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(Adenoma liver cell)
2,993 results
  • A rare synchrony of adenocarcinoma of the ampulla with an ileal gastrointestinal stromal tumor: A case report. [Case Reports]
    World J Gastrointest Oncol. 2022 Nov 15; 14(11):2253-2265.Matli VVK, Zibari GB, … Morris J
  • CONCLUSIONS: This case is distinctive because the patient was diagnosed with two synchronous and extremely rare high-grade primary malignancies, i.e., an ampullary adenocarcinoma arising from a high-grade dysplastic TVAoA with a high-grade ileal GIST. An AoA can occur sporadically and in a familial inheritance pattern in the setting of FAPS. We emphasize screening and surveillance colonoscopy when one encounters an AoA in upper endoscopy to check for FAPS. An AoA is a premalignant lesion, particularly in the setting of FAPS that carries a high risk of metamorphism to an ampullary adenocarcinoma. Final diagnosis should be based on a histopathologic study of the surgically resected ampullary specimen and not on endoscopic forceps biopsy. The diagnosis of AoA is usually incidental on upper endoscopy. However, patients can present with constitutional symptoms such as significant weight loss and obstructive symptoms such as painless jaundice, both of which occurred in our patient. Patient underwent ampullectomy with clear margins and ileal GIST resection. Patient is currently on imatinib adjuvant therapy and showed complete metabolic response on follow up PET scan.
  • A nationwide assessment of hepatocellular adenoma resection: Indications and pathological discordance. [Journal Article]
    Hepatol Commun. 2023 Jan 01; 7(1):e2110.Haring MPD, Elfrink AKE, … Dutch Benign Liver Tumor Group
  • Hepatocellular adenomas (HCAs) are benign liver tumors associated with bleeding or malignant transformation. Data on the indication for surgery are scarce. We analyzed indications and outcome of patients operated for HCAs < 50 mm compared to HCAs ≥ 50 mm. Changes in final postoperative diagnosis were assessed. We performed a retrospective study that included patients who underwent resection for (…
  • Hepatocellular Adenoma in an Infant With Burn-McKeown Syndrome: Report of a Case. [Case Reports]
    Pediatr Dev Pathol. 2022 Nov-Dec; 25(6):668-671.González IA, Surrey LF, Russo P
  • Hepatocellular adenomas (HCA) in infants are exceedingly rare with only 5 cases reported to the best of our knowledge, all of them preceding the classification of HCA. Here we present an autopsy case of a 9-month-old girl with Burn-McKeown syndrome with an incidental liver nodule in the right lobe measuring 1.5 cm in greatest dimension. The lesion was composed of an unencapsulated proliferation o…
  • The roles of the tumor suppressor parafibromin in cancer. [Review]
    Front Cell Dev Biol. 2022; 10:1006400.Zheng HC, Xue H, Zhang CY
  • In this review, we discuss parafibromin protein, which is encoded by CDC73. A mutation in this gene causes hyperparathyroidism-jaw tumor (HPT-JT) syndrome, an autosomal dominant disease. CDC73 is transcriptionally downregulated by the Wilms' tumor suppressor gene WT1 and translationally targeted by miR-182-3p and miR-155. In the nucleus, parafibromin binds to RNA polymerase II and PAF1 complex fo…
  • Focal Benign Liver Lesions and Their Diagnostic Pitfalls. [Review]
    Radiol Clin North Am. 2022 Sep; 60(5):755-773.Reizine E, Mulé S, Luciani A
  • Focal hepatic lesions are frequently discovered incidentally on cross-sectional imaging or abdominal ultrasound, and in the general population, a vast majority of those incidental findings are benign entities. However, the formal diagnosis of benign liver lesions is not always straightforward and may require advanced imaging modalities, such as MRI with hepatobiliary contrast agent or contrast-en…
  • Benign liver tumours: understanding molecular physiology to adapt clinical management. [Review]
    Nat Rev Gastroenterol Hepatol. 2022 11; 19(11):703-716.Nault JC, Paradis V, … Zucman-Rossi J
  • Improvements in understanding the pathophysiology of the different benign liver nodules have refined their nosological classification. New criteria have been identified using imaging, histology and molecular analyses for a precise diagnosis of these tumours. Improvement in the classification of liver tumours provides a more accurate prediction of disease progression and has modified patient manag…
  • Spontaneous neoplasms in harbour porpoises Phocoena phocoena. [Journal Article]
    Dis Aquat Organ. 2022 Jun 23; 149:145-154.Gregor KM, Lakemeyer J, … Wohlsein P
  • Harbour porpoises are widely distributed in the North Atlantic and represent the most abundant cetacean species in the North and Baltic Seas. Spontaneous neoplasms are relatively rarely reported in cetaceans, and only little is known about neoplasia in harbour porpoises. Thus, archival material was reviewed for spontaneous neoplasms in harbour porpoises recorded during post-mortem examinations be…
  • An Overview of Neoplasia in Captive Wild Felids in Southern Italy Zoos. [Journal Article]
    Front Vet Sci. 2022; 9:899481.d'Aquino I, Piegari G, … Russo V
  • The aim of this study was to evaluate the frequency of neoplasms in captive wild felids in Southern Italy zoos over a 13-year period (2008-2021) and to investigate macroscopic and histologic tumor findings in these animals. A total of 24 cases were necropsied, 9 males and 15 females, with age ranging from 6 to 19 years, including 12 tigers (Panthera tigris), 7 leopards (Panthera pardus), 4 lions …
  • Hepatocellular adenoma: Where are we now? [Editorial]
    World J Gastroenterol. 2022 Apr 14; 28(14):1384-1393.Wang X, Zhang X
  • Hepatocellular adenoma (HCA) is a benign hepatocellular neoplasm, commonly occurs in young women with a history of oral contraceptive use. Complications including hemorrhage and malignant transformation necessitate the need for a thorough understanding of the underlying molecular signatures in this entity. Recent molecular studies have significantly expanded our knowledge of HCAs. The well-develo…
  • MRI Appearance of Focal Lesions in Liver Iron Overload. [Review]
    Diagnostics (Basel). 2022 Apr 02; 12(4)Pecorelli A, Franceschi P, … Golfieri R
  • Liver iron overload is defined as an accumulation of the chemical element Fe in the hepatic parenchyma that exceeds the normal storage. When iron accumulates, it can be toxic for the liver by producing inflammation and cell damage. This can potentially lead to cirrhosis and hepatocellular carcinoma, as well as to other liver lesions depending on the underlying condition associated to liver iron o…
  • [Importance of surgery in distant metastatic pancreatic neuroendocrine neoplasms]. [Review]
    Chirurgie (Heidelb). 2022 Aug; 93(8):758-764.Billmann F, Nieβen A, Hackert T
  • The majority of patients with pancreatic neuroendocrine neoplasms (pNEN) already present with distant metastases at diagnosis. The heterogeneity of pNEN and the broad spectrum of treatment options make adequate patient selection and an evidence-based strategy essential. In metastatic pNEN both primary resection and resection of liver metastases have been shown to improve overall survival. Surgica…
  • Subtyping of hepatocellular adenoma: a machine learning-based approach. [Journal Article]
    Virchows Arch. 2022 Jul; 481(1):49-61.Liu Y, Liu YZ, … Yeh MM
  • Subtyping of hepatocellular adenoma (HCA) is an important task in practice as different subtypes may have different clinical outcomes and management algorithms. Definitive subtyping is currently dependent on immunohistochemical and molecular testing. The association between some morphologic/clinical features and HCA subtypes has been reported; however, the predictive performance of these features…
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