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(Adrenal insufficiency chronic)
1,795 results
  • Paracoccidioidomycosis and Addison's syndrome - case report. [Journal Article]
    Trop Doct. 2023 Jan 30 [Online ahead of print]Lazzaretti GS, Sena LMC, … Reichert PR
  • Paracoccidioidomycosis is caused by a fungus (Paracoccidioides brasiliensis), which is endemic to Brazil. It is most frequently found in the lungs, with haematogenous and lymphatic spread. The condition is more prevalent in men, between 30 and 60 years old, commonly rural workers. It is the third leading cause of death among chronic infectious diseases today. The systemic disease has an insidious…
  • Variations in cortisol response in patients with known and suspected adrenal insufficiency. [Journal Article]
    Medicine (Baltimore). 2022 Dec 30; 101(52):e32557.Mahzari M, AlSohaim A, … Saleh Y
  • Adrenal insufficiency (AI) is a relatively rare disease. While the adrenocorticotropic hormone (ACTH) stimulation test remains as one of the commonly used diagnostic test for AI, to date there is no consensus on the cortisol cutoff value post-ACTH stimulation test. This study aimed to investigate and characterize the cortisol response after the standard ACTH stimulation test in a group of Saudi A…
  • Alteration in glucocorticoids secretion and metabolism in patients affected by cystic fibrosis. [Journal Article]
    Front Endocrinol (Lausanne). 2022; 13:1074209.Podgórski R, Sumińska M, … Mazur A
  • Cystic fibrosis (CF) is an inherited syndrome associated with a mutation in a cystic fibrosis transmembrane conductance regulator gene, composed of exocrine gland dysfunction involving multiple systems that may result in chronic respiratory infections, pancreatic enzyme deficiency, and developmental disorders. Our study describes for the first time the urinary profile of glucocorticoid metabolite…
  • Saturated very long-chain fatty acids regulate macrophage plasticity and invasiveness. [Journal Article]
    J Neuroinflammation. 2022 Dec 17; 19(1):305.Zierfuss B, Buda A, … Weinhofer I
  • Saturated very long-chain fatty acids (VLCFA, ≥ C22), enriched in brain myelin and innate immune cells, accumulate in X-linked adrenoleukodystrophy (X-ALD) due to inherited dysfunction of the peroxisomal VLCFA transporter ABCD1. In its severest form, X-ALD causes cerebral myelin destruction with infiltration of pro-inflammatory skewed monocytes/macrophages. How VLCFA levels relate to macrophage a…
  • Seizure from water intoxication following bowel preparation: a case report. [Case Reports]
    BMC Nephrol. 2022 12 15; 23(1):402.Chiang TH, Tan JH, … Fang KC
  • CONCLUSIONS: In addition to the use of certain well-documented medications and the presence of comorbidities that can lead to hyponatremia, clinicians should also be aware of the use of desmopressin as an important risk factor. Thorough history taking can guide individualized bowel preparation regimens to minimize the risk of undesired complications.
  • Case Report of Disseminated Adrenal Histoplasmosis and Secondary Adrenal Insufficiency. [Case Reports]
    Cureus. 2022 Oct; 14(10):e30614.Jagadish I, Chen WJ, … Shoela R
  • Histoplasmosis is a chronic, infectious disease caused by the environmental fungus H. capsulatum, primarily affecting the respiratory system. In immunocompromised patients, histoplasmosis can become severely complicated due to dissemination into various other organ systems. Adrenal insufficiency is an uncommon complication of disseminated histoplasmosis, as its manifestation requires necrotizing …
  • StatPearls: Adrenal Insufficiency (Nursing) [BOOK]
    StatPearls. StatPearls Publishing: Treasure Island (FL)Huecker MR, Bhutta BS, … Bossuah KABOOK
  • Adrenal insufficiency ranges from mild nonspecific symptoms to life-threatening shock condition. Adrenal insufficiency is a diagnosis that will not be made unless the clinician maintains a level of suspicion. The decreasing or suppressed adrenal function may be masked until stress or illness triggers an adrenal crisis.[1][2][3] An important distinction in these patients is the presence of mineral…
  • StatPearls: Adrenal Insufficiency [BOOK]
    StatPearls. StatPearls Publishing: Treasure Island (FL)HueckerMartin R.MRUniversity of LouisvilleBhuttaBeenish S.BSSheikh Zayed Hospital, LahoreDominiqueElvitaEWyckoff Heights Medical CenterBOOK
  • The adrenal gland is made up of two parts, the cortex and the medulla. The adrenal cortex produces hormones necessary for normal body functioning; deficiency of these hormones results in adrenal insufficiency. The cortex is responsible for producing glucocorticoids, mineralocorticoids, and androgens. Destruction or dysfunction of the adrenal cortex mainly causes glucocorticoid and mineralocortico…
  • Long-Term Toxicities of Immune Checkpoint Inhibitor (ICI) in Melanoma Patients. [Journal Article]
    Curr Oncol. 2022 10 20; 29(10):7953-7963.Tong J, Kartolo A, … Baetz T
  • ICI therapy has greatly improved patient outcomes in melanoma, but at the cost of immune-related adverse events (irAEs). Data on the chronicity of irAEs, especially in real-world settings, are currently limited. We performed a retrospective chart review of 161 adult patients with melanoma treated with at least one cycle of ICI regimen in the adjuvant or metastatic setting: 129 patients received P…
  • Recurrence of Hypophysitis After Immune Checkpoint Inhibitor Rechallenge. [Case Reports]
    Oncologist. 2022 Dec 09; 27(12):e967-e969.Park BC, Jung S, … Johnson DB
  • Immune checkpoint inhibitor (ICI)-induced hypophysitis is an immune-mediated pituitary inflammation that tends to cause long-term pituitary deficiency. Management of ICI-induced hypophysitis includes corticosteroids for acute inflammation and long-term hormone replacement due to irreversible pituitary cell damage. We report a case of recurrent hypophysitis following ICI rechallenge for metastatic…
  • Aldosterone in chronic kidney disease and renal outcomes. [Journal Article]
    Eur Heart J. 2022 10 11; 43(38):3781-3791.Verma A, Vaidya A, … Waikar SS
  • CONCLUSIONS: Higher serum aldosterone levels among individuals with CKD are independently associated with an increased risk for kidney disease progression, irrespective of concomitant diabetes. These findings provide mechanistic support for MR antagonists in delaying CKD progression and suggest that they may also have a role in those without diabetes.
  • Current Medical Treatment for Alcohol-Associated Liver Disease. [Review]
    J Clin Exp Hepatol. 2022 Sep-Oct; 12(5):1333-1348.Ayares G, Idalsoaga F, … Arab JP
  • Alcohol-associated liver disease is one of the main causes of chronic liver disease. It comprises a clinical-histologic spectrum of presentations, from steatosis, steatohepatitis, to different degrees of fibrosis, including cirrhosis and severe necroinflammatory disease, called alcohol-associated hepatitis. In this focused update, we aim to present specific therapeutic interventions and strategie…
  • Approach of Heterogeneous Spectrum Involving 3beta-Hydroxysteroid Dehydrogenase 2 Deficiency. [Review]
    Diagnostics (Basel). 2022 Sep 07; 12(9)Nicola AG, Carsote M, … Tircă T
  • We aim to review data on 3beta-hydroxysteroid dehydrogenase type II (3βHSD2) deficiency. We identified 30 studies within the last decade on PubMed: 1 longitudinal study (N = 14), 2 cross-sectional studies, 1 retrospective study (N = 16), and 26 case reports (total: 98 individuals). Regarding geographic area: Algeria (N = 14), Turkey (N = 31), China (2 case reports), Morocco (2 sisters), Anatolia …
  • New Approach to Addison Disease: Oral Manifestations Due to Endocrine Dysfunction and Comorbidity Burden. [Review]
    Diagnostics (Basel). 2022 Aug 28; 12(9)Bugălă NM, Carsote M, … Alexandru DO
  • This review highlights oral anomalies with major clinical impact in Addison disease (AD), including dental health and dermatologic features, through a dual perspective: pigmentation issues and AD comorbidities with oral manifestations. Affecting 92% of AD patients, cutaneomucosal hyperpigmentation is synchronous with or precedes general manifestations by up to a decade, underlying melanocytic inf…
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