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(Administering Medications to Children)
343 results
  • Development of an Inline Dry Powder Inhaler for Oral or Trans-Nasal Aerosol Administration to Children. [Journal Article]
    J Aerosol Med Pulm Drug Deliv 2019Farkas D, Hindle M, … Longest W
  • CONCLUSIONS: In conclusion, this study has proposed and initially developed an efficient inline DPI for delivering spray-dried formulations to children using positive pressure operation. Actuation of the device with positive pressure enabled effective N2L aerosol administration with a DPI, which may be beneficial for subjects who are too young to use a mouthpiece or to simultaneously treat the nasal and lung airways of older children.
  • Metabolic bone disease of prematurity: causes, recognition, prevention, treatment and long-term consequences. [Review]
    Arch Dis Child Fetal Neonatal Ed 2019; 104(5):F560-F566Chinoy A, Mughal MZ, Padidela R
  • Metabolic bone disease of prematurity (MBDP) is characterised by skeletal demineralisation, and in severe cases it can result in fragility fractures of long bones and ribs during routine handling. MBDP arises from prenatal and postnatal factors. Infants who are born preterm are deprived of fetal mineral accumulation, 80% of which occurs in the third trimester. Postnatally, it is difficult to main…
  • Extraskeletal Calcifications in Hutchinson-Gilford Progeria Syndrome. [Journal Article]
    Bone 2019; 125:103-111Gordon CM, Cleveland RH, … Gordon LB
  • CONCLUSIONS: Extraskeletal calcifications increased with age in children with HGPS and were composed of hydroxyapatite. The urinary calcium/creatinine ratio and TRP were elevated for age while FGF23 was decreased. Magnesium decreased and PTH increased after lonafarnib therapy which may alter the ability to mobilize calcium. These findings demonstrate that children with HGPS with normal renal function and an unremarkable Ca × Pi develop extraskeletal calcifications by an unidentified mechanism that may involve decreased plasma magnesium and FGF23. Calcium carbonate accelerated their development and is, therefore, not recommended for routine supplementation in these children.
  • Radix Sophorae flavescentis versus no intervention or placebo for chronic hepatitis B. [Journal Article]
    Cochrane Database Syst Rev 2019; 4:CD013089Liang N, Kong Z, … Liu JP
  • CONCLUSIONS: The included trials lacked data on health-related quality of life, hepatitis B-related mortality, and hepatitis B-related morbidity. The effects of Radix Sophorae flavescentis on all-cause mortality and on the proportion of participants with serious adverse events and adverse events considered 'not to be serious' remain unclear. We advise caution in interpreting results showing that Radix Sophorae flavescentis reduced the proportion of people with detectable HBV-DNA and detectable HBeAg because the trials reporting on these outcomes are at high risk of bias and both outcomes are non-validated surrogate outcomes. We were unable to obtain information on the design and conduct of a large number of trials; therefore, we were deterred from including them in our review. Undisclosed funding may influence trial results and may lead to poor trial design. Given the wide usage of Radix Sophorae flavescentis, we need large, unbiased, high-quality placebo-controlled randomised trials in which patient-centred outcomes are assessed.
  • Care performed by family caregivers of children submitted to hematopoietic stem cell transplantation. [Journal Article]
    Rev Lat Am Enfermagem 2019; 27:e3120Gomes IM, Lacerda MR, … Tonin L
  • CONCLUSIONS: the different aspects in which the caregiver acts in the care of the child were understood. Such care equips the health team to elaborate measures for guidance and preparation of home care that are effective and directed to the needs of the patient and their family. The understanding of the care that they accomplish enables the caregiver a greater understanding of their role, as well as of the decisions they will make by their being under treatment.
  • Pyronaridine-artesunate for treating uncomplicated Plasmodium falciparum malaria. [Meta-Analysis]
    Cochrane Database Syst Rev 2019; 1:CD006404Pryce J, Hine P
  • CONCLUSIONS: Pyronaridine-artesunate was efficacious against uncomplicated P falciparum malaria, achieved a PCR-adjusted treatment failure rate of less than 5% at days 28 and 42, and may be at least as good as, or better than other marketed ACTs.Pyronaridine-artesunate increases the risk of episodes of raised ALT > 5 x ULN. This meets criteria for mild drug-induced liver injury. On one instance this was linked to raised bilirubin, indicating moderate drug-induced liver injury. No episodes of severe drug-induced liver injury were reported. The findings of this review cannot fully inform a risk-benefit assessment for an unselected population. Readers should remain aware of this uncertainty when considering use of pyronaridine-artesunate in patients with known or suspected pre-existing liver dysfunction, and when co-administering with other medications which may cause liver dysfunction.
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