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82,397 results
  • Suppression of lusitropy as a disease mechanism in cardiomyopathies. [Review]
    Front Cardiovasc Med. 2022; 9:1080965.Marston S, Pinto JR
  • In cardiac muscle the action of adrenaline on β1 receptors of heart muscle cells is essential to adjust cardiac output to the body's needs. Adrenergic activation leads to enhanced contractility (inotropy), faster heart rate (chronotropy) and faster relaxation (lusitropy), mainly through activation of protein kinase A (PKA). Efficient enhancement of heart output under stress requires all of these …
  • The ubiquitous catechol moiety elicits siderophore and angucycline production in Streptomyces. [Journal Article]
    Commun Chem. 2022 Feb 03; 5(1):14.van Bergeijk DA, Elsayed SS, … van Wezel GP
  • Actinobacteria are a rich source of bioactive molecules, and genome sequencing has shown that the vast majority of their biosynthetic potential has yet to be explored. However, many of their biosynthetic gene clusters (BGCs) are poorly expressed in the laboratory, which prevents discovery of their cognate natural products. To exploit their full biosynthetic potential, better understanding of the …
  • Preventing food allergy fatalities. [Review]
    Arch Dis Child. 2023 Jan 23 [Online ahead of print]Foong RX, Patel NB, … Fox AT
  • Fatal anaphylaxis to food is thankfully rare, but every death is a potentially avoidable tragedy. Usually, there will be a coronial inquest to establish the 'how and why' for each death. Reviewing these food allergy-related deaths identifies a number of common themes and risk factors. While some are non-modifiable (such as age, gender and ethnicity), others are and include delayed epinephrine adm…
  • Food Allergy Management for Adolescents Using Behavioral Incentives: A Randomized Trial. [Journal Article]
    Pediatrics. 2023 Jan 23 [Online ahead of print]Dupuis R, Feuerstein-Simon R, … Cannuscio CC
  • CONCLUSIONS: Text message nudges alone were unsuccessful at promoting EAI-carrying but text message nudges combined with modest financial incentives almost doubled EAI-carriage rates among those who received the intervention compared with the control group. However, even with the intervention, adolescents with food allergies carried their EAI <50% of the time. Alternative strategies for making EAIs accessible to adolescents at all times should be implemented.
  • Mobility Coupled with Motivation Promotes Survival: The Evolution of Cognition as an Adaptive Strategy. [Review]
    Biology (Basel). 2023 Jan 03; 12(1)Stefano GB, Kream RM, Esch T
  • Morphine plays a critical regulatory role in both simple and complex plant species. Dopamine is a critical chemical intermediate in the morphine biosynthetic pathway and may have served as a primordial agonist in developing catecholamine signaling pathways. While dopamine remains the preeminent catecholamine in invertebrate neural systems, epinephrine is the major product of catecholamine synthet…
  • Case report: An unusual case of cecal mucosal bleeding. [Case Reports]
    JGH Open. 2023 Jan; 7(1):72-74.Kamara MS, Sugawa C
  • Cecal mucosal bleeding is an undocumented and rare cause of lower gastrointestinal (GI) bleeding. We present a case of a 73-year-old woman with end-stage renal disease and paroxysmal atrial fibrillation on apixaban who presented with lower gastrointestinal bleed. She was found to have symptomatic, acute chronic anemia requiring multiple packed red blood cell transfusions. Colonoscopy revealed a l…
  • Circulating fatty acid-binding protein 4 response to acute aerobic exercise in healthy men. [Journal Article]
    Int J Sports Med. 2023 Jan 19 [Online ahead of print]Numao S, Uchida R, … Nakagaichi M
  • This study aimed to investigate the association between changes in FABP4 concentration and hormones and metabolites levels during and after acute low- and moderate-intensity aerobic exercise in healthy men. Eleven healthy men (24.4 ± 1.4 years) were administered three trials in random order: 1) low-intensity aerobic exercise trial (LE trial; acute exercise at 40% peak oxygen uptake [Vo2peak] + be…
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