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13,485 results
  • Acetaminophen, ibuprofen, and tramadol analgesic interactions after adenotonsillectomy. [Journal Article]
  • PAPaediatr Anaesth 2018 Aug 16
  • Hannam JA, Anderson BJ, Potts A
  • CONCLUSIONS: Ibuprofen has an EC50 for analgesia in children similar to that of adults (3.95 mg/L; 95%CI 2.57-7.53, vs 5-10 mg/L adults). The maximum effect from combination therapy (ie, 65% reduction in pain score) achieves satisfactory analgesia with commonly used doses but increased dose adds little additional benefit. The addition of tramadol to this analgesic mixture prolongs analgesia duration.
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