- Characterization of a glutamate-cysteine ligase in Bombyx mori. [Journal Article]Mol Biol Rep. 2023 Jan 13 [Online ahead of print]MB
- Glutamate-cysteine ligase (GCL) is a crucial enzyme involved in the synthesis of glutathione (GSH). Despite various studies on glutathione transferase, and its essential role in detoxification and resistance to oxidative stress, GSH synthesis has not been described in Bombyx mori (silkworms) to date. Silkworms form part of the lepidopterans that are considered as a model of agricultural pests. Th…
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- Production of active Exendin-4 in Nicotiana benthamiana and its application in treatment of type-2 diabetics. [Journal Article]
- GLP-1 (Glucagon-like peptide-1) is a peptide that stimulates insulin secretion from the β-cell for glycemic control of the plasma blood glucose level. Its mimetic exenatide (synthetic Exendin-4) with a longer half-life of approximately 3.3-4 h is widely used in clinical application to treat diabetes. Currently, exenatide is chemically synthesized. In this study, we report that the GLP-1 analogue …
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- Antibacterial Effects of Henna (Lawsonia inermis) Leaf Extracts (Chloroform) Against Two Food Borne and Nosocomial Infection Causing Pathogens: Staphylococcus aureus and Escherichia coli. [Journal Article]Mymensingh Med J. 2023 Jan; 32(1):83-89.MM
- Evaluation of the in vitro antibacterial activity of Chloroform extracts isolated from Henna (Lawsonia inermis) leaf against two food born & nosocomial infection causing pathogens, gram-positive Staphylococcus aureus and gram-negative Escherichia coli. This interventional study was carried out during the period of January 2021 to December 2021 in the Department of Pharmacology and Therapeutics in…
- Neurochemical phenotypes of huntingtin-associated protein 1 in reference to secretomotor and vasodilator neurons in the submucosal plexuses of rodent small intestine. [Journal Article]Neurosci Res. 2022 Dec 26 [Online ahead of print]NR
- Huntingtin-associated protein 1(HAP1) is an immunohistochemical marker of the stigmoid body (STB). Brain and spinal cord regions with lack of STB/HAP1 immunoreactivity are always neurodegenerative targets, whereas STB/HAP1 abundant regions are usually spared from neurodegeneration. In addition to the brain and spinal cord, HAP1 is abundantly expressed in the excitatory and inhibitory motor neuron…
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- Role of Environmental Sustainability, Psychological and Managerial Supports for Determining Bankers' Green Banking Usage Behavior: An Integrated Framework. [Journal Article]
- CONCLUSIONS: The study contributed to existing literature validating the proposed holistic framework applying TRA and three contemporary dimensions explaining bankers' behavior toward green banking practice. Finally, the implementers should focus on green banking practices as green banking is one of the key strategies to protect the environment, assure social justice, and create economic success.
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- Framing of COVID-19 in Newspapers: A Perspective from the US-Mexico Border. [Journal Article]
- The degree to which the media report a health emergency affects the seriousness with which the people respond to combat the health crisis. Engagement from local newspapers in the US has received scant scrutiny, even though there is a sizable body of scholarship on the analysis of COVID-19 news. We fill this void by focusing on the Rio Grande Valley area of the US-Mexico border. To understand the …
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- Knowledge, attitudes and practices (KAP) of street food vendors on food safety in selected areas of Bangladesh. [Journal Article]
- This study determined the food-safety situation of street food by analyzing the KAP of street food vendors (SFVs). A quantitative descriptive cross-sectional study was conducted among the 266 SFVs through structured questionnaire from October to December, 2020. Majority of the SFVs were male (92.86%), age between 35 to 44 years (34.21%), married (83.83%), had primary education (46.99%), experienc…
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- Exploring the role of the endogenous opiate system in the pathogenesis of anemia in an opiate receptor knock-out model of Restless Legs Syndrome. [Journal Article]
- Restless Legs Syndrome (RLS) is characterized by bothersome leg discomfort accompanied by an urge to move to obtain relief and symptoms are worse at night and on lying down. There is at least partial and temporary relief with activity. It is also an opioid responsive disorder, often accompanied by iron deficiency with or without anemia, and inflammation may be a precipitating factor in some cases…
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- Participatory approaches in primary health care related implementation research in low-and middle-income countries: A narrative review. [Review]
- CONCLUSIONS: This review reveals the gap in implementation research incorporating participatory approaches in the field of PHC. Limited studies have been conducted which indicate the need and scope of implementation research with participatory approaches in the PHC field.
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- Improvement of dermatological symptoms in patients with Bachmann-Bupp syndrome using difluoromethylornithine treatment. [Case Reports]Pediatr Dermatol. 2022 Nov 28 [Online ahead of print]PD
- Bachmann-Bupp syndrome (OMIM #619075) is a novel autosomal dominant disorder caused by variants in the c-terminus of the ornithine decarboxylase 1 gene, resulting in increased levels of ornithine decarboxylase. This case report includes two patients diagnosed with Bachmann-Bupp syndrome who were treated with difluoromethylornithine through compassionate use approval from the United States Food an…
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- Clinically Relevant Drug Interactions with Monoamine Oxidase Inhibitors. [Journal Article]
- Monoamine oxidase inhibitors (MAOI) are a class of drugs that were originally developed for the treatment of depression but have since been expanded to be used in management of affective and neurological disorders, as well as stroke and aging-related neurocognitive changes. Ranging from irreversible to reversible and selective to non-selective, these drugs target the monoamine oxidase (MAO) enzym…
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- Author reply. [Letter]Intern Med J. 2022 Nov; 52(11):2018.IM
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- Naphazoline and oxymetazoline are superior to epinephrine in enhancing the cutaneous analgesia of lidocaine in rats. [Journal Article]Fundam Clin Pharmacol. 2022 Nov 17 [Online ahead of print]FC
- This study observed the cutaneous analgesic effect of adrenergic agonists when combined with lidocaine. We aimed at the usefulness of four adrenergic agonists and epinephrine as analgesics or as tools to prolong the effect of local anesthetics using a model of cutaneous trunci muscle reflex (pinprick pain) in rats. We showed that subcutaneous four adrenergic agonists and epinephrine, as well as t…
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- Introducing a Novel Combination Therapy with Macrolides for the Treatment of Chronic Rhinosinusitis: A Randomized Controlled Trial. [Randomized Controlled Trial]
- CONCLUSIONS: In combination with conventional therapies for CRS in adults, a four-week course of treatment with azithromycin is more effective than clarithromycin.Trial Registration Number: IRCT20201209049661N1.
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- Identification and quantification of microplastics in agricultural farmland soil and textile sludge in Bangladesh. [Journal Article]Sci Total Environ. 2023 Feb 01; 858(Pt 3):160118.ST
- Although microplastic (MP) pollution of aquatic ecosystems is a high-priority study topic, the issue of terrestrial environment and textile manufacturing waste has received little attention. Thus, this study was carried out to investigate the presence of MPs in agricultural land near textile industries and textile sludge samples in Bangladesh. Thirty-two soil samples from four agricultural farmla…
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- Effectiveness of Skill-Building Interventions for Informal Caregivers of Adults with Cancer: a Systematic Review. [Review]
- Over 19 million people worldwide were diagnosed with cancer in 2020. Informal caregivers of adults with cancer play an important role in helping their loved ones with cancer yet often receive little support in developing the necessary skills for caregiving. A systematic review of skill-building interventions for informal caregivers of adults with cancer was conducted across three electronic datab…
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- Advances in pharmacotherapy for rosacea: what is the current state of the art? [Review]Expert Opin Pharmacother. 2022 Nov; 23(16):1845-1854.EO
- Rosacea is a chronic and relapsing facial dermatosis that encompasses a wide spectrum of clinical phenotypes (transient/persistent erythema, telangiectasias, papules/pustules, edema, phymatous changes, and ocular symptoms) often with uncomfortable symptoms such as flushing, pain, burning, edema, and dryness. Current pharmacological treatment includes topical agents, spanning from several conventi…
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- Conceptualization of head-heart-hands model for developing an effective 21st century teacher. [Review]
- Celebrities, athletes and even politicians are frequently identified as role models for most impressionable students. But the reality is, outside of their own home, one of the greatest role models in a student's life is standing in front of the classroom. Teachers are people to look up to and emulate. This paper attempts to discover some of the essential qualities and skills that would help teach…
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- NetRank Recovers Known Cancer Hallmark Genes as Universal Biomarker Signature for Cancer Outcome Prediction. [Journal Article]
- Gene expression can serve as a powerful predictor for disease progression and other phenotypes. Consequently, microarrays, which capture gene expression genome-wide, have been used widely over the past two decades to derive biomarker signatures for tasks such as cancer grading, prognosticating the formation of metastases, survival, and others. Each of these signatures was selected and optimized f…
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- A Prospective, Randomized, Double-Blind Study on the Efficacy of Different Modes of Topical Application of Nasal Anesthetics in the Diagnostic Nasal Endoscopy Procedure. [Journal Article]
- Introduction In the current otorhinolaryngology practice, technology has always been an essential part. Therefore, diagnostic nasal endoscopy (DNE) has become a vital examination in today's practice. In order to visualize the nasal cavity in a systematic manner without any discomfort to both patient and doctor, the nose should be well anesthetized and decongested. Objective The study is to compar…
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- Can oxymetazoline simulate the outcomes of septoplasty and inferior turbinate reduction surgery? [Journal Article]Int Forum Allergy Rhinol. 2022 Oct 18 [Online ahead of print]IF
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- Combinations of Pilocarpine and Oxymetazoline for the Pharmacological Treatment of Presbyopia: Two Randomized Phase 2 Studies. [Journal Article]
- CONCLUSIONS: On the basis of the results of the 2 Phase 2 studies, AGN-190584, a reading drop containing an optimized concentration of pilocarpine HCl (1.25%) delivered using a proprietary formulation, was developed and is currently under investigation in Phase 3 studies.
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- COVID-19 hospitalization with later long COVID in a person with Down syndrome. [Case Reports]
- Viruses that induce pulmonary difficulties and auto-inflammation are more common in people with Down syndrome. They also have a higher number of comorbidities associated with a worse prognosis than the overall population. Adult patients with acute COVID-19 are increasingly being diagnosed with Long COVID. However, patients with Down syndrome with later long COVID-19 are the first example document…
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- Benefits and safety of Oxymetazoline cream 1% on rosacea-associated erythema: A systematic review and analysis of clinical evidence. [Review]J Cosmet Dermatol. 2023 Jan; 22(1):103-110.JC
- CONCLUSIONS: These real-world data on Oxymetazoline cream 1% in rosacea-associated erythema may help making clinic decision and informing treatment expectations, and more clinic trials on longer-term dosing or the combination treatment with oral medication and energy-based therapy are worth exploring.
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- Construction of the active aging index in Bangladesh: challenges and opportunities. [Journal Article]
- CONCLUSIONS: Effective initiatives are needed to improve the individual scores of each of the three dimensions of the AAI. Attention should be given to addressing the gender and residential variations in all three dimensions of the AAI. The incorporation of indicator-specific measures is essential to the existing plan of action and programs to improve the situation of the older population that is poorly and moderately active. This result will help policymakers from concerned ministries to focus on specific dimensions to improve the AAI situation in the country. A nationally representative study is needed regularly to monitor the AAI situation.
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- Effects of Moringa oleifera on working memory: an experimental study with memory-impaired Wistar rats tested in radial arm maze. [Journal Article]
- Memory impairment is a serious problem that has a significant negative impact on survival and quality of life. When used for a long time, drugs used to treat memory loss become less effective and have more side effects, making therapy more difficult. Different medicinal plants are now being highlighted because of their valuable applications and low risk of adverse effects. Moringa oleifera is one…
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- Adipocyte coculture induces a pro-inflammatory, fibrotic, angiogenic, and proliferative microenvironment in uterine leiomyoma cells. [Journal Article]
- CONCLUSIONS: Adipocytes release inflammatory, fibrotic, and angiogenic factors, along with FFAs, which contribute to a tumor-friendly microenvironment that may promote leiomyoma growth and can represent a new target for leiomyoma prevention and treatment.
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- Polymerase chain reaction-based snake origin tracing in commercial venom crystals by targeting the mitochondrial D-loop. [Journal Article]Toxicon. 2022 Nov; 219:106933.T
- Snake venom is a valuable raw material for numerous therapeutic formulations because of its life-saving pharmacological potential. However, due to their high price, fake "snake venoms" have captured a significant portion of the global market, and there is currently no reliable reported DNA-based method available for quickly distinguishing between fakes and originals. Therefore, in this study, a s…
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- Detection of Leptin Using Electrocatalyst Mediated Impedimetric Sensing. [Journal Article]ACS Biomater Sci Eng. 2022 Sep 23 [Online ahead of print]AB
- Obesity is a complex disorder associated with immense health consequences including high risk of cardiovascular diseases, diabetes, and cancer. Abnormality in the thyroid gland, genetics, less physical activity, uptake of excessive diet, and leptin resistance are critical factors in the development of obesity. To determine the treatment strategy, understanding the pathophysiology of obesity is cr…
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- Planetary Health Education and Capacity Building for Healthcare Professionals in a Global Context: Current Opportunities, Gaps and Future Directions. [Review]
- The emerging concept of planetary health needs to be discussed in a more organized and sustainable way within the global public health and healthcare disciplines. Therefore, planetary health should be considered a cardinal component of the global academic framework for healthcare professionals. The availability of related curricula and courses is crucial to equip health professionals in this rela…
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