- Metformin induces pyroptosis in leptin receptor-defective hepatocytes via overactivation of the AMPK axis. [Journal Article]Cell Death Dis. 2023 Feb 03; 14(2):82.CD
- Metformin is the biguanide of hepatic insulin sensitizer for patients with non-alcohol fatty liver disease (NAFLD). Findings regarding its efficacy in restoring blood lipids and liver histology have been contradictory. In this study, we explore metformin's preventive effects on NAFLD in leptin-insensitive individuals. We used liver tissue, serum exosomes and isolated hepatocytes from high-fat die…
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- Berberine Alleviates the Damage, Oxidative Stress and Mitochondrial Dysfunction of PC12 Cells Induced by High Glucose by Activating the KEAP1/Nrf2/ARE Pathway. [Journal Article]Mol Biotechnol. 2023 Feb 03 [Online ahead of print]MB
- Diabetic encephalopathy (DE) is one of the major chronic complications of diabetes mellitus. This study aims to investigate the inhibitory effect of berberine (BBR) on the damage of PC12 cells induced by high glucose (HG). Differentiated PC12 cells were treated with different concentrations of glucose/BBR. The cell morphology, cell viability, lactate dehydrogenase (LDH) activity, apoptosis, oxida…
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- Antifungal activity and metabolomics analysis of Piper sarmentosum extracts against Fusarium graminearum. [Journal Article]J Appl Microbiol. 2023 Feb 03 [Online ahead of print]JA
- CONCLUSIONS: PSE is a promising anti-mildew agent that inhibits the growth of F. graminearum in food and feed. PSE (1 and 2 mg ml-1) may exert antifungal properties by inhibiting fungal purine nucleotide synthesis and enhancing the level of L-isoleucine compared with the control groups.
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- Long-term immune reconstitution in ADA-deficient patients treated with elapegademase: a real-world experience. [Journal Article]J Allergy Clin Immunol Pract. 2023 Feb 01 [Online ahead of print]JA
- CONCLUSIONS: REVCOVI® is effective for the management of ADA-SCID.
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- Updated management guidelines for adenosine deaminase deficiency. [Journal Article]J Allergy Clin Immunol Pract. 2023 Feb 01 [Online ahead of print]JA
- Inherited defects in the Adenosine deaminase (ADA) gene typically cause severe combined immunodeficiency (SCID). In addition to infections, ADA-deficient patients can present with neurodevelopmental, behavioral, hearing, skeletal, lung, heart, skin, kidney, urogenital, and liver abnormalities. Some patients also suffer from autoimmunity and malignancies. In recent years, there have been remarkabl…
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- RNA m6A methylation across the transcriptome. [Review]Mol Cell. 2023 Feb 02; 83(3):428-441.MC
- Since the early days of foundational studies of nucleic acids, many chemical moieties have been discovered to decorate RNA and DNA in diverse organisms. In mammalian cells, one of these chemical modifications, N6-methyl adenosine (m6A), is unique in a way that it is highly abundant not only on RNA polymerase II (RNAPII) transcribed, protein-coding transcripts but also on non-coding RNAs, such as …
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- Unique effect of clozapine on adenosine A2A-dopamine D2 receptor heteromerization. [Journal Article]Biomed Pharmacother. 2023 Feb 01; 160:114327.BP
- The striatal dopamine D2 receptor (D2R) is generally accepted to be involved in positive symptoms of schizophrenia and is a main target for clinically used antipsychotics. D2R are highly expressed in the striatum, where they form heteromers with the adenosine A2A receptor (A2AR). Changes in the density of A2AR-D2R heteromers have been reported in postmortem tissue from patients with schizophrenia…
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- Long afterglow particle enables spectral and temporal light management to boost photosynthetic efficiency. [Journal Article]J Colloid Interface Sci. 2023 Jan 20; 638:76-83.JC
- Herein, we develop a strategy of matched spectral and temporal light management to improve photosynthetic efficiency by co-assembling natural thylakoid membrane (TM) with artificial long afterglow particle (LAP). To be specific, LAP with excellent stability and biocompatibility possesses the capabilities of light conversion and storage, optically-matched with the absorption of TM. These favorable…
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- Paroxysmal AF Ablation Using a Novel Variable-Loop Biphasic Pulsed Field Ablation Catheter Integrated With a 3D Mapping System: 1-Year Outcomes of the Multicenter inspIRE Study. [Journal Article]Circ Arrhythm Electrophysiol. 2023 Feb 03 [Online ahead of print]CA
- Background - The inspIRE study evaluated safety and effectiveness of a fully integrated biphasic pulsed field ablation (PFA) system with a variable loop circular catheter for the treatment of drug-refractory paroxysmal atrial fibrillation (AF). Methods - Subjects underwent pulmonary vein isolation (PVI) with the PFA system, using at least 12 applications per vein; adenosine/isoproterenol was admi…
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- Loss of C3a and C5a receptors promotes adipocyte browning and attenuates diet-induced obesity via activating inosine/A2aR pathway. [Journal Article]Cell Rep. 2023 Feb 02; 42(2):112078.CR
- Complement activation is thought to underline the pathologic progression of obesity-related metabolic disorders; however, its role in adaptive thermogenesis has scarcely been explored. Here, we identify complement C3a receptor (C3aR) and C5a receptor (C5aR) as critical switches to control adipocyte browning and energy balance in male mice. Loss of C3aR and C5aR in combination, more than individua…
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- Mechanism of Molecular Activity of Yolkin-a Polypeptide Complex Derived from Hen Egg Yolk-in PC12 Cells and Immortalized Hippocampal Precursor Cells H19-7. [Journal Article]Mol Neurobiol. 2023 Feb 03 [Online ahead of print]MN
- Food-derived bioactive peptides able to regulate neuronal function have been intensively searched and studied for their potential therapeutic application. Our previous study showed that a polypeptide complex yolkin, isolated from hen egg yolk as a fraction accompanying immunoglobulin Y (IgY), improved memory and cognitive functions in rats. However, the mechanism activated by the yolkin is not ex…
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- Dye encapsulation and one-pot synthesis of microporous-mesoporous zeolitic imidazolate frameworks for CO2 sorption and adenosine triphosphate biosensing. [Journal Article]Dalton Trans. 2023 Feb 03 [Online ahead of print]DT
- One-pot co-precipitation of target molecules e.g. organic dyes and the synthesis of a crystal containing microporous-mesoporous regimes of zeolitic imidazolate frameworks-8 (ZIF-8) are reported. The synthesis method can be used for cationic (rhodamine B (RhB), methylene blue (MB)), and anionic (methyl blue (MeB)) dyes. The crystal growth of the ZIF-8 crystals takes place via an intermediate phase…
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- Prenatal exposure to valproic acid induces alterations in the expression and activity of purinergic receptors in the embryonic rat brain. [Journal Article]Folia Neuropathol. 2022; 60(4):390-402.FN
- Purinergic signalling is involved in the control of several processes related to brain development, such as neurogenesis and gliogenesis, migration and differentiation of neuronal precursors, synaptogenesis and synaptic elimination to achieve a fully wired and efficient mature brain. Therefore, any deregulation of purine-dependent signalling mediated by stimulation of specific adenosine and purin…
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- Cancer Cells Employ the Most Prolific RNA Editors: A Closer Look at the Single-Cell Level. [Editorial]
- Adenosine-to-inosine (A-to-I) RNA editing is a major source of nucleotide diversification that has significant mechanistic implications in cancer progression and treatment response. However, its activity and prevalence have not yet been systematically determined at a single-cell resolution. Chan and colleagues revealed widespread A-to-I RNA editing events in single cancer cells through an in-dept…
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- ADATscan - A flexible tool for scanning exomes for wobble inosine-dependent codons reveals a neurological bias for genes enriched in such codons in humans and mice. [Journal Article]MicroPubl Biol. 2023; 2023MB
- The conversion of adenosine to inosine at the wobble position of select tRNAs is essential for decoding specific codons in bacteria and eukarya. In eukarya, wobble inosine modification is catalyzed by the heterodimeric ADAT complex containing ADAT2 and ADAT3. Human individuals homozygous for loss of function variants in ADAT3 exhibit intellectual disability disorders. We created a flexible comput…
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- Ablation of Adar1 in myeloid cells imprints a global antiviral state in the lung and heightens early immunity against SARS-CoV-2. [Journal Article]Cell Rep. 2023 Jan 31; 42(1):112038.CR
- Under normal homeostatic conditions, self-double-stranded RNA (self-dsRNA) is modified by adenosine deaminase acting on RNA 1 (ADAR1) to prevent the induction of a type I interferon-mediated inflammatory cascade. Antigen-presenting cells (APCs) sense pathogen-associated molecular patterns, such as dsRNA, to activate the immune response. The impact of ADAR1 on the function of APCs and the conseque…
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- Reduction of anaerobic glycolysis contributes to angiotensin II-induced podocyte injury with foot process effacement. [Journal Article]Kidney Int. 2023 Jan 30 [Online ahead of print]KI
- Activation of the renin-angiotensin system is associated with podocyte injury and has been well demonstrated as a pivotal factor in the progression of chronic kidney disease. Podocyte energy metabolism is crucial for maintaining their physiological functions. However, whether renin-angiotensin system activation promotes chronic kidney disease progression by disturbing the energy metabolism of pod…
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- The Effect of Adenosine Signaling on Memory Impairment Induced by Pentylenetetrazole in Zebrafish. [Journal Article]Neurochem Res. 2023 Feb 02 [Online ahead of print]NR
- Epilepsy is characterized by the manifestation of spontaneous and recurrent seizures. The high prevalence of comorbidities associated with epilepsy, such as cognitive dysfunction, affects the patients quality of life. Adenosine signaling modulation might be an effective alternative to control seizures and epilepsy-associated comorbidities. This study aimed to verify the role of adenosine modulati…
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- Selenium-enriched foods and their ingredients: As intervention for the vicious cycle between autophagy and overloaded stress responses in Alzheimer's disease. [Journal Article]Crit Rev Food Sci Nutr. 2023 Feb 02 [Online ahead of print]CR
- Dysfunctional autophagy induced by excessive reactive oxygen species (ROS) load and inflammation accelerates the development of Alzheimer's disease (AD). Recently, there has been an increasing interest in selenium-enriched ingredients (SEIs), such as selenoproteins, selenoamino acids and selenosugars, which could improve AD through antioxidant and anti-inflammation, as well as autophagy modulatin…
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- Hair Follicle Survival After Extended Storage in Hypothermic Media Supplemented With Liposomal ATP. [Journal Article]Dermatol Surg. 2023 Feb 01; 49(2):214-215.DS
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- Dual-Cascade Activatable Nanopotentiators Reshaping Adenosine Metabolism for Sono-Chemodynamic-Immunotherapy of Deep Tumors. [Journal Article]Adv Sci (Weinh). 2023 Feb 02 [Online ahead of print]AS
- Immunotherapy is an attractive treatment strategy for cancer, while its efficiency and safety need to be improved. A dual-cascade activatable nanopotentiator for sonodynamic therapy (SDT) and chemodynamic therapy (CDT)-cooperated immunotherapy of deep tumors via reshaping adenosine metabolism is herein reported. This nanopotentiator (NPMCA) is constructed through crosslinking adenosine deaminase …
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- Neuropathic pain: Mechanisms and therapeutic strategies. [Review]
- The physiopathology and neurotransmission of pain are of an owe inspiring complexity. Our ability to satisfactorily suppress neuropathic or other forms of chronic pain is limited. The number of pharmacodynamically distinct and clinically available medications is low and the successes achieved modest. Pain Medicine practitioners are confronted with the ethical dichotomy imposed by Hippocrates: On …
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- Adenosine receptors differentially mediate enteric glial cell death induced by Clostridioides difficile Toxins A and B. [Journal Article]
- Increased risk of intestinal dysfunction has been reported in patients after Clostridioides difficile infection (CDI). Enteric glial cells (EGCs), a component of the enteric nervous system (ENS), contribute to gut homeostasis. Previous studies showed that adenosine receptors, A2A and A2B, modulate inflammation during CDI. However, it is unknown how these receptors can modulate the EGC response to…
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- AMPK Activation Restores Salivary Function Following Radiation Treatment. [Journal Article]J Dent Res. 2023 Feb 01 [Online ahead of print]JD
- Head and neck cancers represent a significant portion of cancer diagnoses, with head and neck cancer incidence increasing in some parts of the world. Typical treatment of early-stage head and neck cancers includes either surgery or radiotherapy; however, advanced cases often require surgery followed by radiation and chemotherapy. Salivary gland damage following radiotherapy leads to severe and ch…
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- Structural basis for substrate selection by the SARS-CoV-2 replicase. [Journal Article]
- The SARS-CoV-2 RNA-dependent RNA polymerase coordinates viral RNA synthesis as part of an assembly known as the replication-transcription complex (RTC)1. Accordingly, the RTC is a target for clinically approved antiviral nucleoside analogues, including remdesivir2. Faithful synthesis of viral RNAs by the RTC requires recognition of the correct nucleotide triphosphate (NTP) for incorporation into …
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- Benzo(a)pyrene-induced mitochondrial respiration and glycolysis disturbance in human neuroblastoma cells. [Journal Article]J Toxicol Sci. 2023; 48(2):87-97.JT
- Mammalian cells generate ATP through mitochondrial respiration and glycolysis. Mitochondria not only play a key role in cell energy metabolism but also in cell cycle regulation. As a neurotoxic pollutant, benzo(a)pyrene (BaP) can trigger neuronal oxidative damage and apoptosis. However, the features of BaP-induced energy metabolism disturbance in SH-SY5Y cells has rarely been addressed. This stud…
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- Comprehensive profiling of endogenous phytohormones and expression analysis of 1-aminocyclopropane-1-carboxylic acid synthase gene family during fruit development and ripening in octoploid strawberry (Fragaria× ananassa). [Journal Article]Plant Physiol Biochem. 2023 Jan 18; 196:186-196.PP
- The non-climacteric octoploid strawberry (Fragaria × ananassa Duchesne ex Rozier) was used as a model to study its regulation during fruit ripening. High performance liquid chromatography electrospray tandem-mass spectrometry (HPLC-ESI-MS/MS) was employed to profile 28 different endogenous phytohormones in strawberry. These include auxins, cytokinins (CKs), abscisic acid (ABA), ethylene precursor…
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- Structural basis of V-ATPase VO region assembly by Vma12p, 21p, and 22p. [Journal Article]Proc Natl Acad Sci U S A. 2023 Feb 07; 120(6):e2217181120.PN
- Vacuolar-type adenosine triphosphatases (V-ATPases) are rotary proton pumps that acidify specific intracellular compartments in almost all eukaryotic cells. These multi-subunit enzymes consist of a soluble catalytic V1 region and a membrane-embedded proton-translocating VO region. VO is assembled in the endoplasmic reticulum (ER) membrane, and V1 is assembled in the cytosol. However, V1 binds VO …
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- The ion transporter Na+-K+-ATPase enables pathological B cell survival in the kidney microenvironment of lupus nephritis. [Journal Article]Sci Adv. 2023 Feb 03; 9(5):eadf8156.SA
- The kidney is a comparatively hostile microenvironment characterized by highsodium concentrations; however, lymphocytes infiltrate and survive therein in autoimmune diseases such as lupus. The effects of sodium-lymphocyte interactions on tissue injury in autoimmune diseases and the mechanisms used by infiltrating lymphocytes to survive the highsodium environment of the kidney are not known. Here,…
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- NMR metabolomics analysis of Escherichia coli cells treated with Turkish propolis water extract reveals nucleic acid metabolism as the major target. [Journal Article]J Appl Microbiol. 2022 Dec 14 [Online ahead of print]JA
- CONCLUSIONS: Our results suggest that PWE inhibits the growth of E. coli BW25113 by affecting nucleic acid metabolism to a great extent. To the best of our knowledge, this is the first study to evaluate the global metabolic response of a bacterium to propolis.
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