- Clitoral Hemangioma - Rarest Cause of Clitoromegaly. [Case Reports]J Indian Assoc Pediatr Surg. 2022 Nov-Dec; 27(6):751-752.JI
- Clitoromegaly in female child is a rare condition. This is often associated with androgen excess in disorders of sexual differentiation usually congenital adrenal hyperplasia. Nonhormonal causes of clitoromegaly are rare and are commonly due to neurofibromatosis, epidermoid cyst, rhabdomyosarcoma, and very rarely hemangioma. Hemangioma is one of the common benign neoplasms of infancy, usually loc…
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- A Rare Case of Renal Cell Carcinoma With Inferior Vena Cava Invasion: A Life-Threatening Complication. [Case Reports]Cureus. 2022 Dec; 14(12):e32978.C
- Renal cell carcinoma (RCC) arises from the renal tubular epithelial cells and comprises a group of heterogenous renal tumors. Renal tumors can metastasize to involve almost any body organ, the common sites being the lung, liver, bone, brain, adrenal gland, head, neck, and rarely, inferior vena cava (IVC), leading to lethal outcomes. We present a case of RCC with IVC invasion in a patient who pres…
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- Deoxyguanosine kinase mutation F180S is associated with a lean phenotype in mice. [Journal Article]Int J Obes (Lond). 2023 Jan 28 [Online ahead of print]IJ
- CONCLUSIONS: Taken together, DGUOK mutation F180S leads to a lean phenotype, with lower glucose, insulin, and lipid levels rendering this mouse model not only useful for the study of MDDS forms but also for deciphering mechanisms resulting in a lean phenotype.
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- Surgical findings and outcomes after unilateral adrenalectomy for primary hyperaldosteronism in cats: a multi-institutional retrospective study. [Journal Article]J Feline Med Surg. 2023 Jan; 25(1):1098612X221135124.JF
- CONCLUSIONS: Adrenalectomy appears to be a safe and effective treatment with a high rate of survival and a low rate of major complications. Long-term medical treatment was not required.
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- Initial presentation of renal cell carcinoma as a vaginal mass with excessive bleeding. [Case Reports]
- CONCLUSIONS: We present an extremely rare case of renal cell carcinoma manifested by profuse genital bleeding from a vaginal metastasis. In such cases, especially if the vaginal lesion does not appear as the primary vaginal carcinoma, we must consider the possibility of metastasis from renal carcinoma.
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- A rare case of multiple paragangliomas in the head and neck, retroperitoneum and duodenum: A case report and review of the literature. [Case Reports]
- Pheochromocytomas and paragangliomas (PGLs) are rare non-epithelial neuroendocrine neoplasms of the adrenal medulla and extra-adrenal paraganglia respectively. Duodenal PGL is quite rare and there are only two previous reports. Herein, we report a case of multiple catecholamines (CAs)-producing PGLs in the middle ear, retroperitoneum, and duodenum, and review the literature of duodenal PGLs. A 40…
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- Intestinal tuberculosis in a patient with Cushing's syndrome. [Case Reports]
- A 39-year-old woman presented with cushingoid features was worked up and diagnosed to have ACTH-independent Cushing's syndrome. Computed tomography of the whole abdomen revealed a left adrenal mass. She was scheduled for elective laparoscopic left adrenalectomy, however, a few days prior to the surgery, the patient had hematochezia. Colonoscopy revealed multiple ulcers on the terminal ileum, to w…
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- A rare case of co-secreting adrenocortical oncocytoma. [Case Reports]Urol Case Rep. 2023 Jan; 46:102285.UC
- Here we present a rare case of a large co-secreting adrenocortical oncocytoma undergoing laparoscopic retroperitoneal-to-open removal. Our case was referred for surgical opinion as a result of a left suprarenal mass being identified as part of a work-up for new onset hirsutism and post-menopausal bleeding. We provide example of our surgical approach as well as discussion on this unique adrenal tu…
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- ONCOCYTIC ADRENOCORTICAL CARCINOMA IN A YOUNG PATIENT. [Case Reports]Acta Endocrinol (Buchar). 2022 Jul-Sep; 18(3):383-386.AE
- CONCLUSIONS: Surgery remains the mainstay of treatment, but most of the patients present late with large masses and eventually become unsuitable for curative resection.
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- GIANT ADRENAL GANGLIONEUROMA AND MYELOLIPOMA: A RARE CASE OF COLLISION TUMOR. [Case Reports]Acta Endocrinol (Buchar). 2022 Jul-Sep; 18(3):379-382.AE
- CONCLUSIONS: Ganglioneuroma coexistence with myelolipoma is a rare finding in the adrenal gland. Therefore, histopathology is imperative in such cases for a definitive diagnosis.
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- Newborn screening for X-linked adrenoleukodystrophy in Italy: Diagnostic algorithm and disease monitoring. [Journal Article]Front Neurol. 2022; 13:1072256.FN
- CONCLUSIONS: The primary aim of this study was to develop a model able to improve the early diagnosis and subsequent follow-up and timely treatment of X-ALD.
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- Neoplastic signatures: Comparative proteomics of canine hepatobiliary neuroendocrine tumors to normal niche tissue. [Journal Article]PLoS One. 2023; 18(1):e0280928.Plos
- Hepatobiliary neuroendocrine neoplasms are rare cancers in humans and dogs. To date, no large-scale primary hepatobiliary neoplasm omics analyses exist in any species. This limits the development of diagnostic biomarkers and targeted therapeutics. Neuroendocrine cancers are a heterogenous group of neoplasms categorized by their tissue-of-origin. Because the anatomic niche of neuroendocrine neopla…
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- Vaginal Reconstruction in Patients with vaginal agenesis: Options and Outcome: A single-center experience. [Journal Article]
- CONCLUSIONS: Vaginal agenesis is associated with several sexual disorders and despite the various surgical options available, the best procedure in terms of fewer complications and best surgical outcome is yet to be determined.
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- ACTH-independent production of 11-oxygenated androgens and glucocorticoids in an adrenocortical adenoma. [Case Reports]Eur J Endocrinol. 2022 Dec 01; 187(6):K39-K45.EJ
- CONCLUSIONS: Due to its rarity, biochemical and histologic characteristics of androgen and glucocorticoid co-secreting adrenocortical adenomas are largely unknown. Herein, we report a case of adrenocortical adenoma that caused marked hyperandrogenemia and mild autonomous cortisol secretion. In this study, we investigated serum steroid profiles using liquid chromatography-tandem mass spectrometry (LC-MS/MS) and histologic characteristics of the resected tumor. LC-MS/MS revealed highly elevated levels of 11-oxygenated androgens which have not been well studied in adrenal tumors. The expression patterns of steroidogenic enzymes determined by immunohistochemistry supported the results of steroid profiling and suggested the capacity of the tumor cells to produce 11-oxygenated androgens. Measurement of 11-oxygenated steroids should facilitate a better understanding of androgen-producing adrenocortical neoplasms.
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- [Steroid profiling characteristics in pediatrc adrenal diseases]. [Journal Article]Probl Endokrinol (Mosk). 2022 Nov 03; 68(6):110-120.PE
- CONCLUSIONS: Results of our study steroid profiling can be used as additional differential diagnosis method in patients with adrenocortical adenomas with or without hormonal hyperproduction (ACTH-independent Cushing syndrome and incidentaloma). Further studies are needed to identify steroid markers for subtyping pediatric adrenal diseases.
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- Corticomedullary Mixed Tumor of the Adrenal Gland with Apparent 18F-Fluorodeoxyglucose Activity But No 68GA-DOTATATE Uptake on Positron Emission Tomography/Computed Tomography. [Journal Article]
- Corticomedullary mixed tumor (CMT) is a single adrenal tumor mass composed histologically by an admixture of adrenal cortical and medullary cells. It is a rare condition, with approximately 20 cases reported to date. To our knowledge, the positron emission tomography (PET) imaging findings of this mostly benign tumor have not been reported in the literature. We present a case of CMT who was evalu…
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- The True Value of Quantitative Imaging for Adrenal Mass Characterization: Reality or Possibility? [Editorial]
- The widespread use of cross-sectional imaging modalities, such as computed tomography (CT) and magnetic resonance imaging (MRI), in the evaluation of abdominal disorders has significantly increased the number of incidentally detected adrenal abnormalities, particularly adrenal masses [...].
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- Accentuated 123ImIBG uptake by the left lobe of the liver - A clue to nowhere. [Case Reports]J Pak Med Assoc. 2022 Oct; 72(10):2124-2125.JP
- A 57-year-old male was imaged with 123I mIBG for left sided suprarenal mass. The planar and SPECT-CT acquisitions revealed features consistent with a left sided pheochromocytoma. There was physiological and high uptake in the hypertrophied left lobe of the liver which was normal at both MRI and non-contrast CT. Asymmetrical increased 123I mIBG uptake in the left lobe of the liver as compared to t…
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- Incidental, Solitary, and Unilateral Adrenal Metastasis as the Initial Manifestation of Lung Adenocarcinoma. [Case Reports]
- An adrenal incidentaloma is an adrenal mass ≥ 1 cm in size discovered on imaging performed for indications other than suspected adrenal disease. It has variable etiologies, which can be benign or malignant, including primary or metastatic disease. We present a rare case of metastatic lung adenocarcinoma with isolated unilateral adrenal metastases, presenting as an adrenal incidentaloma in an asym…
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- Laparoscopic left nephro-adrenalectomy for renal vein leiomyosarcoma using (ICG) fluorescence and 3D-CT reconstruction: A case report. [Case Reports]Ann Ital Chir. 2022 Dec 06; 11AI
- CONCLUSIONS: In this case, use intraoperative ICG fluorescence associated with preoperative 3D-CT was a valuable support for surgery.
- Adrenal Liposarcoma: A Novel Presentation of Multiple Endocrine Neoplasia Type 1. [Case Reports]
- CONCLUSIONS: Liposarcomas should be included in the differential of MEN1-related tumors.
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- A Rare Case of Thoracoabdominal Paraganglioma: A Case Report and Literature Review. [Case Reports]
- Pheochromocytomas and paragangliomas are rare neuroendocrine tumors. Pheochromocytomas are derived from chromaffin cells of the adrenal medulla, while paragangliomas arise from the extra-adrenal autonomic paraganglia. Paragangliomas can derive from either parasympathetic or sympathetic paraganglia. The majority of parasympathetic ganglia-derived paragangliomas are nonfunctional and symptoms arise…
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- The Etiological Profile of Adrenal Incidentalomas. [Journal Article]
- Introduction An adrenal incidentaloma (AI) is an unsuspected tumor in one or both adrenal glands, which is discovered incidentally on an imaging exam not prompted by adrenal exploration. The etiologies can be multiple; they condition therapeutic management. The objective of our study is to describe the etiological and therapeutic profiles of AI in our department. Materials and methods A retrospec…
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- Pheochromocytoma/paraganglioma screening: low rates in at-risk populations. [Editorial]
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- [Adrenal tumors: diagnostics, perioperative management and surgical treatment]. [Journal Article]Urologie. 2023 Jan 18 [Online ahead of print]U
- Space-occupying lesions of the adrenal glands are one of the most frequent tumors; however, only a fraction of approximately 20% need further diagnostics and treatment. The diagnostic standard is native computed tomography (CT). For larger tumors and those that cannot be clearly classified as benign, the supplementary radiological modalities magnetic resonance imaging (MRI), contrast CT and 18F-f…
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- Intracardiac paraganglioma with a cough as the first symptom. [Case Reports]
- CONCLUSIONS: Pheochromocytomas and paragangliomas (PPGLs) are a kind of neuroendocrine tumors. PPGLs can cause secondary hypertension, and lead to a series of clinical syndromes, including myocardial injury, metabolic changes, and so on. The occurrence of PPGIs is related to gene mutation. Biochemical detection, imaging examination, and genetic testing can help diagnose. The tumor should be surgically removed as soon as possible after the diagnosis. As a functional tumor, PPGLs should be fully prepared before surgery to avoid anesthesia and huge fluctuations in blood pressure during and after surgery, or the occurrence of fatal hypertensive crisis and intractable hypotension after tumor resection. Adequate preoperative preparation directly affects the prognosis of patients after surgery. Therefore, multidisciplinary cooperation before, during, and after the operation is extremely important.
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- A PROSPECTIVE ANALYSIS OF THE METYRAPONE SHORT TEST USING TARGETED AND UNTARGETED METABOLOMICS. [Journal Article]Neuroendocrinology. 2023 Jan 16 [Online ahead of print]N
- Introduction The present study aimed to prove the metyrapone short test in a day clinic to be suitable for examining the integrity of the hypothalamic-pituitary-adrenal (HPA) axis in patients with suspected secondary and tertiary adrenal insufficiency and to identify novel effector molecules in acute stress response. Methods 44 patients were prospectively enrolled. Based on stimulated 11-deoxycor…
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- Transfer of Injected Triamcinolone into Human Milk of a Lactating Patient Suffering from Idiopathic Granulomatous Mastitis. [Case Reports]Breastfeed Med. 2023 Jan; 18(1):74-77.BM
- Background: Idiopathic granulomatous mastitis (IGM) is a chronic inflammatory condition of the mammary gland that presents as a painful mass, and it must be distinguished from both infectious mastitis and breast cancer. When diagnosed during lactation, it can result in significant distress and early weaning. Injection of triamcinolone has been used as a successful treatment method, but safety in …
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- Reference intervals for plasma, urinary, and salivary concentrations of free metanephrines in dogs: Relevance to the diagnosis of pheochromocytoma. [Journal Article]J Vet Intern Med. 2023 Jan 13 [Online ahead of print]JV
- CONCLUSIONS: With establishment of these RIs, biochemical testing for PCC in dogs can be substantially improved. Measurement of pNMN is superior to pMN in dogs with PCC.
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- Cardiac arrest as initial presentation of pheochromocytoma in a young. [Journal Article]Cardiol Young. 2023 Jan 12 [Online ahead of print]CY
- We reported a case of pheochromocytoma with initial presentation of cardiac arrest. The patient underwent implantable cardioverter defibrillator for primary prevention but subsequently experienced repeated implantable cardioverter defibrillator shocks and syncopal episodes. A mass was found in the adrenal gland by CT, which was confirmed by anatomopathological analysis of the surgical specimen.
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