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299,310 results
  • Base editing as a genetic treatment for spinal muscular atrophy. [Preprint]
    bioRxiv. 2023 Jan 21Alves CRR, Ha LL, … Kleinstiver BP
  • Spinal muscular atrophy (SMA) is a devastating neuromuscular disease caused by mutations in the SMN1 gene. Despite the development of various therapies, outcomes can remain suboptimal in SMA infants and the duration of such therapies are uncertain. SMN2 is a paralogous gene that mainly differs from SMN1 by a C•G-to-T•A transition in exon 7, resulting in the skipping of exon 7 in most SMN2 transcr…
  • Anionic Phospholipids Control Mechanisms of GPCR-G Protein Recognition. [Preprint]
    bioRxiv. 2023 Jan 13Thakur N, Ray AP, … Eddy MT
  • G protein-coupled receptors (GPCRs) are embedded in phospholipids that strongly influence drug-stimulated signaling. Anionic lipids are particularly important for GPCR signaling complex formation, but a mechanism for this role is not understood. Using NMR spectroscopy, we visualized the impact of anionic lipids on the function-related conformational equilibria of the human A 2A adenosine receptor…
  • Big Data analytics for improved prediction of ligand binding and conformational selection. [Journal Article]
    Front Mol Biosci. 2022; 9:953984.Gupta S, Baudry J, Menon V
  • This research introduces new machine learning and deep learning approaches, collectively referred to as Big Data analytics techniques that are unique to address the protein conformational selection mechanism for protein:ligands complexes. The novel Big Data analytics techniques presented in this work enables efficient data processing of a large number of protein:ligand complexes, and provides bet…
  • The Integrative Studies on the Functional A-to-I RNA Editing Events in Human Cancers. [Journal Article]
    Genomics Proteomics Bioinformatics. 2023 Jan 25 [Online ahead of print]Wu S, Fan Z, … Zhou X
  • Adenosine-to-inosine (A-to-I) RNA editing, constituting nearly 90% of all RNA editing events in humans, has been reported to contribute to the tumorigenesis in diverse cancers. However, the comprehensive map for functional A-to-I RNA editing events in cancers is still insufficient. To fill this gap, we systematically and intensively analyzed multiple tumorigenic mechanisms of A-to-I RNA editing e…
  • [Roles and mechanisms of m6A modification regulating RP11-426A6.5 in laryngeal squamous cell carcinoma]. [Journal Article]
    Zhonghua Er Bi Yan Hou Tou Jing Wai Ke Za Zhi. 2022 Dec 07; 57(12):1470-1478.Yan BR, Wang P, … Sun YN
  • Objective: To investigate the roles of N6-methyladenosine (m6A) modification in regulating RP11-426A6.5 in the development of laryngeal squamous cell carcinoma (LSCC). Methods: The methylation and expression levels of lncRNAs were identified and important lncRNAs were screened utilizing long non-coding RNA (lncRNA) m6A methylation microarray. Cancer and para cancer tissue samples were taken from …
  • Ribavirin extends the lifespan of Caenorhabditis elegans through AMPK-TOR Signaling. [Journal Article]
    Eur J Pharmacol. 2023 Jan 24 [Online ahead of print]Zhang G, Liu H, … Zhuang Z
  • Aging is a process accompanied by widespread degenerative changes which are a major cause of human disease and disability. One goal of aging research is to develop interventions or drugs that can extend organism lifespan and treat age-related diseases. Here, we report the identification of a broad spectrum anti-viral agent, ribavirin, as a potential pharmacological aging intervention. Ribavirin e…
  • Neural regulation of ILC2s in allergic airway inflammation. [Review]
    Front Allergy. 2022; 3:1094259.Thomas CM, Peebles RS
  • The sympathetic nervous system (SNS) and parasympathetic nervous system (PNS) regulate the effector functions of group 2 innate lymphoid cells (ILC2s) through β2 adrenergic receptor (ADRB2) and nicotinic/muscarinic cholinergic receptor signaling, respectively. To further maintain the critical balance between host-protective and pathogenic type 2 inflammation in the lungs, neuropeptides neuromedin…
  • mRNA m6 A methylation in wood frog brain is maintained during freezing and anoxia. [Journal Article]
    J Exp Zool A Ecol Integr Physiol. 2023 Jan 26 [Online ahead of print]Wade S, Hadj-Moussa H, Storey KB
  • Freeze tolerance is an adaptive strategy that wood frogs (Rana sylvatica) use to survive the subzero temperatures of winter. It is characterized by a variety of metabolic and physiological changes that facilitate successful freezing and anoxia. As both mRNA regulation and posttranslation protein modification have been implicated in freeze tolerance, we hypothesized that posttranslational RNA regu…
  • Gene regulation in activated microglia by adenosine A3 receptor agonists: a transcriptomics study. [Journal Article]
    Purinergic Signal. 2023 Jan 27 [Online ahead of print]Lillo A, Serrano-Marín J, … Franco R
  • Most neurodegenerative disorders, including the two most common, Alzheimer's disease (AD) and Parkinson's disease (AD), course with activation of microglia, the resident innate immune cells of the central nervous system. A3 adenosine receptor (A3R) agonists have been proposed to be neuroprotective by regulating the phenotype of activated microglia. RNAseq was performed using samples isolated from…
  • TadA orthologs enable both cytosine and adenine editing of base editors. [Journal Article]
    Nat Commun. 2023 Jan 26; 14(1):414.Zhang S, Yuan B, … Cheng TL
  • Cytidine and adenosine deaminases are required for cytosine and adenine editing of base editors respectively, and no single deaminase could enable concurrent and comparable cytosine and adenine editing. Additionally, distinct properties of cytidine and adenosine deaminases lead to various types of off-target effects, including Cas9-indendepent DNA off-target effects for cytosine base editors (CBE…
  • Base type determines the effects of nucleoside monophosphates on microalgae-bacteria symbiotic systems. [Journal Article]
    Chemosphere. 2023 Jan 23; 317:137943.Zheng L, Ren M, … Xie E
  • Microalgae are promising sources of clean energy. Bioflocculation by cocultured bacteria is an effective way to harvest microalgae. As a key foundation for microorganisms, phosphorus is theoretically effective in shaping microalgae production and flocculation. In this study, the impacts of 23 nucleoside monophosphates on Auxenochlorella pyrenoidosa growth, lipid synthesis, and self-settlement and…
  • Second-Generation CD73 Inhibitors Based on a 4,6-Biaryl-2-thiopyridine Scaffold. [Journal Article]
    ChemMedChem. 2023 Jan 26 [Online ahead of print]Ghoteimi R, Braka A, … Peyrottes S
  • Various series of 4,6-biaryl-2-thiopyridine derivatives were synthesized and evaluated as potential ecto-5'-nucleotidase (CD73) inhibitors. Two synthetic routes were explored and the coupling of 4,6-disubstituted 3-cyano-2-chloro-pyridines with selected thiols allowed us to explore the structural diversity. Somehow divergent results were obtained in biological assays on CD73 inhibition using eith…
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