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Unbound Medicine.
(Adenovirus infections)
13,346 results
  • The APOBEC3B cytidine deaminase is an adenovirus restriction factor. [Journal Article]
    PLoS Pathog. 2023 Feb 06; 19(2):e1011156.Lejeune N, Mathieu S, … Gillet NA
  • Human adenoviruses (HAdVs) are a large family of DNA viruses counting more than a hundred strains divided into seven species (A to G). HAdVs induce respiratory tract infections, gastroenteritis and conjunctivitis. APOBEC3B is a cytidine deaminase that restricts several DNA viruses. APOBEC3B is also implicated in numerous cancers where it is responsible for the introduction of clustered mutations …
  • Role of Polymerase Chain Reaction-Based Diagnosis of Respiratory Viruses in Febrile Neutropenic Patients. [Journal Article]
    Cureus. 2023 Jan; 15(1):e33314.Madhuravasal Krishnan J, Jayaraman D, … Scott JX
  • Background Neutropenic patients are commonly affected by respiratory infections, whereas respiratory viral infections causing high morbidity and mortality are routinely diagnosed in developing countries like India. Our study aimed to investigate the prevalence of respiratory viral infections in pediatric cancer patients with febrile neutropenia.  Methods This prospective study was performed on 45…
  • Duck cGAS inhibits DNA and RNA virus replication by activating IFNs and antiviral ISGs. [Journal Article]
    Front Immunol. 2023; 14:1101335.Lin C, Zheng M, … Chen S
  • Cyclic GMP-AMP Synthase (cGAS) is a pivotal adaptor of the signaling pathways involving the pattern recognition receptors and plays an important role in apoptosis and immune regulation. The cGAS function in mammals has been investigated extensively; however, the function of duck cGAS (du-cGAS) in response to viral infections is still unclear. This study aimed to clone the mallard (Anas platyrhync…
  • Circulation of respiratory viruses during the COVID-19 pandemic in The Gambia. [Journal Article]
    Gates Open Res. 2022; 6:148.Jarju S, Senghore E, … de Silva TI
  • Background: In many countries, non-pharmaceutical interventions to limit severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) transmission resulted in significant reductions in other respiratory viruses. However, similar data from Africa are limited. We explored the extent to which viruses such as influenza and rhinovirus co-circulated with SARS-CoV-2 in The Gambia during the COVID-19 pan…
  • Respiratory Virus Infections during the COVID-19 Pandemic Revealed by Multiplex PCR Testing in Japan. [Journal Article]
    Microbiol Spectr. 2023 Feb 01 [Online ahead of print]Yamashita S, Ikegame S, … Koto H
  • Under the strict quarantine policy imposed to combat the COVID-19 (coronavirus disease 2019) pandemic in Japan, the prevalence of respiratory infections by viruses other than SARS-CoV-2 (severe acute respiratory syndrome coronavirus 2) has been largely unknown. However, such information on viral circulation is important in order to develop better management policies that are based on scientific d…
  • Inhibition of PIKFYVE kinase interferes ESCRT pathway to suppress RNA virus replication. [Journal Article]
    J Med Virol. 2023 Jan 25 [Online ahead of print]Luo Z, Liang Y, … Wu J
  • ESCRT (Endosomal sorting complex required for transport) is essential in the functional operation of endosomal transport in envelopment and budding of enveloped RNA viruses. However, in non-enveloped RNA viruses such as enteroviruses of the Picornaviridae family, the precise function of ESCRT pathway in viral replication remains elusive. Here, we initially evaluated that ESCRT pathway is importan…
  • Acute Liver Failure in a Child With Adenovirus Detected by PCR in the Explanted Liver. [Case Reports]
    Pediatrics. 2023 Feb 01; 151(2)Boster JM, Dominguez SR, … Feldman AG
  • As of June 15, 2022, the Centers for Disease Control and Prevention has reported 296 pediatric patients under investigation for hepatitis of unknown etiology in the United States; the World Health Organization has reported 650 probable cases worldwide. One of the leading hypotheses for this cluster of cases is adenovirus, a virus that commonly causes respiratory or gastrointestinal symptoms in he…
  • Viral and Bacterial Respiratory Pathogens during the COVID-19 Pandemic in Israel. [Journal Article]
    Microorganisms. 2023 Jan 09; 11(1)Oster Y, Abu Ahmad W, … Elinav H
  • CONCLUSIONS: After an immediate decline in non-SARS-CoV-2 respiratory infections, each pathogen has a different pattern during a 2-year follow-up. These patterns might be influenced by intrinsic factors of each pathogen and different risk reduction behaviors of the population. Since some of these measures will remain in the following years, we cannot predict the timing of return to pre-COVID-19 normalcy.
  • CXADR: From an Essential Structural Component to a Vital Signaling Mediator in Spermatogenesis. [Review]
    Int J Mol Sci. 2023 Jan 09; 24(2)Zhang Y, Lui WY
  • Canonical coxsackievirus and adenovirus receptor (CXADR) is a transmembrane component of cell junctions that is crucial for cardiac and testicular functions via its homophilic and heterophilic interaction. CXADR is expressed in both Sertoli cells and germ cells and is localized mainly at the interface between Sertoli-Sertoli cells and Sertoli-germ cells. Knockout of CXADR in mouse Sertoli cells s…
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