- Effectiveness and safety of rectal dexibuprofen versus oral ibuprofen for closure of patent ductus arteriosus in preterm infants with gestational age<34 weeks: A pilot study. [Journal Article]Int J Immunopathol Pharmacol. 2023 Jan-Dec; 37:3946320231152993.IJ
- This pilot study aimed to explore the effectiveness and safety of dexibuprofen suppository in the treatment of PDA in preterm infants. Preterm infants with gestational age <34 weeks and color Doppler echocardiographic evidence of hemodynamically significant PDA (hs PDA) with systemic hypoperfusion was intended to be included into this study since January 2020. As of January 1, 2021, this trial ha…
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- Comparative evaluation of effect of different premedication agents on efficacy of Articaine: A randomized contol trial. [Journal Article]J Oral Biol Craniofac Res. 2023 Mar-Apr; 13(2):218-223.JO
- CONCLUSIONS: The results of the study showed that there is no significant effect of different premedication agents on the efficacy of 4% Articaine in teeth with symptomatic irreversible pulpitis.
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- Fixed Dose Versus Loose Dose: Analgesic Combinations. [Review]Cureus. 2023 Jan; 15(1):e33320.C
- Combinations of drugs may be fixed (two or more entities in a single product) or loose (two or more agents taken together but as individual agents) to help address multimechanistic pain. The use of opioids plus nonopioids can result in lower opioid consumption without sacrificing analgesic benefits. Drug combinations may offer additive or synergistic benefits. A variety of fixed-dose combination …
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- Synthesis of cerium oxide embedded perovskite type bismuth ferrite nanocomposites for sonophotocatalysis of aqueous micropollutant ibuprofen. [Journal Article]RSC Adv. 2023 Jan 11; 13(4):2574-2586.RA
- Ibuprofen is potentially toxic and carcinogenic for freshwater ecosystems and poses a serious threat to human health by affecting kidney function. The present study focused on the sunlight-controlled degradation of ibuprofen from water using a novel magnetically separable cerium oxide-embedded bismuth ferrite heterostructure. Catalysts were synthesized by solvothermal and co-precipitation methods…
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- Characterizing interspecies differences in gastric fluid properties to improve understanding of in vivo oral drug formulation performance. [Journal Article]Eur J Pharm Sci. 2023 Feb 01; 183:106386.EJ
- An in-depth understanding of the properties of gastric fluid(s) prior to an in vivo pharmacokinetic investigation can vastly improve predictions of in vivo performance. Previously, properties of animal and human gastric fluids have been characterized with varying methods. Unfortunately, characterization has often not been thorough, and some properties, such as density and viscosity, have not been…
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- Bio-Synthesis of TiO2 using Grape Leaves Extract and its Application for Photocatalytic Degradation of Ibuprofen from Aqueous Solution. [Journal Article]Environ Technol. 2023 Feb 03 [Online ahead of print]ET
- In this study, titanium oxide nanoparticle was fabricated using the extract of grape leaves (referred asGL-TiO2 NPs), using the green synthesis process, and then explores its ability for photodegradation of ibuprofen (IBU) under UV light in the batch system. UV-Vis, BET, FTIR, XRD, and SEM-EDX tests were made to identify the catalyst's structure and shape. Moreover, the effects of different opera…
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- [Effect of electroacupuncture intervention on relieving pain and inflammation by suppressing TLR4/NF-κB signaling in rats with primary dysmenorrhea]. [Journal Article]Zhen Ci Yan Jiu. 2023 Jan 25; 48(1):63-70.ZC
- CONCLUSIONS: EA intervention could relieve inflammatory response and pain in PDM rats, which may be related to its effect in reducing TLR4 expression, inhibiting NF-κB activation and down-regulating inflammatory factors levels of IL-1β and IL-18.
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- The efficacy of oral pain relief cocktail during pan-retinal photocoagulation for diabetic retinopathy: a randomized clinical trial. [Journal Article]
- CONCLUSIONS: No evidence of the pain-relieving effect of N, P or NP was found during PRP.
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- Vascular and pulmonary effects of ibuprofen on neonatal lung development. [Journal Article]Respir Res. 2023 Feb 02; 24(1):39.RR
- CONCLUSIONS: In conclusion, ibuprofen has dual effects on lung development: adverse effects on angiogenesis and beneficial effects on alveolarization and inflammation. Therefore, extrapolation of the beneficial effects of ibuprofen to premature infants with BPD should be done with extreme caution.
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- Variability in Pain Management Practices for Pediatric Anterior Cruciate Ligament Reconstruction. [Journal Article]J Pediatr Orthop. 2023 Jan 09 [Online ahead of print]JP
- CONCLUSIONS: Substantial variability exists in pain management practices in pediatric ACLR. There is a need for more evidence-based practice guidelines regarding pain management.
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- Masking the Taste of Fixed-Dose Combination Drugs: Particular NSAIDs Can Efficiently Mask the Bitterness of Famotidine. [Journal Article]Chem Pharm Bull (Tokyo). 2023; 71(2):148-153.CP
- This study aimed to evaluate the bitterness of famotidine (FAM) combined with each of three non-steroidal anti-inflammatory drugs (NSAIDs): ibuprofen (IBU), flurbiprofen (FLU), and naproxen (NAP), which have potential as fixed-dose combination (FDC) drugs. We evaluated the bitterness of FAM and each NSAID by taste sensor AN0 and C00, respectively. FAM showed high sensor output representing sensit…
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- Evaporation-induced fractal patterns: A bridge between uniform pattern and coffee ring. [Journal Article]J Colloid Interface Sci. 2023 Jan 24; 637:522-532.JC
- The rich variety of patterns induced by evaporating drops containing particles has significant guidance for coating processes, inkjet printing, and nanosemiconductors. However, most existing works construct a uniform pattern by suppressing the coffee ring effect, and establishing the connection between them is still an academic challenge.
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- Physicochemical Stability of the Extemporaneous Ibuprofen Oral Suspension in "Wagner" Base. [Journal Article]Int J Pharm Compd. 2023 Jan-Feb; 27(1):72-77.IJ
- This article discusses a new method for the preparation of extemporaneous ibuprofen-based suspensions for use in paediatric patients. This method allows the preparation of extemporaneous suspensions up to concentrations of 200 mg/5 mL by using a liquid base named "Wagner." A comprehensive physicochemical stability study was conducted on the formulation at a drug concentration of 200 mg/5 mL by pe…
- Formulation, Evaluation, and Characterization of Ibuprofen Nanocrystals Tablets with Conventional Market Product. [Journal Article]Int J Pharm Compd. 2023 Jan-Feb; 27(1):60-71.IJ
- The objective of this study was to prepare and evaluate ibuprofen nanocrystals using isopropyl alcohol and stabilizer sodium lauryl sulphate by way of the precipitation method. The nanocrystals were prepared by the bottom-up approach of the precipitation technique. This technique involves the use of an organic phase, which is completely miscible in the external aqueous phase. The ratio used for o…
- The analysis of reason for the presence and treatment of chronic inflammation of the paranasal sinuses in own material. [Journal Article]Otolaryngol Pol. 2023 Feb 03; 77(2):1-5.OP
- CONCLUSIONS: The main symptoms among patients with chronic inflammation of paranasal sinuses were: nasal congestion + rhinorrhea, nasal congestion + rhinorrhea + smell impairment and nasal congestion + rhinorrhea+ headache. The most common probable causes for chronic inflammation of nasal sinuses among the examined patients were: anatomical anomalies, allergies, irritant factors, including tobacco smoke. Depending on the assessment of the severity of changes in the paranasal sinuses according to the Lund- Mackay scale, it appears that medium and large inflammatory lesions prevailed in the examined patients.
- Repurposing some of the Well-Known Non-Steroid Anti-Inflammatory Drugs [Nsaids] for Cancer Treatment. [Journal Article]Curr Top Med Chem. 2023 Jan 30 [Online ahead of print]CT
- Drug repurposing is a strategy used to develop new treatments based on approved or investigational drugs outside the scope of their original clinical indication. Since this approach benefits from the original toxicity data of the repurposed drugs, the drug-repurposing strategy is time-saving, and inexpensive. It has a higher success rate compared to traditional drug discovery. Several repurposing…
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- Response of hepatic biochemical parameters and neurotoxicity to carbamazepine and ibuprofen in Oreochromis mossambicus. [Journal Article]Fish Physiol Biochem. 2023 Jan 30 [Online ahead of print]FP
- Globally, the prevalence and pollution of pharmaceutical drugs in aquatic environments have been steadily increasing. This study sought to evaluate the effects of 14 days of exposure to environmental-relevant doses (ibuprofen 0.5, 5, and 50 µg/L, and carbamazepine 0.005, 1, and 10 µg/L) of the nonsteroidal anti-inflammatory drugs ibuprofen and carbamazepine in the freshwater fish Oreochromis moss…
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- Interaction of Ibuprofen with Partially Unfolded Bovine Serum Albumin in the Presence of Ionic Micelles and Oligosaccharides at Different λex and pH: A Spectroscopic Analysis. [Journal Article]
- The interaction between the plasma protein bovine serum albumin (BSA) and the drug ibuprofen (IBU) has been investigated at three different pH values (7.4, 6.5, and 8.0) in the presence of oligosaccharides and surfactants. The interaction analysis of BSA with oligosaccharides and surfactants has also been studied in the absence of the drug ibuprofen. The results obtained give convenient and effic…
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- Does Facial Fracture Management Require Opioids? A Pilot Trial of a Narcotic-Minimizing Analgesia Protocol for Operative Facial Trauma. [Journal Article]J Craniofac Surg. 2023 Jan 30 [Online ahead of print]JC
- Opioid minimization in the acute postoperative phase is timely in the era of the opioid epidemic. The authors hypothesize that patients with facial trauma receiving multimodal, narcotic-minimizing pain management in the perioperative period will consume fewer morphine milligram equivalents (MMEs) while maintaining adequate pain control compared with a traditional analgesia protocol. An IRB-approv…
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- Pharmacokinetic and Pharmacodynamic Herb-Drug Interactions of Common Over-the-Counter Pain Medications. [Review]Biomed Chromatogr. 2023 Jan 29 [Online ahead of print]BC
- Pain is one of the most common reasons for seeking medical intervention, and self-medication with over-the-counter medications and/or traditional herbal remedies has become increasingly popular. In this review, original articles on understanding possible herb-drug interaction between traditional herbs and four major pain medication: acetaminophen, aspirin, ibuprofen, and naproxen were compiled an…
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- Chemical and biological tracers to identify source and transport pathways of septic system contamination to streams in areas with low permeability soils. [Journal Article]Sci Total Environ. 2023 Jan 26 [Online ahead of print]ST
- Septic systems are widely used in rural areas that lack centralized sewage treatment systems. Incomplete removal of domestic wastewater contaminants in septic systems can lead to leaching of nutrients (P and N), bacteria/viruses, and trace contaminants to surrounding groundwater and surface water. This study focuses on delineating the fate of wastewater contaminants in localities in which septic …
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- Nonsteroidal anti-inflammatory drugs (NSAIDs) and nucleotide analog GS-441524 conjugates with potent in vivo efficacy against coronaviruses. [Journal Article]
- Coronaviruses (CoVs) infect a broad range of hosts, including humans and various animals, with a tendency to cross the species barrier, causing severe harm to human society and fostering the need for effective anti-coronaviral drugs. GS-441524 is a broad-spectrum antiviral nucleoside with potent anti-CoVs activities. However, its application is limited by poor oral bioavailability. Herein, we des…
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- Efficacy of Different Ibuprofen Formulations with Two Prescription Methods on Post Endodontic Pain of Teeth with Irreversible Pulpitis: A Randomized Clinical Trial. [Journal Article]
- CONCLUSIONS: Based on this randomized clinical trial, there was no significant difference in the pain intensity of patients using ibuprofen and ibuprofen lysine. Additionally, there was no significant difference in the degree of pain between the on-demand and regular groups, despite the fact that patients in the on-demand group used less medications. Due to the multiple negative effects of NSAIDs, it would be wise to prescribe ibuprofen on demand.
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- Comparing the Efficacy of Premedication with Ibuprofen in Combination with an Inferior Alveolar Nerve Block and Primary Buccal Infiltration in Mandibular Molars with Irreversible Pulpitis: A Triple-blinded Randomized Clinical Trial. [Journal Article]
- CONCLUSIONS: Based on this triple-blinded randomized clinical study, mandibular molars with irreversible pulpitis were not thoroughly anesthetized by a combination of IANB+BI after premedication with ibuprofen (600 mg), even though anesthesia success was improved significantly by ibuprofen premedication.
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- Twin Screw Melt Granulation: Alternative Approach for Improving Solubility and Permeability of a Non-steroidal Anti-inflammatory Drug Ibuprofen. [Journal Article]AAPS PharmSciTech. 2023 Jan 26; 24(1):47.AP
- The current research is focused on investigating the suitability of the twin screw melt granulation (TSMG) approach for improving the solubility of a non-steroidal anti-inflammatory (NSAIDs) drug (ibuprofen), by developing granules using lipid surfactants. The solubility of the drug within the solid lipid excipients (Gelucire® 48/16 and Gelucire® 50/13) was determined by differential scanning cal…
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- Anti-inflammatory Therapy Protects Spiral Ganglion Neurons After Aminoglycoside Antibiotic-Induced Hair Cell Loss. [Journal Article]Neurotherapeutics. 2023 Jan 25 [Online ahead of print]N
- Destruction of cochlear hair cells by aminoglycoside antibiotics leads to gradual death of the spiral ganglion neurons (SGNs) that relay auditory information to the brain, potentially limiting the efficacy of cochlear implants. Because the reasons for this cochlear neurodegeneration are unknown, there are no neuroprotective strategies for patients. To investigate this problem, we assessed transcr…
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- Anxiolytic and anticonvulsant effect of Ibuprofen derivative through GABAergic neuromodulation in adult Zebrafish. [Journal Article]J Biomol Struct Dyn. 2023 Jan 25 [Online ahead of print]JB
- Anxiety and epilepsy affect millions of people worldwide, and the treatment of these pathologies involves the use of Benzodiazepines, drugs that have serious adverse effects such as dependence and sedation, so the discovery of new anxiolytic and antiepileptic drugs are necessary. Many routes for synthesizing ibuprofen derivatives have been developed, and these derivatives have shown promising pha…
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- Element- and enantiomer-selective visualization of molecular motion in real-time. [Journal Article]
- Ultrafast optical-domain spectroscopies allow to monitor in real time the motion of nuclei in molecules. Achieving element-selectivity had to await the advent of time resolved X-ray spectroscopy, which is now commonly carried at X-ray free electron lasers. However, detecting light element that are commonly encountered in organic molecules, remained elusive due to the need to work under vacuum. He…
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- Risk of COVID-19 Diagnosis and Hospitalisation in Patients with Osteoarthritis or Back Pain Treated with Ibuprofen Compared to Other NSAIDs or Paracetamol: A Network Cohort Study. [Journal Article]
- CONCLUSIONS: In patients with osteoarthritis or back pain, we found no differential risks of incident COVID-19 diagnosis or COVID-19 hospitalisation for ibuprofen users compared with other ns-NSAIDs, COX-2i or paracetamol. Our findings support regulatory recommendations that NSAIDs, including ibuprofen, should be prescribed as indicated in the same way as before the COVID-19 pandemic, especially for those who rely on ibuprofen or NSAIDs to manage chronic arthritis or musculoskeletal pain symptoms.
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- Effects of chemical compounds on the activity of the N-Acetyl-β-D-Glucosaminidase of the marine prawn, Palaemon serratus: screening in vitro. [Journal Article]Environ Toxicol Chem. 2023 Jan 24 [Online ahead of print]ET
- N-acetyl-β-D-Glucosaminidase (NAGase) is important for crustaceans as the enzyme activity is necessary for the moulting process. The present study aimed to assess the sensitivity of the Palaemon serratus NAGase activity to a set of compounds of diverse chemical families, in a context of in vitro exposures. Compounds representing different chemical families were selected according to their abundan…
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