- [A Case of Recurrent Gastric Cancer of Multiple Organ Metastasis with Long-Term Survival Due to Multimodal Treatment]. [Case Reports]Gan To Kagaku Ryoho. 2022 Dec; 49(13):1730-1732.GT
- A 67-year-old man was introduced to examine for abnormal findings in physical examination. Upper gastrointestinal endoscopy detected the 3 lesions and diagnosed multiple gastric cancers with biopsy. Laparoscopic total gastrectomy was performed and final pathological diagnosis was pT2N1M0, pStage ⅡA with HER2 positive(3+). Adjuvant chemotherapy was not administrated. CT findings 6 months after pro…
- Central nervous system involvement at initial diagnosis of extranodal NK/T-cell lymphoma: a retrospective study of a consecutive 12-year case series. [Journal Article]Ann Hematol. 2023 Feb 02 [Online ahead of print]AH
- Patients with central nervous system (CNS) involvement at initial diagnosis of extranodal NK/T-cell lymphoma (ENKTL) are exceedingly rare, and the clinicopathologic features of CNS involvement have not been well characterized. In this study, we reviewed 662 patients with ENKTL from August 2008 to September 2019. Their clinical and pathological features, treatments, and survival outcomes were anal…
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- Meta-analysis of reported presacral myelolipomas, including a report of a new case. [Case Reports]
- CONCLUSIONS: Presacral myelolipomas are rare and its etiology remains unclear. Surgical resection is indicated in symptomatic lesions and lesions > 4 cm. More clinical and pathological research on this rare entity is warranted.
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- Dynamic Total-Body PET/CT Imaging Reveals Kinetic Distribution of 68Ga-DOTATATE in Normal Organs. [Journal Article]
- CONCLUSIONS: Uptake and clearance of 68Ga-DOTATATE, in terms of kinetic constants, were different in different organs. The kinetic parameters of 68Ga-DOTATATE in different organs provide a reference for future dynamic PET imaging.
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- Relative adrenal insufficiency is a risk factor and endotype of sepsis - A proof-of-concept study to support a precision medicine approach to guide glucocorticoid therapy for sepsis. [Journal Article]
- 25-60% of septic patients experience relative adrenal insufficiency (RAI) and glucocorticoid (GC) is frequently used in septic patients. However, the efficacy of GC therapy and whether GC therapy should be based on the status of RAI are highly controversial. Our poor understanding about the pathogenesis of RAI and a lack of RAI animal model present significant barriers to address these critical i…
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- Surgical findings and outcomes after unilateral adrenalectomy for primary hyperaldosteronism in cats: a multi-institutional retrospective study. [Multicenter Study]J Feline Med Surg. 2023 Jan; 25(1):1098612X221135124.JF
- CONCLUSIONS: Adrenalectomy appears to be a safe and effective treatment with a high rate of survival and a low rate of major complications. Long-term medical treatment was not required.
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- Acute psychotic episode inaugurating a primary hyperaldosteronism: a case report. [Case Reports]Pan Afr Med J. 2022; 43:103.PA
- Psychiatrist manifestations-especially acute psychotic episode-of primary hyperaldosteronism is not very common in the scientific literature. The main symptoms are high blood pressure and hypokalemia, the diagnosis seems to be based on the determination of aldosterone and plasma renin activity, also the treatment includes majorly adrenalectomy. The take-away lesson from this case is to think of o…
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- Hypoxia signaling pathway: A central mediator in endocrine tumors. [Review]
- Adequate oxygen levels are essential for the functioning and maintenance of biological processes in virtually every cell, albeit based on specific need. Thus, any change in oxygen pressure leads to modulated activation of the hypoxia pathway, which affects numerous physiological and pathological processes, including hematopoiesis, inflammation, and tumor development. The Hypoxia Inducible Factors…
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- [Morphological predictors of the efficacy of mitotane therapy in adrenocortical cancer]. [Journal Article]Probl Endokrinol (Mosk). 2023 Jan 08; 68(6):76-88.PE
- CONCLUSIONS: Consistent with the findings in our study, low expression of RRM1, CYP2W1 and SOAT1 was associated with worse DFS with antitumor therapy. The results of the work indicate the need to assess the levels of immunoreactivity of these markers in patients with ACC before starting treatment with mitotane in order to predict the efficiency of therapy.
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- Two-institution results of Stereotactic Body Radiation Therapy (SBRT) for treating adrenal gland metastases from liver cancer. [Journal Article]
- CONCLUSIONS: Our results suggest that SBRT is a safe and effective technique to treat AGM from liver cancer, especially for small GTV (< 34.5ml). Moreover, the small metastatic lesion volume, fewer metastatic lesions, and intervention of systemic therapy are more likely to improve OS.
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- Adrenal Gland Primary Neuroblastoma in an Adult Patient: A Case Report and Literature Review. [Case Reports]
- Neuroblastoma (NB) is an undifferentiated malignant tumor of the sympathetic ganglia, occurring in children under 5 years of age. However, it is a rare histology in adult patients, occurring once per every 10 million patients per year. We present the case of a 68-year-old male patient presented to our department for right lumbar pain, asthenia, loss of weight and altered general status. The contr…
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- The Role of Glucocorticoids in Breast Cancer Therapy. [Review]
- Glucocorticoids (GCs) are anti-inflammatory and immunosuppressive steroid molecules secreted by the adrenal gland and regulated by the hypothalamic-pituitary-adrenal (HPA) axis. GCs present a circadian release pattern under normal conditions; they increase their release under stress conditions. Their mechanism of action can be via the receptor-independent or receptor-dependent pathway. The recept…
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- Favourable prognosis in metastatic adrenal carcinoma: An unexpected outcome. [Case Reports]J Pak Med Assoc. 2022 Oct; 72(10):2101-2104.JP
- The case of a 45-year-old male patient diagnosed with European Network for the Study of Adrenal Tumours (ENSAT) criteria, stage IV adrenocortical carcinoma (ACC) with unexpectedly prolonged survival is being reported. The patient underwent resection of stage IV ACC and despite suboptimal adherence to postoperative mitotane and chemotherapy, had a prolonged survival spanning almost seven years. Th…
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- Intraluminal Small Bowel Metastasis From Primary Lung Cancer. [Case Reports]
- Lung cancer is the leading cause of cancer-related death worldwide, with frequent metastases to the brain, liver, adrenal glands, and bone. The incidence of intraluminal small bowel metastases of the lung is extremely rare and poorly documented within the literature. Few case studies have been published since the late 1980s and early 1990s. However, little is known about this rare form of metasta…
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- Laparoscopic left nephro-adrenalectomy for renal vein leiomyosarcoma using (ICG) fluorescence and 3D-CT reconstruction: A case report. [Case Reports]Ann Ital Chir. 2022 Dec 06; 11AI
- CONCLUSIONS: In this case, use intraoperative ICG fluorescence associated with preoperative 3D-CT was a valuable support for surgery.
- Adrenocortical carcinoma metastasis. A long story. [Case Reports]Ann Ital Chir. 2022 Dec 27; 11AI
- CONCLUSIONS: This is a very unusual case of double ACC metastases, discovered after the end of standard follow-up and locally treated. The patient is recurrence-free 12 months after these procedures. Minimally invasive approach to treat symptomatic cholecystectomy was used in order to avoid pancreato-biliary complications. This study emphasized the necessity to realize tailored protocols for the follow-up of rare neoplasia, as ACC.
- The management of postoperative disease recurrence in patients with adrenocortical carcinoma: a retrospective study in 106 patients. [Journal Article]Eur J Endocrinol. 2023 Jan 10; 188(1)EJ
- CONCLUSIONS: This study shows that patients with ACC have a better prognosis when the disease recurs as a single lesion and supports the use of locoregional treatments to treat disease recurrence.
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- [Adrenal tumors: diagnostics, perioperative management and surgical treatment]. [Journal Article]Urologie. 2023 Jan 18 [Online ahead of print]U
- Space-occupying lesions of the adrenal glands are one of the most frequent tumors; however, only a fraction of approximately 20% need further diagnostics and treatment. The diagnostic standard is native computed tomography (CT). For larger tumors and those that cannot be clearly classified as benign, the supplementary radiological modalities magnetic resonance imaging (MRI), contrast CT and 18F-f…
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- Volume-outcome relationship in adrenal surgery from 2009-2017 in Germany-a retrospective study. [Journal Article]Eur J Endocrinol. 2023 Jan 10; 188(1)EJ
- CONCLUSIONS: The annual caseload of adrenal resections varies considerably among German hospitals. Our findings suggest that surgery in high-volume centers is advantageous for patient outcomes although fatal complications are rare.
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- Intracardiac paraganglioma with a cough as the first symptom. [Case Reports]
- CONCLUSIONS: Pheochromocytomas and paragangliomas (PPGLs) are a kind of neuroendocrine tumors. PPGLs can cause secondary hypertension, and lead to a series of clinical syndromes, including myocardial injury, metabolic changes, and so on. The occurrence of PPGIs is related to gene mutation. Biochemical detection, imaging examination, and genetic testing can help diagnose. The tumor should be surgically removed as soon as possible after the diagnosis. As a functional tumor, PPGLs should be fully prepared before surgery to avoid anesthesia and huge fluctuations in blood pressure during and after surgery, or the occurrence of fatal hypertensive crisis and intractable hypotension after tumor resection. Adequate preoperative preparation directly affects the prognosis of patients after surgery. Therefore, multidisciplinary cooperation before, during, and after the operation is extremely important.
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- Transfer of Injected Triamcinolone into Human Milk of a Lactating Patient Suffering from Idiopathic Granulomatous Mastitis. [Case Reports]Breastfeed Med. 2023 Jan; 18(1):74-77.BM
- Background: Idiopathic granulomatous mastitis (IGM) is a chronic inflammatory condition of the mammary gland that presents as a painful mass, and it must be distinguished from both infectious mastitis and breast cancer. When diagnosed during lactation, it can result in significant distress and early weaning. Injection of triamcinolone has been used as a successful treatment method, but safety in …
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- The diagnosis and management of pheochromocytoma and paraganglioma during pregnancy. [Review]
- Diagnosis of pheochromocytoma or paraganglioma (PPGL) in pregnancy has been associated historically with high rates of materno-fetal morbidity and mortality. Recent evidence suggests outcomes are improved by recognition of PPGL before or during pregnancy and appropriate medical management with alpha-blockade. Whether antepartum surgery (before the third trimester) is required remains controversia…
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- Targeting of a New Node in Lipid Metabolism as a Potential Treatment Strategy for ACC. [Editorial]
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- Laparoscopic adrenalectomy of pheochromocytoma following management of severe aortic stenosis with transcatheter aortic valve replacement under monitored anesthesia care sedation: a case report. [Case Reports]
- CONCLUSIONS: This case report demonstrated the successful approach of managing severe aortic stenosis through a transcatheter aortic valve replacement using monitored anesthesia care sedation prior to laparoscopic adrenalectomy of a symptomatic pheochromocytoma.
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- [A Long-Term Survival Case of Paraganglioma Treated with Repeated Surgical Resection]. [Case Reports]Hinyokika Kiyo. 2022 Dec; 68(12):385-390.HK
- We report a case of long-term survival in paraganglioma treated with repetitive surgery. A 32-year-old man was seen at the hospital because of hypertension and headache. On biochemical tests, elevated serum and urinary levels of noradrenaline were noted. Abdominal computed tomographic (CT) scan revealed a tumor 50 mm in diameter on the dorsal region of the inferior vena cava, superior to the rena…
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- Same-day comparative protocol PET/CT-PET/MRI [68 Ga]Ga-DOTA-TOC in paragangliomas and pheochromocytomas: an approach to personalized medicine. [Journal Article]
- CONCLUSIONS: PET/MRI showed minor advantages over conventional PET/CT in the detection of new lesions but increased the intensity of SSRs expression in a significant number of them, opening the door to select which patients and clinical settings can benefit from performing PET/MRI.
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- Adrenocortical carcinoma with venous tumor invasion: is there a role for mini-invasive surgery? [Journal Article]Langenbecks Arch Surg. 2023 Jan 10; 408(1):17.LA
- CONCLUSIONS: The DFS of patients with VI from ACC is influenced by the staging and the extension of the venous invasion; the staging influences the OS. The mini-invasive approach seems feasible in selected patients; however, further studies investigating the oncological outcomes are needed. A mini-invasive approach for adrenal tumors with venous invasion is an explorable option in very selected patients.
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- Huge Hematoma as First Manifestation of Adrenocortical Carcinoma: A Case Report. [Case Reports]Am J Case Rep. 2023 Jan 09; 24:e937569.AJ
- BACKGROUND Adrenocortical carcinoma (ACC) is a rare malignancy associated with unfavorable prognosis. It is mainly diagnosed in the fifth or sixth decade of life. Symptoms of ACC are associated with hormonal activity, presence of metastases, and size of the tumor. The treatment and prognosis depend on the stage of the disease assessed with the ENSAT staging system. CASE REPORT A 38-year-old White…
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- Commentary on "Laparoscopic approach of pediatric adrenal tumors". [Letter]
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- Stereotactic MR-Guided Radiotherapy for Adrenal Gland Metastases: First Clinical Results. [Journal Article]
- Stereotactic MR-guided Radiotherapy (MRgRT) is an interesting treatment option for adrenal gland metastases (AGM). We reviewed data from 12 consecutive patients treated with MRgRT for an AGM in our center between 14 November 2019 and 17 August 2021. Endpoints were tolerance assessment, the impact of adaptive treatment on target volume coverage and organs at risk (OAR) sparing, local control (LC),…
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