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289 results
  • Nanoliposome-loaded antifungal drugs for dermal administration: A review. [Journal Article]
    Curr Med Mycol. 2021 Mar; 7(1):71-78.Asadi P, Mehravaran A, … Akhtari J
  • Cutaneous fungal infections are the fourth most common health problem, which involves approximately one billion people worldwide. Drug delivery to the skin seems to be the best choice for superficial fungal infections. Topical formulations can release a sufficient amount of drug in therapeutical concentrations and permeate higher layers of the skin like the stratum corneum. As the outermost layer…
  • Tolnaftate inhibits ergosterol production and impacts cell viability of Leishmania sp. [Journal Article]
    Bioorg Chem. 2020 09; 102:104056.Yamamoto ES, de Jesus JA, … Passero LFD
  • Leishmaniasis is an infectious disease caused by protozoan parasites of the genus Leishmania. The treatment of all forms of leishmaniasis relies on first-line drug, pentavalent antimonial, and in cases of drug failure, the second-line drug amphotericin B has been used. Besides the high toxicity of drugs, parasites can be resistant to antimonial in some areas of the World, making it necessary to p…
  • UPLC-based assay to assess the hydrophobicity of Antibody-Drug Conjugate (ADC) payloads. [Journal Article]
    J Chromatogr B Analyt Technol Biomed Life Sci. 2020 Jun 01; 1146:122075.Pysz I, Jackson PJM, … Thurston DE
  • Antibody-Drug Conjugates (ADCs) consist of antibodies attached to cytotoxic small molecules or biological agents (i.e., payloads) through chemical linkers which may be cleavable or non-cleavable. The development of new ADCs is challenging, particularly the process of attaching the linker-payload construct to the antibody (i.e., the conjugation process). One of the major problems associated with c…
  • Drugs and Lactation Database (LactMed): Tolnaftate [BOOK]
    Drugs and Lactation Database (LactMed). National Library of Medicine (US): Bethesda (MD)BOOK
  • Topical tolnaftate has not been studied during breastfeeding and no data are available on the extent of its absorption after topical application. Because it is probably poorly absorbed after topical application, it is considered a low risk to the nursing infant. Avoid application to the nipple area and ensure that the infant's skin does not come into direct contact with the areas of skin that hav…
  • Naphthalene, a versatile platform in medicinal chemistry: Sky-high perspective. [Review]
    Eur J Med Chem. 2019 Jan 01; 161:252-276.Makar S, Saha T, Singh SK
  • Naphthalene, a cytotoxic moiety, is an extensively explored aromatic conjugated system with applications in various pathophysiological conditions viz. anticancer, antimicrobial, anti-inflammatory, antiviral, antitubercular, antihypertensive, antidiabetic, anti-neurodegenerative, antipsychotic, anticonvulsant, antidepressant. Naphthalene epoxides and naphthoquinones are most reactive metabolites o…
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