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64,436 results
  • Inhibition of multiple CDKs potentiates colon cancer chemotherapy via p73-mediated DR5 induction. [Journal Article]
    Oncogene. 2023 Jan 31 [Online ahead of print]Tong J, Tan X, … Zhang L
  • Targeting cyclin-dependent kinases (CDKs) has recently emerged as a promising therapeutic approach against cancer. However, the anticancer mechanisms of different CDK inhibitors (CDKIs) are not well understood. Our recent study revealed that selective CDK4/6 inhibitors sensitize colorectal cancer (CRC) cells to therapy-induced apoptosis by inducing Death Receptor 5 (DR5) via the p53 family member…
  • Carbon Dioxide Potentiates Flucytosine Susceptibility in Cryptococcus neoformans. [Journal Article]
    Microbiol Spectr. 2023 Jan 31 [Online ahead of print]Jezewski AJ, Ristow LC, Krysan DJ
  • Cryptococcal meningoencephalitis remains a global health threat with limited treatment options. Currently, the most effective treatment regimens are based on a combination therapy of flucytosine with either amphotericin B or fluconazole. Slow but steady progress is being made toward universal access to flucytosine-based therapies. The broadening access to flucytosine combination therapies will be…
  • The development of BVDU: An odyssey. [Review]
    Antivir Chem Chemother. 2023 Jan-Dec; 31:20402066231152971.De Clercq E
  • Brivudin, ((E)-5-(2-bromovinyl)-2'-deoxyuridine (BVDU) can be considered the gold standard for the treatment of varicella-zoster virus (VZV) infections, such as herpes zoster (shingles). It is available for clinical use in most European countries (except for the UK) and over the whole world (except for the US and Canada). Besides VZV its activity spectrum also includes various other herpesviruses…
  • [A real-world study on the efficacy and safety analysis of paclitaxel liposome in advanced breast cancer]. [Journal Article]
    Zhonghua Zhong Liu Za Zhi. 2023 Jan 23; 45(1):88-94.Sun CX, Wang SS, … Yin YM
  • Objective: To explore the application and efficacy of paclitaxel liposome in the treatment of advanced breast cancer among Chinese population in the real world. Methods: The clinical characteristics of patients with advanced breast cancer who received paclitaxel liposome as salvage treatment from January 1, 2016 to August 31, 2019 in 11 hospitals were collected and retrospectively analyzed. The p…
  • Novel carboxymethyl cellulose-halloysite-polyethylene glycol nanocomposite for improved 5-FU delivery. [Journal Article]
    Int J Biol Macromol. 2023 Jan 25 [Online ahead of print]Ghasemizadeh H, Pourmadadi M, … Díez-Pascual AM
  • Drug nano-carriers are crucial for achieving targeted treatment against cancer disorders with minimal side effects. In this study, a pH-responsive nanocomposite based on halloysite nanotube (HNT) coated with carboxymethyl cellulose (CMC)/polyethylene glycol (PEG) hydrogel for controlled delivery of 5-Fluorouracil (5-FU), a hydrophobic chemotherapy drug prescribed for different types of cancers wa…
  • Antimetabolite in the Management of Odontogenic Keratocyst-A Case Report. [Case Reports]
    J Maxillofac Oral Surg. 2023 Mar; 22(1):132-135.Banala P, Reddy GS, … Bhavani M
  • Odontogenic keratocyst (OKC) is an aggressive cystic lesion of the jaw with high growth and recurrence. Patients are usually asymptomatic and detected during routine radiographic examination. Management of OKC varies from conservative procedures like simple Enucleation and peripheral ostectomy to aggressive resection. More attention is given to new treatment protocols to form them simple and succ…
  • Ginkgo Biflavones Cause p53 Wild-Type Dependent Cell Death in a Transcription-Independent Manner of p53. [Journal Article]
    J Nat Prod. 2023 Jan 26 [Online ahead of print]Zhang S, Sun Y, … Xu X
  • Ginkgo biloba, as a medicinal plant in both traditional and western medicine, emerged as a potential therapeutic agent for the management of a variety of diseases, but ginkgo biflavones (bilobetin, isoginkgetin, and ginkgetin) application in cancer therapy and underlying mechanisms of action remained elusive. In the present study, we identified ginkgo biflavones as potential p53 activators that c…
  • Alleviative effects of glutamate against chemotherapeutic agent-induced intestinal mucositis. [Journal Article]
    J Physiol Pharmacol. 2022 Aug; 73(4)Jonan S, Hamouda N, … Amagase K
  • 5-Fluorouracil (5-FU) is one of the most widely used chemotherapeutic agents; however, it often causes intestinal mucositis with severe diarrhea. An efficient treatment strategy to reduce this side effect is lacking. Glutamate (Glu), a nonessential amino acid, is the most important energy source in the small intestine and has been shown to maintain intestinal morphology, barrier function, and ant…
  • Common Dermatologic Conditions in Skin of Color. [Journal Article]
    Am Fam Physician. 2023 Jan; 107(1):26-34.Frazier WT, Proddutur S, Swope K
  • Individuals with skin of color represent a diverse population of racial and ethnic backgrounds, including but not limited to Black or African American, American Indian or Alaska Native, Asian American or Pacific Islander, Hispanic or Latino, and Middle Eastern or North African. Dermatologic health disparities exist in part because of systemic racism and are exacerbated by inadequate physician tra…
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