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55,283 results
  • Synthesis and biological profile of substituted benzimidazoles. [Journal Article]
  • CCChem Cent J 2018 Dec 01; 12(1):125
  • Vashist N, Sambi SS, … Mani V
  • CONCLUSIONS: The synthesized benzimidazole compounds were evaluated for their antimicrobial activity using the tube dilution method and were found to exhibit good antimicrobial potential against selected Gram negative and positive bacterial and fungal species. The compounds were also assessed for their anticancer activity exhibited using the SRB assay and were found to elicit antiproliferative activity against MCF7 breast cancer cell line, which was comparable to the standard drug.Antimicrobial screening results indicated that compounds 1, 2 and 19 to be promising antimicrobial agents against selected microbial species and comparable to standard drugs which included norfloxacin and fluconazole. The anticancer screening results revealed that compounds, 12, 21, 22 and 29 to show the highest activity against MCF7 and their IC50 values were more potent than 5-fluorouracil.
  • Chemotherapy in Patients with Hereditary Angioedema. [Journal Article]
  • ARAnticancer Res 2018; 38(12):6801-6807
  • Morelli C, Formica V, … Roselli M
  • CONCLUSIONS: The stress induced by chemotherapy such a standard oxaliplatin/fluorouracil increases the risk of attacks in patients with HAE. However, circulating biomarkers such as D-dimers, C3 and C1-inhibitor functional may serve as early predictors of acute HAE crisis.
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