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Unbound Medicine.
(Adult onset diabetes)
196,467 results
  • CO-OCCURRENCE OF NEPHRONOPHTHISIS TYPE 1 AND ALSTRÖM SYNDROME: A CASE REPORT. [Case Reports]
    Nephron. 2023 Feb 06 [Online ahead of print]Rossoni L, Lugani F, … La Porta E
  • We describe the unique case of a patient in whom two ciliopathies with autosomal recessive transmission were clinically and molecularly diagnosed: Nephronophthisis type1 (NPHP1) and Alström Syndrome (AS). NPHP1 is one of the main genetic causes of terminal kidney failure in childhood. AS is an ultra-rare multi-systemic disease, characterized by progressive kidney disease, hepatic failure, dystrop…
  • International evidence-based guidelines on hypertension and type 2 diabetes mellitus: A systematic review. [Review]
    J Public Health Res. 2023 Jan; 12(1):22799036221146913.Melichova J, Sivco P, … Majdan M
  • This systematic review provides a high-quality, comprehensive summary of recommendations on hypertension (HT) and type 2 diabetes mellitus (T2DM), accentuating patient blood pressure, HbA1c levels, patterns of drug treatment, management, and screening of these diseases. The overall objective of the review is to support adapting existing clinical practice guidelines in Indonesia, Vietnam, and Myan…
  • Type 2 diabetes mellitus, physical activity, and neuromusculoskeletal complications. [Journal Article]
    J Neurosci Rural Pract. 2022 Oct-Dec; 13(4):705-710.Jena D, Sahoo J, … Kumar S
  • CONCLUSIONS: Neuromusculoskeletal complications of T2DM are common and can result in significant disability in this population. Low PA is very common among T2DM patients and an important contributor to the development of complications. Health-care providers should consider PA an integral component of the management protocol for T2DM patients.
  • Preclinical evaluation of tolvaptan and salsalate combination therapy in a Pkd1-mouse model. [Journal Article]
    Front Mol Biosci. 2023; 10:1058825.Song X, Leonhard WN, … Peters DJM
  • Background: Autosomal dominant polycystic kidney disease (ADPKD) is the most common genetic disorder and an important cause of end stage renal disease (ESRD). Tolvaptan (a V2R antagonist) is the first disease modifier drug for treatment of ADPKD, but also causes severe polyuria. AMPK activators have been shown to attenuate cystic kidney disease. Methods: In this study, we tested the efficacy of t…
  • Exploring the Implications of New-Onset Diabetes in COVID-19: A Narrative Review. [Review]
    Cureus. 2023 Jan; 15(1):e33319.Pergolizzi J, LeQuang JAK, … Varrassi G
  • Post-viral new-onset diabetes has been an important feature of the COVID-19 pandemic. It is not always clear if new-onset diabetes is the unmasking of a previously undiagnosed condition, the acceleration of prediabetes, or new-onset diabetes that would not have otherwise occurred. Even asymptomatic cases of COVID-19 have been associated with new-onset diabetes. Diabetes that emerges during acute …
  • From worms to humans: Understanding intestinal lipid metabolism via model organisms. [Journal Article]
    Biochim Biophys Acta Mol Cell Biol Lipids. 2023 Feb 02 [Online ahead of print]Kozan DW, Derrick JT, … Farber SA
  • The intestine is responsible for efficient absorption and packaging of dietary lipids before they enter the circulatory system. This review provides a comprehensive overview of how intestinal enterocytes from diverse model organisms absorb dietary lipid and subsequently secrete the largest class of lipoproteins (chylomicrons) to meet the unique needs of each animal. We discuss the putative relati…
  • Clinical expert consensus on the assessment and protection of pancreatic islet β-cell function in type 2 diabetes mellitus. [Review]
    Diabetes Res Clin Pract. 2023 Feb 02 [Online ahead of print]Zhu J, Han J, … Pancreatic Islet β-cell Expert Panel of the Chinese Diabetes Society and Endocrinology Society of Jiangsu Medical Association
  • Islet β-cell dysfunction is a basic pathophysiological characteristic of type 2 diabetes mellitus. Appropriate assessment of islet β-cell function is beneficial to better management ofT2DM. Protecting islet β-cell function is vital to delay the progress of type 2 diabetes mellitus. Therefore, the Pancreatic Islet β-cell Expert Panel of the Chinese Diabetes Society and Endocrinology Society of Jia…
  • Diabetes mellitus: Lessons from COVID-19 for monkeypox infection. [Review]
    Prim Care Diabetes. 2023 Jan 30 [Online ahead of print]Ruiz-Pacheco JA, Castillo-Díaz LA, … Gómez-Navarro B
  • CONCLUSIONS: High incidence of diabetes together with the cessation of smallpox vaccination has left large numbers of the human population unprotected against monkeypox. The best option for the population remains confined to the prevention of infection as well as the use of hypoglycemic agents that have also been shown to improve immune mechanisms associated with viral protection.
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