ahead of print]VR
- An improved understanding of the CT characteristics for histologically confirmed primary intestinal tumors would be helpful for guiding prognosis and treatment plans in affected dogs. This retrospective, multi-center, analytical study aimed to evaluate the CT characteristics for the differentiation of adenocarcinoma, lymphoma, and spindle cell sarcoma (SCS) in dogs. Thirty-seven dogs who underwen…
- Publisher Full Text (DOI)
- Rare cause of obstructive icterus in a young patient. [Case Reports]Vnitr Lek. 2022 Winter; 68(E-8):18-22.VL
- In this case report is discussed the diagnosis of papillary carcinoma in the case of a patient in whose age the occurrence of the disease is very rare. The patient underwent a series of non-invasive and invasive examinations, the results of which eventually led to a surgical solution of the suspected lesion (Wipples procedure). Histological examination of the resection confirmed mixed type ampula…
- Publisher Full Text (DOI)
- The use of histopathological subtyping in patients with ampullary cancer: a nationwide analysis. [Journal Article]
- CONCLUSIONS: Despite recent improvements in the use of subtyping in ampullary cancer, the distinction between intestinal, pancreatobiliary, and mixed subtypes is only made in a minority of patients. Nationwide efforts are required to standardize the pathological distinction of the various subtypes of ampullary cancer.
- PMC Free PDF
- Tissue and cell specific properties of enterochromaffin cells affect the fate of tumorigenesis toward non-endocrine adenocarcinoma of the small intestine. [Journal Article]Am J Physiol Gastrointest Liver Physiol. 2022 Dec 20 [Online ahead of print]AJ
- Small intestinal neuroendocrine tumor SI-NETs are serotonin-secreting well-differentiated neuroendocrine tumors of putative enterochromaffin (EC) cell origin. However, EC cell-derived tumorigenesis remains poorly understood. Here we examined whether the gain of Myc and the loss of RB1 and Trp53 function in EC cells result in SI-NET using tryptophan hydroxylase 1 (TPH1) Cre-ERT2-driven RB1fl Trp53…
- Publisher Full Text (DOI)
- Somatostatinoma of the Ampulla of Vater: A Systematic Review. [Systematic Review]J Gastrointestin Liver Dis. 2022 Dec 17; 31(4):459-466.JG
- CONCLUSIONS: Somatostatinomas of the ampulla of Vater are rare malignancies that require increased physicians' suspicion and accurate surgical approach in order to achieve optimal therapeutic results.
- Publisher Full Text (DOI)
- Laparoscopic Transduodenal Ampullectomy: How We Have Standardized the Technique (with Video). [Case Reports]Ann Surg Oncol. 2023 Feb; 30(2):1156-1157.AS
- CONCLUSIONS: After standardization of the surgical processes, laparoscopic TDA was safe for highly selected patients. However, long-term follow-up is required to observe the quality of life and survival of patients.
- Publisher Full Text (DOI)
- Heterochronous multiple metastasis of lung adenocarcinoma to the small intestine: A case report. [Letter]Asian J Surg. 2022 Dec 08 [Online ahead of print]AJ
- Publisher Full Text (DOI)
- Unexpected adhesive bowel obstruction after endoscopic submucosal dissection of early sigmoid colon cancer. [Case Reports]
- Various complications of colorectal endoscopic submucosal dissection (ESD) have been reported, including bleeding, penetration, perforation, and coagulation syndrome. However, the occurrence of bowel obstruction after ESD is rare. We report a case of adhesive bowel obstruction after ESD for a laterally spreading tumor in the sigmoid colon. The 35-mm tumor was successfully removed by ESD without i…
- PMC Free PDF
- StatPearls: Small Bowel Cancer [BOOK]StatPearls. StatPearls Publishing: Treasure Island (FL)BOOK
- Small bowel cancer encompasses a series of malignant lesions that may be identified throughout the small intestine (SI). The small bowel lies between the stomach and the large intestine (LI/colon) and is comprised of three different sections, the duodenum, jejunum, and ileum to the level of the ileocecal valve which provides the terminal transition point between the SI and the LI. While there are…
- Rare squamous cell carcinoma of the jejunum causing perforated peritonitis: A case report. [Case Reports]
- CONCLUSIONS: SI tumors are very rare compared to those originating in other digestive organs. Due to its insidious onset, the diagnosis of this disease is usually delayed. Clinicians must pay close attention to digestive symptoms such as persistent abdominal pain and melena.
- PMC Free PDF
- Risk factors for small intestinal adenocarcinomas that are common in the proximal small intestine. [Review]
- The frequency of primary small intestinal adenocarcinoma is increasing but is still low. Its frequency is approximately 3% of that of colorectal adenocarcinoma. Considering that the small intestine occupies 90% of the surface area of the gastrointestinal tract, small intestinal adenocarcinoma is very rare. The main site of small intestinal adenocarcinoma is the proximal small intestine. Based on …
- PMC Free PDF
- A case of pyloric gland adenoma with high-grade dysplasia in the duodenum arising from heterotopic gastric mucosa observed over 5 years. [Case Reports]
- Pyloric gland adenoma (PGA) in the duodenum is a rare gastric phenotype duodenal neoplasm. Although heterotopic gastric mucosa in the duodenum has been recognized as a benign lesion, it is a potential precursor of PGA and gastric phenotype adenocarcinoma. Herein, we present a case follow-up of endoscopic and histological changes in the PGA in the duodenum from low-grade to high-grade dysplasia. P…
- Publisher Full Text (DOI)
- Adenocarcinoma of the Ampulla of Vater: A Case Report on a Rare Condition. [Case Reports]
- An ampullary carcinoma (AC) is defined as cancer that arises in the ampulla of Vater (AV). It is a tiny opening in the beginning segment of the small intestine called the duodenum. Pancreatic and bile duct fluids are pumped into the intestines via the AV. There are various factors listed as the causes of AC. A 45-year-old male presented to the emergency department with complaints of pain in the a…
- PMC Free PDF
- Clinicopathological characteristics and prognostic factors of elderly small intestine adenocarcinoma using propensity score matching analysis: a study based on SEER database. [Journal Article]
- CONCLUSIONS: Surgery could bring benefit to survival for elderly SIA patients, and the early stage of the disease was another significant prognostic factor.
- Publisher Full Text (DOI)
- Role of Intestinal Microbes in Chronic Liver Diseases. [Review]
- With the recent availability and upgrading of many emerging intestinal microbes sequencing technologies, our research on intestinal microbes is changing rapidly. A variety of investigations have found that intestinal microbes are essential for immune system regulation and energy metabolism homeostasis, which impacts many critical organs. The liver is the first organ to be traversed by the intesti…
- PMC Free PDF
- Small Bowel Adenocarcinoma: 10-Year Experience in a Cancer Center-The Ottawa Hospital (TOH). [Journal Article]
- (1) Background: Small bowel adenocarcinoma (SBA) is one of the predominant primary small bowel cancers that has a dismal outcome. We aim to report 10 years of experience in SBA management at a regional cancer centre in Canada.; (2) Methods: We retrospectively analysed clinical and pathological data of patients diagnosed with an SBA between 2011 and 2021 at the Ottawa Hospital (TOH), Ottawa, Canad…
- PMC Free PDF
- Impact of Diabetes on Short-Term and Long-Term Outcomes of Ampullary Adenocarcinoma Patients after Curative Pancreatoduodenectomy. [Journal Article]
- CONCLUSIONS: Diabetes may adversely affect the recurrence of patients with AC after curative pancreaticoduodenectomy, leading to an increased risk of poor prognosis in early-stage patients. Further studies involving a large sample size are needed to validate our results.
- PMC Free PDF
- The Role of Novel Motorized Spiral Enteroscopy in the Diagnosis of Cecal Tumors. [Case Reports]
- Small bowel and ileocecal diseases remain a diagnostic and therapeutic challenge, despite the introduction of various modalities for deep enteroscopy. Novel Motorized Spiral Enteroscopy is an innovative technology that uses an overtube with a raised spiral at the distal end to pleat the small intestine. It consumes less time and meets both the diagnostic and therapeutic needs of small bowel disea…
- PMC Free PDF
- Early Discovery Of Small Bowel Adenocarcinoma In a Patient Admitted For 4 Acute Intestinal Intussusception. [Case Reports]
- CONCLUSIONS: The most common symptoms of adenocarcinoma of the small bowel are obstruction, overt or covert bleeding, weight loss and jaundice. Because the small bowel has long been relatively inaccessible to routine endoscopy, the diagnosis of small bowel adenocarcinoma was often delayed for several months after the onset of symptoms. Therefore, in case of suspicion of this type of cancer, a thorough evaluation should be undertaken. Nowadays, endoscopy of the small bowel is widely available, allowing an earlier non-invasive diagnosis.
- PMC Free PDF
- Genomic characterization reveals distinct mutation landscapes and therapeutic implications in neuroendocrine carcinomas of the gastrointestinal tract. [Journal Article]
- CONCLUSIONS: GI-NECs harbor distinct genomic landscapes and demonstrate significant genetic heterogeneity across different anatomic locations. Moreover, potentially actionable alterations and prognostic factors were revealed for GI-NECs.
- PMC Free PDF
- A rare case of long-term survival of a patient who underwent radical operations for sextuple malignancies. [Case Reports]
- Multiple cancer patients who achieve long-term survival are sometimes encountered. Multiple carcinogenesis may occur due to genetic or environmental characteristics. We report the case of a 74-year-old woman who was diagnosed with synchronous double carcinoma of the duodenal papilla and gall bladder without clinical symptoms, who underwent postoperative follow-up for familiar adenomatous polyposi…
- Publisher Full Text (DOI)
- Survival in patients with neuroendocrine tumors of the colon, rectum and small intestine. [Journal Article]Am J Surg. 2023 01; 225(1):58-65.AJ
- CONCLUSIONS: Surgical resection may improve 5-year OS for NECs of the SI and colon, except in the rectum where survival was reduced. More frequent surveillance and timely initiation of systemic therapy should be considered for rectal NECs.
- Publisher Full Text (DOI)
- Is single tract jejunal interposition better than double tract reconstruction after proximal gastrectomy? [Review]
- Double tract reconstruction (DTR) is the main digestive tract reconstruction method after proximal gastrectomy (PG). Single tract jejunal interposition (STJI) derived from the double tract reconstruction is also increasingly used in clinical practice. However, there is still a great controversy as to which of the two reconstruction methods can achieve better results. In this study, we systematica…
- Publisher Full Text (DOI)
- Personal comorbidities and their subsequent risks for liver, gallbladder and bile duct cancers. [Journal Article]Int J Cancer. 2023 Mar 15; 152(6):1107-1114.IJ
- Many environmental risk factors for hepatobiliary cancers are known but whether they are associated with specific cancer types is unclear. We present here a novel approach of assessing standardized incidence ratios (SIRs) of previously diagnosed comorbidities for hepatocellular carcinoma (HCC), gallbladder cancer (GBC), cholangiocarcinoma (CCA) and ampullary cancer. The 13 comorbidities included …
- Publisher Full Text (DOI)