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13,276 results
  • Evidence of the impact of systemic inflammation on neuroinflammation from a non-bacterial endotoxin animal model. [Journal Article]
  • JNJ Neuroinflammation 2018 May 17; 15(1):147
  • Huang C, Irwin MG, … Chang RCC
  • CONCLUSIONS: Our results suggest that (1) cognitive dysfunction is associated with an unbalanced pro-inflammatory and anti-inflammatory response, tauopathy, and gliosis; (2) cognitive dysfunction, gliosis, and tauopathy following laparotomy can persist well beyond the immediate postoperative period; and (3) anti-inflammatory drugs can act rapidly to attenuate inflammatory responses in the brain and negatively modulate neuropathological changes to improve cognition. These findings may have implications for the duration of therapeutic strategies aimed at curtaining cognitive dysfunction following surgery.
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