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(Adrenocorticosteroids as anticancer agents)
52,349 results
  • Effect of dexamethasone implant on intraocular cytokines in diabetic macular edema. [Journal Article]
    Indian J Ophthalmol. 2023 Feb; 71(2):363-368.Pillai GS, Gupta A, … Ravindran GC
  • CONCLUSIONS: Our study suggests that dexamethasone acts more on IC than VEGF in DME. This is significant in the first 3 months with a rebound effect on IL-6 after 3 months. Our study also suggests that repeat injection of DEX in DME should be done at 3 months to prevent deterioration of visual acuity (VA) and worsening of CMT.
  • Older Adults and Immune Thrombocytopenia: Considerations for the Clinician. [Review]
    Clin Interv Aging. 2023; 18:115-130.Crickx E, Mahévas M, … Godeau B
  • Many epidemiological studies have shown that the incidence of immune thrombocytopenia (ITP) increases after age 60 years and peaks in patients over age 80 years. Therefore, ITP is a concern for physicians taking care of older patients, especially regarding its diagnosis and management. The diagnostic work-up should exclude other causes of thrombocytopenia and secondary ITP, including myelodysplas…
  • Immune checkpoint inhibitor-mediated hypophysitis: no place like home. [Journal Article]
    Clin Med (Lond). 2023 Jan; 23(1):81-84.Cooksley T, Knight T, … Adam S
  • Ambulatory emergency care forms a fundamental part of the strategy of trying to ensure safe and sustainable acute care services. Immune checkpoint inhibitor(ICI)-mediated hypophysitis is an important life-threatening complication of therapy. Patients presenting with clinical features and findings consistent with ICI-mediated hypophysitis were considered in the current study. In the absence of sev…
  • Corticosteroids for the management of cancer-related fatigue in adults with advanced cancer. [Review]
    Cochrane Database Syst Rev. 2023 Jan 23; 1:CD013782.Sandford A, Haywood A, … Hardy JR
  • CONCLUSIONS: There is insufficient evidence to support or refute the use of systemic corticosteroids in adults with cancer and CRF. We included four small studies that provided very low-certainty of evidence for the efficacy of corticosteroids in the management of CRF. Further high-quality randomised controlled trials with larger sample sizes are required to determine the effectiveness of corticosteroids in this setting.
  • Vitamin A Status in Preterm Infants Is Associated with Inflammation and Dexamethasone Exposure. [Journal Article]
    Nutrients. 2023 Jan 14; 15(2)Rossholt ME, Wendel K, … Moltu SJ
  • Vitamin A has a key role in lung development and its deficiency is associated with an increased risk of bronchopulmonary dysplasia. This secondary cohort analysis of the ImNuT trial (Immature, Nutrition Therapy NCT03555019) aimed to (1) explore vitamin A status in preterm infants <29 weeks gestation and (2) assess the influence of inflammation and postnatal dexamethasone exposure on vitamin A con…
  • The Role of Glucocorticoids in Breast Cancer Therapy. [Review]
    Curr Oncol. 2022 Dec 25; 30(1):298-314.Mitre-Aguilar IB, Moreno-Mitre D, … Mendoza-Almanza G
  • Glucocorticoids (GCs) are anti-inflammatory and immunosuppressive steroid molecules secreted by the adrenal gland and regulated by the hypothalamic-pituitary-adrenal (HPA) axis. GCs present a circadian release pattern under normal conditions; they increase their release under stress conditions. Their mechanism of action can be via the receptor-independent or receptor-dependent pathway. The recept…
  • Localization diagnosis of adrenocorticotrophic hormone-dependent Cushing's syndrome: two case reports and literature review. [Case Reports]
    Ann Palliat Med. 2022 Dec; 11(12):3804-3817.Qiu Y, Zhao H, … Li Q
  • CONCLUSIONS: The differentiation between CD and EAS should be comprehensively evaluated in combination with the medical history, function tests, pituitary MRI, and other tests. If the function test results are discordant or pituitary MRI shows the lesion diameter is less than 6 mm, BIPSS should be further performed to confirm the diagnosis. The lesions of EAS are complex and diverse, and it is necessary to pay attention to imaging examinations of the neck-to-pelvis to locate lesion and provide direction for subsequent treatment.
  • [Low dosed prednisolone in older patients with rheumatoid arthritis]. [Journal Article]
    Ned Tijdschr Geneeskd. 2022 Nov 30; 166van der Goes MC
  • Glucocorticoids are used in the treatment of rheumatoid arthritis since many decades. Glucocorticoids are proven effective in decreasing inflammatory activity of this disease and in retarding the progression of erosive joint damage. However, they also have multiple possible adverse effects, which are depending on dose and duration of treatment. Due to increasing treatment options (i.e. biologic a…
  • Cytokine release syndrome induced by pembrolizumab: A case report. [Case Reports]
    Medicine (Baltimore). 2022 Dec 09; 101(49):e31998.Zhang X, Fu Z, Yan C
  • CONCLUSIONS: To our knowledge, this is the first case of delirium and CRS that occurred twice in a short period of time. This patient had no immune-related adverse reactions during the previous 9 immunotherapy sessions. This adverse reaction occurred after the inflammation of the wisdom teeth and was presumed to be related to an overstimulation of the immune response due to infection. Premature discontinuation of hormones for the patient's 1st treatment of CRS may be the reason for the 2nd occurrence of CRS. Therefore, timely and full course of glucocorticosteroids is a key therapeutic measure to cause CRS after the use of immune checkpoint inhibitors.
  • Glucocorticoids for croup in children. [Review]
    Cochrane Database Syst Rev. 2023 01 10; 1:CD001955.Aregbesola A, Tam CM, … Klassen TP
  • CONCLUSIONS: The evidence that glucocorticoids reduce symptoms of croup at two hours, shorten hospital stays, and reduce the rate of return visits or (re)admissions has not changed in this update. A smaller dose of 0.15 mg/kg of dexamethasone may be as effective as the standard dose of 0.60 mg/kg. More RCTs are needed to strengthen the evidence for effectiveness of low-dose dexamethasone at 0.15 mg/kg to treat croup.
  • [Chronic psychological stress exacerbates aortic medial calcification via glucocorticoids]. [Journal Article]
    Sheng Li Xue Bao. 2022 Dec 25; 74(6):927-938.Li YQ, Huang PN, … Wang XN
  • Chronic psychological stress can promote vascular diseases, such as hypertension and atherosclerosis. This study aims to explore the effects and mechanism of chronic psychological stress on aortic medial calcification (AMC). Rat arterial calcification model was established by nicotine gavage in combination with vitamin D3 (VitD3) intramuscular injection, and rat model of chronic psychological str…
  • Bilateral adrenal and pulmonary haemorrhages as an initial presentation of polycythaemia vera. [Case Reports]
    BMJ Case Rep. 2022 Dec 08; 15(12)Cilia K, Borg J, … Farrugia E
  • We report a case of a man in his early 60s presenting with bilateral adrenal and pulmonary haemorrhages as an initial presentation of polycythaemia vera (PV). Symptomatology included severe compressive chest pain radiating to epigastrium, with unremarkable physical findings, parameters and ECG. Blood investigations showed an elevated haemoglobin (174 g/L, reference range (RR): 141-172g/L) and hae…
  • Do new drugs for diabetic macular edema offer a safer option? [Journal Article]
    Expert Opin Drug Saf. 2022 Dec; 21(12):1453-1457.Mathis T, Kodjikian L
  • The last decade has witnessed important advances in retinal drug discovery, administered intravitreally, allowing high intraocular concentration and low systemic passage. However, local and systemic adverse events have been described and should be discussed before proposing treatment. In diabetes mellitus specifically, the choice of molecule and treatment regimen should limit the therapeutic burd…
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