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17,268 results
  • Fixed Dose Versus Loose Dose: Analgesic Combinations. [Review]
    Cureus. 2023 Jan; 15(1):e33320.Pergolizzi J, Varrassi G, … Magnusson P
  • Combinations of drugs may be fixed (two or more entities in a single product) or loose (two or more agents taken together but as individual agents) to help address multimechanistic pain. The use of opioids plus nonopioids can result in lower opioid consumption without sacrificing analgesic benefits. Drug combinations may offer additive or synergistic benefits. A variety of fixed-dose combination …
  • Vascular and pulmonary effects of ibuprofen on neonatal lung development. [Journal Article]
    Respir Res. 2023 Feb 02; 24(1):39.Chen X, Han D, … Wagenaar GTM
  • CONCLUSIONS: In conclusion, ibuprofen has dual effects on lung development: adverse effects on angiogenesis and beneficial effects on alveolarization and inflammation. Therefore, extrapolation of the beneficial effects of ibuprofen to premature infants with BPD should be done with extreme caution.
  • Evaporation-induced fractal patterns: A bridge between uniform pattern and coffee ring. [Journal Article]
    J Colloid Interface Sci. 2023 Jan 24; 637:522-532.Wang F, Yuan Q
  • The rich variety of patterns induced by evaporating drops containing particles has significant guidance for coating processes, inkjet printing, and nanosemiconductors. However, most existing works construct a uniform pattern by suppressing the coffee ring effect, and establishing the connection between them is still an academic challenge.
  • Physicochemical Stability of the Extemporaneous Ibuprofen Oral Suspension in "Wagner" Base. [Journal Article]
    Int J Pharm Compd. 2023 Jan-Feb; 27(1):72-77.Spennacchio A, Lopedota A, … Denora N
  • This article discusses a new method for the preparation of extemporaneous ibuprofen-based suspensions for use in paediatric patients. This method allows the preparation of extemporaneous suspensions up to concentrations of 200 mg/5 mL by using a liquid base named "Wagner." A comprehensive physicochemical stability study was conducted on the formulation at a drug concentration of 200 mg/5 mL by pe…
  • The analysis of reason for the presence and treatment of chronic inflammation of the paranasal sinuses in own material. [Journal Article]
    Otolaryngol Pol. 2023 Feb 03; 77(2):1-5.Ratajczyk-Socha N, Olszewski J
  • CONCLUSIONS: The main symptoms among patients with chronic inflammation of paranasal sinuses were: nasal congestion + rhinorrhea, nasal congestion + rhinorrhea + smell impairment and nasal congestion + rhinorrhea+ headache. The most common probable causes for chronic inflammation of nasal sinuses among the examined patients were: anatomical anomalies, allergies, irritant factors, including tobacco smoke. Depending on the assessment of the severity of changes in the paranasal sinuses according to the Lund- Mackay scale, it appears that medium and large inflammatory lesions prevailed in the examined patients.
  • Repurposing some of the Well-Known Non-Steroid Anti-Inflammatory Drugs [Nsaids] for Cancer Treatment. [Journal Article]
    Curr Top Med Chem. 2023 Jan 30 [Online ahead of print]Sousa SM, Xavier CPR, … Palmeira A
  • Drug repurposing is a strategy used to develop new treatments based on approved or investigational drugs outside the scope of their original clinical indication. Since this approach benefits from the original toxicity data of the repurposed drugs, the drug-repurposing strategy is time-saving, and inexpensive. It has a higher success rate compared to traditional drug discovery. Several repurposing…
  • Pharmacokinetic and Pharmacodynamic Herb-Drug Interactions of Common Over-the-Counter Pain Medications. [Review]
    Biomed Chromatogr. 2023 Jan 29 [Online ahead of print]Sun CK, Tsai TH
  • Pain is one of the most common reasons for seeking medical intervention, and self-medication with over-the-counter medications and/or traditional herbal remedies has become increasingly popular. In this review, original articles on understanding possible herb-drug interaction between traditional herbs and four major pain medication: acetaminophen, aspirin, ibuprofen, and naproxen were compiled an…
  • Element- and enantiomer-selective visualization of molecular motion in real-time. [Journal Article]
    Nat Commun. 2023 Jan 24; 14(1):386.Mincigrucci R, Rouxel JR, … Masciovecchio C
  • Ultrafast optical-domain spectroscopies allow to monitor in real time the motion of nuclei in molecules. Achieving element-selectivity had to await the advent of time resolved X-ray spectroscopy, which is now commonly carried at X-ray free electron lasers. However, detecting light element that are commonly encountered in organic molecules, remained elusive due to the need to work under vacuum. He…
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