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262,005 results
  • The influence of chemotherapy on adenosine-producing B cells in patients with head and neck squamous cell carcinoma. [Journal Article]
  • OOncotarget 2018 Jan 19; 9(5):5834-5847
  • Ziebart A, Huber U, … Schuler PJ
  • CONCLUSIONS: Platinum-based anti-tumor-therapy reduces the number of adenosine-producing B cells and, consequently, potential immunosuppression within the tumor environment. Breg function in terms of ADO production and their potential capacity to suppress CD4+T cells are promoted by methotrexate treatment amplifying anti-inflammatory therapeutic effects. Our results add to the understanding of how chemotherapeutic drugs can influence the human immune system and may therefore help to orchestrate standard oncologic therapy with new immune modulating approaches.
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