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299,417 results
  • Updated management guidelines for adenosine deaminase deficiency. [Journal Article]
    J Allergy Clin Immunol Pract. 2023 Feb 01 [Online ahead of print]Grunebaum E, Booth C, … Kohn DB
  • Inherited defects in the Adenosine deaminase (ADA) gene typically cause severe combined immunodeficiency (SCID). In addition to infections, ADA-deficient patients can present with neurodevelopmental, behavioral, hearing, skeletal, lung, heart, skin, kidney, urogenital, and liver abnormalities. Some patients also suffer from autoimmunity and malignancies. In recent years, there have been remarkabl…
  • RNA m6A methylation across the transcriptome. [Review]
    Mol Cell. 2023 Feb 02; 83(3):428-441.Sendinc E, Shi Y
  • Since the early days of foundational studies of nucleic acids, many chemical moieties have been discovered to decorate RNA and DNA in diverse organisms. In mammalian cells, one of these chemical modifications, N6-methyl adenosine (m6A), is unique in a way that it is highly abundant not only on RNA polymerase II (RNAPII) transcribed, protein-coding transcripts but also on non-coding RNAs, such as …
  • Unique effect of clozapine on adenosine A2A-dopamine D2 receptor heteromerization. [Journal Article]
    Biomed Pharmacother. 2023 Feb 01; 160:114327.Valle-León M, Casajuana-Martin N, … Ciruela F
  • The striatal dopamine D2 receptor (D2R) is generally accepted to be involved in positive symptoms of schizophrenia and is a main target for clinically used antipsychotics. D2R are highly expressed in the striatum, where they form heteromers with the adenosine A2A receptor (A2AR). Changes in the density of A2AR-D2R heteromers have been reported in postmortem tissue from patients with schizophrenia…
  • Cancer Cells Employ the Most Prolific RNA Editors: A Closer Look at the Single-Cell Level. [Editorial]
    Cancer Res. 2023 Feb 03; 83(3):351-353.Luo Y, Liang H
  • Adenosine-to-inosine (A-to-I) RNA editing is a major source of nucleotide diversification that has significant mechanistic implications in cancer progression and treatment response. However, its activity and prevalence have not yet been systematically determined at a single-cell resolution. Chan and colleagues revealed widespread A-to-I RNA editing events in single cancer cells through an in-dept…
  • The Effect of Adenosine Signaling on Memory Impairment Induced by Pentylenetetrazole in Zebrafish. [Journal Article]
    Neurochem Res. 2023 Feb 02 [Online ahead of print]Bertoncello KT, Bonan CD
  • Epilepsy is characterized by the manifestation of spontaneous and recurrent seizures. The high prevalence of comorbidities associated with epilepsy, such as cognitive dysfunction, affects the patients quality of life. Adenosine signaling modulation might be an effective alternative to control seizures and epilepsy-associated comorbidities. This study aimed to verify the role of adenosine modulati…
  • Neuropathic pain: Mechanisms and therapeutic strategies. [Review]
    Front Cell Dev Biol. 2023; 11:1072629.Petroianu GA, Aloum L, Adem A
  • The physiopathology and neurotransmission of pain are of an owe inspiring complexity. Our ability to satisfactorily suppress neuropathic or other forms of chronic pain is limited. The number of pharmacodynamically distinct and clinically available medications is low and the successes achieved modest. Pain Medicine practitioners are confronted with the ethical dichotomy imposed by Hippocrates: On …
  • AMPK Activation Restores Salivary Function Following Radiation Treatment. [Journal Article]
    J Dent Res. 2023 Feb 01 [Online ahead of print]Meyer RK, Gilman KE, … Limesand KH
  • Head and neck cancers represent a significant portion of cancer diagnoses, with head and neck cancer incidence increasing in some parts of the world. Typical treatment of early-stage head and neck cancers includes either surgery or radiotherapy; however, advanced cases often require surgery followed by radiation and chemotherapy. Salivary gland damage following radiotherapy leads to severe and ch…
  • Structural basis for substrate selection by the SARS-CoV-2 replicase. [Journal Article]
    Nature. 2023 Feb 01 [Online ahead of print]Malone BF, Perry JK, … Darst SA
  • The SARS-CoV-2 RNA-dependent RNA polymerase coordinates viral RNA synthesis as part of an assembly known as the replication-transcription complex (RTC)1. Accordingly, the RTC is a target for clinically approved antiviral nucleoside analogues, including remdesivir2. Faithful synthesis of viral RNAs by the RTC requires recognition of the correct nucleotide triphosphate (NTP) for incorporation into …
  • Structural basis of V-ATPase VO region assembly by Vma12p, 21p, and 22p. [Journal Article]
    Proc Natl Acad Sci U S A. 2023 Feb 07; 120(6):e2217181120.Wang H, Bueler SA, Rubinstein JL
  • Vacuolar-type adenosine triphosphatases (V-ATPases) are rotary proton pumps that acidify specific intracellular compartments in almost all eukaryotic cells. These multi-subunit enzymes consist of a soluble catalytic V1 region and a membrane-embedded proton-translocating VO region. VO is assembled in the endoplasmic reticulum (ER) membrane, and V1 is assembled in the cytosol. However, V1 binds VO …
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