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299,364 results
  • Stereoselective Assembly of Hydrogen-Bonded Anionic Cages Dictated by Organophosphate-Based Chiral Nodes. [Journal Article]
    Angew Chem Int Ed Engl. 2023 Feb 01 [Online ahead of print]Zuo W, Tao Y, … Jia C
  • Inspired by the signal transduction function of organophosphates in biological systems, bioactive organophosphates were utilized for the first time as chiral nodes to dictate the stereoselective assembly of hydrogen-bonded anionic cages. Phosphonomycin (antibiotics), tenofovir (antivirals), adenosine monophosphate (natural product, AMP) and clindamycin phosphate (antibiotics) were assembled respe…
  • Toll-Like Receptor 4 (TLR4) and AMPK Relevance in Cardiovascular Disease. [Review]
    Adv Pharm Bull. 2023 Jan; 13(1):36-47.Vaez H, Soraya H, … Gholikhani T
  • Toll-like receptors (TLRs) are essential receptors of the innate immune system, playing a significant role in cardiovascular diseases. TLR4, with the highest expression among TLRs in the heart, has been investigated extensively for its critical role in different myocardial inflammatory conditions. Studies suggest that inhibition of TLR4 signaling pathways reduces inflammatory responses and even p…
  • Does Drinking Coffee Reduce the Incidence of Parkinson's Disease? [Review]
    Cureus. 2023 Jan; 15(1):e34296.Ko TK
  • Parkinson's disease (PD) is an increasing threat to first-world nations as their population ages, with around one in 100 suffering from it by age 60. Incurable, with treatments that do little to delay disease progression, PD induces severe disability and even death in those afflicted. The search for preventative measures has revealed the widely used psychoactive stimulant caffeine, which competit…
  • Reprogramming the tumor microenvironment with biotechnology. [Review]
    Biomater Res. 2023 Jan 31; 27(1):5.Kim M, Lee NK, … Park CG
  • The tumor microenvironment (TME) is a unique environment that is developed by the tumor and controlled by tumor-induced interactions with host cells during tumor progression. The TME includes immune cells, which can be classified into two types: tumor- antagonizing and tumor-promoting immune cells. Increasing the tumor treatment responses is associated with the tumor immune microenvironment. Targ…
  • Platelet P2Y1 receptor exhibits constitutive G protein signaling and β-arrestin 2 recruitment. [Journal Article]
    BMC Biol. 2023 Feb 01; 21(1):14.Ribes A, Garcia C, … Pons V
  • CONCLUSIONS: This study sheds new light on P2Y1-R pharmacology, highlighting for the first time the existence of a constitutively active P2Y1-R population in human platelets. Given the recent interest of P2Y12-R constitutive activity in patients with diabetes, this study suggests that modification of constitutive P2Y1-R signaling might be involved in pathological conditions, including bleeding syndrome or high susceptibility to thrombotic risk. Thus, targeting platelet P2Y1-R constitutive activation might be a promising and powerful strategy for future antiplatelet therapy.
  • A paralog of Pcc1 is the fifth core subunit of the KEOPS tRNA-modifying complex in Archaea. [Journal Article]
    Nat Commun. 2023 Feb 01; 14(1):526.Daugeron MC, Missoury S, … Basta T
  • In Archaea and Eukaryotes, the synthesis of a universal tRNA modification, N6-threonyl-carbamoyl adenosine (t6A), is catalyzed by the KEOPS complex composed of Kae1, Bud32, Cgi121, and Pcc1. A fifth subunit, Gon7, is found only in Fungi and Metazoa. Here, we identify and characterize a fifth KEOPS subunit in Archaea. This protein, dubbed Pcc2, is a paralog of Pcc1 and is widely conserved in Archa…
  • CD73-dependent adenosine signaling through Adora2b drives immunosuppression in ductal pancreatic cancer. [Journal Article]
    Cancer Res. 2023 Jan 31 [Online ahead of print]Faraoni EY, Singh K, … Bailey-Lundberg JM
  • The microenvironment that surrounds pancreatic ductal adenocarcinoma (PDAC) is profoundly desmoplastic and immunosuppressive. Understanding triggers of immunosuppression during the process of pancreatic tumorigenesis would aid in establishing targets for effective prevention and therapy. Here, we interrogated differential molecular mechanisms dependent on cell of origin and subtype that promote i…
  • ENPP1 Immunobiology as a Therapeutic Target. [Journal Article]
    Clin Cancer Res. 2023 Jan 31 [Online ahead of print]Ruiz-Fernandez de Cordoba B, Martinez-Monge R, Lecanda F
  • ENPP1 (Ecto-nucleotide pyrophosphatase/ phosphodiesterase) participates in the hydrolysis of different purine nucleotides in an array of physiological processes. However, ENPP1 is frequently overexpressed in local relapses, and tumor metastases, which associates with poor prognosis and survival in a range of solid tumors. ENPP1 promotes an immunosuppressive tumor microenvironment (TME) by tilting…
  • Mechanism of regulation of the Helicobacter pylori Cagβ ATPase by CagZ. [Journal Article]
    Nat Commun. 2023 Jan 30; 14(1):479.Wu X, Zhao Y, … Wu Y
  • The transport of the CagA effector into gastric epithelial cells by the Cag Type IV secretion system (Cag T4SS) of Helicobacter pylori (H. pylori) is critical for pathogenesis. CagA is recruited to Cag T4SS by the Cagβ ATPase. CagZ, a unique protein in H. pylori, regulates Cagβ-mediated CagA transport, but the underlying mechanisms remain unclear. Here we report the crystal structure of the cytos…
  • Hierarchical stringent response behaviors of activated sludge system to stressed conditions. [Journal Article]
    Sci Total Environ. 2023 Jan 27 [Online ahead of print]Hang Z, Tong P, … Li Z
  • The stringent response of activated sludge systems to either stressed or harmful environments is important for the stable operation of activated sludge, which is examined by taking copper ion (Cu2+) as a stress model in this study. When weak stress was employed (Cu2+ ≤ 2.5 mg/L), the N-acyl-homoserine lactones (AHLs) of C6-, C8-, and C10-HSL increased by 30 %, 13 %, and 127 %, respectively, while…
  • F1Fo adenosine triphosphate (ATP) synthase is a potential drug target in non-communicable diseases. [Review]
    Mol Biol Rep. 2023 Jan 30 [Online ahead of print]Singh V
  • F1Fo adenosine triphosphate (ATP) synthase, also known as the complex V, is the central ATP-producing unit in the cells arranged in the mitochondrial and plasma membranes. F1Fo ATP synthase also regulates the central metabolic processes in the human body driven by proton motive force (Δp). Numerous studies have immensely contributed toward highlighting its regulation in improving energy homeostas…
  • Hemostatic effects of FmocF-ADP hydrogel consisted of Fmoc-Phenylalanine and ADP. [Journal Article]
    Amino Acids. 2023 Jan 30 [Online ahead of print]Qin T, Huang X, … Ding Y
  • During trauma and surgery, bleeding is a major concern. One of the crucial strategies for hemostasis is the use of biological hemostatic material. Herein, we reported an amino acid-based hydrogel FmocF-ADP hydrogel, which consisted of N-[(9H-fluoren-9-ylmethoxy) carbonyl]-3-phenyl-L-alanine (FmocF) and adenosine diphosphate (ADP) sodium solution. The hydrogel was created by FmocF self-assembling …
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