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(AeroBid M)
14 results
  • In Silico Drug Repurposing in Multiple Sclerosis Using scRNA-Seq Data. [Journal Article]
    Int J Mol Sci. 2023 Jan 04; 24(2)Shevtsov A, Raevskiy M, … Medvedeva Y
  • Multiple sclerosis (MS) is an autoimmune disease of the central nervous system still lacking a cure. Treatment typically focuses on slowing the progression and managing MS symptoms. Single-cell transcriptomics allows the investigation of the immune system-the key player in MS onset and development-in great detail increasing our understanding of MS mechanisms and stimulating the discovery of the t…
  • Drugs and Lactation Database (LactMed): Flunisolide [BOOK]
    Drugs and Lactation Database (LactMed). National Library of Medicine (US): Bethesda (MD)BOOK
  • Although not measured, the amounts of inhaled corticosteroids absorbed into the maternal bloodstream and excreted into breastmilk are probably too small to affect a breastfed infant. Reviewers and an expert panel consider inhaled and oral corticosteroids acceptable to use during breastfeeding.[1][2][3]
  • Flunisolide for the treatment of asthma. [Review]
    Expert Rev Clin Pharmacol. 2014 May; 7(3):251-8.Melani AS
  • Inhaled corticosteroids (ICSs) are recommended for treatment of persistent asthma. Several ICSs are available and delivered by a variety of devices. After the banning of chlorofluorocarbon (CFC), a formulation of hydrofluoroalkane (HFA)-flunisolide marketed with an in-built spacer has been developed, complying with the request of efficacy and safety for children and adults. It delivers an aerosol…
  • Bronchodilators and corticosteroids in the treatment of asthma. [Journal Article]
    Drugs Today (Barc). 1998 Mar; 34(3):203-23.Vianna EO, Martin RJ
  • Despite advancements in treatment, the incidence of asthma, asthma-related deaths and hospitalizations for asthma have increased significantly during the past decade. Although asthma mortality may now be decreasing, reasons for the worsening of morbidity and mortality in asthma remain unclear. These unexpected changes in asthma severity have sparked renewed interest in research into the pathogene…
  • Systemic effect comparisons of six inhaled corticosteroid preparations. [Randomized Controlled Trial]
    Am J Respir Crit Care Med. 2002 May 15; 165(10):1377-83.Martin RJ, Szefler SJ, … Sorkness CA
  • The goal of this study was to establish a reliable method to evaluate systemic bioavailability and to determine equisystemic effects (microgram dose producing equal systemic cortisol suppression) of inhaled corticosteroids (ICS). Steroid naive asthma subjects (n = 156) were enrolled at six centers. A 1-week doubling dose design was used for each of six ICS and matched placebos for a total of four…
  • Time dependent effects of glucocorticoids on adrenocorticotropin secretion of rat pituitaries ex-vivo. [Journal Article]
    J Pharm Pharmacol. 2000 Jan; 52(1):93-8.Bruns R, Rohdewald P
  • Different glucocorticoids have been compared with respect to the inhibition of corticotropin-releasing factor (CRF)-mediated adrenocorticotropin (ACTH) secretion from pituitary fragments of the rat. The influence of time of exposure to glucocorticoids and glucocorticoid concentration has been investigated. CRF-stimulated ACTH secretion of perifused rat pituitary fragments was measured by a chemil…
  • Treatment of perennial rhinitis with flunisolide corticosteroid spray. [Randomized Controlled Trial]
    Ann Allergy. 1979 Mar; 42(3):139-44.Jones LM, Spector SL, … Taylor-Dawson K
  • Flunisolide nasal spray was compared to its propylene and polyethylene glycol vehicle in a randomized double-blind study of 20 adult patients with perennial rhinitis. After a two-week baseline period patients received either active flunisolide 50 microgram q.i.d. or placebo for four weeks. Laboratory studies included serum 8 a.m. cortisols, nasal air-flow measurements and nasal smears for eosinop…
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