- Insulin Fact Sheet in Type 1 and 2 Diabetes Mellitus and Trends of Antidiabetic Medication Use in Insulin Users with Type 2 Diabetes Mellitus: 2002 to 2019. [Journal Article]Diabetes Metab J. 2023 Feb 07 [Online ahead of print]DM
- CONCLUSIONS: The proportion of the patients using basal or rapid acting analogs increased among all insulin users in both T1DM and T2DM patients. Among patients with T2DM, the proportion of patients using antidiabetic medications in addition to insulin was significantly increased compared to those who used insulin alone.
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- Health literacy levels in patients with type 2 diabetes in an affluent Gulf country: a cross-sectional study. [Journal Article]BMJ Open. 2023 Feb 06; 13(2):e069489.BO
- CONCLUSIONS: The low health literacy levels found in outpatients with diabetes may be a major challenge to optimising diabetes care in the UAE. In addition to health services strategies, targeted educational and behavioural interventions for the older population and those with less formal education are necessary.
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- Chronic physiologic hyperglycemia impairs insulin-mediated suppression of plasma glucagon concentration in healthy humans. [Journal Article]Metabolism. 2023 Feb 04 [Online ahead of print]M
- CONCLUSIONS: Sustained (48-72 h) physiologic hyperglycemia (+50 mg/dl) caused whole body insulin resistance and impaired insulin-mediated suppression of glucagon secretion, suggesting a role for glucotoxicity in development of hyperglucagonemia in T2DM.
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- CO-OCCURRENCE OF NEPHRONOPHTHISIS TYPE 1 AND ALSTRÖM SYNDROME: A CASE REPORT. [Case Reports]Nephron. 2023 Feb 06 [Online ahead of print]N
- We describe the unique case of a patient in whom two ciliopathies with autosomal recessive transmission were clinically and molecularly diagnosed: Nephronophthisis type1 (NPHP1) and Alström Syndrome (AS). NPHP1 is one of the main genetic causes of terminal kidney failure in childhood. AS is an ultra-rare multi-systemic disease, characterized by progressive kidney disease, hepatic failure, dystrop…
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- Pharmacology Focus: Mitigating the Risk of Overbasalization in Patients with Type 2 Diabetes Mellitus. [Journal Article]S D Med. 2022 Aug; 75(8):376-377.SD
- Contextual factors for the successful implementation of self-management interventions for chronic diseases: A qualitative review of reviews. [Review]Chronic Illn. 2023 Feb 06 [Online ahead of print]CI
- CONCLUSIONS: For the successful implementation of SMIs, it is crucial to take CFs on several levels into account simultaneously. Person-centered care, by tailoring SMIs to patients' needs and circumstances, may increase the successful uptake, application and implementation of SMIs in real-life practice. The next step will be to identify the most important CFs according to various stakeholders through a group consensus process.
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- International evidence-based guidelines on hypertension and type 2 diabetes mellitus: A systematic review. [Review]J Public Health Res. 2023 Jan; 12(1):22799036221146913.JP
- This systematic review provides a high-quality, comprehensive summary of recommendations on hypertension (HT) and type 2 diabetes mellitus (T2DM), accentuating patient blood pressure, HbA1c levels, patterns of drug treatment, management, and screening of these diseases. The overall objective of the review is to support adapting existing clinical practice guidelines in Indonesia, Vietnam, and Myan…
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- Effectiveness and safety of hydrogen inhalation as an adjunct treatment in Chinese type 2 diabetes patients: A retrospective, observational, double-arm, real-life clinical study. [Journal Article]Front Endocrinol (Lausanne). 2022; 13:1114221.FE
- CONCLUSIONS: HI as an adjunct therapy ameliorates glycemic control, lipid metabolism, insulin resistance and AE incidence of T2DM patients after 6-month treatment, presenting a noteworthy inspiration to existing clinical diabetic treatment.
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- Integrated lipids biomarker of the prediabetes and type 2 diabetes mellitus Chinese patients. [Journal Article]Front Endocrinol (Lausanne). 2022; 13:1065665.FE
- Dyslipidemia is a hallmark of T2DM, and as such, analyses of lipid metabolic profiles in affected patients have the potential to permit the development of an integrated lipid metabolite-based biomarker model that can facilitate early patient diagnosis and treatment.
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- Type 2 Diabetes Mellitus and its comorbidity, Alzheimer's disease: Identifying critical microRNA using machine learning. [Journal Article]Front Endocrinol (Lausanne). 2022; 13:1084656.FE
- MicroRNAs (miRNAs) are critical regulators of gene expression in healthy and diseased states, and numerous studies have established their tremendous potential as a tool for improving the diagnosis of Type 2 Diabetes Mellitus (T2D) and its comorbidities. In this regard, we computationally identify novel top-ranked hub miRNAs that might be involved in T2D. We accomplish this via two strategies: 1) …
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- Type 2 diabetes mellitus, physical activity, and neuromusculoskeletal complications. [Journal Article]J Neurosci Rural Pract. 2022 Oct-Dec; 13(4):705-710.JN
- CONCLUSIONS: Neuromusculoskeletal complications of T2DM are common and can result in significant disability in this population. Low PA is very common among T2DM patients and an important contributor to the development of complications. Health-care providers should consider PA an integral component of the management protocol for T2DM patients.
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- Preclinical evaluation of tolvaptan and salsalate combination therapy in a Pkd1-mouse model. [Journal Article]Front Mol Biosci. 2023; 10:1058825.FM
- Background: Autosomal dominant polycystic kidney disease (ADPKD) is the most common genetic disorder and an important cause of end stage renal disease (ESRD). Tolvaptan (a V2R antagonist) is the first disease modifier drug for treatment of ADPKD, but also causes severe polyuria. AMPK activators have been shown to attenuate cystic kidney disease. Methods: In this study, we tested the efficacy of t…
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- Evaluation of Indian Diabetes Risk Score and Random Blood Sugar Testing for Opportunistic Screening of Type 2 Diabetes Patients at a District Hospital of Gujarat. [Journal Article]Indian J Community Med. 2022 Oct-Dec; 47(4):517-521.IJ
- CONCLUSIONS: This study has found that sequential screening using a simple diabetes risk score like IDRS followed by RBS is having higher accuracy and reduced cost of opportunistic screening of type 2 diabetes. Adopting sequential screening using IDRS as first step of screening followed by RBS in those found as high risk by IDRS is recommended.
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- Benefits of Huang Lian mediated by gut microbiota on HFD/STZ-induced type 2 diabetes mellitus in mice. [Journal Article]Front Endocrinol (Lausanne). 2023; 14:1120221.FE
- CONCLUSIONS: These results indicated that the anti-diabetic activity of HL was achieved, at least partly, by regulating the structure of the gut microbiota and the composition of BAs.
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- Theabrownin ameliorates liver inflammation, oxidative stress, and fibrosis in MCD diet-fed C57BL/6J mice. [Journal Article]Front Endocrinol (Lausanne). 2023; 14:1118925.FE
- Nonalcoholic steatohepatitis (NASH), also known as metabolic steatohepatitis, is a clinical syndrome with pathological changes like alcoholic hepatitis but without a history of excessive alcohol consumption. NASH is closely related to metabolic disorders such as obesity, insulin resistance, type 2 diabetes mellitus, and hyperlipidemia. Its main characteristics are hepatocyte steatosis with hepato…
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- The protective effects of lipoxin A4 on type 2 diabetes mellitus: A Chinese prospective cohort study. [Journal Article]Front Endocrinol (Lausanne). 2023; 14:1109747.FE
- CONCLUSIONS: Higher LXA4 levels are significantly associated with a lower risk of T2DM development. The present findings would be helpful in understanding the effect of LXA4 on T2DM development at the population level.
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- Effectiveness of Diabetes Case Conferencing Program on Diabetes Management. [Journal Article]Int J Integr Care. 2023 Jan-Mar; 23(1):2.IJ
- CONCLUSIONS: Glycaemia, weight and cardiovascular risk factors improved following case conferencing consultations in a primary care setting.
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- Stress CMR T1-mapping technique for assessment of coronary microvascular dysfunction in a rabbit model of type II diabetes mellitus: Validation against histopathologic changes. [Journal Article]Front Cardiovasc Med. 2022; 9:1066332.FC
- CONCLUSIONS: The stress T1 response correlated well with the histopathologic measures in T2DM rabbits, indicating that it may serve as a sensitive CMD-related indicator in early T2DM.
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- Cognitive impairment with Type 2 Diabetes Mellitus among community-dwelling older adults in Chile: Prevalence, risk factors and cognitive characteristics. [Journal Article]Front Hum Neurosci. 2022; 16:1070611.FH
- CONCLUSIONS: The present study confirms the high prevalence of CI with T2DM among Chilean older adults in a community-based population. T2DM is significantly associated with a higher risk of CI, and age, education, presence of dyslipidemia, and duration of T2DM are risk factors. T2DM patients with CI are impaired in multiple cognitive domains, even after adjusting covariables, resulting in an amnesic multi-domain cognitive profile.
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- Exploring the Implications of New-Onset Diabetes in COVID-19: A Narrative Review. [Review]Cureus. 2023 Jan; 15(1):e33319.C
- Post-viral new-onset diabetes has been an important feature of the COVID-19 pandemic. It is not always clear if new-onset diabetes is the unmasking of a previously undiagnosed condition, the acceleration of prediabetes, or new-onset diabetes that would not have otherwise occurred. Even asymptomatic cases of COVID-19 have been associated with new-onset diabetes. Diabetes that emerges during acute …
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- Sleep Duration and the Risk of Type 2 Diabetes: A Community-Based Cohort Study with a 16-Year Follow-up. [Journal Article]Endocrinol Metab (Seoul). 2023 Feb 06 [Online ahead of print]EM
- CONCLUSIONS: This study confirmed the effect of sleep deprivation on the risk of T2DM throughout the 16-year follow-up period. This impact was confined to non-obese or young individuals and men. We observed a significant interaction between sleep duration and obesity.
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- [Nomogram analysis of risk factors for diabetic neuropathy in primary type 2 diabetic mellitus patients in Zhejiang Province]. [Journal Article]Zhonghua Nei Ke Za Zhi. 2023 Feb 01; 62(2):169-175.ZN
- Objective: To investigate the risk factors of diabetic nephropathy (DN) in primary type 2 diabetes mellitus (T2DM) patients and to quantitatively analyze the risk of DN by nomogram modeling. Methods: A total of 1 588 primary T2DM patients from 17 townships and streets in Zhejiang Province were enrolled from June 2018 to August 2018 in this cross-sectional study, with an average age of (56.8±10.1)…
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- Assessment of body fat mass, anthropometric measurement and cardiometabolic risk in children and adolescents with achondroplasia and hypochondroplasia. [Journal Article]Endocr J. 2023 Feb 04 [Online ahead of print]EJ
- Achondroplasia is a rare skeletal dysplasia characterized by rhizomelic short stature, whose prevalence is about 1 per 25,000 births. For some patients with achondroplasia, excess body weight is one of the major concerns due to an impaired linear growth. Epidemiological studies revealed a premature onset of cardiovascular or cerebrovascular events in achondroplasia. An association between obesity…
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- TRPV1 dysfunction impairs gastric nitrergic neuromuscular relaxation in high fat diet induced diabetic gastroparesis mice. [Journal Article]Am J Pathol. 2023 Feb 03 [Online ahead of print]AJ
- Diabetic gastroparesis (DGP) is characterized by delayed gastric emptying of solid food without mechanical obstruction. Nitrergic neuron-mediated fundus relaxation and intragastric peristalsis are pivotal for gastric emptying and are impaired in patients with DGP. Transient receptor potential vanilloid 1 (TRPV1) ion channels are expressed in gastrointestinal vagal afferent nerves and have potenti…
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- From worms to humans: Understanding intestinal lipid metabolism via model organisms. [Journal Article]Biochim Biophys Acta Mol Cell Biol Lipids. 2023 Feb 02 [Online ahead of print]BB
- The intestine is responsible for efficient absorption and packaging of dietary lipids before they enter the circulatory system. This review provides a comprehensive overview of how intestinal enterocytes from diverse model organisms absorb dietary lipid and subsequently secrete the largest class of lipoproteins (chylomicrons) to meet the unique needs of each animal. We discuss the putative relati…
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- Clinical expert consensus on the assessment and protection of pancreatic islet β-cell function in type 2 diabetes mellitus. [Review]Diabetes Res Clin Pract. 2023 Feb 02 [Online ahead of print]DR
- Islet β-cell dysfunction is a basic pathophysiological characteristic of type 2 diabetes mellitus. Appropriate assessment of islet β-cell function is beneficial to better management ofT2DM. Protecting islet β-cell function is vital to delay the progress of type 2 diabetes mellitus. Therefore, the Pancreatic Islet β-cell Expert Panel of the Chinese Diabetes Society and Endocrinology Society of Jia…
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- Th1 bias of liver mucosal-associated invariant T cells promotes hepatic gluconeogenesis in type 2 diabetes mellitus. [Journal Article]Diabetes Metab Res Rev. 2023 Feb 04 [Online ahead of print]DM
- CONCLUSIONS: Our data implicate an increased Th1-like MAIT cell subset in the liver of newly diagnosed T2DM subjects, which induces hyperglycemia by promoting hepatic gluconeogenesis. It provides novel insights into the immune regulation of metabolic homeostasis. This article is protected by copyright. All rights reserved.
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- Cognitive behavior therapy for diabetes distress, depression, health anxiety, quality of life and treatment adherence among patients with type-II diabetes mellitus: a randomized control trial. [Journal Article]
- CONCLUSIONS: It is concluded that cognitive behavior therapy is an effective and promising intervention for depressive symptoms, diabetes distress, and health anxiety which also helps the person to promote quality of life, treatment adherence and physical activity.
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- Diabetes mellitus: Lessons from COVID-19 for monkeypox infection. [Review]
- CONCLUSIONS: High incidence of diabetes together with the cessation of smallpox vaccination has left large numbers of the human population unprotected against monkeypox. The best option for the population remains confined to the prevention of infection as well as the use of hypoglycemic agents that have also been shown to improve immune mechanisms associated with viral protection.
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